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TLN2 Gene

protein-coding   GIFtS: 56

GC15P039762
talin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
talin 21 2     DKFZp451B10112
KIAA03201 2 3 5     DKFZp686K09792
ILWEQ1 2     DKFZp686I09762
talin-22     

External Ids:    HGNC: 154471   Entrez Gene: 836602   Ensembl: ENSG000001719147   UniProtKB: Q9Y4G63   

Export aliases for TLN2 gene to outside databases

Previous GC identifers: GC15P058780 GC15P055987 GC15P060518 GC15P060655 GC15P060726 GC15P062939


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLN2:
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of
actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This
protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with
unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.
(provided by RefSeq)

UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6
Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an
important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity
(By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLN2 gene promoter:
         TBP   POU3F2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   FOXL1   Nkx2-2   GCNF-1   GCNF-2   NF-1   C/EBPbeta   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TLN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15-q21   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q15-q21

TLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLN2 gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P039762:  view genomic region     (about GC identifiers)

Start:
39,762,354 bp from pter
End:
39,959,569 bp from pter
Size:
197,216 bases
Orientation:
plus strand

1 alternative location:
Chr15+ 62,939,477-63,136,830     
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6 (See protein sequence)
Recommended Name: Talin-2  
Size: 2542 amino acids; 271613 Da
Subunit: Interacts directly with PIP5K1C
Subcellular location: Cell junction, focal adhesion. Cell junction, synapse. Cell membrane; Peripheral membrane
protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=Focal adhesion plaques and synapses
Secondary accessions: A6NLB8

Explore the universe of human proteins at neXtProt for TLN2: NX_Q9Y4G6 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055874.2  

    ENSEMBL proteins: 
    ENSP00000303476 ENSP00000390602 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for TLN2 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/9 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726 ruffle IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005856 cytoskeleton ----
    GO:0005886 plasma membrane IEA--
    GO:0005911 cell-cell junction IC15494027
    About this table

    TLN2 for ontologies           About GeneDecksing



    Antibodies for TLN2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TLN2
    R&D Systems Antibodies for TLN2 (Talin2)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for TLN2 
    Browse antibodies at Epitomics

    Assays for TLN2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLN2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TLN2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TLN2 for domains           About GeneDecksing

    5/13 InterPro domains/families (see all 13):
     IPR019748 FERM_central
     IPR006077 Vinculin/catenin
     IPR002558 ILWEQ
     IPR015710 Talin-rel
     IPR015224 Talin_cent

    Graphical View of Domain Structure for InterPro Entry Q9Y4G6

    ProtoNet protein and cluster: Q9Y4G6

    2 Blocks protein families:
    IPB000299 Band 4.1 domain
    IPB002558 I/LWEQ domain


    UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6
    Similarity: Contains 1 FERM domain
    Similarity: Contains 1 I/LWEQ domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TLN2_HUMAN, Q9Y4G6
    Function: As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an
    important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity
    (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLN2
    Sigma-Aldrich shRNA for TLN2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TLN2
    OriGene shRNA RFP (see all 2): TLN2
    OriGene basic RS shRNA (see all 2): TLN2
    OriGene siRNA: TLN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLN2 
    miRNA:Sigma-Aldrich microRNA Mimics for TLN2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLN2 
    7 SABiosciences Assays for microRNAs that regulate TLN2:
    hsa-miR-577 hsa-miR-873 hsa-miR-200c hsa-miR-429 hsa-miR-194 hsa-miR-331-3p hsa-miR-1289

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TLN2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLN2
    OriGene untagged cDNA clones in CMV expression vector: TLN2
    OriGene 3'-UTR clone: TLN2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TLN2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TLN2 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779 actin binding NAS10320934
    GO:0004871 signal transducer activity ----
    GO:0005158 insulin receptor binding IEA--
    GO:0005198 structural molecule activity NAS10320934
    GO:0005200 structural constituent of cytoskeleton IEA--
    About this table

    TLN2 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Tln2):

    behavior/neurologicallethality-prenatal/perinatalmusclenormal

    TLN2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TLN2 for pathways           About GeneDecksing

    5 Millipore Pathways for TLN2
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cytoskeleton remodeling Integrin outside-in signaling
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Cytoskeleton remodeling FAK signaling
    Cell adhesion Integrin inside-out signaling

    5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  TLN2
        FAK Signaling
    Crosstalk between Dendritic Cells and Natural Killer Cells
    Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
    Integrin Signaling
    ERK/MAPK Signaling

