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TIMD4 Gene

protein-coding GIFtS: 48

GC05M151439

T-cell immunoglobulin and mucin domain containing 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
T-cell immunoglobulin and mucin domain containing 4¹ ²		T-cell membrane protein 4² ³
TIM-4² ³		FLJ27515²
TIM4² ³		T-cell immunoglobulin and mucin domain-containing protein 4²
TIMD-4² ³		SMUCKLER²

External Ids:	HGNC: 25132¹	Entrez Gene: 91937²	Ensembl: ENSG00000145850⁷	UniProtKB: Q96H15³

Export aliases for TIMD4 gene to outside databases

Previous GC identifer: GC05M156278

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15

Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell

proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TIMD4 gene promoter:
         Nkx2-2   GATA-1   NF-kappaB   NF-kappaB1   ISGF-3   XBP-1   AP-1   PPAR-gamma1   PPAR-gamma2   HNF-4alpha2
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TIMD4

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q33.3 Ensembl cytogenetic band: 5q33.3 HGNC cytogenetic band: 5q33.3

TIMD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TIMD4 gene location

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M151439: view genomic region (about GC identifiers)

Start:	151,439,934 bp from pter
End:	151,483,898 bp from pter
Size:	43,965 bases
Orientation:	minus strand

1 alternative location:

Chr5- 156,346,293-156,390,266

RefSeq DNA sequence:

NC_000005.9 NT_023133.13

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15 (See protein sequence)

Recommended Name: T-cell immunoglobulin and mucin domain-containing protein 4 precursor

Size: 378 amino acids; 41578 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Explore the universe of human proteins at neXtProt for TIMD4: NX_Q96H15

REFSEQ proteins (2 alternative transcripts):

NP_001140198.1 NP_612388.2

ENSEMBL proteins:

ENSP00000385973 ENSP00000385882 ENSP00000274532

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for TIMD4 (TIM-4)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TIMD4
	GenScript Custom Purified and Recombinant Proteins Services for TIMD4
	Sino Biological Recombinant Protein for TIMD4
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

TIMD4 for ontologies About GeneDecksing

Antibodies for TIMD4:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TIMD4
	R&D Systems Antibodies for TIMD4 (TIM-4)
	OriGene Antibodies (see all 2): TIMD4
	GenScript Custom Superior Antibodies Services for TIMD4
	Novus Biologicals Antibodies for TIMD4
	Browse antibodies at Epitomics

Assays for TIMD4:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TIMD4
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TIMD4

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TIMD4 for domains About GeneDecksing

4 InterPro domains/families:

IPR007110 Ig-like

IPR003599 Ig_sub

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

Graphical View of Domain Structure for InterPro Entry Q96H15

ProtoNet protein and cluster: Q96H15

1 Blocks protein family: IPB003599 Immunoglobulin subtype

UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15

Domain: Recognizes phosphatidyl serine via its immunoglobulin domain

Similarity: Belongs to the immunoglobulin superfamily. TIM family

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TIMD4_HUMAN, Q96H15

Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell

proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TIMD4 Sigma-Aldrich shRNA for TIMD4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TIMD4 OriGene shRNA RFP (see all 2): TIMD4 OriGene basic RS shRNA (see all 2): TIMD4 OriGene siRNA (see all 2): TIMD4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TIMD4

miRNA:		Sigma-Aldrich microRNA Mimics for TIMD4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TIMD4
		Search SABiosciences for Assays for microRNAs that regulate TIMD4

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TIMD4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TIMD4 OriGene untagged cDNA clones in CMV expression vector: TIMD4 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TIMD4
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TIMD4

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--

About this table

TIMD4 for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Timd4):

hematopoietic system

immune system

TIMD4 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for TIMD4

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TIMD4

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TIMD4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TIMD4 Sigma-Aldrich shRNA for TIMD4
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TIMD4 OriGene shRNA RFP (see all 2): TIMD4 OriGene basic RS shRNA (see all 2): TIMD4 OriGene siRNA (see all 2): TIMD4
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TIMD4

miRNA:		Sigma-Aldrich microRNA Mimics for TIMD4 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TIMD4
		Search SABiosciences for Assays for microRNAs that regulate TIMD4

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TIMD4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TIMD4 OriGene untagged cDNA clones in CMV expression vector: TIMD4 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TIMD4

Primers:		OriGene genome-wide validated SYBR primer pairs: TIMD4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TIMD4: PPH17196A

