Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



TFB1M Gene

protein-coding   GIFtS: 55

GC06M153141
transcription factor B1, mitochondrial
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
transcription factor B1, mitochondrial1 2     CGI-751
mtTFB1 2     homolog of yeast mitochondrial transcription factor B2
Mitochondrial 12S rRNA dimethylase 12 3     mitochondrial dimethyladenosine transferase 12
h-mtTFB12 3     dimethyladenosine transferase 1, mitochondrial2
hTFB1M2 3     EC 2.1.1.-3
mtTFB12 3     h-mtTFB3
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 12 3     Mitochondrial transcription factor B13
CGI752 5     

External Ids:    HGNC: 170371   Entrez Gene: 511062   Ensembl: ENSG000000296397   UniProtKB: Q8WVM03   

Export aliases for TFB1M gene to outside databases

Previous GC identifers: GC06M155054 GC06M155474 GC06M155609 GC06M155670


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TFB1M:
The protein encoded by this gene is a dimethyltransferase that methylates the conserved stem loop of mitochondrial 12S
rRNA. The encoded protein also is part of the basal mitochondrial transcription complex and is necessary for
mitochondrial gene expression. The methylation and transcriptional activities of this protein are independent of one
another. Variations in this gene may influence the severity of aminoglycoside-induced deafness (AID).

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
Function: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at
the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with
POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity

Gene Wiki entry for TFB1M

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TFB1M gene promoter:
         Sp1   POU3F2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   MEF-2A   FOXJ2 (long isoform)   Elk-1   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TFB1M

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TFB1M 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.1-q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.1-q25.3

TFB1M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TFB1M gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M153141:  view genomic region     (about GC identifiers)

Start:
153,141,066 bp from pter
End:
153,197,997 bp from pter
Size:
56,932 bases
Orientation:
minus strand

1 alternative location:
Chr6- 155,578,643-155,635,627     
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0 (See protein sequence)
Recommended Name: Dimethyladenosine transferase 1, mitochondrial precursor  
Size: 346 amino acids; 39543 Da
Subunit: Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAH05183.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence;
Secondary accessions: Q05DR0 Q9Y384

Explore the universe of human proteins at neXtProt for TFB1M: NX_Q8WVM0 

REFSEQ proteins: NP_057104.2  

ENSEMBL proteins: 
ENSP00000356134 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: TFB1M
GenScript Custom Purified and Recombinant Proteins Services for TFB1M 
Novus Biologicals Protein for TFB1M
Novus Biologicals Lysates for TFB1M
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
GO:0042645 mitochondrial nucleoid IDA18063578
About this table

TFB1M for ontologies           About GeneDecksing



Antibodies for TFB1M: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for TFB1M
Browse R&D Systems for Antibodies
OriGene Antibodies: TFB1M
GenScript Custom Superior Antibodies Services for TFB1M 
Novus Biologicals Antibodies for TFB1M
Browse antibodies at Epitomics

Assays for TFB1M: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TFB1M 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for TFB1M 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TFB1M for domains           About GeneDecksing

5 InterPro domains/families:
 IPR011530 rRNA_adenine_dimethylase
 IPR023165 rRNA_Ade_diMease-like
 IPR020596 rRNA_Ade_Mease_Trfase_CS
 IPR001737 rRNA_Ade_methylase_transferase
 IPR020598 rRNA_Ade_methylase_Trfase_N

Graphical View of Domain Structure for InterPro Entry Q8WVM0

ProtoNet protein and cluster: Q8WVM0

1 Blocks protein family: IPB001737 Ribosomal RNA adenine dimethylase

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
Function: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at
the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with
POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity
Induction: By the nuclear respiratory factors NRF1 and NRF2/GABPB2 and PGC-1 coactivators
Enzyme Number (IUBMB): EC 2.1.1.- 

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for TFB1M
Sigma-Aldrich shRNA for TFB1M
OriGene 29mer shRNA kits in GFP-retroviral vector: TFB1M
OriGene shRNA RFP: TFB1M
OriGene basic RS shRNA: TFB1M
OriGene siRNA: TFB1M
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TFB1M 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TFB1M 
Search SABiosciences for Assays for microRNAs that regulate TFB1M

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: TFB1M
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TFB1M
OriGene untagged cDNA clones in CMV expression vector (see all 3): TFB1M
OriGene 3'-UTR clone: TFB1M 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for TFB1M 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for TFB1M 

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO IDQualified GO termEvidencePubMed IDs
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity IEA--
GO:0003677 DNA binding IEA--
GO:0003712 transcription cofactor activity ----
GO:0005515 protein binding IPI12897151
GO:0008168 methyltransferase activity IEA--
About this table

TFB1M for ontologies           About GeneDecksing

Animal Models: 9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tfb1m):

cardiovascular systemcellularembryogenesisgrowth/sizelethality-prenatal/perinatal
life span-post-weaning/agingmusclenervous systemvision/eye

