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TFAP4 Gene

protein-coding GIFtS: 52

GC16M004247

transcription factor AP-4 (activating enhancer binding protein 4)
(Previous name: transcription factor AP-4 (activating enhancer-binding protein 4) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
transcription factor AP-4 (activating enhancer binding protein 4)¹ ²		Activating enhancer-binding protein 4² ³
bHLHc41¹ ² ³		Class C basic helix-loop-helix protein 41² ³
AP-4¹ ²		transcription factor AP-4²
transcription factor AP-4 (activating enhancer-binding protein 4)¹ ²		BHLHC41³

External Ids:	HGNC: 11745¹	Entrez Gene: 7023²	Ensembl: ENSG00000090447⁷	UniProtKB: Q01664³

Export aliases for TFAP4 gene to outside databases

Previous GC identifers: GC16M004330 GC16M004307

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFAP4:

Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for

DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both

viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 (PubMed 2833704); Hu

et al., 1990 (PubMed 2123466)).(supplied by OMIM)

UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664

Function: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence

5'-CAGCTG-3'

Gene Wiki entry for TFAP4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TFAP4 gene promoter:
         GATA-1   CREB   deltaCREB   GATA-2   MyoD   C/EBPalpha   AP-2gamma   AP-2alphaA   TBP   TFIID
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TFAP4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TFAP4

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13

TFAP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFAP4 gene location

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M004247: view genomic region (about GC identifiers)

Start:	4,274,201 bp from pter
End:	4,289,950 bp from pter
Size:	15,750 bases
Orientation:	minus strand

1 alternative location:

Chr16- 4,307,187-4,323,001

RefSeq DNA sequence:

NC_000016.9 NT_010393.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664 (See protein sequence)

Recommended Name: Transcription factor AP-4

Size: 338 amino acids; 38726 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer

Subcellular location: Nucleus

Secondary accessions: O60409

Explore the universe of human proteins at neXtProt for TFAP4: NX_Q01664

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003214.1

ENSEMBL proteins:

ENSP00000204517 ENSP00000379987

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	OriGene Purified Protein: TFAP4 OriGene Protein Over-expression Lysate: TFAP4
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	Novus Biologicals Proteins for TFAP4
	Novus Biologicals Lysate for TFAP4
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	19505873
GO:0017053	transcriptional repressor complex	ISS	--

About this table

TFAP4 for ontologies About GeneDecksing

Antibodies for TFAP4:

	Millipore Mono- and Polyclonal Antibodies for the study of TFAP4
	Sigma-Aldrich Antibodies for TFAP4
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	Novus Biologicals Antibodies for TFAP4
	Browse antibodies at Epitomics

Assays for TFAP4:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TFAP4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TFAP4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TFAP4 for domains About GeneDecksing

2 InterPro domains/families:

IPR001092 HLH_DNA-bd_dom

IPR011598 HLH_DNA-bd

Graphical View of Domain Structure for InterPro Entry Q01664

ProtoNet protein and cluster: Q01664

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TFAP4_HUMAN, Q01664

Function: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence

5'-CAGCTG-3'

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for TFAP4 Sigma-Aldrich shRNA for TFAP4
		OriGene 29mer shRNA kits in GFP-retroviral vector: TFAP4 OriGene shRNA RFP: TFAP4 OriGene basic RS shRNA: TFAP4 OriGene siRNA: TFAP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TFAP4

miRNA:		Sigma-Aldrich microRNA Mimics for TFAP4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TFAP4
		8/12 SABiosciences Assays for microRNAs that regulate TFAP4 (see all 12):
		hsa-miR-1274a hsa-miR-520e hsa-miR-495 hsa-miR-302a hsa-miR-548k hsa-miR-1274b hsa-miR-373 hsa-miR-144

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TFAP4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TFAP4 OriGene untagged cDNA clones in CMV expression vector: TFAP4 OriGene 3'-UTR clone: TFAP4 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TFAP4
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TFAP4

Genatlas biochemistry entry for TFAP4:

transcription factor AP-4,activating enhancer binding protein 4,involved in signal-mediated trafficking of integral

membrane proteins

5/15 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 15):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IDA	9931457
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--
GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	IDA	2833704
GO:0003713	NOT transcription coactivator activity	IDA	11171123
GO:0005515	protein binding	IPI	19505873

About this table

TFAP4 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for TFAP4

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TFAP4

5/18 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 18):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	IDA	19505873
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IDA	18818310
GO:0007090	regulation of S phase of mitotic cell cycle	IDA	18818310
GO:0008285	negative regulation of cell proliferation	IMP	18818310
GO:0010629	negative regulation of gene expression	--	--