REFSEQ mRNAs for TIMD4 gene (2 alternative transcripts):

NM_001146726.1 NM_138379.2

Additional cDNA sequence:

AK131025.1 AK301337.1 AK312746.1 BC008988.1 CR603034.1

2 DOTS entries:

DT.97783175 DT.92066900

24/29 AceView cDNA sequences (see all 29):

BX439191 AI218853 BE550640 BE552351 BP371340 NM_138379 AA861640 AA400536

AW516351 CR603034 BC008988 AK131025 BX448841 AW274868 BQ182903 AI476417

BX281207 BF338867 AI149724 AI862534 AA936598 AW292593 AA843555 BU958106

highest scoring ESTs for TIMD4:

BC008988 BF338867 AI862534 BQ182903 BX448841 CR603034 H53024 NM_138379 AA400490 AA400536

Unigene Cluster for TIMD4:

T-cell immunoglobulin and mucin domain containing 4

Hs.334907 [show with all ESTs]

Unigene Representative Sequence: BM559521

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TIMD4

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10
SP1:											-								-
SP2:																			-
SP3:

About this scheme

ECgene alternative splicing isoforms for TIMD4
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000407087 ENST00000406964(uc003lwg.2) ENST00000274532(uc003lwh.2 uc010jii.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TIMD4 expression in normal and diseased human tissues

¹ / ²

1 probe-set matching TIMD4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1552280_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

TIMD4 gene electronic northern expression

About these images

CGAP SAGE TAG: ACACTCCAGT

SOURCE GeneReport for Unigene cluster: Hs.334907

Primers:		OriGene genome-wide validated SYBR primer pairs: TIMD4 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TIMD4: PPH17196A

SABiosciences Custom PCR Arrays for TIMD4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TIMD4 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TIMD4¹	--	T-cell immunoglobulin and mucin domain containing 4	71.46(n) 58.31(a)	489160 XM_546278.2 XP_546278.2
chimpanzee (Pan troglodytes)	TIMD4¹	--	T-cell immunoglobulin and mucin domain containing 4	99.03(n) 97.62(a)	462217 XM_518057.2 XP_518057.2
cow (Bos taurus)	TIMD4¹	--	T-cell immunoglobulin and mucin domain containing 4	71.91(n) 62.02(a)	507549 NM_001075320.1 NP_001068788.1
mouse (Mus musculus)	Timd4^{1 , 5}	11 (28.09 cM)⁵	T-cell immunoglobulin and mucin domain containing 4^{1, 5}	68.53(n)¹ 55.16(a)¹	276891¹ NM_178759.4¹ NP_848874.3¹ AI121497⁵ AK046560⁵ (see all 11)
chicken (Gallus gallus)	TIMD4¹	--	T-cell immunoglobulin and mucin domain containing 4	48.45(n) 37.79(a)	416250 NM_001006149.1 NP_001006149.1

About this table Species with no ortholog for TIMD4

ENSEMBL Gene Tree for TIMD4 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TIMD4 gene

HAVCR2² HAVCR1²

TIMD4 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1345616^1,2	C,A,H,	156351674(-)	`GTTCTC/TCTTCC`	2	--	int¹ trp³		10		NA EA WA	578
rs1345617^1,2	C,F,O,A,H,	156351503(-)	`CAAAAC/GAAGTC`	2	--	int¹		15		MN NS EA NA WA	1196
rs1345618^1,2	C,F,O,A,H,	156351347(-)	`TTTATA/GTAGCT`	2	--	int¹		15		NS EA NA WA	1064
rs1363232^1,2	C,F,O,A,H,	156383422(-)	`ACTCAC/TGCTTC`	2	--	int¹		18		NS EA NA WA	902
rs1975026^1,2	C	156370829(-)	`tgcctC/Tggcct`	2	--	int¹		3		NA WA	6
rs2431296^1,2	--	156387467(+)	`ggctgG/Tagtgc`	2	--	int¹		0	--	--	--	--
rs2431297^1,2	--	156387578(+)	`acgccC/Tggcta`	2	--	int¹		0	--	--	--	--
rs2455422^1,2	--	156387568(+)	`acatgC/Tcacca`	2	--	int¹		0	--	--	--	--
rs2862057^1,2	C,F,A,H,	156355151(+)	`tacaaC/Aataca`	2	--	int¹		5		NA WA	80
rs2862058^1,2	C,F,O,A,	156355375(+)	`aaaacA/Gtcagc`	2	--	int¹		15		NS EA NA WA	1064