TFB1M for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for TFB1M 

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TFB1M

5/235 Interacting proteins for TFB1M (ENSP000003561343 Q8WVM01, 2) via UniProtKB, MINT, and/or STRING (see all 235)
InteractantInteraction Details
GeneCardExternal ID(s)
TFAMQ000591, 2EBI-2615570,EBI-1049924 MINT-8079030
POLRMTO004112STRING: ENSP00000215591 MINT-8079030
AARS2Q5JTZ92MINT-8079030
AASSQ9UDR52MINT-8079030
ACAD9Q9H8452MINT-8079030
About this table

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000154 rRNA modification IEA--
GO:0006355 regulation of transcription, DNA-dependent ----
GO:0031167 rRNA methylation ----
GO:0045449 regulation of transcription IEA--
About this table

TFB1M for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

TFB1M for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TFB1M
2 Novoseek chemical compound relationships for TFB1M gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
rrna 58.3 4 17031457 (2), 15542390 (1)
adenine 49.8 2 15110318 (1)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for TFB1M
Sigma-Aldrich shRNA for TFB1M
OriGene 29mer shRNA kits in GFP-retroviral vector: TFB1M
OriGene shRNA RFP: TFB1M
OriGene basic RS shRNA: TFB1M
OriGene siRNA: TFB1M
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TFB1M 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TFB1M 
Search SABiosciences for Assays for microRNAs that regulate TFB1M
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: TFB1M
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TFB1M
OriGene untagged cDNA clones in CMV expression vector (see all 3): TFB1M
OriGene 3'-UTR Clone: TFB1M 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for TFB1M 
Primers: OriGene genome-wide validated SYBR primer pairs: TFB1M
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TFB1M: PPH15798A

REFSEQ mRNAs for TFB1M gene: 

NM_016020.3  

Additional cDNA sequence: 

AF151833.1 AK289484.1 BC005183.1 BC017788.1 BC054007.1 CR595073.1 

11 DOTS entries:

DT.86846782  DT.99928812  DT.100746277  DT.97839404  DT.121368986  DT.100028155  DT.121369086  DT.40116452 
DT.75120902  DT.91995891  DT.92018285 

24/136 AceView cDNA sequences (see all 136):

BU634088 BM714985 AA405744 BC017788 BM707664 BF196459 CA305915 CR595073 
AI628397 AI973020 BU733204 BC005183 BM676688 R47388 AA761808 AW104676 
BM559871 AA450024 AI638236 AA044637 AA749175 BU849912 CB854716 BM771868 

highest scoring ESTs for TFB1M:

AA432011 AA447468 AA452652 AA477681 AF151833 AL712448 AW392861 BC005183 BC017788 BC054007 

Unigene Cluster for TFB1M:

Transcription factor B1, mitochondrial
Hs.279908  [show with all ESTs]
Unigene Representative Sequence: BM465245


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TFB1M

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:              -           -                     
SP2:                          -                     
SP3:              -                                 

About this scheme

ECgene alternative splicing isoforms for TFB1M
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000466349 ENST00000468889 ENST00000487586 ENST00000480390 ENST00000475849
ENST00000489874 ENST00000495806 ENST00000470239 ENST00000367166(uc003qqj.3 uc003qqk.2)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TFB1M expression in normal and diseased human tissues

1  / 2  / 3

7 probe-sets matching TFB1M gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
65161_at2, 3 U95-C 1 1.00 1.00 0.49 1.12 W30719 0.80 1.00 0.91 1
53772_g_at2, 3 U95-B 1 0.94 1.00 0.95 1.05 AI217938 0.60 0.75 0.68 1
53767_at2, 3 U95-B 1 0.94 1.00 0.96 0.83 AI217938 0.60 0.75 0.68 1
219169_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016020 0.60 1.00 0.82 1
228075_x_at2, 3 U133-B 1 0.91 1.00 -- -- AI341648 0.40 0.67 0.55 1
219169_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
228075_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table

TFB1M for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
TFB1M gene expression
TFB1M gene electronic northern expression
TFB1M gene sage expression
About these images

CGAP SAGE TAG: GAGATGTCTT

SOURCE GeneReport for Unigene cluster: Hs.279908

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
Tissue specificity: Ubiquitously expressed

Primers: OriGene genome-wide validated SYBR primer pairs: TFB1M
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TFB1M: PPH15798A
    SABiosciences Custom PCR Arrays for TFB1M 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TFB1M gene from 5/12 species (see all 12)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TFB1M1   -- transcription factor B1, mitochondrial 87.95(n)
88.92(a)
476253  XM_533459.2  XP_533459.2 
chimpanzee
(Pan troglodytes)
TFB1M1   -- transcription factor B1, mitochondrial 99.52(n)
99.71(a)
737921  XM_001143221.1  XP_001143221.1 
rat
(Rattus norvegicus)
Tfb1m1   -- transcription factor B1, mitochondrial 85.64(n)
86.73(a)
308140  NM_181474.2  NP_852139.2 
mouse
(Mus musculus)
Tfb1m1 , 5 17 (2.01 cM)5
transcription factor B1, mitochondrial1, 5 85.64(n)1
86.14(a)1
2244811  NM_146074.11  NP_666186.11 
 AF5089715  AI4292075  (see all 9)
chicken
(Gallus gallus)
TFB1M1   -- transcription factor B1, mitochondrial 72.81(n)
74.27(a)
428608  XM_426165.2  XP_426165.2 
About this table        Species with no ortholog for TFB1M

