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TNFRSF1A Gene

protein-coding GIFtS: 71

GC12M006308

tumor necrosis factor receptor superfamily, member 1A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TNFR1)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
tumor necrosis factor receptor superfamily, member 1A¹ ²		FPF² ⁵
TNFAR¹ ² ³ ⁵		tumor necrosis factor receptor superfamily member 1A²
TNFR1² ³ ⁵		tumor necrosis factor-alpha receptor²
CD120a¹ ²		p55-R²
TNFR60¹ ²		tumor necrosis factor receptor type 1²
TNF-R55¹ ²		tumor necrosis factor binding protein 1²
TNF-R-I¹ ²		TBP1²
TNF-R¹ ²		tumor necrosis factor receptor 1A isoform beta²
TNF-R1² ³		TNFR55²
TNFR-I² ³		MGC19588²
p60² ³		Tumor necrosis factor receptor 1³
TNF-RI² ³		CD120a antigen³
p55² ³		Tumor necrosis factor receptor type I³

External Ids:	HGNC: 11916¹	Entrez Gene: 7132²	Ensembl: ENSG00000067182⁷	UniProtKB: P19438³

Export aliases for TNFRSF1A gene to outside databases

Previous GC identifers: GC12M006292 GC12M006412

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF1A:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major

receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function

as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins

TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal

transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to

be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a

mechanism of the disease. (provided by RefSeq)

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438

Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits

caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8

proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases)

mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and

activation of the acid sphingomyelinase

Gene Wiki entry for TNFRSF1A

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF1A gene promoter:
         AP-1   CREB   deltaCREB   STAT1beta   CUTL1   STAT1alpha   STAT1   STAT5A   IRF-1   Sp1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TNFRSF1A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.2 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.2

TNFRSF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF1A gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M006308: view genomic region (about GC identifiers)

Start:	6,291,179 bp from pter
End:	6,304,533 bp from pter
Size:	13,355 bases
Orientation:	minus strand

1 alternative location:

Chr12- 6,437,924-6,451,261

RefSeq DNA sequence:

NC_000012.11 NT_009759.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 1A precursor

Size: 455 amino acids; 50495 Da

Subunit: Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a

novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting

proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This

complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4,

BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein

Subcellular location: Cell membrane; Single-pass type I membrane protein. Secreted

PDB structures from and Proteopedia :

1EXT (3D)

1FT4 (3D)

1ICH (3D)

1NCF (3D)

1TNR (3D)

Secondary accessions: A8K4X3 B2RDE4 B3KPQ1 B4DQB7 B4E309 Q9UCA4

Alternative splicing: 3 isoforms: P19438-1 P19438-2 P19438-3

Explore the universe of human proteins at neXtProt for TNFRSF1A: NX_P19438

Post-translational modifications:

The soluble form is produced from the membrane form by proteolytic processing¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001056.1

ENSEMBL proteins:

ENSP00000162749 ENSP00000413224

Human Recombinant Proteins

	Millipore Purified and/or Recombinant TNFRSF1A Protein
	Sigma-Aldrich Proteins for TNFRSF1A
	R&D Systems Recombinant & Natural Proteins for TNFRSF1A (TNF RI/TNFRSF1A)
	Enzo Life Sciences proteins for TNFRSF1A
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TNFRSF1A
	GenScript Custom Purified and Recombinant Proteins Services for TNFRSF1A
	Novus Biologicals Proteins for TNFRSF1A
	Novus Biologicals Lysate for TNFRSF1A
	Sino Biological Recombinant Protein for TNFRSF1A
	ProSpec Recombinant Protein for TNFRSF1A

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	12189246
GO:0005886	plasma membrane	EXP	12887920
GO:0005887	integral to plasma membrane	TAS	1698610
GO:0043234	protein complex	IEA	--
GO:0045121	membrane raft	IDA	17010968

About this table

TNFRSF1A for ontologies About GeneDecksing

Antibodies for TNFRSF1A:

