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TNFRSF18 Gene

protein-coding GIFtS: 59

GC01M000410

tumor necrosis factor receptor superfamily, member 18
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
tumor necrosis factor receptor superfamily, member 18¹ ²		Glucocorticoid-induced TNFR-related protein² ³
AITR¹ ² ³ ⁵		TNF receptor superfamily activation-inducible protein²
GITR¹ ² ³ ⁵		tumor necrosis factor receptor superfamily member 18²
Activation-inducible TNFR family receptor² ³		GITR-D²

External Ids:	HGNC: 11914¹	Entrez Gene: 8784²	Ensembl: ENSG00000186891⁷	UniProtKB: Q9Y5U5³

Export aliases for TNFRSF18 gene to outside databases

Previous GC identifers: GC01M000665 GC01M000890 GC01M001015 GC01M001044 GC01M001179 GC01M001128

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF18:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to have

increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological

self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this

receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced

transcript variants of this gene encoding distinct isoforms have been reported. (provided by RefSeq)

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5

Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial

cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK

pathway

Gene Wiki entry for TNFRSF18

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF18 gene promoter:
         GATA-3   NF-kappaB1   NF-kappaB   STAT1beta   STAT1alpha   STAT1   GATA-1   GATA-2   GR-alpha   p53
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TNFRSF18

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TNFRSF18

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.3

TNFRSF18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF18 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M000410: view genomic region (about GC identifiers)

Start:	410,603 bp from pter
End:	413,804 bp from pter
Size:	3,202 bases
Orientation:	minus strand

1 alternative location:

Chr1- 1,138,888-1,142,071

RefSeq DNA sequence:

NC_000001.10 NT_004350.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 18 precursor

Size: 241 amino acids; 26000 Da

Subunit: Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Secondary accessions: B1AME1 O95851 Q9NYJ9

Alternative splicing: 2 isoforms: Q9Y5U5-1 Q9Y5U5-2

Explore the universe of human proteins at neXtProt for TNFRSF18: NX_Q9Y5U5

REFSEQ proteins (3 alternative transcripts):

NP_004186.1 NP_683699.1 NP_683700.1

ENSEMBL proteins:

ENSP00000328207 ENSP00000368570 ENSP00000368567

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for TNFRSF18
	R&D Systems Recombinant & Natural Proteins for TNFRSF18 (GITR/TNFRSF18)
	Enzo Life Sciences proteins for TNFRSF18
	OriGene Purified Protein: TNFRSF18 OriGene Protein Over-expression Lysate: TNFRSF18
	GenScript Custom Purified and Recombinant Proteins Services for TNFRSF18
	Novus Biologicals Proteins for TNFRSF18
	Novus Biologicals Lysates for TNFRSF18
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	IEA	--
GO:0009897	external side of plasma membrane	--	--

About this table

TNFRSF18 for ontologies About GeneDecksing

Antibodies for TNFRSF18:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TNFRSF18
	R&D Systems Antibodies for TNFRSF18 (GITR/TNFRSF18)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for TNFRSF18
	Novus Biologicals Antibodies for TNFRSF18
	Browse antibodies at Epitomics

Assays for TNFRSF18:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for TNFRSF18 (GITR/TNFRSF18)
	GenScript Custom Assay Services for TNFRSF18
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF18 for domains About GeneDecksing

2 InterPro domains/families:

IPR001368 TNFR_Cys_rich_reg

IPR022318 TNFR_18

Graphical View of Domain Structure for InterPro Entry Q9Y5U5

ProtoNet protein and cluster: Q9Y5U5

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5

Similarity: Contains 3 TNFR-Cys repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5

Function: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial

cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK

pathway

Induction: Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for TNFRSF18 Sigma-Aldrich shRNA Panels and shRNA for TNFRSF18
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TNFRSF18 OriGene shRNA RFP (see all 3): TNFRSF18 OriGene basic RS shRNA (see all 3): TNFRSF18 OriGene siRNA (see all 3): TNFRSF18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF18

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF18
		Search SABiosciences for Assays for microRNAs that regulate TNFRSF18