About this table

TFAP4 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

TFAP4 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TFAP4
1 Novoseek chemical compound relationship for TFAP4 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	35.6	1	2123466 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for TFAP4 Sigma-Aldrich shRNA for TFAP4
		OriGene 29mer shRNA kits in GFP-retroviral vector: TFAP4 OriGene shRNA RFP: TFAP4 OriGene basic RS shRNA: TFAP4 OriGene siRNA: TFAP4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TFAP4

miRNA:		Sigma-Aldrich microRNA Mimics for TFAP4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TFAP4
		8/12 SABiosciences Assays for microRNAs that regulate TFAP4 (see all 12):
		hsa-miR-1274a hsa-miR-520e hsa-miR-495 hsa-miR-302a hsa-miR-548k hsa-miR-1274b hsa-miR-373 hsa-miR-144

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TFAP4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TFAP4 OriGene untagged cDNA clones in CMV expression vector: TFAP4 OriGene 3'-UTR Clone: TFAP4 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TFAP4

Primers:		OriGene genome-wide validated SYBR primer pairs: TFAP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TFAP4: PPH07177A

REFSEQ mRNAs for TFAP4 gene:

NM_003223.2

Additional cDNA sequence:

BC010576.1 CR541726.1 CR605422.1 CR610803.1 S73885.1 X57435.1

6 DOTS entries:

DT.455041 DT.100720185 DT.100810845 DT.95107157 DT.100763870 DT.91983108

24/73 AceView cDNA sequences (see all 73):

CR541726 BU159415 BC010576 BQ441928 BC039696 BM450579 CR610803 AL527330

BQ216830 CR605422 BE254143 BX348748 BX473142 BX333075 AI052469 BX112687

BM755885 BX371672 AA314453 CA314763 BU172406 BV198722 S73885 BX389541

highest scoring ESTs for TFAP4:

S73885 AA216567 BC010576 BE254143 BF529726 BG479910 BI766776 BM450579 BU159415 BU171481

Unigene Cluster for TFAP4:

Transcription factor AP-4 (activating enhancer binding protein 4)

Hs.513305 [show with all ESTs]

Unigene Representative Sequence: S73885

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000204517(uc010uxg.1) ENST00000396765

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TFAP4 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching TFAP4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39638_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	S73885	1.00	1.00	1.00	1
205688_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003223	0.60	1.00	0.82	1
205688_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

TFAP4 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

TFAP4 gene electronic northern expression

About these images

CGAP SAGE TAG: GTTGGGGGTA

SOURCE GeneReport for Unigene cluster: Hs.513305

Expression variation in blood from EXPOLDB for TFAP4

Primers:		OriGene genome-wide validated SYBR primer pairs: TFAP4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TFAP4: PPH07177A

SABiosciences Custom PCR Arrays for TFAP4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TFAP4 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TFAP4¹	--	transcription factor AP-4 (activating enhancer binding more	93.87(n) 97.33(a)	490029 XM_547149.2 XP_547149.2
cow (Bos taurus)	TFAP4¹	--	transcription factor AP-4 (activating enhancer binding more	93.83(n) 95.82(a)	540757 XM_612982.3 XP_612982.2
rat (Rattus norvegicus)	Tcfap4¹	--	transcription factor AP4	90.73(n) 97.34(a)	360482 XM_340756.3 XP_340757.2
mouse (Mus musculus)	Tcfap4^{1 , 5}	16 (2.45 cM)⁵	transcription factor AP4^{1, 5}	91.12(n)¹ 97.63(a)¹	83383¹ NM_031182.2¹ NP_112459.1¹ AF161262⁵ AI642933⁵ (see all 9)
chicken (Gallus gallus)	TFAP4¹	--	transcription factor AP-4 (activating enhancer binding more	92.04(n) 98.51(a)	430233 XM_427787.2 XP_427787.2

About this table Species with no ortholog for TFAP4

ENSEMBL Gene Tree for TFAP4 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs251730^1,2	C,F,A,H,	4310895(+)	`GGAGAT/AGCCGT`	1	--	int¹		6	NA WA	132
rs251731^1,2	C,F,A,H,	4310709(+)	`GCCCCC/TCTCAA`	1	--	int¹		9	EA NA WA	266
rs251732^1,2	C,F,A,	4310468(+)	`CGCAGC/GTGCTG`	2	H Q	mis¹ ref¹ ese³		7	NS NA EA WA	338
rs251733^1,2	C,H,	4321605(+)	`CTAGGT/ACCAAA`	1	--	int¹		10	MN NA EA WA	690
rs251734^1,2	C,F,	4321441(+)	`CGTAGA/GACGCC`	1	--	int¹		2	NA WA	122
rs251735^1,2	C,F,A,	4320672(+)	`GGTATC/GCTCCA`	1	--	int¹		12	EA NS NA WA	2124
rs251736^1,2	C,F,A,	4318455(+)	`tgttcG/Atggct`	1	--	int¹		14	MN NS EA NA WA	1124
rs251737^1,2	C,F,A,	4318305(+)	`acgtgT/Cctgta`	1	--	int¹		4	NA WA	8
rs251738^1,2	C,F,	4318294(+)	`ggtgtC/Tgtggg`	1	--	int¹		2	NA	4
rs251739^1,2	C,F,	4318206(+)	`tgggcG/Agatca`	1	--	int¹		3	NA	6