	Millipore Mono- and Polyclonal Antibodies for the study of TNFRSF1A
	Sigma-Aldrich Antibodies for TNFRSF1A
	R&D Systems Antibodies for TNFRSF1A (TNF RI/TNFRSF1A)
	Cell Signaling Technology (CST) Antibodies for TNFRSF1A (TNF-R1)
	OriGene Antibodies: TNFRSF1A
	GenScript Custom Superior Antibodies Services for TNFRSF1A
	Novus Biologicals Antibodies for TNFRSF1A
	Epitomics antibodies for TNFRSF1A

Assays for TNFRSF1A:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for TNFRSF1A (TNF RI/TNFRSF1A)
	GenScript Custom Assay Services for TNFRSF1A
	Enzo Life Sciences assays for TNFRSF1A
	Uscn ELISAs and CLIAs for TNFRSF1A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF1A for domains About GeneDecksing

4 InterPro domains/families:

IPR001368 TNFR_Cys_rich_reg

IPR020419 TNFR_1A

IPR011029 DEATH-like

IPR000488 Death

Graphical View of Domain Structure for InterPro Entry P19438

ProtoNet protein and cluster: P19438

2 Blocks protein families:

IPB000488 Death domain

IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438

Domain: The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD)

is both necessary and sufficient for activation of N-SMASE

Domain: Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are

involved in the interaction with TRPC4AP (By similarity)

Similarity: Contains 1 death domain

Similarity: Contains 4 TNFR-Cys repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438

Function: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits

caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8

proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases)

mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and

activation of the acid sphingomyelinase

Inhib. RNA:		Millipore RNAi Products for the Analysis of TNFRSF1A Gene knock-down
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TNFRSF1A Sigma-Aldrich shRNA Panels and shRNA for TNFRSF1A
		OriGene 29mer shRNA kits in GFP-retroviral vector: TNFRSF1A OriGene shRNA RFP: TNFRSF1A OriGene basic RS shRNA: TNFRSF1A OriGene siRNA: TNFRSF1A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF1A

miRNA:		Sigma-Aldrich microRNA Mimics for TNFRSF1A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF1A
		3 SABiosciences Assays for microRNAs that regulate TNFRSF1A:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TNFRSF1A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TNFRSF1A OriGene untagged cDNA clones in CMV expression vector (see all 2): TNFRSF1A OriGene 3'-UTR clone: TNFRSF1A Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TNFRSF1A
		Sino Biological Human cDNA Clone for TNFRSF1A

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TNFRSF1A

Genatlas biochemistry entry for TNFRSF1A:

tumor necrosis factor receptor superfamily,member 1A,involved at least in two independent pathways,acidic

sphingomyelinase controlling expression of multiple TNF-responsive genes,including the apoptotic pathway,neutral

sphingomyelinase critical for the inflammatory and proliferative responses induced by TNF

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005031	tumor necrosis factor receptor activity	TAS	2158863
GO:0005515	protein binding	IPI	7758105
GO:0032403	protein complex binding	IEA	--

About this table

TNFRSF1A for ontologies About GeneDecksing

Animal Models: 15/25 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Tnfrsf1a) (see all 25):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
embryogenesis	endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	limbs/digits/tail

TNFRSF1A for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

TNFRSF1A for pathways About GeneDecksing

5/9 Millipore Pathways for TNFRSF1A (see all 9)

	Transcription NF-kB signaling pathway
	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival Caspase cascade
	Immune response IL-9 signaling pathway
	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway

5/28 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for TNFRSF1A (see all 28)

	Germ Cell-Sertoli Cell Junction Signaling
	HMGB1 Signaling
	Dendritic Cell Maturation
	LXR/RXR Activation
	TNFR1 Signaling

2 Cell Signaling Technology (CST) Pathways for TNFRSF1A

	Insulin Receptor Signaling
	Death Receptor Signaling

5/9 Kegg Pathways (Kegg details for TNFRSF1A) (see all 9):

	hsa04010 MAPK signaling pathway
	hsa04060 Cytokine-cytokine receptor interaction
	hsa04210 Apoptosis
	hsa04920 Adipocytokine signaling pathway
	hsa05010 Alzheimer's disease

SABiosciences Pathway-Focused PCR Arrays including TNFRSF1A (see all 11): PAHS-003A PAHS-012A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TNFRSF1A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF1A

