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TP73 Gene

protein-coding   GIFtS: 62

GC01P002864
tumor protein p73
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
tumor protein p731 2
P731 2 3
p53-like transcription factor2 3
p53-related protein2 3
OTTHUMP000000034802
OTTHUMP000000034792

External Ids:    HGNC: 120031   Entrez Gene: 71612   Ensembl: ENSG000000789007   UniProtKB: O153503   

Export aliases for TP73 gene to outside databases

Previous GC identifers: GC01P003007 GC01P003526 GC01P003142 GC01P003352 GC01P003283 GC01P003592


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TP73:
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and
development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and
thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed
(likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript
variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, however,
the biological validity and the full-length nature of most variants have not been determined. (provided by RefSeq)

UniProtKB/Swiss-Prot: P73_HUMAN, O15350
Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73
isoforms. May be a tumor suppressor protein

Gene Wiki entry for TP73 (P73)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TP73 gene promoter:
         AREB6   Egr-1   Nkx3-1   Nkx3-1 v1   Nkx3-1 v3   Nkx3-1 v2   Nkx3-1 v4   p53   YY1   CUTL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TP73

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TP73 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.3

TP73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TP73 gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P002864:  view genomic region     (about GC identifiers)

Start:
2,864,839 bp from pter
End:
2,945,657 bp from pter
Size:
80,819 bases
Orientation:
plus strand

1 alternative location:
Chr1+ 3,569,084-3,652,765     
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: P73_HUMAN, O15350 (See protein sequence)
Recommended Name: Tumor protein p73  
Size: 636 amino acids; 69623 Da
Cofactor: Binds 1 zinc ion per subunit (By similarity)
Subunit: Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL tyrosine
kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha
does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma,
isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9.
Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain)
Subcellular location: Nucleus. Note=Accumulates in the nucleus in response to DNA damage
Miscellaneous: Maps to a chromosome region frequently mutated in diverse cell lines of human cancer. Appears not to be
frequently mutated in human cancers, in contrast to p53. Hemizygosity is observed in neuroblastoma and
oligodendroglioma
Miscellaneous: Activated and stabilized by interaction with RANBP9
PDB structures from and Proteopedia :
1COK (3D)    1DXS (3D)    2KBY (3D)    2WQI (3D)    2WQJ (3D)    2WTT (3D)    2XIP (3D)    
Secondary accessions: B7Z9C1 O15351 Q17RN8 Q5TBV5 Q5TBV6 Q8NHW9 Q8TDY5 Q8TDY6 Q9NTK8
Alternative promoter usage, Alternative splicing: 9 isoforms:  O15350-1   O15350-2   O15350-3   O15350-4   O15350-5   O15350-6   O15350-8   O15350-9   
O15350-10   

Explore the universe of human proteins at neXtProt for TP73: NX_O15350 

Post-translational modifications:

  • Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not
  • affect transcriptional activity1
  • Higher levels of phosphorylation seen in the brain from patients with Huntington disease1
  • Ubiquitinated; leading to its degradation by the proteasome1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001119712.1  NP_001119713.1  NP_001119714.1  NP_005418.1  


    ENSEMBL proteins: 
    ENSP00000346423 ENSP00000367545 ENSP00000367539 ENSP00000340740 ENSP00000367529 ENSP00000350366 
    ENSP00000367534 ENSP00000367537 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: TP73
    OriGene Protein Over-expression Lysate: TP73
    GenScript Custom Purified and Recombinant Proteins Services for TP73 
    Novus Biologicals Lysate for TP73
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785 chromatin ISS--
    GO:0005634 nucleus ISS--
    GO:0005667 transcription factor complex ISS--
    GO:0005829 cytosol ISS--
    About this table

    TP73 for ontologies           About GeneDecksing



    Antibodies for TP73: 
    Millipore Mono- and Polyclonal Antibodies for the study of TP73
    Sigma-Aldrich Antibodies for TP73
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for TP73  (p73)
    OriGene Antibodies: TP73
    GenScript Custom Superior Antibodies Services for TP73 
    Novus Biologicals Antibodies for TP73
    Epitomics antibodies for TP73

