TSKU Gene
protein-coding GIFtS : 47
GC11P072791
tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) (Previous names: leucine rich repeat containing 54, tsukushin )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: LRRC54 )
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Aliases & Descriptionsfor TSKU gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions tsukushi small leucine rich proteoglycan homolog (Xenopus laevis)1 2 LRRC542 3 TSK1 2 3 5 E2-induced gene 4 protein2 3 E2IG41 2 3 5 tsukushi homolog2 tsukushin1 2 tsukushi, small leucine rich proteoglycan2 leucine rich repeat containing 541 2 Tsukushi3 Leucine-rich repeat-containing protein 542 3
Export aliases for TSKU gene to outside databases Previous GC identifers: GC11P076171 GC11P076494
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Summariesfor TSKU gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor TSKU gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for TSKU Other transcription factors Search SABiosciences Chromatin IP Primers for TSKU Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TSKU
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.5 HGNC cytogenetic band: 11q13.5 TSKU Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P072791: view genomic region
(about GC identifiers )
Start:
72,791,984 bp from pter
End:
72,806,897 bp from pter
Size:
14,914 bases
Orientation:
plus strand
1 alternative location : Chr 11+ 76,494,285-76,509,197
RefSeq DNA sequence: NC_000011.9 NT_167190.1
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Proteinsfor TSKU gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8 (See
protein sequence )Recommended Name: Tsukushin precursor Size : 353 amino acids; 37807 Da
Subcellular location : Secreted (Potential)
Secondary accessions : B3KQT7 Q6UXK1 Q9UG10 Q9UJX9Explore the universe of human proteins at neXtProt for TSKU: NX_Q8WUA8
REFSEQ proteins: NP_056331.2 ENSEMBL proteins: ENSP00000332668 ENSP00000387819 Human Recombinant Proteins 1 Gene Ontology (GO) cellular component term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
About this table
TSKU for ontologies About GeneDecksing Antibodies for TSKU: Assays for TSKU:
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Protein
Domains/ Familiesfor TSKU gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TSKU for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8WUA8 ProtoNet protein and cluster: Q8WUA8
1 Blocks protein family : IPB000372 Cysteine-rich flanking region UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8 Similarity : Contains 9 LRR (leucine-rich) repeats
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Gene Functionfor TSKU gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: TSK_HUMAN, Q8WUA8 Induction : By 17-beta-estradiol
1 Gene Ontology (GO) molecular function term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IEA --
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TSKU for ontologies About GeneDecksing
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Pathways & Interactionsfor TSKU gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for TSKU SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TSKU 1 Interacting protein for TSKU (Q8WUA8 2 ) via UniProtKB, MINT, and/or STRING About this table
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Drugs & Compoundsfor TSKU gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for TSKU
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Transcriptsfor TSKU gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for TSKU gene: NM_015516.3
Additional cDNA sequence: AF191019.1 AK075476.1 AK091475.1 AK126536.1 AK313405.1 AL110276.1 AY358317.1 BC020975.1 BT007440.1
10 DOTS entries : DT.417669 DT.100777424 DT.100754481 DT.120701703 DT.100777423 DT.91768837 DT.91768832 DT.120701695
DT.120701697 DT.40215150 24/258 AceView cDNA sequences (see all 258 ):
BG697318 BF724678 AI884558 BE336901 AI269100 BF724254 BU526767 AI074139 BE786245 BU846213 AA558470 BF725906 BM723751 CA489754 BG056788 AI074399 CB242473 AI613032 BX324381 AA305745 BC020975 AA335297 AL110276 BG327574
highest scoring ESTs for TSKU :AI702079 AA009451 AA009735 AA045801 AA045868 AA088181 AA299901 AA305745 AA335281 AA335297 Unigene Cluster for TSKU:
Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) Hs.8361 [show with all ESTs ] Unigene Representative Sequence: AK126536 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000333090 (uc001oxt.2 ) ENST00000439807
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Expression for TSKU gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section TSKU expression in normal and diseased human tissues 1 / 2 / 3
3 probe-sets matching TSKU gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
46313_at2 , 3
U95-B
1
1.00
1.00
1.00
1.00
AI702079
1.00
1.00
1.00
1
218245_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_015516
0.60
1.00
0.82
1
218245_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
About this table
TSKU for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GGCATCAGGG SOURCE GeneReport for Unigene cluster: Hs.8361 SABiosciences Custom PCR Arrays for TSKU
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Orthologsfor TSKU gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for TSKU gene from 5/8 species (see all 8 )
About this table Species with no ortholog for TSKU ENSEMBL Gene Tree for TSKU (if available)
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Paralogsfor TSKU gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section --
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Genomic Variantsfor TSKU gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 11 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for TSKU (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TSKU: --
QIAGEN SeqTarget long-range PCR primers for resequencing TSKU
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Disorders & Mutationsfor TSKU gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TSKU for disorders About GeneDecksing
OMIM: 608015 Export disorders and mutations for TSKU gene to outside databases
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Medical Newsfor TSKU gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor TSKU gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 9 PubMed articles for TSKU gene integrated from 7 sources : (articles sorted by number of sources associating them with TSKU) Effects of estrogen on global gene expression: identification of novel targets of estrogen action. (PubMed id 11085516) 1 , 2 , 3 Charpentier A.H.... Aldaz C.M. (2000) Comparative analysis of gene regulation by the transc ription factor PPARalpha between mouse and human. (PubMed id 19710929) 1 , 3 Rakhshandehroo M....Kersten S. (2009) Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743) 1 , 2 Otsuki T....Isogai T. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 Clark H.F.... Gray A.M. (2003) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748) 1 Colland F....Gauthier J.M. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TSKU gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TSKU gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TSKU gene
(According to HUGE )
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Specialized Databases showing TSKU gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for TSKU gene: Search GeneIP for patents involving TSKU GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TSKU gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for TSKU
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