5/162 Interacting proteins for TNFRSF1A (P19438^{1, 2} ENSP00000162749³) via UniProtKB, MINT, and/or STRING (see all 162)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRADD	Q15628¹^,², ENSP00000341268³	EBI-299451,EBI-359215 MINT-14992 MINT-14991 MINT-14993 STRING: ENSP00000341268
RIPK1	Q13546¹, ENSP00000369773³	EBI-299451,EBI-358507 STRING: ENSP00000369773
NSMAF	Q92636², ENSP00000038176³	MINT-5115828 STRING: ENSP00000038176
TNF	P01375¹^,²	EBI-299451,EBI-359977 MINT-48045 MINT-49295
CSNK1A1	P48729¹	EBI-299451,EBI-1383726

About this table

5/18 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 18):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006693	prostaglandin metabolic process	IEA	--
GO:0006915	apoptosis	TAS	--
GO:0006952	defense response	--	--
GO:0006954	inflammatory response	ISS	--
GO:0007165	signal transduction	IEA	--

About this table

TNFRSF1A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

TNFRSF1A for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF1A
10/108 Novoseek chemical compound relationships for TNFRSF1A gene (see all 108)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
solamargine	68.7	7	8954074 (2), 18078328 (1), 11108802 (1)
etanercept	67.5	33	11458980 (2), 12452839 (2), 18408954 (2), 10949736 (1) (see all 25)
tab-1	62.9	2	17439942 (1), 17673602 (1)
tri (d)	60	4	16631736 (1), 15357952 (1)
bcma	56	7	9846698 (2), 10903733 (2), 16357320 (1), 14720511 (1)
infliximab	43.3	12	16265686 (2), 19180495 (2), 17618693 (1), 15372221 (1) (see all 7)
ceramide	42.1	12	15721320 (2), 9810003 (1), 15817701 (1), 9743381 (1) (see all 9)
endotoxin	36.9	23	9950912 (3), 9684796 (3), 9075062 (2), 10353534 (2) (see all 10)
cysteine	30.1	27	7567962 (3), 9921712 (2), 10964568 (1), 11175303 (1) (see all 20)
gp 130	27.9	7	10622477 (1), 9890661 (1), 10414448 (1), 18779056 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Millipore RNAi Products for the Analysis of TNFRSF1A Gene knock-down
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TNFRSF1A Sigma-Aldrich shRNA Panels and shRNA for TNFRSF1A
		OriGene 29mer shRNA kits in GFP-retroviral vector: TNFRSF1A OriGene shRNA RFP: TNFRSF1A OriGene basic RS shRNA: TNFRSF1A OriGene siRNA: TNFRSF1A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF1A

miRNA:		Sigma-Aldrich microRNA Mimics for TNFRSF1A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF1A
		3 SABiosciences Assays for microRNAs that regulate TNFRSF1A:
		hsa-miR-29c hsa-miR-29a hsa-miR-29b

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TNFRSF1A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TNFRSF1A OriGene untagged cDNA clones in CMV expression vector (see all 2): TNFRSF1A OriGene 3'-UTR Clone: TNFRSF1A Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TNFRSF1A

Primers:		OriGene genome-wide validated SYBR primer pairs: TNFRSF1A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TNFRSF1A: PPH00346A

REFSEQ mRNAs for TNFRSF1A gene:

NM_001065.3

Additional cDNA sequence:

AK056611.1 AK291088.1 AK308061.1 AK315509.1 AY182755.1 BC010140.2 CR593985.1 CR596841.1

CR597821.1 CR606215.1 CR622520.1 EU927389.1 M33294.1 M58286.1 M60275.1 M63121.1

24/38 DOTS entries (see all 38):

DT.100834768 DT.100834760 DT.100834763 DT.95320606 DT.100834766 DT.100834775 DT.100834769 DT.65286582

DT.100837461 DT.100840631 DT.121189379 DT.121189284 DT.121189378 DT.40208840 DT.87077608 DT.121189349

DT.91847911 DT.95137580 DT.121189298 DT.121189408 DT.95137577 DT.121189292 DT.121189354 DT.95137593

24/368 AceView cDNA sequences (see all 368):

