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TNFRSF6B Gene

protein-coding GIFtS: 56

GC20P059059

tumor necrosis factor receptor superfamily, member 6b, decoy
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
tumor necrosis factor receptor superfamily, member 6b, decoy¹ ²		Decoy receptor 3² ³
DCR3¹ ² ³ ⁵		Decoy receptor for Fas ligand² ³
M68¹ ² ³		DJ583P15.1.1²
TR6¹ ² ³		tumor necrosis factor receptor superfamily member 6B²
DcR3¹ ³		OTTHUMP00000031583²

External Ids:	HGNC: 11921¹	Entrez Gene: 8771²	Ensembl: ENSG00000243509⁷	UniProtKB: O95407³

Export aliases for TNFRSF6B gene to outside databases

Previous GC identifers: GC20P062166 GC20U900077 GC20P063052 GC20P063016 GC20P061761 GC20P062326

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TNFRSF6B:

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a

regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with

death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and

it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript

variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. (provided by

RefSeq)

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407

Function: Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis

Gene Wiki entry for TNFRSF6B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TNFRSF6B gene promoter:
         NF-kappaB1   NF-kappaB   AP-1   c-Fos   c-Jun   GATA-3   GATA-2   GATA-1   YY1   AREB6
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TNFRSF6B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TNFRSF6B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.3 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.3

TNFRSF6B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TNFRSF6B gene location

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P059059: view genomic region (about GC identifiers)

Start:	59,059,262 bp from pter
End:	59,063,014 bp from pter
Size:	3,753 bases
Orientation:	plus strand

1 alternative location:

Chr20+ 62,328,021-62,330,037

RefSeq DNA sequence:

NC_000020.10 NT_011333.6

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407 (See protein sequence)

Recommended Name: Tumor necrosis factor receptor superfamily member 6B precursor

Size: 300 amino acids; 32680 Da

Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for TNFRSF6B: NX_O95407

REFSEQ proteins (2 alternative transcripts):

NP_003814.1 NP_116563.1

ENSEMBL proteins:

ENSP00000359013

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for TNFRSF6B
	R&D Systems Recombinant & Natural Proteins for TNFRSF6B (DcR3/TNFRSF6B)
	Enzo Life Sciences proteins for TNFRSF6B
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): TNFRSF6B
	GenScript Custom Purified and Recombinant Proteins Services for TNFRSF6B
	Novus Biologicals Protein for TNFRSF6B
	Novus Biologicals Lysate for TNFRSF6B
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005625	soluble fraction	TAS	9872321

About this table

TNFRSF6B for ontologies About GeneDecksing

Antibodies for TNFRSF6B:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibody Arrays and Antibodies for TNFRSF6B
	R&D Systems Antibodies for TNFRSF6B (DcR3/TNFRSF6B)
	Cell Signaling Technology (CST) Antibodies for TNFRSF6B (dcr3)
	OriGene Antibodies: TNFRSF6B
	GenScript Custom Superior Antibodies Services for TNFRSF6B
	Novus Biologicals Antibodies for TNFRSF6B
	Browse antibodies at Epitomics

Assays for TNFRSF6B:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for TNFRSF6B (DcR3/TNFRSF6B)
	GenScript Custom Assay Services for TNFRSF6B
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TNFRSF6B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TNFRSF6B for domains About GeneDecksing

1 InterPro domain/family:

IPR001368 TNFR_Cys_rich_reg

Graphical View of Domain Structure for InterPro Entry O95407

ProtoNet protein and cluster: O95407

1 Blocks protein family: IPB001368 TNFR/CD27/30/40/95 cysteine-rich region

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407

Similarity: Contains 4 TNFR-Cys repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407

Function: Decoy receptor for the cytotoxic ligands TNFS14/LIGHT and TNFSF6/FASL. Protects against apoptosis

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for TNFRSF6B Sigma-Aldrich shRNA Panels and shRNA for TNFRSF6B
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TNFRSF6B OriGene shRNA RFP (see all 3): TNFRSF6B OriGene basic RS shRNA (see all 3): TNFRSF6B OriGene siRNA (see all 2): TNFRSF6B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF6B

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF6B
		Search SABiosciences for Assays for microRNAs that regulate TNFRSF6B

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TNFRSF6B OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TNFRSF6B OriGene untagged cDNA clones in CMV expression vector (see all 3): TNFRSF6B OriGene 3'-UTR clone (see all 2): TNFRSF6B Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): TNFRSF6B
		Sino Biological Human cDNA Clone for TNFRSF6B

