Aliases &
Descriptions
for TRIM54 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| tripartite motif-containing 541 2 | | OTTHUMP000001225982 | | RING finger protein 301 2 3 | | muRF32 | | MURF1 2 3 | | MURF33 | | MURF-31 2 | | MuRF-33 | | Muscle-specific RING finger protein 32 3 | | MuRF33 | | RNF302 3 | | MuRF3 | | muscle-specific RING-finger protein 32 | | Muscle-specific RING finger protein3 | | tripartite motif-containing protein 542 | | |
Export aliases for TRIM54 gene to outside databasesPrevious GC identifers: GC02P027418 GC02P027506 |
Summaries
for TRIM54 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM54:
The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteinsRNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers,which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striatedmuscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by RefSeq)
UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2Function: May bind and stabilize microtubules during myotubes formation (By similarity)
|
Genomic Views
for TRIM54 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM54 gene promoter:
E2F-2 E2F-5 E2F-4 E2F-3a E2F-1 E2F RORalpha2 POU2F1 RREB-1 RelA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM54
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3TRIM54 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P027247: view genomic region
(about GC identifiers)
Start:
|
27,247,000 bp from pter |
End:
|
27,272,529 bp from pter |
Size:
|
25,530 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr2+ 27,505,330-27,530,307 |
RefSeq DNA sequence:- NC_000002.11 NT_022184.15
|
Proteins
for TRIM54 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 54 Size: 358 amino acids; 40301 Da
Subunit: Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probablywith TRIM55
Subcellular location: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z-disk (By similarity).Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity)
Sequence caution: Sequence=AAY24296.1; Type=Erroneous initiation; Sequence=CAC32841.1; Type=Erroneous initiation;Sequence=CAC32842.1; Type=Erroneous initiation;
Secondary accessions: A5D8T7 Q53SY4 Q9BYV3Alternative splicing: 2 isoforms: Q9BYV2-1 Q9BYV2-2 Explore the universe of human proteins at neXtProt for TRIM54: NX_Q9BYV2
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_115935.3 NP_912730.2
ENSEMBL proteins: ENSP00000369413 ENSP00000296098 ENSP00000369415
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
TRIM54 for ontologies About GeneDecksing
Antibodies for TRIM54:
Assays for TRIM54: |
Protein
Domains/
Families
for TRIM54 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM54 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9BYV2ProtoNet protein and cluster: Q9BYV2 2 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger
UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2Similarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 COS domainSimilarity: Contains 1 RING-type zinc finger |
Gene Function
for TRIM54 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2Function: May bind and stabilize microtubules during myotubes formation (By similarity)
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
TRIM54 for ontologies About GeneDecksing
Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Trim54):
TRIM54 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRIM54 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TRIM54
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM54
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
TRIM54 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIM54 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TRIM54
|
Transcripts
for TRIM54 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TRIM54 gene (2 alternative transcripts): NM_032546.3 NM_187841.2 Additional cDNA sequence: AJ291714.1 AK300699.1 BC141807.1 5 DOTS entries: DT.97810288 DT.91755592 DT.91717945 DT.100739790 DT.75102302 24/40 AceView cDNA sequences (see all 40): BU633919 AJ291714 AI971801 BM680943 AI352333 NM_187841 NM_032546 BF058468 F26252 BM726338 AI631150 CA417215 AA428229 AA868267 F23238 AI005475 AJ403135 AA182748 AA808889 BF941825 AA625641 CA423690 AW294748 CA423735
 highest scoring ESTs for TRIM54:AJ291714 BM680943 BU633919 CA417215 CA423690 CA423735 AJ573393 AJ574408 BF855619 BM726338 Unigene Cluster for TRIM54: Tripartite motif-containing 54 Hs.516036 [show with all ESTs]Unigene Representative Sequence: NM_032546
GeneLoc Exon Structure
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380073 ENST00000296098(uc002rjn.2 uc002rjo.2) ENST00000380075
ENST00000488321 ENST00000485306
|
Expression
for TRIM54 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TRIM54 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching TRIM54 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 61774_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.98 |
0.89 |
AI262941 |
0.80 |
0.80 |
0.80 |
1 |
| 88391_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
0.98 |
1.12 |
AA428229 |
0.60 |
0.75 |
0.68 |
1 |
| 233669_s_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AA868267 |
0.60 |
0.75 |
0.68 |
1 |
| 233669_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TRIM54 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CACCTGGCTG
SOURCE GeneReport for Unigene cluster: Hs.516036
UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2Tissue specificity: Specifically expressed in heart and skeletal muscle
SABiosciences Custom PCR Arrays for TRIM54
|
Orthologs
for TRIM54 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TRIM54 gene from 5/7 species (see all 7)
About this table Species with no ortholog for TRIM54
ENSEMBL Gene Tree for TRIM54 (if available) |
Paralogs
for TRIM54 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TRIM54 gene
- TRIM132 FSD1L2 TRIM632 TRIM592 TRIM92 TRIM672 TRIM552 FSD12
TRIM54 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM54 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TRIM54 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRIM54
1 CNV: 7262
1 Indel: 97796 | | QIAGEN SeqTarget long-range PCR primers for resequencing TRIM54 |
|
Disorders & Mutations
for TRIM54 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM54 for disorders About GeneDecksing
OMIM: 606474
Export disorders and mutations for TRIM54 gene to outside databases
|
Medical News
for TRIM54 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TRIM54 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for TRIM54 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with TRIM54)- Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PubMed id 11243782)1, 2, 3 Centner T....Labeit S. (2001)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PubMed id 11927605)1 McElhinny A.S.... Gregorio C.C. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Regulation of microtubule dynamics and myogenic differentiation by MURF, a striated muscle RING-finger protein. (PubMed id 10953002)1 Spencer J.A....Olson E.N. (2000)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
- Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction. (PubMed id 12917430)7 Kitamura K....Nishimune Y. (2003)
|
External Searches for TRIM54 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM54 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM54 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM54 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TRIM54 gene:
Search GeneIP for patents involving TRIM54
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM54 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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