BQ723672 BX397891 CR597821 BM694442 AU142163 BU158498 BX399373 AU280523

CD671768 BU189221 CR596841 BM767536 CR622520 BC010140 CB134521 BM756214

BU181102 BQ880824 BM982071 BQ027050 BI870917 CF454049 BM789569 BG180101

highest scoring ESTs for TNFRSF1A:

M58286 AI815635 AU076821 AU100531 AU124446 AU124519 AU125021 AU125646 AU125680 AU125694

Unigene Cluster for TNFRSF1A:

Tumor necrosis factor receptor superfamily, member 1A

Hs.279594 [show with all ESTs]

Unigene Representative Sequence: NM_001065

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TNFRSF1A (see all 12)

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2	^	3a	·	3b	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10a	·	10b	^	11a	·	11b	^
SP1:													-						-																				-				-		-
SP2:													-						-										-		-								-				-		-
SP3:													-				-		-		-		-																-				-		-
SP4:																																							-						-
SP5:																																							-				-		-		-

ExUns:	12	^	13	^	14
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TNFRSF1A
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000162749(uc001qnt.2 uc001qnu.2 uc010sey.1 uc010sez.1 uc009zek.2)

ENST00000440083(uc010sfa.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TNFRSF1A expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching TNFRSF1A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1563_s_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M58286	1.00	1.00	1.00	1
207643_s_at²^{, 3}	U133-A	1	0.91	1.00	--	--	NM_001065	0.60	1.00	0.82	1
207643_s_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

About this table

TNFRSF1A for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

TNFRSF1A gene electronic northern expression

About these images

CGAP SAGE TAG: TTACACTAAT

SOURCE GeneReport for Unigene cluster: Hs.279594

Primers:		OriGene genome-wide validated SYBR primer pairs: TNFRSF1A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TNFRSF1A: PPH00346A

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF1A (see all 11): PAHS-003A PAHS-012A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TNFRSF1A gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TNFRSF1A¹	--	tumor necrosis factor receptor superfamily, member more	82.39(n) 76.52(a)	403634 XM_849381.1 XP_854474.1
chimpanzee (Pan troglodytes)	TNFRSF1A¹	--	tumor necrosis factor receptor superfamily, member more	91.37(n) 89.76(a)	466934 XM_522334.2 XP_522334.2
cow (Bos taurus)	TNFRSF1A¹	--	tumor necrosis factor receptor superfamily, member more	77.03(n) 68.02(a)	282527 NM_174674.2 NP_777099.1
rat (Rattus norvegicus)	Tnfrsf1a¹	--	tumor necrosis factor receptor superfamily, member more	75.08(n) 66.22(a)	25625 NM_013091.1 NP_037223.1
mouse (Mus musculus)	Tnfrsf1a^{1 , 5}	6 (59.32 cM)⁵	tumor necrosis factor receptor superfamily, member more^{1, 5}	73.47(n)¹ 66.21(a)¹	21937¹ NM_011609.3¹ NP_035739.2¹ AK154388⁵ AK159989⁵ (see all 28)

About this table Species with no ortholog for TNFRSF1A

ENSEMBL Gene Tree for TNFRSF1A (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TNFRSF1A gene

TNFRSF25²

TNFRSF1A for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs767455^1,2	C,F,A,	6450945(+)	`ACCAGT/CGGCAG`	2	/P	ref¹ syn¹ ese³		28		NA EA NS MN	1705
rs877249^1,2	C,F,	6443812(-)	`GTGGTT/GCACGG`	1	--	int¹		3		NS WA	96
rs887477^1,2	C,F,A,H,	6445982(-)	`GGGACG/TGGGGA`	1	--	int¹		27		EA NA NS MN WA	2794
rs1800692^1,2	C,F,A,	6442346(-)	`GCGCTC/TCTCCT`	1	--	int¹ trp³		15		EA NS MN NA WA	2068
rs1800693^1,2	C,F,	6440009(-)	`GGAGAA/GGTGAC`	1	--	int¹		14		NS EA NA	1796
rs1860545^1,2	C,F,O,	6446777(-)	`GACATC/TGTCAA`	1	--	int¹		19		NS EA NA WA	1322
rs2234649^1,2	C,F,	6451363(-)	`GCCAGA/CTCTGG`	1	--	ng5¹		16		NS MN EA WA	1626
rs2284344^1,2	C,F,A,H,	6445329(-)	`GCTGGC/GGTCCC`	1	--	int¹		9		EA NA	1723
rs2363888^1,2	--	6443748(+)	`accctC/Tcacca`	1	--	int¹		0	--	--	--	--
rs4149569^1,2	C,F,A,H,	6452468(-)	`tttagG/Caggct`	1	--	ng5¹		6		NS NA	102