    Assays for TP73: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TP73 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TP73 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TP73 for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10):
     IPR011615 p53_DNA-bd
     IPR002117 p53_tumour_suppressor
     IPR012346 p53/RUNT-type_TF_DNA-bd
     IPR013761 SAM_type
     IPR001660 SAM

    Graphical View of Domain Structure for InterPro Entry O15350

    ProtoNet protein and cluster: O15350

    3 Blocks protein families:
    IPB001660 Sterile alpha motif SAM
    IPB010991 p53
    IPB011510 Sterile alpha motif homology 2


    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Domain: Possesses an acidic transactivation domain, a central DNA binding domain and a C-terminal oligomerization
    domain that binds to the ABL tyrosine kinase SH3 domain
    Domain: The WW-binding motif mediates interaction with WWOX
    Similarity: Belongs to the p53 family
    Similarity: Contains 1 SAM (sterile alpha motif) domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Function: Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are
    pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73
    isoforms. May be a tumor suppressor protein
    Induction: Not induced by DNA damage. Isoforms lacking the transactivation domain block gene induction

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for TP73
    Sigma-Aldrich shRNA Panels and shRNA for TP73
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): TP73
    OriGene shRNA RFP (see all 4): TP73
    OriGene basic RS shRNA (see all 4): TP73
    OriGene siRNA (see all 4): TP73
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TP73 
    miRNA:Sigma-Aldrich microRNA Mimics for TP73
    Sigma-Aldrich microRNA target validation systems for TP73 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TP73 
    Search SABiosciences for Assays for microRNAs that regulate TP73

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TP73
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): TP73
    OriGene untagged cDNA clones in CMV expression vector (see all 4): TP73
    OriGene 3'-UTR clone (see all 4): TP73 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TP73 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TP73 

    Genatlas biochemistry entry for TP73:
    tumor protein 73,with two alternatively spliced isoforms,alpha and beta,activating transcription of p53-responsive
    genes and inhibiting cell growth by inducing apoptosis,also target of ABL1 (c-ABL) in response to DNA damage in a
    mismatch repair-dependent apoptosis,monoallelicaly expressed (?,paternally imprinted),frequently deleted in
    neuroblastoma in advanced stage but unlikely to be a suppressor gene in neuroblastoma,and other tumors (see TSG1A)
    (not in oligodendrogliomas,in colorectal or in oesophageal carcinomas),overexpressed in bladder carcinoma

    5/14 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 14):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039 p53 binding ISS--
    GO:0003677 DNA binding ----
    GO:0003682 chromatin binding ISS--
    GO:0003684 damaged DNA binding ISS--
    GO:0003690 double-stranded DNA binding ISS--
    About this table

    TP73 for ontologies           About GeneDecksing

    Animal Models: 15/22 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trp73) (see all 22):

    behavior/neurologicalcardiovascular systemcellularcraniofacialdigestive/alimentary
    embryogenesisendocrine/exocrine glandgrowth/sizehearing/vestibular/earhematopoietic system
    homeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatallife span-post-weaning/aging

    TP73 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TP73 for pathways           About GeneDecksing

    1 Millipore Pathway for TP73
        Development Notch Signaling Pathway

    4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  TP73
        p53 Signaling
    Aryl Hydrocarbon Receptor Signaling
    ATM Signaling
    14-3-3-mediated Signaling

    2 Kegg Pathways  (Kegg details for TP73):
        hsa04115 p53 signaling pathway
    hsa04722 Neurotrophin signaling pathway

        SABiosciences Pathway-Focused PCR Arrays including TP73 (see all 6): PAHS-012A PAHS-027A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TP73
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TP73