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TNFRSF6B

Genatlas biochemistry entry for TNFRSF6B:

tumor necrosis factor receptor superfamily,member 6B,binding Fas ligand (TNFRSF6) and inhibiting FasL induced

apoptosis,amplified in primary lung and colon tumors

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005515	protein binding	IPI	10318773

About this table

TNFRSF6B for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

TNFRSF6B for pathways About GeneDecksing

1 Millipore Pathway for TNFRSF6B

Apoptosis and survival FAS signaling cascades

1 Kegg Pathway (Kegg details for TNFRSF6B):

hsa04060 Cytokine-cytokine receptor interaction

SABiosciences Pathway-Focused PCR Arrays including TNFRSF6B: PAHS-063A PAHS-3012A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TNFRSF6B

1 Interacting protein for TNFRSF6B (O95407¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNFSF14	O43557¹	EBI-524171,EBI-524131

About this table

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--
GO:0006916	anti-apoptosis	TAS	9872321

About this table

TNFRSF6B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

TNFRSF6B for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TNFRSF6B
1 Novoseek chemical compound relationship for TNFRSF6B gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphatidylinositol	11.3	3	14688085 (1), 19050262 (1), 14697332 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for TNFRSF6B Sigma-Aldrich shRNA Panels and shRNA for TNFRSF6B
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TNFRSF6B OriGene shRNA RFP (see all 3): TNFRSF6B OriGene basic RS shRNA (see all 3): TNFRSF6B OriGene siRNA (see all 2): TNFRSF6B
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF6B

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF6B
		Search SABiosciences for Assays for microRNAs that regulate TNFRSF6B

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TNFRSF6B OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TNFRSF6B OriGene untagged cDNA clones in CMV expression vector (see all 3): TNFRSF6B OriGene 3'-UTR Clone (see all 2): TNFRSF6B Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): TNFRSF6B

Primers:		OriGene genome-wide validated SYBR primer pairs: TNFRSF6B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TNFRSF6B: PPH01179A

REFSEQ mRNAs for TNFRSF6B gene (2 alternative transcripts):

NM_003823.2 NM_032945.2

Additional cDNA sequence:

AF104419.1 AF134240.1 AF217793.1 AF217794.1 AF217795.1 AK000485.1 AK299332.1 AK302508.1

AK304798.1 AL080127.1 AY124378.1 AY124379.1 AY358279.1 BC017065.1 BC034349.1

17 DOTS entries:

DT.101980777 DT.99984254 DT.100746777 DT.40230565 DT.100026806 DT.100746778 DT.97770485 DT.110158

DT.120825067 DT.426887 DT.102833296 DT.95349828 DT.91765245 DT.120824862 DT.75164637 DT.97792267

DT.100749378

24/190 AceView cDNA sequences (see all 190):

AF217795 AI304479 BM784181 AI446656 AW135723 AY124378 BF001490 NM_016434

BE877829 AI857725 AU099288 BQ019285 BM857412 NM_003823 AF104419 AW955349

BM742134 AY358279 BF987793 BE467871 AA326540 BU623385 BM784338 NM_032957

highest scoring ESTs for TNFRSF6B:

AA025673 AA158406 AA514270 AA577603 AA603704 AA613366 AF104419 AF217794 AI185297 AI282851

Unigene Cluster for TNFRSF6B:

Tumor necrosis factor receptor superfamily, member 6b, decoy

Hs.434878 [show with all ESTs]

Unigene Representative Sequence: AF217795

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369996

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TNFRSF6B expression in normal and diseased human tissues

¹ / ² / ³

2 probe-sets matching TNFRSF6B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
206467_x_at²^{, 3}	U133-A	2	1.00	0.50	--	--	NM_003823	0.60	0.83	0.73	1
206467_x_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

TNFRSF6B gene electronic northern expression

About these images

CGAP SAGE TAG: ACACCCTGTG

SOURCE GeneReport for Unigene cluster: Hs.434878

Expression variation in blood from EXPOLDB for TNFRSF6B

UniProtKB/Swiss-Prot: TNF6B_HUMAN, O95407

Tissue specificity: Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node,

trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and

in SW480 colon carcinoma cells

Primers:		OriGene genome-wide validated SYBR primer pairs: TNFRSF6B Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TNFRSF6B: PPH01179A