About this table

HapMap Linkage Disequilibrium images for TNFRSF1A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TNFRSF1A: --

QIAGEN SeqTarget long-range PCR primers for resequencing TNFRSF1A

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFRSF1A for disorders About GeneDecksing

OMIM: 191190 disorders: 142680

UniProtKB/Swiss-Prot: TNR1A_HUMAN, P19438

Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis

factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by

recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main

complication and occurs in 25% of cases

10/91 Novoseek disease relationships for TNFRSF1A gene (see all 91)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumor necrosis factor receptor-associated periodic syndrome	92.3	36	11817598 (2), 15492850 (2), 15570662 (2), 11318938 (1) (see all 26)
necrosis	92	1452	10561634 (6), 7573266 (5), 1648538 (5), 12406325 (4) (see all 99)
tumors	82.5	1294	10561634 (6), 7573266 (5), 14598359 (5), 1648538 (5) (see all 99)
hereditary periodic fever syndromes	71.6	1	15071491 (1)
relapsing fever	61	12	11953985 (3), 10902757 (2), 15071491 (1), 11175303 (1) (see all 6)
rheumatoid arthritis	59.8	41	9391689 (6), 9219699 (2), 7621589 (2), 9290265 (2) (see all 27)
inflammation	59.3	55	9391689 (2), 17852784 (2), 9865650 (2), 9330935 (1) (see all 44)
familial mediterranean fever	56.6	8	11318938 (1), 16019157 (1), 12209523 (1), 15502081 (1) (see all 6)
muckle-wells syndrome	53.4	1	16019157 (1)
autoimmune diseases	41.8	21	15280569 (1), 19386778 (1), 20173385 (1), 11007755 (1) (see all 15)

About this table

1 PharmGKB disease relationship for TNFRSF1A gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Locus Specific Mutation Databases (LSDB): TNFRSF1A
Human Gene Mutation Database (HGMD): TNFRSF1A
Genetic Association Database (GAD): TNFRSF1A
Human Genome Epidemiology (HuGE) Navigator: TNFRSF1A (117 documents)

Export disorders and mutations for TNFRSF1A gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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ACR: Enbrel (Etanercept) in TNF-Receptor Associated Periodic Fever Syndrome

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/1285 PubMed articles for TNFRSF1A gene, integrated from 7 sources (see all 1285):
(articles sorted by number of sources associating them with TNFRSF1A)

