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TPH1 Gene

protein-coding GIFtS: 60

GC11M017724

tryptophan hydroxylase 1
(Previous name: tryptophan hydroxylase (tryptophan 5-monooxygenase) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: TPRH, TPH)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
tryptophan hydroxylase 1¹ ²		MGC119994²
tryptophan hydroxylase (tryptophan 5-monooxygenase)¹ ²		tryptophan 5-hydroxylase 1²
Tryptophan 5-monooxygenase 1² ³		indoleacetic acid-5-hydroxylase²
TPRH² ³		L-tryptophan hydroxylase²
TRPH² ³		EC 1.14.16.4³
TPH³ ⁵

External Ids:	HGNC: 12008¹	Entrez Gene: 7166²	Ensembl: ENSG00000129167⁷	UniProtKB: P17752³

Export aliases for TPH1 gene to outside databases

Previous GC identifers: GC11M018984 GC11M018081 GC11M018006 GC11M018005 GC11M017997

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TPH1:

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and

rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene

have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic

anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TPH1 gene promoter:
         TBP   TFIID   E4BP4   STAT3   RORalpha2   STAT1   STAT1alpha   STAT1beta   Pax-6   ATF6
         Other transcription factors

Search SABiosciences Chromatin IP Primers for TPH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3-p14 Ensembl cytogenetic band: 11p15.1 HGNC cytogenetic band: 11p15.3-p14

TPH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TPH1 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M017724: view genomic region (about GC identifiers)

Start:	17,724,789 bp from pter
End:	17,745,045 bp from pter
Size:	20,257 bases
Orientation:	minus strand

1 alternative location:

Chr11- 18,041,196-18,062,309

RefSeq DNA sequence:

NC_000011.9 NT_009237.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TPH1_HUMAN, P17752 (See protein sequence)

Recommended Name: Tryptophan 5-hydroxylase 1

Size: 444 amino acids; 50985 Da

Cofactor: Fe(2+) ion

Subunit: Multimer of identical subunits

PDB structures from and Proteopedia :

1IN9 (3D)

1MLW (3D)

3HF6 (3D)

3HF8 (3D)

3HFB (3D)

Secondary accessions: O95188 O95189 Q16736 Q3KPG8

Alternative splicing: 2 isoforms: P17752-1 P17752-2

Explore the universe of human proteins at neXtProt for TPH1: NX_P17752

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004170.1

ENSEMBL proteins:

ENSP00000343550 ENSP00000403831 ENSP00000250018

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Precursors for TPH1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TPH1 OriGene Protein Over-expression Lysate: TPH1
	GenScript Custom Purified and Recombinant Proteins Services for TPH1
	Novus Biologicals Proteins for TPH1
	Novus Biologicals Lysates for TPH1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	EXP	12379098
GO:0043005	neuron projection	--	--

About this table

TPH1 for ontologies About GeneDecksing

Antibodies for TPH1:

	Millipore Mono- and Polyclonal Antibodies for the study of TPH1
	Sigma-Aldrich Antibody Arrays and Antibodies for TPH1
	R&D Systems Antibodies for TPH1 (Tryptophan Hydroxylase, Tryptophan Hydroxylase 1/TPH-1)
	OriGene Antibodies: TPH1
	GenScript Custom Superior Antibodies Services for TPH1
	Novus Biologicals Antibodies for TPH1
	Epitomics antibodies for TPH1

Assays for TPH1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TPH1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TPH1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TPH1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR002912 ACT-bd

IPR019774 Aromatic-AA_hydroxylase_C

IPR005963 Trp_5_mOase

IPR019773 Tyrosine_3-monooxygenase-like

IPR001273 ArAA_hydroxylase

Graphical View of Domain Structure for InterPro Entry P17752

ProtoNet protein and cluster: P17752

2 Blocks protein families:

IPB001273 Aromatic amino acid hydroxylase

IPB002912 Amino acid-binding ACT

UniProtKB/Swiss-Prot: TPH1_HUMAN, P17752

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family

Similarity: Contains 1 ACT domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TPH1_HUMAN, P17752

