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TLR6 Gene

protein-coding   GIFtS: 63

GC04M038149
toll-like receptor 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
toll-like receptor 61 2
CD2861 2
OTTHUMP000001587302
OTTHUMP000002181872
OTTHUMP000002181882
CD286 antigen3

External Ids:    HGNC: 167111   Entrez Gene: 103332   Ensembl: ENSG000001741307   UniProtKB: Q9Y2C93   

Export aliases for TLR6 gene to outside databases

Previous GC identifers: GC04P039066 GC04M038992 GC04M038663 GC04M038725 GC04M038650 GC04M038504 GC04M038828


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TLR6:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in
pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share
structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are
expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective
immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with
toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. (provided by RefSeq)

UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9
Function: Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6,
leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal
macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and
B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2

summary for TLR6:
Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the
innate immune system. TLRs generally exist as homodimers (although TLR2-TLR6 heterodimers have been
reported) and are found on immune cells such as macrophages, B lymphocytes and mast cells. Toll-like
receptors are activated by molecules associated with biological threat and are highly specific towards
evolutionary conserved entities on microbes, such as bacterial cell-surface lipopolysaccharides, flagella
and unmethylated CpG islands. It has been suggested that some toll-like receptors may have endogenous
ligands, such as Hsp60 and fibrinogen, and this has promoted speculation that endogenous toll-like receptor
activators may have a pathological role in autoimmune disease. Activation of toll-like receptors initiates
downstream signaling cascades, initially via the adapter molecules MyD88, Trap, Trif and Tram, which
converge on the PI 3-K and NF-kappaB pathways and regulate intracellular kinases and gene expression. This
can stimulate an inflammatory and/or antigen-specific immune response. The signaling cascade coupled to
toll-like receptor activation is very similar to that of interleukin-1 receptor (IL-1R) activation.

Gene Wiki entry for TLR6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TLR6 gene promoter:
         CREB   deltaCREB   TGIF   COUP-TF1   HNF-4alpha2   GCNF-1   GCNF-2   FOXJ2 (long isoform)   STAT5A   PPAR-gamma2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TLR6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p16.1

TLR6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TLR6 gene location

GeneLoc gene densities for chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M038149:  view genomic region     (about GC identifiers)

Start:
38,149,688 bp from pter
End:
38,182,936 bp from pter
Size:
33,249 bases
Orientation:
minus strand

1 alternative location:
Chr4- 38,828,223-38,858,438     
RefSeq DNA sequence:
NC_000004.11  NT_016297.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9 (See protein sequence)
Recommended Name: Toll-like receptor 6 precursor  
Size: 796 amino acids; 91880 Da
Subunit: Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains (By
similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle,
phagosome membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: B3Y640 B6CH35 B6RFS4 B6RFS5

Explore the universe of human proteins at neXtProt for TLR6: NX_Q9Y2C9 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006059.2  

    ENSEMBL proteins: 
    ENSP00000371376 ENSP00000424718 ENSP00000423326 ENSP00000392315 ENSP00000389600 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for TLR6
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TLR6
    GenScript Custom Purified and Recombinant Proteins Services for TLR6 
    Novus Biologicals Protein for TLR6
    Novus Biologicals Lysate for TLR6
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane TAS--
    GO:0005887 integral to plasma membrane TAS10231569
    GO:0016021 integral to membrane ----
    GO:0030670 phagocytic vesicle membrane IEA--
    GO:0031224 intrinsic to membrane ----
    About this table

    TLR6 for ontologies           About GeneDecksing



    Antibodies for TLR6: 
    Millipore Mono- and Polyclonal Antibodies for the study of TLR6
    Sigma-Aldrich Antibodies for TLR6
    R&D Systems Antibodies for TLR6
    OriGene Antibodies (see all 2): TLR6
    GenScript Custom Superior Antibodies Services for TLR6 
    Novus Biologicals Antibodies for TLR6
    Browse antibodies at Epitomics

