Aliases &
Descriptions
for THEG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| Theg homolog (mouse)1 2 | | CT561 2 3 | | Cancer/testis antigen 562 3 | | Theg homolog2 | | testis-specific2 | | MGC261382 |
Export aliases for THEG gene to outside databasesPrevious GC identifers: GC19M000302 GC19M000313 |
Summaries
for THEG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for THEG:
This gene is specifically expressed in the nucleus of haploid male germ cells. It encodes a protein that may beinvolved in the regulation of germ cell nuclear functions. Alternatively spliced transcript variants encoding distinctisoforms have been reported. (provided by RefSeq)
UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0Function: May be involved (but not essential) in spermatogenesis (By similarity)
|
Genomic Views
for THEG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the THEG gene promoter:
HNF-4alpha2 AP-1 COUP-TF1 c-Jun c-Fos RFX1 AREB6 YY1 HSF2 RP58
Other transcription factors
Search SABiosciences Chromatin IP Primers for THEG
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3THEG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M000131: view genomic region
(about GC identifiers)
Start:
|
131,302 bp from pter |
End:
|
145,247 bp from pter |
Size:
|
13,946 bases |
Orientation:
|
minus strand |
1 alternative location:
RefSeq DNA sequence:- NC_000019.9 NT_011255.14
|
Proteins
for THEG gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0 (See
protein sequence)Recommended Name: Testicular haploid expressed gene protein Size: 379 amino acids; 43444 Da
Subunit: Interacts with CCT5 (By similarity)
Subcellular location: Nucleus (By similarity). Note=Localized predominantly in the nucleus of haploid round spermatid(By similarity)
Secondary accessions: A6NMJ8Alternative splicing: 2 isoforms: Q9P2T0-1 Q9P2T0-2 Explore the universe of human proteins at neXtProt for THEG: NX_Q9P2T0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_057669.1 NP_954672.1
ENSEMBL proteins: ENSP00000264820 ENSP00000340088
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
THEG for ontologies About GeneDecksing
Antibodies for THEG:
Assays for THEG: |
Protein
Domains/
Families
for THEG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
THEG for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9P2T0ProtoNet protein and cluster: Q9P2T0 UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0Similarity: Contains 6 THEG repeats |
Gene Function
for THEG gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0Function: May be involved (but not essential) in spermatogenesis (By similarity)
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
THEG for ontologies About GeneDecksing
Animal Models: 3 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Theg):
THEG for phenotypes About GeneDecksing
|
Pathways & Interactions
for THEG gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for THEG
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for THEG
1 Interacting protein for THEG (Q9P2T01, 2) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
THEG for ontologies About GeneDecksing
|
Drugs & Compounds
for THEG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for THEG
|
Transcripts
for THEG gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for THEG gene (2 alternative transcripts): NM_016585.3 NM_199202.1 Additional cDNA sequence: AB033129.1 AF268610.1 BC028574.2 2 DOTS entries: DT.75151807 DT.101975273 13 AceView cDNA sequences: BC028574 NM_199202 AF268610 BQ436576 NM_016585 AB033129 AW592414 BE792048 BP356751 BI829530 BG716992 AW173089 AI377385
 highest scoring ESTs for THEG:AB033129 AF268610 BC028574 BG716992 BI829530 AI377385 AW173089 AW592414 NM_016585 NM_199202 Unigene Cluster for THEG: Theg homolog (mouse) Hs.250002 [show with all ESTs]Unigene Representative Sequence: NM_016585
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for THEG
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for THEG
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000346878 ENST00000342640(uc002lol.2 uc002lom.2)
|
Expression
for THEG gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| THEG expression in normal and diseased human tissues
1 / 2 / 3 2 probe-sets matching THEG gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 220808_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
NM_016585 |
0.60 |
1.00 |
0.82 |
1 |
| 220808_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCTGAGGTGT
SOURCE GeneReport for Unigene cluster: Hs.250002
UniProtKB/Swiss-Prot: THEG_HUMAN, Q9P2T0Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for THEG
|
Orthologs
for THEG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for THEG gene from 4 species
About this table Species with no ortholog for THEG
ENSEMBL Gene Tree for THEG (if available) |
Paralogs
for THEG gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for THEG gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for THEG (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for THEG
2 CNVs: 4065 32228 | | QIAGEN SeqTarget long-range PCR primers for resequencing THEG |
|
Disorders & Mutations
for THEG gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
THEG for disorders About GeneDecksing
OMIM: 609503
Export disorders and mutations for THEG gene to outside databases
|
Medical News
for THEG gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for THEG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for THEG gene integrated from 7 sources:
(articles sorted by number of sources associating them with THEG)- Alternative splicing, chromosome assignment and subcellular localization of the testicular haploid expressed gene (THEG). (PubMed id 11173852)1, 2, 3 Mannan A....Burfeind P. (2000)
- Insertional mutation of the murine kisimo locus caused a defect in spermatogenesis. (PubMed id 10747865)1, 2 Yanaka N....Mori C. (2000)
- An empirical framework for binary interactome mapping . (PubMed id 19060904)1 Venkatesan K....Vidal M. (2009)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Male mice lacking the Theg (testicular haploid expressed gene) protein undergo normal spermatogenesis and are fertile. (PubMed id 12748127)1 Mannan A.U....Engel W. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for THEG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing THEG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing THEG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing THEG gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for THEG gene:
Search GeneIP for patents involving THEG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for THEG gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for THEG |
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 | | | ELISAs and CLIAs for THEG |
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