    5/21 Interacting proteins for TP73 (ENSP000003675453 O153501, 2) via UniProtKB, MINT, and/or STRING (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192STRING: ENSP00000361423 MINT-3388834 MINT-7309761
    EP300Q094722STRING: ENSP00000263253 MINT-13681
    HMGB1P094291EBI-389606,EBI-389432
    WWOXQ9NZC72MINT-60129 MINT-60098 MINT-60104 MINT-60132 MINT-60099 MINT-60101 MINT-60131 MINT-60106 MINT-60103 MINT-60130 MINT-60102 MINT-60128 MINT-60105 MINT-60100
    ITCHQ96J022MINT-3389196 MINT-3389321 MINT-3389044 MINT-3389118 MINT-3389173 MINT-3389070 MINT-3389148 MINT-3389300
    About this table

    5/33 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 33):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS--
    GO:0001836 release of cytochrome c from mitochondria IEA--
    GO:0002347 response to tumor cell IEA--
    GO:0006298 mismatch repair TAS10391249
    GO:0006355 regulation of transcription, DNA-dependent ----
    About this table

    TP73 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TP73 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TP73
    10/33 Novoseek chemical compound relationships for TP73 gene (see all 33)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    noxa 63 19 20195489 (3), 20160496 (2), 15572378 (2), 16899408 (1) (see all 9)
    cisplatin 56 94 16815295 (6), 16135520 (5), 16526280 (5), 16773194 (4) (see all 39)
    o6-methylguanine 44.4 4 16231140 (1), 19347729 (1), 14654977 (1), 15197802 (1)
    dmso 44 23 17287142 (2), 15805112 (1), 11423969 (1), 16630058 (1) (see all 16)
    5-aza-2'deoxycytidine 42.8 7 15015578 (3), 15609309 (1), 14733783 (1), 16193303 (1)
    adriamycin 31.1 26 11269743 (5), 19523927 (2), 15849742 (2), 15678153 (1) (see all 8)
    amino acid 23.3 1 10383137 (1)
    doxorubicin 8.51 4 19082486 (1), 16631755 (1), 17363502 (1)
    imatinib 8.2 7 18559370 (3), 16741250 (2)
    fatty acid 5.23 1 19517019 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for TP73
    Sigma-Aldrich shRNA Panels and shRNA for TP73
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): TP73
    OriGene shRNA RFP (see all 4): TP73
    OriGene basic RS shRNA (see all 4): TP73
    OriGene siRNA (see all 4): TP73
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TP73 
    miRNA: Sigma-Aldrich microRNA Mimics for TP73
    Sigma-Aldrich microRNA target validation systems for TP73 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TP73 
    Search SABiosciences for Assays for microRNAs that regulate TP73
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TP73
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): TP73
    OriGene untagged cDNA clones in CMV expression vector (see all 4): TP73
    OriGene 3'-UTR Clone (see all 4): TP73 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TP73 
    Primers: OriGene genome-wide validated SYBR primer pairs: TP73
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TP73: PPH00725A

    REFSEQ mRNAs for TP73 gene (4 alternative transcripts): 

    NM_001126240.1  NM_001126241.1  NM_001126242.1  NM_005427.2  

    Additional cDNA sequence: 

    AB055065.1 AB055066.1 AK295669.1 AK302118.1 AK304177.1 AK304784.1 AK310432.1 AY040827.1 
    AY040828.1 AY040829.1 BC117251.1 BC117253.1 CR599961.1 Y11416.1 

    8 DOTS entries:

    DT.100748937  DT.406070  DT.95098410  DT.97824210  DT.100018189  DT.121356582  DT.121356601  DT.91967156 

    24/32 AceView cDNA sequences (see all 32):

    AB055065 Y11416 AB055066 AY040828 AA908299 AY040827 BM471663 BX280538 
    BX348733 AY040829 NM_005427 BX349978 CR599961 BQ669420 BI092821 BF304617 
    BI087031 AA614544 AL528847 BE295836 BX108274 BE798870 AA936771 AL563268 

    highest scoring ESTs for TP73:

    AA936771 AB055065 AB055066 AY040827 AY040828 AY040829 BF813649 BG210348 BI017128 BI087031 

    Unigene Cluster for TP73:

    Tumor protein p73
    Hs.697294  [show with all ESTs]
    Unigene Representative Sequence: NM_005427


    GeneLoc Exon Structure

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354437 ENST00000378295(uc009vll.2 uc001akq.2 uc001akp.2 uc010nzk.1 uc010nzl.1)
    ENST00000378290 ENST00000346387 ENST00000378280(uc010nzj.1) ENST00000357733
    ENST00000378285 ENST00000378288(uc001akr.2 uc009vlk.1 uc001aks.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TP73 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching TP73 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    220804_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005427 0.60 1.00 0.82 1
    232546_at2 U133-B 1 0.82 1.00 -- -- -- -- -- -- --
    1554379_a_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    220804_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    232546_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TP73 gene expression
    TP73 gene electronic northern expression
    TP73 gene sage expression
    About these images

    CGAP SAGE TAG: TGGTACCGCC

    SOURCE GeneReport for Unigene cluster: Hs.697294

    UniProtKB/Swiss-Prot: P73_HUMAN, O15350
    Tissue specificity: Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain,
    kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in
    fetal tissue

    Primers: OriGene genome-wide validated SYBR primer pairs: TP73
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TP73: PPH00725A
        SABiosciences Expression via Pathway-Focused PCR Arrays including TP73 (see all 6): PAHS-012A PAHS-027A  


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TP73 gene from 5/7 species (see all 7)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TP731   -- tumor protein p73 88.59(n)
    90.69(a)
    489620  XM_546740.2  XP_546740.2 
    cow
    (Bos taurus)
    TP731   -- tumor protein p73 88.95(n)
    91.32(a)
    515105  XM_593064.3  XP_593064.3 
    rat
    (Rattus norvegicus)
    Tp731   -- tumor protein p73 87.08(n)
    93.27(a)
    362675  XM_342992.3  XP_342993.3 
    mouse
    (Mus musculus)
    Trp731 , 5 4 (83.79 cM)5
    transformation related protein 731, 5 85.93(n)1
    90.85(a)1
    220621  NM_011642.21  NP_035772.11 
     AA4376665  AB2215945  (see all 14)
    chicken
    (Gallus gallus)
    TP731   -- tumor protein p73 79.85(n)
    83.25(a)
    419382  XM_417545.2  XP_417545.2 
    About this table        Species with no ortholog for TP73

    ENSEMBL Gene Tree for TP73 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for TP73 gene
    TP632  TP532  

    TP73 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1089 NCBI SNPs in TP73 are shown (see all 1089)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7328991,2
    C,F,3586818(-) GGTCCC/TCCGGC 1 -- int12Minor allele frequency- T:0.08WA 52
    rs7329011,2
    C,F,A,3586250(+) ACTCAC/TGCAGC 1 -- int110Minor allele frequency- T:0.06NS EA NA WA 680
    rs7329021,2
    C,F,A,3586283(+) GTGGAC/TGGCAG 1 -- int16Minor allele frequency- T:0.09NA WA 252
    rs7329031,2
    C,F,3586450(+) CCTGCG/AGACAC 1 -- int19Minor allele frequency- A:0.03NA EA NS WA 753
    rs7478271,2
    C,F,A,3636347(-) GGAAGT/GACAGC 4 -- int15Minor allele frequency- G:0.08NS EA 506
    rs7478281,2
    C,F,A,3636226(-) TAAGCA/GGGTAG 4 -- int17Minor allele frequency- G:0.06MN NS EA WA 742
    rs7509631,2
    C,F,A,3605950(-) CGCCCG/ATCTCT 4 -- int1 ng515Minor allele frequency- A:0.11NA EA 344
    rs7510351,2
    C,F,A,3608594(+) CAGGCG/AAGGAT 4 -- int110Minor allele frequency- A:0.05NS EA NA WA 848
    rs7551591,2
    C,A,3580783(-) GTGGAG/AGCCCT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs7551601,2
    C,F,A,3580816(-) GCGCCT/CCTGGT 1 -- int13Minor allele frequency- C:0.37EA WA NA 140
    About this table