SABiosciences Expression via Pathway-Focused PCR Arrays including TNFRSF6B: PAHS-063A PAHS-3012A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TNFRSF6B gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	TNFRSF6B¹	--	tumor necrosis factor receptor superfamily, member more	81.77(n) 79.14(a)	789154 XM_001255991.1 XP_001255992.1
chicken (Gallus gallus)	TNFRSF6B¹	--	tumor necrosis factor receptor superfamily, member more	64.23(n) 54.38(a)	395096 XM_417434.2 XP_417434.2
zebrafish (Danio rerio)	LOC407674¹	--	hypothetical protein LOC407674	53.11(n) 37.85(a)	407674 XM_001334174.2 XP_001334210.1

About this table Species with no ortholog for TNFRSF6B

ENSEMBL Gene Tree for TNFRSF6B (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TNFRSF6B gene

TNFRSF21² CD40² TNFRSF1B² TNFRSF4² TNFRSF11A² LTBR² NGFR² TNFRSF14²

TNFRSF11B²

TNFRSF6B for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs909341^1,2	C,A,H,	62328742(+)	`AGCAGC/TTCCAG`	4	S	ref¹ syn¹		5		NA EA	166
rs1291205^1,2	C,A,H,	62328829(+)	`GACACG/CCTGTG`	4	/T	ref¹ syn¹		6		EA MN NA	1826
rs1291206^1,2	C,F,O,	62329169(+)	`CACGGG/AGAAAC`	2	--	int¹		11		MN EA NS NA	1506
rs1291207^1,2	C,F,A,	62329412(+)	`TGGCCG/ACTCCT`	2	--	int¹		4		NA	78
rs2257440^1,2	C,F,A,H,	62328267(+)	`GTGTGT/CGCCCA`	4	/C	ref¹ syn¹		7		EA NS NA	1742
rs2258056^1,2	C,F,A,H,	62328453(+)	`AACCGT/CGCCTG`	4	/R	syn¹ ref¹		7		EA NA	70
rs2738787^1,2	C,	62328375(+)	`TACCTG/AGAGCG`	4	/L	syn¹ ref¹		6		NA	82
rs6062496^1,2	C,F,A,	62329099(+)	`CCTGGG/AGAGCT`	2	--	int¹		8		EA NS NA WA	346
rs8114953^1,2	C	62329344(+)	`CCTTCC/TGATGG`	2	--	int¹		1		NS	120
rs11696416^1,2	H	62328889(+)	`GAGGCC/TTGAGG`	2	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for TNFRSF6B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TNFRSF6B
4 CNVs: 35938 0541 4107 30135

QIAGEN SeqTarget long-range PCR primers for resequencing TNFRSF6B

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TNFRSF6B for disorders About GeneDecksing

OMIM: 603361

10/23 Novoseek disease relationships for TNFRSF6B gene (see all 23)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	56.7	47	15475369 (2), 10318773 (2), 12662434 (1), 18723214 (1) (see all 31)
tumors	49.8	108	12740925 (6), 10655513 (5), 12899749 (4), 15475369 (4) (see all 48)
herpes	44.6	6	12566458 (1), 15917993 (1), 17010447 (1), 10318773 (1)
pancreatic carcinoma	41.2	2	12740925 (1)
colon adenocarcinoma	40.8	3	14871535 (1), 10318773 (1), 10655513 (1)
pancreatic cancer	36	12	12794752 (3), 19050262 (2), 11172597 (1), 19466993 (1) (see all 6)
hepatocellular carcinoma	34	18	12899749 (2), 17493386 (2), 16273601 (2), 19195939 (2) (see all 7)
cancer	29.9	33	12899749 (2), 15661928 (2), 18349319 (2), 12397645 (1) (see all 19)
gastric carcinoma	23.8	5	14728836 (2), 12740925 (1), 18991242 (1)
rheumatoid arthritis	22.6	6	19821006 (2), 18757243 (1), 17393415 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: TNFRSF6B (14 documents)

Export disorders and mutations for TNFRSF6B gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/127 PubMed articles for TNFRSF6B gene, integrated from 7 sources (see all 127):
(articles sorted by number of sources associating them with TNFRSF6B)