Catalytic activity: L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin

Enzyme Number (IUBMB): EC 1.14.16.4

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TPH1 Sigma-Aldrich shRNA for TPH1
		OriGene 29mer shRNA kits in GFP-retroviral vector: TPH1 OriGene shRNA RFP: TPH1 OriGene basic RS shRNA: TPH1 OriGene siRNA: TPH1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TPH1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TPH1
		Search SABiosciences for Assays for microRNAs that regulate TPH1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TPH1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TPH1 OriGene untagged cDNA clones in CMV expression vector: TPH1 OriGene 3'-UTR clone: TPH1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TPH1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for TPH1

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	--	--
GO:0004510	tryptophan 5-monooxygenase activity	EXP	12379098
GO:0005506	iron ion binding	IEA	--
GO:0016597	amino acid binding	IEA	--
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	--	--

About this table

TPH1 for ontologies About GeneDecksing

Animal Models: 10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Tph1):

adipose tissue	behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism
muscle	respiratory system	skeleton	skin/coat/nails	touch/vibrissae

TPH1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

TPH1 for pathways About GeneDecksing

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for TPH1

	Tryptophan Metabolism
	Serotonin Receptor Signaling

2 Kegg Pathways (Kegg details for TPH1):

	hsa00380 Tryptophan metabolism
	hsa01100 Metabolic pathways

UniProtKB/Swiss-Prot: TPH1_HUMAN, P17752

Pathway: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2

  SABiosciences Pathway-Focused PCR Arrays including TPH1: PAHS-060A PAHS-096A

  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TPH1
  SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TPH1

5/6 Interacting proteins for TPH1 (ENSP00000343550³) via UniProtKB, MINT, and/or STRING (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDC	ENSP00000339928³	STRING: ENSP00000339928
IDO1	ENSP00000253513³	STRING: ENSP00000253513
TDO2	ENSP00000281525³	STRING: ENSP00000281525
WARS	ENSP00000347495³	STRING: ENSP00000347495
WARS2	ENSP00000235521³	STRING: ENSP00000235521

About this table

5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006950	response to stress	--	--
GO:0008152	metabolic process	--	--
GO:0009072	aromatic amino acid family metabolic process	IEA	--
GO:0042427	serotonin biosynthetic process	IEA	--
GO:0042446	hormone biosynthetic process	TAS	--

About this table

TPH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

TPH1 for compounds About GeneDecksing

Sigma-Aldrich Small Molecules for TPH1:

Small Molecule - Inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for TPH1 available from Tocris Bioscience

Compound	Action	CAS number
p-Chlorophenylalanine	Tryptophan hydroxylase inhibitor	[7424-00-2]

About this table

10/74 Novoseek chemical compound relationships for TPH1 gene (see all 74)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha-monofluoromethyldopa	78.7	1	1974858 (1)
5-hydroxytryptophan	77.5	28	11386854 (2), 9892800 (1), 16023217 (1), 11958527 (1) (see all 16)
tetrahydrobiopterin	77.3	18	9084419 (5), 11472242 (2), 10525150 (1), 12414107 (1) (see all 11)
maoa	76.1	20	16200390 (2), 12502014 (2), 15052272 (2), 15670397 (1) (see all 11)
tetrahydropterin	71.5	1	19281164 (1)
phenylalanine	68.9	34	10321973 (2), 9228951 (1), 10525150 (1), 12414107 (1) (see all 27)
pterin	68.6	2	11747434 (2)
sepiapterin	67.9	1	12414107 (1)
l-amino acid	66.6	16	15012616 (2), 12373866 (1), 10575032 (1), 14764761 (1) (see all 10)
5-hydroxyindoleacetic acid	64.5	19	7506517 (3), 17956909 (2), 9477008 (1), 11150890 (1) (see all 6)

About this table

3 PharmGKB drug compound relationships for TPH1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
antidepressants	PD	15111987
fluvoxamine	PD	11526473
paroxetine	PD	11597824

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TPH1 Sigma-Aldrich shRNA for TPH1
		OriGene 29mer shRNA kits in GFP-retroviral vector: TPH1 OriGene shRNA RFP: TPH1 OriGene basic RS shRNA: TPH1 OriGene siRNA: TPH1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TPH1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TPH1
		Search SABiosciences for Assays for microRNAs that regulate TPH1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: TPH1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TPH1 OriGene untagged cDNA clones in CMV expression vector: TPH1 OriGene 3'-UTR Clone: TPH1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for TPH1