    1 Kegg Pathway  (Kegg details for TLN2):
        hsa04510 Focal adhesion

        SABiosciences Custom Pathway-Focused PCR Arrays for TLN2 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TLN2
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TLN2

    5/563 Interacting proteins for TLN2 (Q9Y4G62 ENSP000003034763) via UniProtKB, MINT, and/or STRING (see all 563)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TLN1Q9Y4902, ENSP000003160293MINT-7947479 STRING: ENSP00000316029
    ITGB2P051072MINT-7226365 MINT-7226134 MINT-7226171 MINT-7226150 MINT-7226403
    ABL1P005192MINT-7226309 MINT-7226142 MINT-7226210
    ABCF1Q8NE712MINT-7947479
    ABCF3Q9NUQ82MINT-7947479
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007016 cytoskeletal anchoring at plasma membrane IEA--
    GO:0007043 cell-cell junction assembly TAS15494027
    GO:0007155 cell adhesion NAS11907066
    GO:0007165 signal transduction ----
    About this table

    TLN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TLN2


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLN2
    Sigma-Aldrich shRNA for TLN2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TLN2
    OriGene shRNA RFP (see all 2): TLN2
    OriGene basic RS shRNA (see all 2): TLN2
    OriGene siRNA: TLN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLN2 
    miRNA: Sigma-Aldrich microRNA Mimics for TLN2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLN2 
    7 SABiosciences Assays for microRNAs that regulate TLN2:
    hsa-miR-577 hsa-miR-873 hsa-miR-200c hsa-miR-429 hsa-miR-194 hsa-miR-331-3p hsa-miR-1289
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TLN2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLN2
    OriGene untagged cDNA clones in CMV expression vector: TLN2
    OriGene 3'-UTR Clone: TLN2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TLN2 
    Primers: OriGene genome-wide validated SYBR primer pairs: TLN2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TLN2: PPH12365A

    REFSEQ mRNAs for TLN2 gene: 

    NM_015059.2  

    Additional cDNA sequence: AL122065.1 

    8 DOTS entries:

    DT.100754091  DT.455182  DT.95214510  DT.40229939  DT.422660  DT.121070150  DT.75107131  DT.431249 

    3 AceView cDNA sequences:

    AL122065 AL042061 BF737572 

    highest scoring ESTs for TLN2:

    AA290618 AA290619 AA291005 AA291006 AA582699 AA854194 AF085910 AI142264 AI249792 AI307663 

    Unigene Clusters for TLN2:

    Talin 2
    Hs.569438  [show with all ESTs], Hs.610975  [show with all ESTs]
    Unigene Representative Sequences: NM_015059, AL122065


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TLN2 (see all 11)

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                        -   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38 ^ 39 ^ 40a · 40b ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^
    SP1:                          -                                         -                                                     -                                 
    SP2:                                                                    -                                                     -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 46 ^ 47 ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b ^ 54a · 54b · 54c
    SP1:                                            -                 -                                 
    SP2:                                            -                 -                                 
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                            -                                                   

    About this scheme

    ECgene alternative splicing isoforms for TLN2
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000494733 ENST00000474847 ENST00000489129 ENST00000306829(uc002alb.3 uc002alc.3 uc010uic.1)
    ENST00000442402 ENST00000472902(uc002ald.2) ENST00000467297

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TLN2 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching TLN2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39765_at2, 3 U95-A 1 0.81 1.00 0.72 1.44 AB002318 0.80 0.88 0.84 1
    81893_at2, 3 U95-D 1 0.50 1.00 0.84 0.60 AI248252 0.60 1.00 0.82 1
    212701_at2, 3 U133-A 1 0.91 1.00 -- -- AB002318 0.80 0.88 0.84 1
    212703_at2, 3 U133-A 1 0.91 1.00 -- -- AV728958 0.80 1.00 0.91 1
    212701_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    212703_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    TLN2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TLN2 gene expression
    TLN2 gene electronic northern expression
    TLN2 gene sage expression
    About these images

