Aliases &
Descriptions
for TSPO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| translocator protein (18kDa)1 2 | | Mitochondrial benzodiazepine receptor2 3 | | PBR1 2 3 5 | | PBS2 5 | | PKBS1 2 3 | | BPBS2 5 | | MBR1 2 3 | | benzodiazapine receptor (peripheral)1 | | BZRP2 3 5 | | PTBR2 | | IBP1 2 | | peripheral benzodiazepine receptor2 | | DBI1 2 | | translocator protein2 | | mDRC1 2 | | benzodiazepine peripheral binding site2 | | pk181 2 | | OTTHUMP000001982512 | | Peripheral-type benzodiazepine receptor2 3 | | PBRS3 |
Export aliases for TSPO gene to outside databasesPrevious GC identifers: GC22P041877 GC22P043547 |
Summaries
for TSPO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TSPO:
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts withsome benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in theflow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptionalsplice variants, encoding different isoforms, have been characterized. (provided by RefSeq)
UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely tocomprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport ofporphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogeniccells (By similarity)
|
Genomic Views
for TSPO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TSPO gene promoter:
CREB deltaCREB c-Myc Max1 NF-kappaB1 SRF NF-kappaB Egr-1 Sp1 GATA-3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TSPO
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TSPO  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.31 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.3TSPO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P026505: view genomic region
(about GC identifiers)
Start:
|
26,505,742 bp from pter |
End:
|
26,517,455 bp from pter |
Size:
|
11,714 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr22+ 43,547,520-43,559,248 |
RefSeq DNA sequence:- NC_000022.10 NT_011520.12
|
Proteins
for TSPO gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536 (See
protein sequence)Recommended Name: Translocator protein Size: 169 amino acids; 18828 Da
Subunit: Interacts with BZRAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1
Subcellular location: Mitochondrion membrane; Multi-pass membrane protein
Secondary accessions: Q53Y59 Q6ICF9 Q96TF6Alternative splicing: 2 isoforms: P30536-1 B1AH88-1 UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88 (See
protein sequence) Recommended Name: Peripheral benzodiazepine receptor-related protein Size: 102 amino acids; 10537 Da
Secondary accessions: Q13849 Q6IAZ7Alternative splicing: 2 isoforms: B1AH88-1 P30536-1 Explore the universe of human proteins at neXtProt for TSPO: NX_B1AH88
REFSEQ proteins (2 alternative transcripts):
NP_000705.2 NP_009295.2
ENSEMBL proteins: ENSP00000379563 ENSP00000405685 ENSP00000328973 ENSP00000392012 ENSP00000338004 ENSP00000355074
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
TSPO for ontologies About GeneDecksing
Antibodies for TSPO:
Assays for TSPO: |
Protein
Domains/
Families
for TSPO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TSPO for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P30536Graphical View of Domain Structure for InterPro Entry B1AH88ProtoNet protein and cluster: P30536 1 Blocks protein family: IPB004307 TspO and MBR related proteins
UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536Similarity: Belongs to the TspO/BZRP family |
Gene Function
for TSPO gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TSPOA_HUMAN, P30536Function: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely tocomprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport ofporphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogeniccells (By similarity)
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
TSPO for ontologies About GeneDecksing
|
Pathways & Interactions
for TSPO gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
TSPO for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for TSPO):  | hsa04080 Neuroactive ligand-receptor interaction |
SABiosciences Pathway-Focused PCR Arrays including TSPO: PAHS-060A PAHS-087A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TSPO
5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7): About this table
TSPO for ontologies About GeneDecksing
|
Drugs & Compounds
for TSPO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
TSPO for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for TSPO |
 Browse Tocris compounds for TSPO
10/119  Novoseek chemical compound relationships for TSPO gene (see all 119)
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| benzodiazepine |
98.6 |
2697 |
8306240 (10), 10664825 (9), 17027961 (8), 8868371 (7) (see all 99) |
| pk 11195 |
94.4 |
93 |
17291492 (3), 16051742 (2), 17555551 (2), 18800007 (2) (see all 52) |
| iomazenil |
93.1 |
17 |
7662908 (1), 12440611 (1), 8691270 (1), 9212889 (1) (see all 16) |
| flumazenil |
92.6 |
89 |
10023509 (3), 8880096 (3), 8282018 (2), 8545530 (2) (see all 73) |
| benzodiazepines |
86.6 |
76 |
1980690 (3), 1637606 (2), 8262176 (2), 14678758 (2) (see all 63) |
| diazepam |
85.1 |
118 |
10576594 (5), 1316281 (3), 8080486 (3), 1321091 (3) (see all 78) |
| bretazenil |
80.1 |
8 |
8981602 (2), 8748388 (1), 9839004 (1), 8868371 (1) (see all 7) |
| zolpidem |
79.1 |
34 |
8925872 (3), 1361878 (3), 11370287 (2), 10755807 (2) (see all 26) |
| gaba |
77 |
122 |
1965016 (6), 2160756 (2), 1649416 (2), 8306240 (2) (see all 76) |
| triakontatetraneuropeptide |
77 |
5 |
19456330 (1), 8380885 (1), 9460762 (1) |
About this table
|
Transcripts
for TSPO gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TSPO gene (2 alternative transcripts): NM_000714.4 NM_007311.3 Additional cDNA sequence: AF075589.1 AF075590.1 AY998017.1 BC001110.2 BT006949.1 CR456409.1 CR457007.1 CR590116.1 CR607955.1 CR609727.1 CR617902.1 CR619651.1 CR621254.1 L21950.1 M36035.1 7 DOTS entries: DT.40127929 DT.98131737 DT.100801819 DT.100643566 DT.97855685 DT.97855686 DT.97821978 24/442 AceView cDNA sequences (see all 442): BE908317 CD370271 CR607955 BM549915 AW328575 BM853651 BU625404 CR619651 AA314709 BM761374 CR617902 BM842268 BM014524 BG575252 BU177060 CR590116 CR456409 BQ773690 BM784742 BM905068 AF075590 BQ182755 AW469169 BM694225
