Aliases &
Descriptions
for TMED2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| transmembrane emp24 domain trafficking protein 21 2 | | FLJ213232 | | RNP241 2 3 | | coated vesicle membrane protein2 | | P24A1 2 | | transmembrane emp24 domain-containing protein 22 | | Membrane protein p24A2 3 | | |
Export aliases for TMED2 gene to outside databasesPrevious GC identifers: GC12P122595 GC12P124069 |
Summaries
for TMED2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363Function: Could have a role in the budding of coatomer-coated and other species of coated vesicles. Could bind cargomolecules to collect them into budding vesicles
Gene Wiki entry for TMED2 |
Genomic Views
for TMED2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMED2 gene promoter:
NRSF form 2 NRSF form 1 CUTL1 SRY Pax-5 deltaCREB CREB STAT3 C/EBPalpha Egr-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMED2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TMED2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.31 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31TMED2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P121030: view genomic region
(about GC identifiers)
Start:
|
121,030,441 bp from pter |
End:
|
121,044,052 bp from pter |
Size:
|
13,612 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr12+ 124,069,076-124,082,681 |
RefSeq DNA sequence:- NC_000012.11 NT_009755.19
|
Proteins
for TMED2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363 (See
protein sequence)Recommended Name: Transmembrane emp24 domain-containing protein 2 precursor Size: 201 amino acids; 22761 Da
Subunit: Interacts with ARFGAP1, inhibiting the GTPase-activating activity of ARFGAP1 (By similarity). Found in acomplex composed at least of SURF4, TMED2 and TMED10
Subcellular location: Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Cytoplasmic vesicle,COPI-coated vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type Imembrane protein. Note=Golgi-derived coatomer-coated vesiclesExplore the universe of human proteins at neXtProt for TMED2: NX_Q15363
REFSEQ proteins: NP_006806.1
ENSEMBL proteins: ENSP00000262225 ENSP00000405845 ENSP00000388691
Human Recombinant Proteins
5/11 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 11): About this table
TMED2 for ontologies About GeneDecksing
Antibodies for TMED2:
Assays for TMED2: |
Protein
Domains/
Families
for TMED2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMED2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15363ProtoNet protein and cluster: Q15363 1 Blocks protein family: IPB000348 emp24/gp25L/p24 family
UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363Similarity: Belongs to the EMP24/GP25L familySimilarity: Contains 1 GOLD domain |
Gene Function
for TMED2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TMED2_HUMAN, Q15363Function: Could have a role in the budding of coatomer-coated and other species of coated vesicles. Could bind cargomolecules to collect them into budding vesicles
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
TMED2 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tmed2):
TMED2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMED2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TMED2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMED2
2 Interacting proteins for TMED2 (Q153631 ENSP000002622253) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
TMED2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMED2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TMED2
|
Transcripts
for TMED2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TMED2 gene: NM_006815.3 Additional cDNA sequence: AK024976.1 AK298167.1 AK303189.1 AK312975.1 BC025957.1 CR541663.1 CR541682.1 CR620150.1 X92098.1 24/31 DOTS entries (see all 31): DT.100679824 DT.75193702 DT.91979006 DT.100676134 DT.100679813 DT.100679819 DT.100758886 DT.100679818 DT.100679821 DT.100679822 DT.97855376 DT.100679814 DT.95263835 DT.95263842 DT.97855375 DT.100679815 DT.121107135 DT.95263820 DT.100679820 DT.100031694 DT.100679825 DT.100861921 DT.121107125 DT.121107126 24/821 AceView cDNA sequences (see all 821): BG778100 CR612554 AA773432 BF724130 AV658574 AA971825 F10166 CA941694 CA445272 CA950234 AA298291 AA999791 AA305298 AA233919 AI471088 AA587489 Z38930 CB146186 AI698520 AI758393 C02110 AU116907 AA447084 AI285454
 highest scoring ESTs for TMED2:AI985603 X92098 AA001157 AA001197 AA028932 AA031517 AA031518 AA081949 AA101171 AA121047 Unigene Cluster for TMED2: Transmembrane emp24 domain trafficking protein 2 Hs.75914 [show with all ESTs]Unigene Representative Sequence: NM_006815
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TMED2
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TMED2
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000262225(uc001ufg.2) ENST00000438031 ENST00000432022
|
Expression
for TMED2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TMED2 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching TMED2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36972_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.99 |
0.87 |
X92098 |
1.00 |
1.00 |
1.00 |
1 |
| 75058_f_at2, 3
|
U95-D |
1 |
1.00 |
1.00 |
0.99 |
1.13 |
AI985603 |
1.00 |
1.00 |
1.00 |
1 |
| 200087_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AK024976 |
0.80 |
1.00 |
0.91 |
1 |
| 204427_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_006815 |
0.60 |
1.00 |
0.82 |
1 |
| 204426_at2, 3
|
U133-A |
2 |
1.00 |
0.91 |
-- |
-- |
NM_006815 |
0.60 |
1.00 |
0.82 |
1 |
| 200087_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 204427_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 204426_at2
|
U133Plus2 |
2 |
1.00 |
0.91 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TMED2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCAAGTTTTT
SOURCE GeneReport for Unigene cluster: Hs.75914
SABiosciences Custom PCR Arrays for TMED2
|
Orthologs
for TMED2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TMED2 gene from 5/18 species (see all 18)
About this table Species with no ortholog for TMED2
ENSEMBL Gene Tree for TMED2 (if available) |
Paralogs
for TMED2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for TMED2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TMED2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMED2
1 CNV: 5313 | | QIAGEN SeqTarget long-range PCR primers for resequencing TMED2 |
|
Disorders & Mutations
for TMED2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for TMED2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TMED2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for TMED2 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with TMED2)- Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. (PubMed id 8663407)1, 2, 3, 7 Blum R....Schulz I. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The cargo receptor p24A facilitates calcium sensing r eceptor maturation and stabilization in the early secretory pathway. (PubMed id 20361938)1 Stepanchick A. and Breitwieser G.E. (2010)
- The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi. (PubMed id 18287528)2 Mitrovic S.... Hauri H.-P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. (PubMed id 17693410)1 Luo W....Reiser G. (2007)
- TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity. (PubMed id 16641999)1 Chen F....Fraser P. (2006)
- Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. (PubMed id 15308636)1 Breuza L....Hauri H.P. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. (PubMed id 11739402)1 Barr F.A.... Koerner R. (2001)
|
External Searches for TMED2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMED2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMED2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMED2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TMED2 gene:
Search GeneIP for patents involving TMED2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMED2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for TMED2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for TMED2 |
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