    CGAP SAGE TAG: AAAGGTTATT

    SOURCE GeneReport for Unigene clusters: Hs.569438 Hs.610975
    Primers: OriGene genome-wide validated SYBR primer pairs: TLN2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TLN2: PPH12365A
        SABiosciences Custom PCR Arrays for TLN2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TLN2 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TLN21   -- talin 2 91.77(n)
    99.13(a)
    478331  XM_859740.1  XP_864833.1 
    chimpanzee
    (Pan troglodytes)
    TLN21   -- talin 2 99.54(n)
    99.69(a)
    453494  XM_001173465.1  XP_001173465.1 
    cow
    (Bos taurus)
    TLN21   -- talin 2 90.85(n)
    98.82(a)
    528252  XM_606666.3  XP_606666.3 
    rat
    (Rattus norvegicus)
    RGD15654161   -- similar to talin 2 89.64(n)
    98.62(a)
    315776  XM_236367.4  XP_236367.3 
    mouse
    (Mus musculus)
    Tln21 , 5 9 (36.39 cM)5
    talin 21, 5 89.68(n)1
    98.7(a)1
    705491  NM_001081242.11  NP_001074711.11 
     AB0932315  AF4670815  (see all 27)
    About this table        Species with no ortholog for TLN2

    ENSEMBL Gene Tree for TLN2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TLN2 gene
    HIP12  TLN12  MESDC12  HIP1R2  

    TLN2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/2203 NCBI SNPs in TLN2 are shown (see all 2203)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs8687041,2
    F,63111400(-) AAACAC/AACACA 1 -- int14Minor allele frequency- A:0.01NS EA 410
    rs8687051,2
    C,F,O,63111365(-) TAAGAA/GCATTC 1 -- int110Minor allele frequency- G:0.12NS EA NA WA 772
    rs8717001,2
    C,F,A,63008489(-) GCAGGA/GGACAT 1 -- int111Minor allele frequency- G:0.07NA EA NS WA 835
    rs8812351,2
    C,F,O,63135978(+) CATCAA/GGGAAC 1 -- ut3111Minor allele frequency- G:0.08MN NS EA NA 974
    rs9374131,2
    C,F,A,H,63075551(-) CGATTC/TTCACC 1 -- int114Minor allele frequency- T:0.02NA NS EA WA 566
    rs9374141,2
    C,F,O,A,H,63063612(-) GCATTG/ACAGTT 1 -- int125Minor allele frequency- A:0.43MN NA NS EA WA 1752
    rs9374151,2
    C,F,A,H,63117224(+) GGGTCG/ACCAAC 1 -- int113Minor allele frequency- A:0.08MN NS EA NA WA 690
    rs9374161,2
    C,F,A,H,63118761(+) GGTGGG/CAGTCC 1 -- int113Minor allele frequency- C:0.10MN NS EA NA WA 666
    rs9374171,2
    C,A,H,63119194(+) CACGGC/GTGGTT 1 -- int110Minor allele frequency- G:0.09MN NA WA 324
    rs9374181,2
    C,F,A,63131117(+) GCAGCT/ATTTGG 2 /A syn1 ref114Minor allele frequency- A:0.31MN NS EA NA WA 2720
    About this table

    HapMap Linkage Disequilibrium images for TLN2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TLN2
         4 Indels: 76980 45354 41738 87705

    QIAGEN SeqTarget long-range PCR primers for resequencing TLN2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TLN2 for disorders           About GeneDecksing

    OMIM: 607349

    Human Genome Epidemiology (HuGE) Navigator: TLN2 (1 document)

    Export disorders and mutations for TLN2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/23 PubMed articles for TLN2 gene, integrated from 7 sources (see all 23):
    (articles sorted by number of sources associating them with TLN2)
    1. Analysis of the mammalian talin2 gene TLN2. (PubMed id 11527381)1, 2, 3 Monkley S.J....Critchley D.R. (2001)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)1, 2 Beausoleil S.A....Gygi S.P. (2004)
    6. Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin. (PubMed id 12422219)1, 2 Di Paolo G.... De Camilli P. (2002)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Proteomic analysis of cerebrospinal fluid from patients with idiopathic temporal lobe epilepsy. (PubMed id 19109932)1, 7 Xiao F....Wang X.F. (2009)
    9. Talin2 is induced during striated muscle differentiation and is targeted to stable adhesion complexes in mature muscle. (PubMed id 17183545)1, 7 Senetar M.A....McCann R.O. (2007)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 83660 HGNC: 15447 AceView: TLN2.2 Ensembl:ENSG00000171914 euGenes: HUgn83660
    ECgene: TLN2 Kegg: 83660 H-InvDB: TLN2

    (According to HUGE)
    About This Section
    HUGE: KIAA0320

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TLN2 gene:
    Search GeneIP for patents involving TLN2

    GeneCards and IP:
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     ELISAs and CLIAs for TLN2
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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