ENSEMBL Gene Tree for TFB1M (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for TFB1M gene
DIMT1L2  

TFB1M for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/492 NCBI SNPs in TFB1M are shown (see all 492)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs562371,2
C,F,O,A,155632762(+) TCCCAC/TGCAAA 1 -- int1104Minor allele frequency- G:0.00NA EA NS PA EU CA WA 7538
rs1629641,2
C,F,155614881(+) TTTATC/TTCCAA 1 -- int15Minor allele frequency- T:0.12NS EA 504
rs1629651,2
C,F,A,155615728(+) AGGACG/AAAAGA 1 -- int111Minor allele frequency- A:0.17NS EA NA WA 638
rs1629661,2
C,F,155615985(+) TTTACG/AACAGT 1 -- int112Minor allele frequency- A:0.17NS EA NA WA 686
rs1629671,2
C,F,155617193(+) CATCCC/GTCCTT 1 -- int115Minor allele frequency- N:0.01NS EA NA WA 854
rs1629681,2
155617230(+) CTGCTC/TACCCT 1 -- int10--------
rs1629691,2
155617241(+) GGAGGG/TTTTAC 1 -- int10--------
rs1629701,2
F,H155618346(+) AAAAAT/CATATA 1 -- int14Minor allele frequency- C:0.01NS EA 408
rs1629711,2
C,F,O,A,H,155619023(+) GCCCAA/TCTGAA 1 -- int125Minor allele frequency- N:0.00NS EA NA WA 1702
rs1629721,2
155622070(+) aagagC/Gtggga 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for TFB1M (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TFB1M
     1 Indel: 28130

QIAGEN SeqTarget long-range PCR primers for resequencing TFB1M 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TFB1M for disorders           About GeneDecksing

OMIM: 607033

UniProtKB/Swiss-Prot: TFB1M_HUMAN, Q8WVM0
  • Note=Variations in TFB1M may influence the clinical expression of aminoglycoside-induced deafness caused by
  • the A1555G mutation in the mitochondrial 12S rRNA

    Human Gene Mutation Database (HGMD): TFB1M
    Human Genome Epidemiology (HuGE) Navigator: TFB1M (4 documents)

    Export disorders and mutations for TFB1M gene to outside databases


    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/28 PubMed articles for TFB1M gene, integrated from 7 sources (see all 28):
    (articles sorted by number of sources associating them with TFB1M)
    1. A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. (PubMed id 11809803)1, 2, 3, 7 McCulloch V.... Shadel G.S. (2002)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. Human mitochondrial transcription factor B1 as a modifier gene for hearing loss associated with the mitochondrial A1555G mutation. (PubMed id 15110318)1, 2, 7 Bykhovskaya Y....Fischel-Ghodsian N. (2004)
    4. Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. (PubMed id 15684387)1, 2, 7 Gleyzer N.... Scarpulla R.C. (2005)
    5. Human mitochondrial transcription factor B1 interacts with the C- terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity. (PubMed id 12897151)1, 2, 7 McCulloch V. and Shadel G.S. (2003)
    6. Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. (PubMed id 12496758)1, 2, 7 Seidel-Rogol B.L.... Shadel G.S. (2003)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    9. Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA. (PubMed id 12068295)1, 2 Falkenberg M....Gustafsson C.M. (2002)
    10. Mutational screening of the Mitochondrial transcription factors B1 and B2 (TFB1M and TFB2M) in Parkinson's disease. (PubMed id 18980857)1, 7 Sanchez-Ferrero E....Alvarez V. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51106 HGNC: 17037 AceView: TFB1M Ensembl:ENSG00000029639 euGenes: HUgn51106
    ECgene: TFB1M H-InvDB: TFB1M

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TFB1M gene:
    Search GeneIP for patents involving TFB1M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for TFB1M Antibodies for TFB1M
     Super-pooled esiRNAs for TFB1M Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TFB1M Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TFB1M
     SeqTarget long-range PCR primers for resequencing TFB1M
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TFB1M
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TFB1M
     GenScript Custom Purified and Recombinant Proteins Services for TFB1M GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TFB1M
     GenScript Custom Assay Services for TFB1M GenScript Custom Superior Antibodies Services for TFB1M
     GenScript Custom overexpressing Cell Line Services for TFB1M CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TFB1M promoter
     Search Chromatin IP Primers for TFB1M
     RT2 qPCR Primer Assay for TFB1M
     GNC Network for TFB1M
     Search for Assays for microRNAs that regulate TFB1M
     SABiosciences Custom PCR Arrays for TFB1M
     Search Tocris compounds for TFB1M
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for TFB1M
     Proteins for TFB1M
     Lysates for TFB1M
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for TFB1M
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    TFB1M gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4