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): TNFRSF18 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): TNFRSF18 OriGene untagged cDNA clones in CMV expression vector (see all 3): TNFRSF18 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): TNFRSF18
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TNFRSF18

Genatlas biochemistry entry for TNFRSF18:

tumor necrosis factor receptor superfamily,member 18,expressed in normal T lymphocytes from

thymus,spleen,lymphonodes,involved in regulation of T cell receptor-mediated cell death

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005031	tumor necrosis factor receptor activity	TAS	10074428

About this table

TNFRSF18 for ontologies About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tnfrsf18):

cellular

hematopoietic system

immune system

TNFRSF18 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

TNFRSF18 for pathways About GeneDecksing

1 Millipore Pathway for TNFRSF18

Apoptosis and survival Apoptotic TNF-family pathways

1 Kegg Pathway (Kegg details for TNFRSF18):

hsa04060 Cytokine-cytokine receptor interaction

SABiosciences Pathway-Focused PCR Arrays including TNFRSF18 (see all 3): PAHS-063A PAHS-074A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF18

5 Interacting proteins for TNFRSF18 (ENSP00000328207³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
IL2	ENSP00000226730³	STRING: ENSP00000226730
IL2RA	ENSP00000369293³	STRING: ENSP00000369293
IL2RB	ENSP00000216223³	STRING: ENSP00000216223
TNFSF18	ENSP00000239468³	STRING: ENSP00000239468
--	ENSP00000276110³	STRING: ENSP00000276110

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--
GO:0006916	anti-apoptosis	TAS	10074428
GO:0007165	signal transduction	TAS	10074428

About this table

TNFRSF18 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF18

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and siRNA for TNFRSF18 Sigma-Aldrich shRNA Panels and shRNA for TNFRSF18
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TNFRSF18 OriGene shRNA RFP (see all 3): TNFRSF18 OriGene basic RS shRNA (see all 3): TNFRSF18 OriGene siRNA (see all 3): TNFRSF18
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF18

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF18
		Search SABiosciences for Assays for microRNAs that regulate TNFRSF18

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): TNFRSF18 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): TNFRSF18 OriGene untagged cDNA clones in CMV expression vector (see all 3): TNFRSF18 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): TNFRSF18

Primers:		OriGene genome-wide validated SYBR primer pairs: TNFRSF18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TNFRSF18: PPH00823A

REFSEQ mRNAs for TNFRSF18 gene (3 alternative transcripts):

NM_004195.2 NM_148901.1 NM_148902.1

Additional cDNA sequence:

AF117297.1 AF125304.1 AF241229.1 AY358877.1 BC152381.1 BC152386.1 BT019531.1 BT019532.1

4 DOTS entries:

DT.75100166 DT.91856189 DT.92417886 DT.95085822

24/27 AceView cDNA sequences (see all 27):

AF125304 AX781601 AX781597 NM_004195 BX115469 NM_148901 AF241229 AF117297

AW084829 AI923712 AI499936 NM_148902 AX781595 AY358877 BQ072868 AX794366

BM920445 AX781599 BP429506 BE047368 BI007820 BU944957 AW300857 BE244247

highest scoring ESTs for TNFRSF18:

AF117297 AF125304 AF241229 AI923712 AY358877 BE244247 BI007820 BI911657 BQ072868 AI499936

Unigene Cluster for TNFRSF18:

Tumor necrosis factor receptor superfamily, member 18

Hs.212680 [show with all ESTs]

Unigene Representative Sequence: NM_004195

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF18

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b
SP1:
SP2:							-

About this scheme

ECgene alternative splicing isoforms for TNFRSF18
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000328596 ENST00000379268(uc001ada.2 uc001adb.2 uc001adc.2 uc001add.2)

ENST00000486728 ENST00000379265

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TNFRSF18 expression in normal and diseased human tissues

¹ / ² / ³

5 probe-sets matching TNFRSF18 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
71144_at²^{, 3}	U95-D	1	0.94	1.00	1.00	1.00	AI923712	0.80	1.00	0.91	1
224553_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF117297	0.80	1.00	0.91	1
223851_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF241229	0.80	1.00	0.91	1
224553_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
223851_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