 highest scoring ESTs for TSPO:M36035 AA007504 AA036726 AA037186 AA056606 AA069479 AA070923 AA099285 AA100452 AA158134 Unigene Cluster for TSPO: Translocator protein (18kDa) Hs.202 [show with all ESTs]Unigene Representative Sequence: BM924710
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TSPO
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TSPO
7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396265 ENST00000428336 ENST00000472378 ENST00000329563 ENST00000445018
ENST00000337554(uc003bdn.2 uc003bdo.2) ENST00000361449
|
Expression
for TSPO gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TSPO expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching TSPO gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 32806_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
M36035 |
1.00 |
1.00 |
1.00 |
1 |
| 202096_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_000714 |
0.60 |
1.00 |
0.82 |
1 |
| 202096_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TSPO for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAATTTTATA
SOURCE GeneReport for Unigene cluster: Hs.202
UniProtKB/Swiss-Prot: TSPOB_HUMAN, B1AH88Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including TSPO: PAHS-060A PAHS-087A
|
Orthologs
for TSPO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TSPO gene from 5/13 species (see all 13)
About this table Species with no ortholog for TSPO
ENSEMBL Gene Tree for TSPO (if available) |
Paralogs
for TSPO gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for TSPO gene
- TSPO22
TSPO for paralogs About GeneDecksing
|
Genomic Variants
for TSPO gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 22 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TSPO (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TSPO
1 CNV: 7352
5 Indels: 40505 62009 40504 46230 41951 | | QIAGEN SeqTarget long-range PCR primers for resequencing TSPO |
|
Disorders & Mutations
for TSPO gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TSPO for disorders About GeneDecksing
OMIM: 109610
10/93 Novoseek disease relationships for TSPO gene (see all 93)
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hepatic encephalopathy |
78.4 |
53 |
8276347 (5), 11687160 (4), 15106178 (4), 2172467 (3) (see all 31) |
| hepatic coma |
60.7 |
5 |
2161396 (1), 9347201 (1), 16563564 (1), 7748297 (1) (see all 5) |
| chronic insomnia |
60.3 |
1 |
19201632 (1) |
| epilepsy temporal lobe |
57.7 |
17 |
11893007 (2), 12199729 (2), 11518000 (2), 10599778 (1) (see all 14) |
| panic disorder |
53.6 |
29 |
10664825 (5), 10023509 (3), 7624108 (3), 9928900 (3) (see all 16) |
| epilepsies partial |
52.8 |
14 |
10390953 (2), 1317662 (2), 8956845 (1), 9795703 (1) (see all 12) |
| anxiety disorders |
48.6 |
10 |
8748388 (1), 1324584 (1), 10103141 (1), 1687977 (1) (see all 10) |
| glioma |
47.8 |
40 |
16026165 (4), 7714547 (3), 9540054 (3), 15276076 (3) (see all 21) |
| stupor |
45.6 |
2 |
1357403 (1), 19477714 (1) |
| epilepsy |
45.2 |
11 |
11882054 (2), 9237052 (1), 8797068 (1), 10390953 (1) (see all 7) |
About this table
Human Gene Mutation Database (HGMD): TSPO
Human Genome Epidemiology (HuGE) Navigator: TSPO (7 documents)
Export disorders and mutations for TSPO gene to outside databases
|
Medical News
for TSPO gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TSPO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/845 PubMed articles for TSPO gene, integrated from 7 sources (see all 845):
(articles sorted by number of sources associating them with TSPO)- The human peripheral benzodiazepine receptor gene: cloning and characterization of alternative splicing in normal tissues and in a patient with congenital lipoid adrenal hyperplasia. (PubMed id 8307574)1, 2, 7 Lin D.... Miller W.L. (1993)
- The human "peripheral-type" benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA. (PubMed id 1326278)1, 3, 7 Chang Y.J....Strauss J.F. (1992)
- Translocator protein (18kDa): new nomenclature for the peripheral- type benzodiazepine receptor based on its structure and molecular function. (PubMed id 16822554)1, 3 Papadopoulos V.... Gavish M. (2006)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. (PubMed id 1847678)1, 3 Riond J....Ferrara P. (1991)
- Expression of peripheral benzodiazepine receptor (PBR) in human tumors: relationship to breast, colorectal, and prostate tumor progression. (PubMed id 14626449)1, 7 Han Z....Papadopoulos V. (2003)
- Effects of peripheral benzodiazepine receptor ligands on proliferation and differentiation of human mesenchymal stem cells. (PubMed id 14584048)1, 7 Lee D.H....Jung J.S. (2004)
- Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation. (PubMed id 15769477)1, 7 Corsi L....Baraldi M. (2005)
- Immunohistochemical assessment of the peripheral benzodiazepine receptor in breast cancer and its relationship with survival. (PubMed id 15041726)1, 7 Galiegue S....Simony-Lafontaine J. (2004)
- Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival. (PubMed id 16868661)1, 7 Vlodavsky E. and Soustiel J.F. (2007)
|
External Searches for TSPO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TSPO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TSPO gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TSPO gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| NIEHS-SNPs | http://egp.gs.washington.edu/data/bzrp/ |
|
| | |
About This Section
| Patent Information for TSPO gene:
Search GeneIP for patents involving TSPO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TSPO gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for TSPO |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for TSPO |
| |
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