Aliases &
Descriptions
for TMX3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| thioredoxin-related transmembrane protein 31 2 3 | | Thioredoxin domain-containing protein 102 3 | | KIAA18301 2 3 | | TXNDC102 3 | | PDIA131 2 | | protein disulfide-isomerase TMX32 | | thioredoxin domain containing 101 2 | | protein disulfide isomerase family A, member 132 | | FLJ207931 2 | | EC 5.3.4.13 |
Export aliases for TMX3 gene to outside databasesPrevious GC identifers: GC18M064493 GC18M066340 |
Summaries
for TMX3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. Mayact as a dithiol oxidase
Gene Wiki entry for TMX3 (TXNDC10) |
Genomic Views
for TMX3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for TMX3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMX3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TMX3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18q22 Ensembl cytogenetic band: 18q22.1 HGNC cytogenetic band: 18q22TMX3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M063058: view genomic region
(about GC identifiers)
Start:
|
63,058,873 bp from pter |
End:
|
63,100,314 bp from pter |
Size:
|
41,442 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr18- 66,340,927-66,382,362 |
RefSeq DNA sequence:- NC_000018.9 NT_025028.14
|
Proteins
for TMX3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7 (See
protein sequence)Recommended Name: Protein disulfide-isomerase TMX3 precursor Size: 454 amino acids; 51872 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein
Sequence caution: Sequence=BAA91381.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAB47459.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B3KV75 Q52LT7 Q8N5J0 Q9NWJ9Alternative splicing: 2 isoforms: Q96JJ7-1 Q96JJ7-2 Explore the universe of human proteins at neXtProt for TMX3: NX_Q96JJ7
Post-translational modifications:
N-glycosylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061895.3
ENSEMBL proteins: ENSP00000402605 ENSP00000299608
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
TMX3 for ontologies About GeneDecksing
Antibodies for TMX3:
Assays for TMX3: |
Protein
Domains/
Families
for TMX3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMX3 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q96JJ7ProtoNet protein and cluster: Q96JJ7 1 Blocks protein family: IPB006662 Thioredoxin type domain
UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7Domain: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By similarity)Similarity: Belongs to the protein disulfide isomerase familySimilarity: Contains 1 thioredoxin domain |
Gene Function
for TMX3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7Function: Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. Mayact as a dithiol oxidaseCatalytic activity: Catalyzes the rearrangement of -S-S- bonds in proteinsBiophysicochemical properties: Redox potential: E(0) is -157 mV;Induction: Not up-regulated by unfolded protein response (UPR)Enzyme Number (IUBMB): EC 5.3.4.1
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003756 | protein disulfide isomerase activity |
IEA | -- | | GO:0016853 | isomerase activity |
IEA | -- |
About this table
TMX3 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMX3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TMX3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMX3
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045454 | cell redox homeostasis |
IEA | -- |
About this table
TMX3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMX3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TMX3
|
Transcripts
for TMX3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TMX3 gene: NM_019022.3 Additional cDNA sequence: AB058733.1 AK000800.1 AK025025.1 AK122715.1 AK295551.1 AK307269.1 AK310389.1 AL832341.1 AL832356.1 BC007690.2 BC018981.2 BC032325.2 BC093792.1 BC093794.1 BC107422.1 BC143400.1 BX647846.1 15 DOTS entries: DT.111940 DT.92428462 DT.100692776 DT.75176531 DT.95265677 DT.100782405 DT.121085015 DT.121085046 DT.121085058 DT.91653114 DT.121085011 DT.75120733 DT.92056442 DT.95235894 DT.91853347 24/141 AceView cDNA sequences (see all 141): AK000800 AA393208 AI091616 AI810971 AV707938 N22084 BC018981 AI373582 BI493204 AL832341 BE047661 BQ433483 AI373289 CA406927 AB058733 AI061047 AI285767 BX647846 BI915934 AA384267 BC007690 BE503286 NM_019022 BI493203 Unigene Cluster for TMX3: Thioredoxin-related transmembrane protein 3 Hs.440534 [show with all ESTs]Unigene Representative Sequence: BX647846
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMX3 (see all 7)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TMX3
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000443099(uc010xfa.1) ENST00000299608(uc002lkf.2 uc010xez.1 uc002lkg.3)
|
Expression
for TMX3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TMX3 expression in normal and diseased human tissues
1 / 2 8 probe-sets matching TMX3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 53878_at2
|
U95-C |
1 |
1.00 |
1.00 |
0.81 |
0.70 |
-- |
-- |
-- |
-- |
-- |
| 48348_at2
|
U95-B |
1 |
1.00 |
1.00 |
0.87 |
1.19 |
-- |
-- |
-- |
-- |
-- |
| 48763_at2
|
U95-C |
1 |
0.94 |
1.00 |
0.81 |
1.39 |
-- |
-- |
-- |
-- |
-- |
| 58264_at2
|
U95-C |
1 |
0.88 |
1.00 |
0.55 |
0.52 |
-- |
-- |
-- |
-- |
-- |
| 83929_at2
|
U95-E |
1 |
0.81 |
1.00 |
0.86 |
1.22 |
-- |
-- |
-- |
-- |
-- |
| 225302_at2
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225302_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1552822_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TMX3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ATATTCTGCC
SOURCE GeneReport for Unigene cluster: Hs.440534
UniProtKB/Swiss-Prot: TMX3_HUMAN, Q96JJ7Tissue specificity: Widely expressed. Expressed in brain, testis, lung, skin, kidney, uterus, bone, stomach, liver,prostate, placenta, eye and muscle
SABiosciences Custom PCR Arrays for TMX3
|
Orthologs
for TMX3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TMX3 gene from 5/10 species (see all 10)
About this table Species with no ortholog for TMX3
ENSEMBL Gene Tree for TMX3 (if available) |
Paralogs
for TMX3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TMX3 gene
- PDIA42 PDIA62 PDIA32 PDIA52
TMX3 for paralogs About GeneDecksing
|
Genomic Variants
for TMX3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 18 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TMX3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMX3
1 CNV: 4061 | | QIAGEN SeqTarget long-range PCR primers for resequencing TMX3 |
|
Disorders & Mutations
for TMX3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMX3 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TMX3 (1 document)
Export disorders and mutations for TMX3 gene to outside databases
|
Medical News
for TMX3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TMX3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for TMX3 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with TMX3)- Identification and characterization of a novel thioredoxin-related transmembrane protein of the endoplasmic reticulum. (PubMed id 15623505)1, 2, 3, 7 Haugstetter J.... Ellgaard L. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
- A male with unilateral microphthalmia reveals a role for TMX3 in eye development. (PubMed id 20485507)1, 7 Chao R....Slavotinek A. (2010)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)2 Imami K.... Ishihama Y. (2008)
- Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain. (PubMed id 17881353)1 Haugstetter J....Ellgaard L. (2007)
|
External Searches for TMX3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMX3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMX3 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TMX3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TMX3 gene:
Search GeneIP for patents involving TMX3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMX3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |
| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for TMX3 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for TMX3 |
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