    Assays for TLR6: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TLR6 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TLR6 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TLR6 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000483 Cys-rich_flank_reg_C
     IPR001611 Leu-rich_rpt
     IPR000157 Toll-Interleukin_rcpt
     IPR017241 Toll-like_receptor
     IPR004075 IL1_rcpt_1

    Graphical View of Domain Structure for InterPro Entry Q9Y2C9

    ProtoNet protein and cluster: Q9Y2C9

    3 Blocks protein families:
    IPB000157 TIR domain
    IPB000483 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9
    Similarity: Belongs to the Toll-like receptor family
    Similarity: Contains 13 LRR (leucine-rich) repeats
    Similarity: Contains 1 TIR domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9
    Function: Participates in the innate immune response to Gram-positive bacteria and fungi. Acts via MYD88 and TRAF6,
    leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal
    macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and
    B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLR6
    Sigma-Aldrich shRNA for TLR6
    OriGene 29mer shRNA kits in GFP-retroviral vector: TLR6
    OriGene shRNA RFP: TLR6
    OriGene basic RS shRNA: TLR6
    OriGene siRNA: TLR6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLR6 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLR6 
    Search SABiosciences for Assays for microRNAs that regulate TLR6

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TLR6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLR6
    OriGene untagged cDNA clones in CMV expression vector: TLR6
    OriGene 3'-UTR clone: TLR6 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TLR6 
    Sino Biological Human cDNA Clone for TLR6

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TLR6 

    Genatlas biochemistry entry for TLR6:
    Drosophila transmembrane receptor Toll homolog 6,predominantly expressed in spleen,thymus,ovary and lung

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity TAS10426995
    GO:0004888 transmembrane receptor activity IEA--
    GO:0005515 protein binding IEA--
    GO:0008034 lipoprotein binding ----
    GO:0042498 diacyl lipopeptide binding IEA--
    About this table

    TLR6 for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Tlr6):

    immune systemreproductive system

    TLR6 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TLR6 for pathways           About GeneDecksing

    1 Millipore Pathway for TLR6
        Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response

    5/8 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  TLR6 (see all 8)
        Toll-like Receptor Signaling
    NF-κB Signaling
    Communication between Innate and Adaptive Immune Cells
    TREM1 Signaling
    Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses

    3 Kegg Pathways  (Kegg details for TLR6):
        hsa04145 Phagosome
    hsa04620 Toll-like receptor signaling pathway
    hsa05142 Chagas disease

        SABiosciences Pathway-Focused PCR Arrays including TLR6 (see all 7): PAHS-018A PAHS-025A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TLR6
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TLR6

    5 Interacting proteins for TLR6 (ENSP000003713763) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRAK1ENSP000003589973STRING: ENSP00000358997
    B4GALT6ENSP000003064593STRING: ENSP00000306459
    MOBPENSP000003466953STRING: ENSP00000346695
    TLR2ENSP000002600103STRING: ENSP00000260010
    --ENSP000003238903STRING: ENSP00000323890
    About this table

    5/17 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 17):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002224 toll-like receptor signaling pathway IEA--
    GO:0002282 microglial cell activation involved in immune response IEA--
    GO:0006954 inflammatory response IEA--
    GO:0006955 immune response TAS10426995
    GO:0007165 signal transduction IEA--
    About this table

    TLR6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TLR6 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TLR6 available from Tocris Bioscience
    CompoundAction CAS number
    GIT 27Immunomodulator; reduces production of pro-inflammatory cytokines[6501-72-0]
    About this table