TNFRSF18 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

TNFRSF18 gene electronic northern expression

About these images

CGAP SAGE TAG: GCCCCCTTCC

SOURCE GeneReport for Unigene cluster: Hs.212680

UniProtKB/Swiss-Prot: TNR18_HUMAN, Q9Y5U5

Tissue specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen

Primers:		OriGene genome-wide validated SYBR primer pairs: TNFRSF18 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TNFRSF18: PPH00823A

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF18 (see all 3): PAHS-063A PAHS-074A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TNFRSF18 gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TNFRSF18¹	--	tumor necrosis factor receptor superfamily, member more	76.4(n) 69.91(a)	606971 XM_843467.1 XP_848560.1
chimpanzee (Pan troglodytes)	TNFRSF18¹	--	tumor necrosis factor receptor superfamily, member more	98.62(n) 96.68(a)	741567 XM_001144452.1 XP_001144452.1
cow (Bos taurus)	TNFRSF18¹	--	tumor necrosis factor receptor superfamily, member more	74.53(n) 67.69(a)	516256 XM_594408.3 XP_594408.2
rat (Rattus norvegicus)	LOC500598¹	--	similar to tumor necrosis factor receptor superfamily, more	67.23(n) 57.98(a)	500598 NM_001024349.1 NP_001019520.1
mouse (Mus musculus)	Tnfrsf18^{1 , 5}	4 (87.76 cM)⁵	tumor necrosis factor receptor superfamily, member more^{1, 5}	68.14(n)¹ 59.29(a)¹	21936¹ NM_009400.2¹ NP_033426.1¹ AF109216⁵ AF229432⁵ (see all 14)

About this table Species with no ortholog for TNFRSF18

ENSEMBL Gene Tree for TNFRSF18 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs946416^1,2	--	1139690(+)	`CCTCCA/GTGCTG`	2	--	int¹		0	--	--	--	--
rs1815606^1,2	C,F,A,H,	1140435(+)	`AGTATT/GTGGTG`	2	--	int¹		17		NA EU NS EA WA	1002
rs2298213^1,2	C,F,	1139202(-)	`GGGCCA/GCCGAC`	3	P	ref¹ syn¹ ut3¹ ese³		5		EA NA EU WA	1556
rs3753344^1,2	C,F,	1142150(+)	`CTGGCG/AGGGAT`	2	--	ng5¹		8		EA NA EU WA	1198
rs3753345^1,2	--	1143093(+)	`AGGCCA/GCCCCG`	2	--	ng5¹		0	--	--	--	--
rs3753346^1,2	C,F,	1143104(+)	`ACGCTC/TGGAAG`	2	--	ng5¹		5		NA EU WA	162
rs3753347^1,2	C,F	1143451(+)	`ATGGCA/GCCATT`	2	--	ng5¹		4		NA EU WA	94
rs3753348^1,2	C,F,	1143657(+)	`ACAGCC/GGGAGA`	2	--	ng5¹		9		NA EU NS EA WA	600
rs3753349^1,2	C,	1144058(+)	`GGCCCC/TGTGTC`	2	--	ng5¹		3		NS EA	298
rs3819001^1,2	C,F,	1138913(-)	`AGGGGA/GCCTTC`	2	--	ut3¹ ese³		8		NA EU NS EA WA	506

About this table

HapMap Linkage Disequilibrium images for TNFRSF18 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TNFRSF18
2 CNVs: 0001 30362

QIAGEN SeqTarget long-range PCR primers for resequencing TNFRSF18

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFRSF18 for disorders About GeneDecksing

