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TEX28 Gene

protein-coding   GIFtS: 47

GC0XM142075
testis expressed 28
(Previous name: chromosome X open reading frame 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CXorf2)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
testis expressed 281 2
fTEX1 2
CXorf22 3
chromosome X open reading frame 21
testis-specific protein TEX282

External Ids:    HGNC: 25631   Entrez Gene: 15272   Ensembl: ENSG000001852547   UniProtKB: O154823   

Export aliases for TEX28 gene to outside databases

Previous GC identifers: GC0XM153154 GC0XM153498


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TEX28
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TEX28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TEX28 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

TEX28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TEX28 gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM142075:  view genomic region     (about GC identifiers)

Start:
142,075,136 bp from pter
End:
142,100,672 bp from pter
Size:
25,537 bases
Orientation:
minus strand

1 alternative location:
ChrX- 153,498,930-153,523,796     
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TEX28_HUMAN, O15482 (See protein sequence)
Recommended Name: Testis-specific protein TEX28  
Size: 410 amino acids; 46131 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: B1B1E8 D3DWW5

Explore the universe of human proteins at neXtProt for TEX28: NX_O15482 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001577.1  

    ENSEMBL proteins: 
    ENSP00000358942 ENSP00000355323 ENSP00000406419 ENSP00000388810 


    Human Recombinant Proteins 
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    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular ----
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane NAS--
    About this table

    TEX28 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TEX28 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TEX28 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR017387 Testis-specific_TEX28
     IPR019394 Predicted_TM_coiled-coil_2

    Graphical View of Domain Structure for InterPro Entry O15482

    ProtoNet protein and cluster: O15482

    UniProtKB/Swiss-Prot: TEX28_HUMAN, O15482
    Similarity: Belongs to the TEX28 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for TEX28
    Sigma-Aldrich shRNA for TEX28
    OriGene 29mer shRNA kits in GFP-retroviral vector: TEX28
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    OriGene siRNA: TEX28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TEX28 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TEX28 
    Search SABiosciences for Assays for microRNAs that regulate TEX28

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TEX28
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TEX28
    OriGene untagged cDNA clones in CMV expression vector: TEX28
    Browse 3'-UTR reporter clones for miRNA target validation 
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TEX28 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674 molecular_function ND--
    About this table

    TEX28 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for TEX28 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TEX28

    1 Interacting protein for TEX28 (O154822) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EPS8Q129292MINT-68345
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction ----
    GO:0008150 biological_process ND--
    About this table

    TEX28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TEX28


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for TEX28
    Sigma-Aldrich shRNA for TEX28
    OriGene 29mer shRNA kits in GFP-retroviral vector: TEX28
    OriGene shRNA RFP: TEX28
    OriGene basic RS shRNA: TEX28
    OriGene siRNA: TEX28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TEX28 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TEX28 
    Search SABiosciences for Assays for microRNAs that regulate TEX28
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TEX28
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TEX28
    OriGene untagged cDNA clones in CMV expression vector: TEX28
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: TEX28 
    Primers: OriGene genome-wide validated SYBR primer pairs: TEX28
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TEX28: PPH11308A

    REFSEQ mRNAs for TEX28 gene: 

    NM_001586.1  

    Additional cDNA sequence: 

    BC026183.1 DQ655913.2 U93720.1 

    2 DOTS entries:

    DT.304154  DT.95288742 

    10 AceView cDNA sequences:

    BI825689 NM_001586 U93720 BI826964 BX280786 BM728212 BC026183 BI459565 
    BM681381 AW629285 

    Unigene Cluster for TEX28:

    Testis expressed 28
    Hs.672606  [show with all ESTs]
    Unigene Representative Sequence: BC026183


    GeneLoc Exon Structure

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369926(uc004fkf.2 uc010nut.1) ENST00000361930(uc004fke.2)
    ENST00000428625 ENST00000439665

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TEX28 expression in normal and diseased human tissues

    1  / 2

    3 probe-sets matching TEX28 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    31715_at2 U95-A 3 0.62 0.56 1.00 1.00 -- -- -- -- --
    207364_at2 U133-A 3 0.82 0.63 -- -- -- -- -- -- --
    207364_at2 U133Plus2 3 0.82 0.63 -- -- -- -- -- -- --
    About this table