Molecular cloning and expression of a receptor for human tumor necrosis factor. (PubMed id 2158863)^{1, 2, 3, 7} Schall T.J....Raab H. (1990)
Heterogeneity among patients with tumor necrosis factor receptor- associated periodic syndrome phenotypes. (PubMed id 13130484)^{1, 2, 4, 7} Aganna E.... McDermott M.F. (2003)
A TNFR1 genotype with a protective role in familial rheumatoid arthritis. (PubMed id 14872483)^{1, 4, 7} Dieude P....Cornelis F. (2004)
A novel missense mutation (C30S) in the gene encoding tumor necrosis factor receptor 1 linked to autosomal-dominant recurrent fever with localized myositis in a French family. (PubMed id 10902757)^{1, 2, 7} Dode C.... Grateau G. (2000)
Association of polymorphisms of the tumour necrosis factor receptors I and II and rheumatoid arthritis. (PubMed id 12730509)^{1, 4, 7} Bayley J.P....Verweij C.L. (2003)
Structure of the human TNF receptor 1 (p60) gene (TNFR1) and localization to chromosome 12p13. (PubMed id 1315717)^{1, 2, 7} Fuchs P.... Ambros P.F. (1992)
Tumor necrosis factor receptor gene polymorphisms in Crohn's disease: association with clinical phenotypes. (PubMed id 15842589)^{1, 4, 7} Waschke K.A....Wild G.E. (2005)
Anemia in rheumatoid arthritis: association with polymorphism in the tumor necrosis factor receptor I and II genes. (PubMed id 16142859)^{1, 4, 7} Glossop J.R....Mattey D.L. (2005)
Tumor necrosis factor, tumor necrosis factor receptors type 1 and 2, lymphotoxin-alpha, and HLA-DRB1 gene polymorphisms in human T-cell lymphotropic virus type I associated myelopathy. (PubMed id 11163081)^{1, 4, 7} Nishimura M....Uchiyama T. (2000)
Novel mutations in TNFRSF1A in patients with typical tumor necrosis factor receptor-associated periodic syndrome and with systemic lupus erythematosus in Japanese. (PubMed id 15492850)^{1, 4, 7} Horiuchi T....Okamura S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7132	HGNC: 11916	AceView: TNFRSF1A	Ensembl:ENSG00000067182	euGenes: HUgn7132
ECgene: TNFRSF1A	Kegg: 7132	H-InvDB: TNFRSF1A

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for TNFRSF1A	Genetics and Cytogenetics in Oncology and Haematology
INFEVERS	http://fmf.igh.cnrs.fr/ISSAID/infevers/disease_menu.php?n=2
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TNFRSF1A
SeattleSNPs	http://pga.gs.washington.edu/data/tnfrsf1a/

Intellectual Property for TNFRSF1A gene
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TNFRSF1A (Gene Symbol)
tumor necrosis factor receptor superfamily, member 1A
TNFAR
TNFR1
CD120a
TNFR60
TNF-R55
TNF-R-I
TNF-R
TNF-R1
TNFR-I
p60
TNF-RI
p55
FPF
tumor necrosis factor receptor superfamily member 1A
tumor necrosis factor-alpha receptor
p55-R
tumor necrosis factor receptor type 1
tumor necrosis factor binding protein 1
TBP1
tumor necrosis factor receptor 1A isoform beta
TNFR55
MGC19588
Tumor necrosis factor receptor 1
CD120a antigen
Tumor necrosis factor receptor type I

CINCA SYNDROME
Spondylitis Ankylosing
HERPES
Leukemia T-Cell
Genetic Susceptibility
sepsis
Hepatitis Chronic
TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PERIODIC SYNDROME
Lymphoma T-Cell
Myocardial Ischemia
Ameloblastoma
Liver diseases
Breast Cancer
anaplastic large cell lymphoma
Edema
Schizophrenia
ALVEOLITIS
Amyloidosis
cell damage
disability
Cancer
Obstruction
malignant ascites
Uveitis
Lymphoma
Cardiomyopathy
COLON ADENOCARCINOMA
Ectodermal Dysplasia
Multiple Sclerosis
Inflammation
Cowpox
Tuberculosis
Monocytic leukemia
MUCKLE-WELLS SYNDROME
Leukemia Hairy Cell
immunodeficiency
Psoriasis
Neutropenia
Hepatitis B
MYELOMA
Rheumatoid Arthritis
Tumors
Autoimmunity
Necrosis
Glioblastoma
Relapsing Fever
virus infection
Viral hepatitis
Malignant Glioma
Shock Septic
Hereditary Periodic Fever Syndromes
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inflammatory joint disease
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Systemic Inflammatory Response Syndrome
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INJECTION SITE REACTION
Lymphocytic Leukemia Chronic B-Cell
Avian Leukosis
autoimmune thyroid disease
SKIN LESION
Paracoccidioidomycosis
STROKE
Graft-Versus-Host Disease
Lymphoma Non-Hodgkins
Synovitis
Lupus Erythematosus Systemic
Arthritis

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TNFRSF1A Gene

protein-coding GIFtS: 71

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