    4 Novoseek chemical compound relationships for TLR6 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    peptidoglycan 66.9 12 18424724 (4), 15661917 (3), 12538701 (1), 12874299 (1) (see all 5)
    flagellin 55.1 1 19270494 (1)
    rantes 16.4 2 19117515 (1), 19019963 (1)
    lipid 0 1 19931471 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TLR6
    Sigma-Aldrich shRNA for TLR6
    OriGene 29mer shRNA kits in GFP-retroviral vector: TLR6
    OriGene shRNA RFP: TLR6
    OriGene basic RS shRNA: TLR6
    OriGene siRNA: TLR6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TLR6 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TLR6 
    Search SABiosciences for Assays for microRNAs that regulate TLR6
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TLR6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TLR6
    OriGene untagged cDNA clones in CMV expression vector: TLR6
    OriGene 3'-UTR Clone: TLR6 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TLR6 
    Primers: OriGene genome-wide validated SYBR primer pairs: TLR6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TLR6: PPH01798A

    REFSEQ mRNAs for TLR6 gene: 

    NM_006068.3  

    Additional cDNA sequence: AB445652.1 

    5 DOTS entries:

    DT.40189829  DT.439547  DT.91841289  DT.101960681  DT.40289093 

    13 AceView cDNA sequences:

    NM_006068 AA810462 AB020807 CA310973 AA381849 CF136926 BI031573 AA831782 
    BF170087 BQ337481 BE814766 AI184710 BI031578 

    highest scoring ESTs for TLR6:

    AB020807 AA381849 BF170087 AI184710 CF136926 NM_006068 AA810462 AA831782 AW404073 BC111755 

    Unigene Clusters for TLR6:

    Toll-like receptor 6
    Hs.575090  [show with all ESTs], Hs.726667  [show with all ESTs]
    Unigene Representative Sequences: NM_006068, AB445652


    GeneLoc Exon Structure

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381950(uc003gtm.2 uc010ifg.1) ENST00000508254 ENST00000514655
    ENST00000440845 ENST00000436693

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TLR6 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching TLR6 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34144_at2, 3 U95-A 1 0.75 1.00 0.94 0.75 AB020807 0.80 0.80 0.80 1
    34145_at2, 3 U95-A 1 0.56 1.00 0.88 1.26 AI184710 0.40 0.67 0.55 1
    207446_at2, 3 U133-A 1 0.64 1.00 -- -- NM_006068 0.40 0.67 0.55 1
    239021_at2 U133-B 1 0.27 1.00 -- -- -- -- -- -- --
    207446_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    239021_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    TLR6 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TLR6 gene expression
    TLR6 gene electronic northern expression
    TLR6 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.575090 Hs.726667

    Expression variation in blood from EXPOLDB for TLR6

    UniProtKB/Swiss-Prot: TLR6_HUMAN, Q9Y2C9
    Tissue specificity: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal
    microvessel endothelial cells

    Primers: OriGene genome-wide validated SYBR primer pairs: TLR6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TLR6: PPH01798A
        SABiosciences Expression via Pathway-Focused PCR Arrays including TLR6 (see all 7): PAHS-018A PAHS-025A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TLR6 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    TLR61   -- toll-like receptor 6 98.7(n)
    98.12(a)
    471167  XM_001139197.1  XP_001139197.1 
    cow
    (Bos taurus)
    TLR61   -- toll-like receptor 6 85.16(n)
    79.59(a)
    407237  NM_001001159.1  NP_001001159.1 
    rat
    (Rattus norvegicus)
    Tlr61   -- toll-like receptor 6 77.78(n)
    74.34(a)
    305353  NM_207604.1  NP_997487.1 
    mouse
    (Mus musculus)
    Tlr61 , 5 5 (33.54 cM)5
    toll-like receptor 61, 5 77.69(n)1
    73.84(a)1
    218991  NM_011604.21  NP_035734.21 
     AB0208085  AF3146365  (see all 9)
    chicken
    (Gallus gallus)
    TLR61   -- toll-like receptor 6 61.61(n)
    55.47(a)
    771173  XM_001234468.1  XP_001234469.1 
    About this table        Species with no ortholog for TLR6