    HapMap Linkage Disequilibrium images for TP73 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TP73
         2 CNVs: 4197 2296
         1 Indel: 24194

    QIAGEN SeqTarget long-range PCR primers for resequencing TP73 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TP73 for disorders           About GeneDecksing

    OMIM: 601990

    10/94 Novoseek disease relationships for TP73 gene (see all 94)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 72.1 594 14719122 (6), 10773878 (6), 10341287 (6), 16007185 (5) (see all 99)
    cancer 64 179 11139314 (4), 19754415 (3), 18583938 (3), 10362363 (3) (see all 99)
    allelic loss 60.4 19 11510689 (1), 11301342 (1), 10023682 (1), 10371354 (1) (see all 15)
    oligodendroglial tumors 54 9 11920588 (5), 12241107 (1), 11487055 (1)
    carcinoma squamous cell 51.8 25 10753204 (2), 17699776 (2), 15180941 (2), 15390192 (2) (see all 19)
    oligodendroglioma 45.6 14 10953317 (3), 9721206 (3), 10732753 (1), 12200621 (1) (see all 5)
    retinoblastoma 38.4 9 18619959 (4), 12584188 (1), 11709051 (1), 19643581 (1) (see all 6)
    plasma cell leukemia 36.9 1 10602435 (1)
    primary tumor 36.5 21 16750334 (4), 10935473 (1), 11859406 (1), 14760085 (1) (see all 12)
    promyelocytic leukemia 35.2 4 19111660 (1), 11559539 (1), 15184504 (1), 15893728 (1)
    About this table

    Human Gene Mutation Database (HGMD): TP73
    Genetic Association Database (GAD): TP73
    Human Genome Epidemiology (HuGE) Navigator: TP73 (41 documents)
    Tumor Gene Database (TGDB): TP73

    Export disorders and mutations for TP73 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/786 PubMed articles for TP73 gene, integrated from 7 sources (see all 786):
    (articles sorted by number of sources associating them with TP73)
    1. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. (PubMed id 9288759)1, 2, 3, 7 Kaghad M....Caput D. (1997)
    2. A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. (PubMed id 12890487)1, 2, 7 Miyazaki K....Nakagawara A. (2003)
    3. Mutational analysis of p73 and p53 in human cancer cell lines. (PubMed id 10362363)1, 2, 7 Yoshikawa H....Harris C.C. (1999)
    4. The emerging p53 gene family. (PubMed id 10203277)1, 2, 7 Kaelin W.G. Jr. (1999)
    5. [Association of two genetic polymorphisms in the 5'untranslated region of exon 2 of the p73 gene and risk of lung cancer] (PubMed id 15921610)1, 4, 7 Hu Z.B....Shen H.B. (2005)
    6. Dinucleotide polymorphism of p73 gene is associated with a reduced risk of lung cancer in a Chinese population. (PubMed id 15578704)1, 4, 7 Hu Z....Shen H. (2005)
    7. Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain. (PubMed id 10449409)1, 2, 7 Chi S.W.... Arrowsmith C.H. (1999)
    8. Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. (PubMed id 9721206)1, 2, 7 Mai M.... Liu W. (1998)
    9. Two new p73 splice variants, gamma and delta, with different transcriptional activity. (PubMed id 9802988)1, 2, 7 De Laurenzi V.... Melino G. (1998)
    10. p73 G4C14-to-A4T14 polymorphism and risk of lung cancer. (PubMed id 15466174)1, 4, 7 Li G....Wei Q. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7161 HGNC: 12003 AceView: TP73 Ensembl:ENSG00000078900 euGenes: HUgn7161
    ECgene: TP73 Kegg: 7161 H-InvDB: TP73

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for TP73 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TP73 gene:
    Search GeneIP for patents involving TP73

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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