About this table

HapMap Linkage Disequilibrium images for TFAP4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TFAP4
1 CNV: 72431

QIAGEN SeqTarget long-range PCR primers for resequencing TFAP4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TFAP4 for disorders About GeneDecksing

OMIM: 600743

Export disorders and mutations for TFAP4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/32 PubMed articles for TFAP4 gene, integrated from 7 sources (see all 32):
(articles sorted by number of sources associating them with TFAP4)

Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. (PubMed id 2123466)^{1, 2, 3, 7} Hu Y.-F.... Tjian R. (1990)
Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. (PubMed id 7933101)^{1, 2, 7} Ou S.H.... Gaynor R.B. (1994)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)^{1, 2} Martin J.... Pennacchio L.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{1, 2} Beausoleil S.A....Gygi S.P. (2004)
Complementary quantitative proteomics reveals that tr anscription factor AP-4 mediates E-box-dependent complex formation for transcri ptional repression of HDM2. (PubMed id 19505873)^{1, 7} Ku W.C....Chen Y.J. (2009)
Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements. (PubMed id 11171123)^{1, 7} Aranburu A....Leanderson T. (2001)
The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. (PubMed id 10438607)^{1, 7} King-Jones K....Lehmann M. (1999)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7023	HGNC: 11745	AceView: TFAP4	Ensembl:ENSG00000090447	euGenes: HUgn7023
ECgene: TFAP4	H-InvDB: TFAP4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for TFAP4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for TFAP4 gene:
Search GeneIP for patents involving TFAP4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TFAP4		Antibodies for TFAP4
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TFAP4
	SeqTarget long-range PCR primers for resequencing TFAP4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TFAP4
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TFAP4

	GenScript Custom Purified and Recombinant Proteins Services for TFAP4		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TFAP4
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Search for Antibodies & Assays

	Regulatory tfbs in TFAP4 promoter
	Search Chromatin IP Primers for TFAP4
	RT² qPCR Primer Assay for TFAP4
	GNC Network for TFAP4
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GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

TFAP4 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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TFAP4 Gene

protein-coding GIFtS: 52

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for TFAP4 gene

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for TFAP4 gene

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Export list of displayed genes

TFAP4 Gene

protein-coding GIFtS: 52

Aliases & Descriptionsfor TFAP4 gene

Summariesfor TFAP4 gene

Genomic Viewsfor TFAP4 gene

Proteinsfor TFAP4 gene

Protein Domains/Familiesfor TFAP4 gene

Gene Functionfor TFAP4 gene

Pathways & Interactionsfor TFAP4 gene

Drugs & Compoundsfor TFAP4 gene

Transcriptsfor TFAP4 gene

Expression for TFAP4 gene

Orthologsfor TFAP4 gene

Paralogsfor TFAP4 gene

Genomic Variantsfor TFAP4 gene

Disorders & Mutationsfor TFAP4 gene

Medical Newsfor TFAP4 gene

Publicationsfor TFAP4 gene

External Searches for TFAP4 gene

Genome Databases showing TFAP4 gene

Other Databases showing TFAP4 gene

Specialized Databases showing TFAP4 gene

Intellectual Propertyfor TFAP4 gene

Productsfor TFAP4 gene

View Random Gene

Aliases &
Descriptions
for TFAP4 gene

Summaries
for TFAP4 gene

Genomic Views
for TFAP4 gene

Proteins
for TFAP4 gene

Protein Domains/
Families
for TFAP4 gene

Gene Function
for TFAP4 gene

Pathways & Interactions
for TFAP4 gene

Drugs & Compounds
for TFAP4 gene

Transcripts
for TFAP4 gene

Expression
for TFAP4 gene

Orthologs
for TFAP4 gene

Paralogs
for TFAP4 gene

Genomic Variants
for TFAP4 gene

Disorders & Mutations
for TFAP4 gene

Medical News
for TFAP4 gene

Publications
for TFAP4 gene

Intellectual Property
for TFAP4 gene

Products
for TFAP4 gene