    ENSEMBL Gene Tree for TLR6 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TLR6 gene
    TLR12  TLR102  TLR52  TLR22  

    TLR6 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/524 NCBI SNPs in TLR6 are shown (see all 524)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 4 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1672511,2
    --38832492(-) ACGTAG/AAGCAA 1 -- int11Minor allele frequency- A:0.00MN 184
    rs1841841,2
    H38832393(-) CTCTAG/AAAATC 1 -- int14Minor allele frequency- A:0.00NS EA 402
    rs1884891,2
    --38832587(-) AATTAA/GAGATT 1 -- int10--------
    rs1909531,2
    --38849900(-) gtacaA/Gatggg 1 -- int10--------
    rs1909541,2
    --38844426(-) tcttcG/Taaatt 1 -- int10--------
    rs2994011,2
    --38849981(-) ttttaA/Gaattt 1 -- int10--------
    rs3650001,2
    --38859747(+) TGACAA/CAAACA 1 -- ng510--------
    rs3662651,2
    H38856267(+) agtacA/Gagctt 1 -- int14Minor allele frequency- G:0.00NS EA 418
    rs3687131,2
    H38845153(-) CCTGTT/GTTACT 1 -- int14Minor allele frequency- G:0.00NS EA 420
    rs3692341,2
    H38845626(-) GCCTAG/TCTACT 1 -- int14Minor allele frequency- T:0.00NS EA 418
    About this table

    HapMap Linkage Disequilibrium images for TLR6 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for TLR6
         3 CNVs: 9472 80259 92051
         1 Indel: 92052

    QIAGEN SeqTarget long-range PCR primers for resequencing TLR6 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TLR6 for disorders           About GeneDecksing

    OMIM: 605403

    4 Novoseek disease relationships for TLR6 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 40.2 4 19019962 (1), 19117515 (1), 18424724 (1), 18159247 (1)
    necrosis 14.9 5 19621822 (1), 19019963 (1), 16960116 (1), 17714490 (1) (see all 5)
    asthma 12.1 5 15266299 (1), 18547625 (1), 16629799 (1), 16505608 (1)
    tumors 0 4 19621822 (1), 19019963 (1), 16960116 (1), 14585198 (1)
    About this table

    Human Gene Mutation Database (HGMD): TLR6
    Genetic Association Database (GAD): TLR6
    Human Genome Epidemiology (HuGE) Navigator: TLR6 (51 documents)

    Export disorders and mutations for TLR6 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/190 PubMed articles for TLR6 gene, integrated from 7 sources (see all 190):
    (articles sorted by number of sources associating them with TLR6)
    1. TLR6: a novel member of an expanding Toll-like receptor family. (PubMed id 10231569)1, 2, 3, 7 Takeuchi O.... Akira S. (1999)
    2. Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma. (PubMed id 15266299)1, 4, 7 Tantisira K....Weiss S.T. (2004)
    3. Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. (PubMed id 11441107)1, 2, 7 Bulut Y.... Arditi M. (2001)
    4. Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease. (PubMed id 16188043)1, 4, 7 Hoffjan S....Epplen J.T. (2005)
    5. Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases. (PubMed id 16374251)1, 4, 7 Pierik M....Vermeire S. (2006)
    6. Natural selection in the TLR-related genes in the course of primate evolution. (PubMed id 18810425)1, 2 Nakajima T....Kimura A. (2008)
    7. Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease. (PubMed id 16081826)1, 4 Schroder N.W....Schumann R.R. (2005)
    8. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. (PubMed id 15812078)1, 4 Sun J....Gronberg H. (2005)
    9. Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. (PubMed id 15661917)1, 7 Nakao Y....Matsumoto M. (2005)
    10. Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. (PubMed id 18159247)1, 7 Kuhlicke J....Eltzschig H.K. (2007)

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    Entrez Gene: 10333 HGNC: 16711 AceView: TLR6 Ensembl:ENSG00000174130 euGenes: HUgn10333
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