    TEX28 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TEX28 gene expression
    TEX28 gene electronic northern expression
    TEX28 gene sage expression
    About these images

    CGAP SAGE TAG: CTGATGCTGA

    SOURCE GeneReport for Unigene cluster: Hs.672606

    UniProtKB/Swiss-Prot: TEX28_HUMAN, O15482
    Tissue specificity: Testis specific

    Primers: OriGene genome-wide validated SYBR primer pairs: TEX28
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TEX28: PPH11308A
        SABiosciences Custom PCR Arrays for TEX28 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TEX28 gene from 5 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TEX281   -- testis expressed 28 76.68(n)
    64.04(a)
    492248  XM_549368.1  XP_549368.1 
    chimpanzee
    (Pan troglodytes)
    TEX281   -- testis expressed 28 99.51(n)
    99.76(a)
    473834  XM_529207.2  XP_529207.2 
    cow
    (Bos taurus)
    TEX281   -- testis expressed 28 74.77(n)
    62.65(a)
    539819  XM_589673.2  XP_589673.2 
    rat
    (Rattus norvegicus)
    Tex281   -- testis expressed 28 71.72(n)
    58.21(a)
    690282  XM_001073954.1  XP_001073954.1 
    mouse
    (Mus musculus)
    Tex281 , 5 X (37.79 cM)5
    testis expressed 281, 5 72.61(n)1
    58.91(a)1
    3853801  XM_358216.11  XP_358216.11 
    About this table        Species with no ortholog for TEX28

    ENSEMBL Gene Tree for TEX28 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TEX28 gene
    TEX28P12  TEX28P22  TMCC12  TMCC32  TMCC22  

    TEX28 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/29 NCBI SNPs in TEX28 are shown (see all 29)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs22668911,2
    C,F,A153505753(+) AGTCAT/CTggcc 1 -- int111Minor allele frequency- C:0.10NS EA NA 787
    rs23150511,2
    C,A,H153504774(+) TCCAGG/AAGGGA 1 -- int1 trp32Minor allele frequency- A:0.33NA WA 3
    rs23150521,2
    --153505004(+) ttcagC/Tggcat 1 -- int10--------
    rs23150531,2
    C,A153505379(+) atcacA/C/Tgcctc 1 -- int14NA WA 7
    rs40635151,2
    --153505355(+) aaaaa-/AAnttgt 1 -- int10--------
    rs59872241,2
    --153504228(+) aaTTCC/TTTCAG 1 -- int10--------
    rs59872251,2
    C153505210(+) TGGTGG/CGCGCC 1 -- int11Minor allele frequency- C:0.50WA 2
    rs59872261,2
    C,F,A,H153505295(+) agatcC/Acgcca 1 -- int12Minor allele frequency- A:0.50NA WA 6
    rs59872271,2
    C,F,A,H153505318(+) ctgggC/Tgacag 1 -- int14Minor allele frequency- T:0.33NA WA 9
    rs59872281,2
    C,F,A,H153505325(+) acagaG/Acgaga 1 -- int14Minor allele frequency- A:0.33NA WA 9
    About this table

    HapMap Linkage Disequilibrium images for TEX28 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TEX28
         4 CNVs: 97108 83868 37014 74085

    QIAGEN SeqTarget long-range PCR primers for resequencing TEX28 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TEX28 for disorders           About GeneDecksing

    OMIM: 300092


    Export disorders and mutations for TEX28 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    8 PubMed articles for TEX28 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with TEX28)
    1. Identification of a gene within the tandem array of red and green color pigment genes. (PubMed id 9268643)1, 2, 3 Hanna M.C.... Kirkness E.F. (1997)
    2. An insertion/deletion TEX28 polymorphism and its appl ication to analysis of red/green visual pigment gene arrays. (PubMed id 15378397)1, 3, 7 Ueyama H....Yamade S. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Evaluation of the X-linked high-grade myopia locus (MYP1) with cone dysfunction and color vision deficiencies. (PubMed id 19098318)1, 7 Metlapally R....Young T.L. (2009)
    5. Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1527 HGNC: 2563 AceView: CXorf2 Ensembl:ENSG00000185254 euGenes: HUgn1527
    ECgene: TEX28 H-InvDB: TEX28

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TEX28 gene:
    Search GeneIP for patents involving TEX28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TEX28
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     ELISAs and CLIAs for TEX28
           

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