Primers:		OriGene genome-wide validated SYBR primer pairs: TPH1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TPH1: PPH05974A

REFSEQ mRNAs for TPH1 gene:

NM_004179.2

Additional cDNA sequence:

AY196346.1 BC106739.1 BC106740.2 X52836.1

5 DOTS entries:

DT.75187391 DT.120695679 DT.65287122 DT.100789255 DT.91697052

24/177 AceView cDNA sequences (see all 177):

AI356576 AI914248 AW589305 AI570539 N47569 AI824319 BQ059321 BM451912

AJ243951 CR596582 AI588851 NM_004179 BP382405 CB133049 AW026847 BE502932

AI733159 F08752 X52836 AI216588 BQ056935 BG756369 AI880317 BP346952

highest scoring ESTs for TPH1:

X52836 AV751479 BC106739 BC106740 BP423529 BX114367 DN992199 AY196345 BE252379 BM451912

Unigene Cluster for TPH1:

Tryptophan hydroxylase 1

Hs.591999 [show with all ESTs]

Unigene Representative Sequence: NM_004179

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000341556 ENST00000417164(uc009yhe.2) ENST00000250018(uc001mnp.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TPH1 expression in normal and diseased human tissues

¹ / ² / ³

1 probe-set matching TPH1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37879_r_at*²^{, 3}	U95-A	1	--	--	1.00	1.00	AF057280	0.20	1.00	0.72	1

About this table

TPH1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

TPH1 gene electronic northern expression

About these images

CGAP SAGE TAG: ATCTCGATGT

SOURCE GeneReport for Unigene cluster: Hs.591999

Expression variation in blood from EXPOLDB for TPH1

UniProtKB/Swiss-Prot: TPH1_HUMAN, P17752

Tissue specificity: Isoform 2 seems to be less widely expressed than isoform 1

Primers:		OriGene genome-wide validated SYBR primer pairs: TPH1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for TPH1: PPH05974A

SABiosciences Expression via Pathway-Focused PCR Arrays including TPH1: PAHS-060A PAHS-096A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TPH1 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	TPH1¹	--	tryptophan hydroxylase 1	93.24(n) 96.4(a)	781941 XM_001250151.1 XP_001250152.1
rat (Rattus norvegicus)	Tph1¹	--	tryptophan hydroxylase 1	86.71(n) 91.22(a)	24848 XM_341862.3 XP_341863.2
mouse (Mus musculus)	Tph1^{1 , 5}	7 (30.43 cM)⁵	tryptophan hydroxylase 1^{1, 5}	85.81(n)¹ 90.09(a)¹	21990¹ NM_009414.2¹ NP_033440.1¹ AF273257⁵ AK146134⁵ (see all 14)
chicken (Gallus gallus)	TPH1¹	--	tryptophan hydroxylase 1	80.2(n) 86.62(a)	395799 NM_204956.1 NP_990287.1
zebrafish (Danio rerio)	tph²	--	tryptophan hydroxylase (tryptophan 5-monooxygenase	76(n)	352943 AF548566.1

About this table Species with no ortholog for TPH1

ENSEMBL Gene Tree for TPH1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TPH1 gene

TPH2² PAH² TH²

TPH1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs169806^1,2	C,F,A,	18059292(+)	`AAATAC/TGGTCT`	1	--	int¹		11		NS EA NA WA	1048
rs172423^1,2	C,F,O,A,	18056225(+)	`AAATAT/CTGTGG`	1	--	int¹		28		EA NA NS WA	1500
rs211100^1,2	H	18043136(+)	`TAACTA/CTACCT`	1	--	int¹		4		NS EA	416
rs211101^1,2	C,H,	18044304(+)	`GATCTT/CTCCCT`	1	--	int¹		11		MN EA NA WA	254
rs211102^1,2	C,F,A,H,	18046493(+)	`CATCAG/ACTAAT`	1	--	int¹		25		NS MN EA NA WA	1306
rs211103^1,2		18047000(+)	`tcggcC/Tcactg`	1	--	int¹		0	--	--	--	--
rs211104^1,2	C,F,A	18054284(+)	`gagacA/Ggggtc`	1	--	int¹		4		NA WA	8
rs211105^1,2	C,F,A,	18055304(+)	`ATTTTT/GGCCGA`	1	--	int¹		21		NS EA NA WA	1280
rs211106^1,2	C,F,A,	18058026(+)	`GCTAGT/CTTTCA`	1	--	int¹		6		MN NA EA	486
rs211107^1,2	C,F,O,A,	18058341(+)	`TAAAAC/AAATGA`	1	--	int¹		16		EA MN NS NA WA	2678