About this table

HapMap Linkage Disequilibrium images for TIMD4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TIMD4: --

QIAGEN SeqTarget long-range PCR primers for resequencing TIMD4

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TIMD4 for disorders About GeneDecksing

OMIM: 610096

Human Genome Epidemiology (HuGE) Navigator: TIMD4 (7 documents)

Export disorders and mutations for TIMD4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/18 PubMed articles for TIMD4 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with TIMD4)

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells fr om patients with system lupus erythematosus. (PubMed id 20140011)^{1, 7} Zhao P....Gao L. (2010)
Significant association between TIM1 promoter polymorphisms and protection against cerebral malaria in Thailand. (PubMed id 18294362)^{1, 7} Nuchnoi P....Patarapotikul J. (2008)
Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population. (PubMed id 20972250)¹ Park M.H....Park H.Y. (2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)
The phosphatidylserine receptors, T cell immunoglobul in mucin proteins 3 and 4, are markers of histiocytic sarcoma and other histioc ytic and dendritic cell neoplasms. (PubMed id 20656318)¹ Dorfman D.M....Freeman G.J. (2010)
Common variants at 30 loci contribute to polygenic dyslipidemia. (PubMed id 19060906)¹ Kathiresan S....Cupples L.A. (2009)
Association of TIM4 promoter polymorphism -1419G>A with childhood asthma in a Chinese Han population. (PubMed id 19392790)¹ Cai P.C....Wu Q.W. (2009)
The phosphatidylserine receptor TIM-4 does not mediate direct signaling. (PubMed id 19217291)¹ Park D....Ravichandran K.S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 91937	HGNC: 25132	AceView: TIMD4	Ensembl:ENSG00000145850	euGenes: HUgn91937
ECgene: TIMD4	H-InvDB: TIMD4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for TIMD4 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for TIMD4 gene:
Search GeneIP for patents involving TIMD4

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TIMD4		Antibodies for TIMD4
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies for TIMD4 (TIM-4)		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for TIMD4 (TIM-4)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TIMD4
	SeqTarget long-range PCR primers for resequencing TIMD4
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TIMD4

	GenScript Custom Purified and Recombinant Proteins Services for TIMD4		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TIMD4
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Search Tocris compounds for TIMD4

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ELISAs and CLIAs for TIMD4

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TIMD4 Gene

protein-coding GIFtS: 48

Aliases &
Descriptions
for TIMD4 gene

Summaries
for TIMD4 gene

Genomic Views
for TIMD4 gene

Proteins
for TIMD4 gene

Protein Domains/
Families
for TIMD4 gene

Gene Function
for TIMD4 gene

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TIMD4 Gene

protein-coding GIFtS: 48

Aliases & Descriptionsfor TIMD4 gene

Summariesfor TIMD4 gene

Genomic Viewsfor TIMD4 gene

Proteinsfor TIMD4 gene

Protein Domains/Familiesfor TIMD4 gene

Gene Functionfor TIMD4 gene

Pathways & Interactionsfor TIMD4 gene

Drugs & Compoundsfor TIMD4 gene

Transcriptsfor TIMD4 gene

Expression for TIMD4 gene

Orthologsfor TIMD4 gene

Paralogsfor TIMD4 gene

Genomic Variantsfor TIMD4 gene

Disorders & Mutationsfor TIMD4 gene

Medical Newsfor TIMD4 gene

Publicationsfor TIMD4 gene

External Searches for TIMD4 gene

Genome Databases showing TIMD4 gene

Other Databases showing TIMD4 gene

Specialized Databases showing TIMD4 gene

Intellectual Propertyfor TIMD4 gene

Productsfor TIMD4 gene

View Random Gene

Aliases &
Descriptions
for TIMD4 gene

Summaries
for TIMD4 gene

Genomic Views
for TIMD4 gene

Proteins
for TIMD4 gene

Protein Domains/
Families
for TIMD4 gene

Gene Function
for TIMD4 gene

Pathways & Interactions
for TIMD4 gene

Drugs & Compounds
for TIMD4 gene

Transcripts
for TIMD4 gene

Expression
for TIMD4 gene

Orthologs
for TIMD4 gene

Paralogs
for TIMD4 gene

Genomic Variants
for TIMD4 gene

Disorders & Mutations
for TIMD4 gene

Medical News
for TIMD4 gene

Publications
for TIMD4 gene

Intellectual Property
for TIMD4 gene

Products
for TIMD4 gene