Aliases &
Descriptions
for TMEM45B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| transmembrane protein 45B1 2 | | FLJ407871 2 | | BC0161531 |
Export aliases for TMEM45B gene to outside databasesPrevious GC identifers: GC11P129191 GC11P129688 |
Summaries
for TMEM45B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM45B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM45B gene promoter:
C/EBPbeta HNF-1A C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM45B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TMEM45B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24.3 Ensembl cytogenetic band: 11q24.3 HGNC cytogenetic band: 11q24.3TMEM45B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P125638: view genomic region
(about GC identifiers)
Start:
|
125,638,021 bp from pter |
End:
|
125,682,185 bp from pter |
Size:
|
44,165 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr11+ 129,685,741-129,729,898 |
RefSeq DNA sequence:- NC_000011.9 NT_033899.8
|
Proteins
for TMEM45B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TM45B_HUMAN, Q96B21 (See
protein sequence)Recommended Name: Transmembrane protein 45B Size: 275 amino acids; 31826 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: A8K2L8Explore the universe of human proteins at neXtProt for TMEM45B: NX_Q96B21
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_620143.1
ENSEMBL proteins: ENSP00000281441
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
TMEM45B for ontologies About GeneDecksing
Antibodies for TMEM45B:
Assays for TMEM45B: |
Protein
Domains/
Families
for TMEM45B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM45B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96B21ProtoNet protein and cluster: Q96B21 UniProtKB/Swiss-Prot: TM45B_HUMAN, Q96B21Similarity: Belongs to the TMEM45 family |
Gene Function
for TMEM45B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
|
Pathways & Interactions
for TMEM45B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TMEM45B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM45B
|
Drugs & Compounds
for TMEM45B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TMEM45B
|
Transcripts
for TMEM45B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TMEM45B gene: NM_138788.3 Additional cDNA sequence: AK098106.1 AK290283.1 AK292058.1 BC016153.1 10 DOTS entries: DT.438794 DT.100751648 DT.97829262 DT.99929312 DT.120752401 DT.120752363 DT.75187624 DT.91641524 DT.92422843 DT.209217 24/128 AceView cDNA sequences (see all 128): BU674569 BU076284 AK098106 BF000269 AA860541 BQ082344 NM_138788 BM741999 BC016153 BX282180 AA470716 AW295567 BM827924 BU076544 CB850847 AW662394 AA627508 BI256410 CA433047 BM263545 BM875635 AA343712 BI334794 BE734498
 highest scoring ESTs for TMEM45B:AI282982 AA313367 AA343712 AA470716 AA503691 AA627508 AA860541 AI052130 AI222949 AI380498 Unigene Cluster for TMEM45B: Transmembrane protein 45B Hs.504301 [show with all ESTs]Unigene Representative Sequence: AK098106
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM45B (see all 6)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TMEM45B
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000281441(uc001qfe.1 uc001qff.1)
|
Expression
for TMEM45B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TMEM45B expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching TMEM45B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 59820_at2, 3
|
U95-B |
1 |
0.81 |
1.00 |
0.73 |
1.03 |
H87671 |
0.80 |
1.00 |
0.91 |
1 |
| 90273_at2, 3
|
U95-E |
1 |
0.50 |
1.00 |
0.78 |
0.99 |
AI282982 |
1.00 |
1.00 |
1.00 |
1 |
| 226226_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AI282982 |
1.00 |
1.00 |
1.00 |
1 |
| 230323_s_at2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
AW242836 |
0.80 |
1.00 |
0.91 |
1 |
| 226226_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230323_s_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TMEM45B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GATGAATCCG
SOURCE GeneReport for Unigene cluster: Hs.504301
SABiosciences Custom PCR Arrays for TMEM45B
|
Orthologs
for TMEM45B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TMEM45B gene from 5/8 species (see all 8)
About this table Species with no ortholog for TMEM45B
ENSEMBL Gene Tree for TMEM45B (if available) |
Paralogs
for TMEM45B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TMEM45B gene
- TMEM45A2 TEDDM12
TMEM45B for paralogs About GeneDecksing
|
Genomic Variants
for TMEM45B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TMEM45B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM45B
1 CNV: 5651 | | QIAGEN SeqTarget long-range PCR primers for resequencing TMEM45B |
|
Disorders & Mutations
for TMEM45B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM45B for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TMEM45B (2 documents)
Export disorders and mutations for TMEM45B gene to outside databases
|
Medical News
for TMEM45B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TMEM45B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
6 PubMed articles for TMEM45B gene integrated from 7 sources:
(articles sorted by number of sources associating them with TMEM45B)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for TMEM45B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM45B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM45B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM45B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TMEM45B gene:
Search GeneIP for patents involving TMEM45B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM45B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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