About this table

HapMap Linkage Disequilibrium images for TPH1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TPH1: --

QIAGEN SeqTarget long-range PCR primers for resequencing TPH1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TPH1 for disorders About GeneDecksing

OMIM: 191060

10/40 Novoseek disease relationships for TPH1 gene (see all 40)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperphenylalaninemia	66.1	2	2109147 (2)
apeced	63.8	10	10946908 (2), 14764761 (1), 18088406 (1), 18274776 (1) (see all 5)
mood disorders	63.6	26	11578639 (3), 11992558 (3), 18977032 (2), 11274651 (2) (see all 14)
bipolar disorder	62.3	24	11472792 (2), 19032713 (2), 9435758 (2), 10716208 (1) (see all 14)
major depression	60	18	16165107 (2), 19590397 (2), 11426508 (1), 16596624 (1) (see all 13)
psychiatric disorder	53.5	22	16467214 (2), 17972101 (1), 16023677 (1), 10673768 (1) (see all 13)
mastocytoma	52.8	7	2110547 (3), 14559114 (1), 10421874 (1), 12354109 (1)
schizophrenia	47.4	47	17870198 (4), 16741719 (3), 19526457 (2), 10899755 (2) (see all 16)
phenylketonurias	44.2	3	17305546 (1), 1974311 (1), 17513427 (1)
carcinoid	42.9	22	9840098 (4), 7575647 (3), 10953292 (3), 7876115 (2) (see all 8)

About this table

1 PharmGKB disease relationship for TPH1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Depression	PD	11597824 11526473 15111987

About this table

Human Gene Mutation Database (HGMD): TPH1
Genetic Association Database (GAD): TPH1
Human Genome Epidemiology (HuGE) Navigator: TPH1 (150 documents)

Export disorders and mutations for TPH1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/467 PubMed articles for TPH1 gene, integrated from 7 sources (see all 467):
(articles sorted by number of sources associating them with TPH1)

Tryptophan hydroxylase gene associated with paroxetine antidepressant activity. (PubMed id 11597824)^{1, 4, 5, 7} Serretti A....Smeraldi E. (2001)
Influence of tryptophan hydroxylase and serotonin transporter genes on fluvoxamine antidepressant activity. (PubMed id 11526473)^{1, 4, 5, 7} Serretti A....Smeraldi E. (2001)
The TPH intron 7 A218C polymorphism and TCI dimension scores in alcohol-dependent patients: hints to nonspecific psychopathology. (PubMed id 15925123)^{1, 4, 7} Anghelescu I....Szegedi A. (2005)
Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders. (PubMed id 15274037)^{1, 4, 7} Serretti A....Zanardi R. (2004)
Genetic variations in tryptophan hydroxylase in suicidal behavior: analysis and meta-analysis. (PubMed id 12915291)^{1, 4, 7} Rujescu D....Moller H.J. (2003)
Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan. (PubMed id 15799788)^{1, 4, 7} Lai T.J....Sun H.S. (2005)
Association of anger-related traits with SNPs in the TPH gene. (PubMed id 12399958)^{1, 4, 7} Rujescu D....Moller H.J. (2002)
Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder. (PubMed id 11426508)^{1, 4, 7} Du L....Hrdina P.D. (2001)
Intronic polymorphism of tryptophan hydroxylase and serotonin transporter: indication for combined effect in predisposition to suicide. (PubMed id 15168220)^{1, 4, 7} Jernej B....Kubat M. (2004)
TPH gene polymorphism and aging: indication of combined effect on the predisposition to violent suicide. (PubMed id 16389591)^{1, 4, 7} Stefulj J....Jernej B. (2006)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7166	HGNC: 12008	AceView: TPH1andDELGEF	Ensembl:ENSG00000129167	euGenes: HUgn7166
ECgene: TPH1	Kegg: 7166	H-InvDB: TPH1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Patent Information for TPH1 gene:
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