A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. (PubMed id 10318773)^{1, 2, 3, 7} Yu K.-Y.... Kwon B.S. (1999)
Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. (PubMed id 9872321)^{1, 2, 3, 7} Pitti R.M.... Ashkenazi A. (1998)
Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster. (PubMed id 10655513)^{1, 2, 7} Bai C.... Caskey C.T. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Decoy receptor 3 expression during the menstrual cycle and pregnancy, and regulation by sex steroids in endometrial cells in vitro. (PubMed id 19246462)^{1, 7} Chen H.F....Ho H.N. (2009)
High DcR3 expression predicts stage pN2-3 in gastric cancer. (PubMed id 18376232)^{1, 7} Wu Y....Xie Q. (2008)
High DcR3 expression predicts stage pN2 in gastric cancer. (PubMed id 18251184)^{1, 7} Wu Y....Chen J. (2007)
Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma. (PubMed id 12794752)^{1, 7} Tsuji S....Imamura M. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8771	HGNC: 11921	AceView: TNFRSF6B	Ensembl:ENSG00000243509	euGenes: HUgn8771
ECgene: TNFRSF6B	Kegg: 8771	H-InvDB: TNFRSF6B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TNFRSF6B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TNFRSF6B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for TNFRSF6B gene:
Search GeneIP for patents involving TNFRSF6B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Predesigned and custom siRNAs for TNFRSF6B		Antibodies for TNFRSF6B
	Explore super-pooled esiRNAs		Proteins for TNFRSF6B
	Lentivirus-delivered shRNAs for TNFRSF6B		Browse microRNA Mimics at Sigma-Aldrich
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies for TNFRSF6B (DcR3/TNFRSF6B)		Cell Culture Products
	ELISAs for TNFRSF6B (DcR3/TNFRSF6B)		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for TNFRSF6B (DcR3/TNFRSF6B)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TNFRSF6B
	SeqTarget long-range PCR primers for resequencing TNFRSF6B
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TNFRSF6B
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TNFRSF6B

	GenScript Custom Purified and Recombinant Proteins Services for TNFRSF6B		GenScript cDNA clones with any tag delivered in your preferred vector for TNFRSF6B
	GenScript Custom Assay Services for TNFRSF6B		GenScript Custom Superior Antibodies Services for TNFRSF6B
	GenScript Custom overexpressing Cell Line Services for TNFRSF6B		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for TNFRSF6B (dcr3)

	Regulatory tfbs in TNFRSF6B promoter
	Search Chromatin IP Primers for TNFRSF6B
	RT² qPCR Primer Assay for TNFRSF6B
	GNC Network for TNFRSF6B
	Search for Assays for microRNAs that regulate TNFRSF6B
	SABiosciences PCR Arrays including TNFRSF6B

Search Tocris compounds for TNFRSF6B

	Browse Sino Biological Proteins and Antibodies
	cDNA Clones for TNFRSF6B
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for TNFRSF6B
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for TNFRSF6B
	Proteins for TNFRSF6B
	Lysates for TNFRSF6B

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for TNFRSF6B

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

TNFRSF6B gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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TNFRSF6B Gene

protein-coding GIFtS: 56

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TNFRSF6B Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor TNFRSF6B gene

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Expression for TNFRSF6B gene

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Genomic Variantsfor TNFRSF6B gene

Disorders & Mutationsfor TNFRSF6B gene

Medical Newsfor TNFRSF6B gene

Publicationsfor TNFRSF6B gene

External Searches for TNFRSF6B gene

Genome Databases showing TNFRSF6B gene

Other Databases showing TNFRSF6B gene

Specialized Databases showing TNFRSF6B gene

Intellectual Propertyfor TNFRSF6B gene

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Aliases &
Descriptions
for TNFRSF6B gene

Summaries
for TNFRSF6B gene

Genomic Views
for TNFRSF6B gene

Proteins
for TNFRSF6B gene

Protein Domains/
Families
for TNFRSF6B gene

Gene Function
for TNFRSF6B gene

Pathways & Interactions
for TNFRSF6B gene

Drugs & Compounds
for TNFRSF6B gene

Transcripts
for TNFRSF6B gene

Expression
for TNFRSF6B gene

Orthologs
for TNFRSF6B gene

Paralogs
for TNFRSF6B gene

Genomic Variants
for TNFRSF6B gene

Disorders & Mutations
for TNFRSF6B gene

Medical News
for TNFRSF6B gene

Publications
for TNFRSF6B gene

Intellectual Property
for TNFRSF6B gene

Products
for TNFRSF6B gene