OMIM: 603905

10/13 Novoseek disease relationships for TNFRSF18 gene (see all 13)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	62.9	72	17067317 (3), 16955181 (2), 16416233 (1), 17468835 (1) (see all 52)
autoimmune diseases	53.4	7	16868552 (1), 16520557 (1), 17359498 (1), 17963343 (1) (see all 6)
autoimmunity	49	1	16368528 (1)
tumors	45.7	56	17914571 (2), 16416233 (1), 19155305 (1), 19935370 (1) (see all 43)
graft-versus-host disease	42.6	2	15249593 (2)
inflammation	19	12	19234165 (1), 19760073 (1), 17525820 (1), 17804566 (1) (see all 5)
rheumatoid arthritis	18.6	3	17359498 (1), 17602748 (1)
cancer	15.7	2	17360848 (1), 16376102 (1)
uveitis	5.9	3	12892739 (2), 15326137 (1)
infection chronic	4.9	1	16368528 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: TNFRSF18 (8 documents)

Export disorders and mutations for TNFRSF18 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/173 PubMed articles for TNFRSF18 gene, integrated from 7 sources (see all 173):
(articles sorted by number of sources associating them with TNFRSF18)

Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand. (PubMed id 10037686)^{1, 2, 3, 7} Kwon B.... Kwon B.S. (1999)
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. (PubMed id 10074428)^{1, 2, 7} Gurney A.L....Ashkenazi A. (1999)
Identification of three novel mRNA splice variants of GITR. (PubMed id 10836847)^{1, 2, 7} Nocentini G.... Riccardi C. (2000)
Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)^{1, 2} Zhang Z. and Henzel W.J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. (PubMed id 9177197)^{1, 3} Nocentini G....Riccardi C. (1997)
Glucocorticoid-induced tumor necrosis factor receptor negatively regulates activation of human primary natural killer (NK) cells by blocking proliferative signals and increasing NK cell apoptosis. (PubMed id 18230609)^{1, 7} Liu B....Nussenblatt R.B. (2008)
Glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) in atopic dermatitis. (PubMed id 16955181)^{1, 7} Baumgartner-Nielsen J....Deleuran B. (2006)
Cancer immunoediting by GITR (glucocorticoid-induced TNF-related protein) ligand in humans: NK cell/tumor cell interactions. (PubMed id 17360848)^{1, 7} Baltz K.M....Salih H.R. (2007)
Glucocorticoid-induced tumor necrosis factor receptor-related protein ligand subverts immunosurveillance of acute myeloid leukemia in humans. (PubMed id 19155305)^{1, 7} Baessler T....Salih H.R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8784	HGNC: 11914	AceView: TNFRSF18	Ensembl:ENSG00000186891	euGenes: HUgn8784
ECgene: TNFRSF18	Kegg: 8784	H-InvDB: TNFRSF18

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for TNFRSF18	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNFRSF18 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for TNFRSF18 gene:
Search GeneIP for patents involving TNFRSF18

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Antibodies for TNFRSF18 (GITR/TNFRSF18)		Cell Culture Products
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for TNFRSF18 (GITR/TNFRSF18)

	Tagged/untagged cDNA clones
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF18
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF18

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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TNFRSF18 promoter
	Search Chromatin IP Primers for TNFRSF18
	RT² qPCR Primer Assay for TNFRSF18
	GNC Network for TNFRSF18
	Search for Assays for microRNAs that regulate TNFRSF18
	SABiosciences PCR Arrays including TNFRSF18

Search Tocris compounds for TNFRSF18

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	Proteins for TNFRSF18
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	Novus Tissue Slides
	Antibodies for TNFRSF18
	Proteins for TNFRSF18
	Lysates for TNFRSF18

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

Browse ELISAs and CLIAs at Uscn

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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TNFRSF18 gene at Home site.

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TNFRSF18 Gene

protein-coding GIFtS: 59

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TNFRSF18 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor TNFRSF18 gene

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External Searches for TNFRSF18 gene

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for TNFRSF18 gene

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for TNFRSF18 gene

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for TNFRSF18 gene

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for TNFRSF18 gene

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for TNFRSF18 gene

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for TNFRSF18 gene

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for TNFRSF18 gene

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for TNFRSF18 gene

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Expression
for TNFRSF18 gene

Orthologs
for TNFRSF18 gene

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Genomic Variants
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Publications
for TNFRSF18 gene

Intellectual Property
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