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Aliases & Descriptionsfor TTC12 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions tetratricopeptide repeat domain 121 2 tetratricopeptide repeat protein 122 TPARM1 2 5 tetratricopeptide repeat protein 12 variant 12 FLJ205351 2 tetratricopeptide repeat protein 12 variant 22 FLJ138591 2 OTTHUMP000001835122 TPR repeat protein 122 3
Export aliases for TTC12 gene to outside databases Previous GC identifers: GC11P112722 GC11P112690 GC11P113185
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Summariesfor TTC12 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TTC12 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TTC12 gene promoter: HOXA9B Meis-1 RFX1 MIF-1 AREB6 Nkx3-1 v4 Nkx3-1 Nkx3-1 v1 Nkx3-1 v2 Nkx3-1 v3 Other transcription factors Search SABiosciences Chromatin IP Primers for TTC12 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TTC12
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.2 HGNC cytogenetic band: 11q23.2 TTC12 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11P109112: view genomic region
(about GC identifiers )
Start:
109,112,836 bp from pter
End:
109,164,715 bp from pter
Size:
51,880 bases
Orientation:
plus strand
1 alternative location : Chr 11+ 113,185,301-113,254,266
RefSeq DNA sequence: NC_000011.9 NT_033899.8
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Proteinsfor TTC12 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: TTC12_HUMAN, Q9H892 (See
protein sequence )Recommended Name: Tetratricopeptide repeat protein 12 Size : 705 amino acids; 78738 Da
Sequence caution : Sequence=BAA91242.1; Type=Erroneous initiation;
Secondary accessions : Q8N5H9 Q9NWY3Alternative splicing : 2 isoforms : Q9H892-1 Q9H892-2 Explore the universe of human proteins at neXtProt for TTC12: NX_Q9H892 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_060338.3 ENSEMBL proteins: ENSP00000402004 ENSP00000395082 ENSP00000400039 ENSP00000413335 ENSP00000419652 ENSP00000315160 ENSP00000376743 ENSP00000423788 ENSP00000278593 ENSP00000429128 Human Recombinant Proteins Antibodies for TTC12: Assays for TTC12:
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Protein
Domains/ Familiesfor TTC12 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TTC12 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry Q9H892 ProtoNet protein and cluster: Q9H892
UniProtKB/Swiss-Prot: TTC12_HUMAN, Q9H892 Similarity : Contains 3 TPR repeats
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Gene Functionfor TTC12 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section 3 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
TTC12 for ontologies About GeneDecksing
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Pathways & Interactionsfor TTC12 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for TTC12 SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TTC12 1 Gene Ontology (GO) biological process term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008152 metabolic process
-- --
About this table
TTC12 for ontologies About GeneDecksing
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Drugs & Compoundsfor TTC12 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for TTC12
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Transcriptsfor TTC12 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for TTC12 gene: NM_017868.3
Additional cDNA sequence: AK000542.1 AK023921.1 AK027161.1 AK091887.1 AK125909.1 AK223117.1 AK292331.1 BC011546.1 BC019086.2
17 DOTS entries : DT.99961473 DT.100020560 DT.108310 DT.100020559 DT.120720437 DT.97779874 DT.91955198 DT.100030480
DT.92424750 DT.70102660 DT.95257432 DT.95269636 DT.65287571 DT.40307708 DT.97854427 DT.91820313 DT.91853573 24/111 AceView cDNA sequences (see all 111 ):
BQ218129 AA399653 NM_017868 AK023921 CF132464 AK027161 AU124478 BM698700 BC011546 BC019086 BC032355 BM473638 BM992919 AK000542 CN478998 BU684868 AI586953 BE261724 AK125909 AW513387 BU680990 AK091887 CD628682 BF725316
highest scoring ESTs for TTC12 :AI799864 AA132777 AK000542 AK023921 AK091887 AL572896 AW076105 BC011546 BC019086 BF980079 Unigene Cluster for TTC12:
Tetratricopeptide repeat domain 12 Hs.288772 [show with all ESTs ] Unigene Representative Sequence: AK125909 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TTC12 (see all 10 ) ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ SP1 :                           -                           SP2 :                                                     SP3 :                                                     SP4 :                                                     SP5 :             -                                        
ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 SP1 :               SP2 :               SP3 :               SP4 :               SP5 :              
About this scheme ECgene alternative splicing isoforms for TTC12 17 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000480233 ENST00000455306 ENST00000464224 (uc001pnx.2 ) ENST00000436332 ENST00000442859 ENST00000429951 ENST00000489064 ENST00000496311 ENST00000483239 ENST00000314756 ENST00000478125 ENST00000393020 ENST00000494714 (uc001pnw.2 )ENST00000462711 ENST00000504025 (uc001pnu.2 uc001pnv.2 ) ENST00000278593 ENST00000520742
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Expression for TTC12 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section TTC12 expression in normal and diseased human tissues 1 / 2 / 3
7 probe-sets matching TTC12 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
43087_at2 , 3
U95-B
1
1.00
1.00
0.77
1.02
AI799864
1.00
1.00
1.00
1
74046_at2 , 3
U95-E
1
0.44
1.00
0.53
1.01
AI971251
0.20
1.00
0.72
1
219587_at2 , 3
U133-A
1
0.91
1.00
--
--
NM_017868
0.60
1.00
0.82
1
215598_at*2 , 3
U133-A
1
0.27
1.00
--
--
AK027161
0.40
1.00
0.76
1
219587_at2
U133Plus2
1
0.91
1.00
--
--
--
--
--
--
--
1554531_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
215598_at*2
U133Plus2
1
0.27
1.00
--
--
--
--
--
--
--
About this table
TTC12 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCCTAGAAAT SOURCE GeneReport for Unigene cluster: Hs.288772 SABiosciences Custom PCR Arrays for TTC12
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Orthologsfor TTC12 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for TTC12 gene from 5/7 species (see all 7 )
About this table Species with no ortholog for TTC12 ENSEMBL Gene Tree for TTC12 (if available)
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Paralogsfor TTC12 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for TTC12 gene STIP1 2
TTC12 for paralogs About GeneDecksing
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Genomic Variantsfor TTC12 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 11 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for TTC12 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TTC12: --
QIAGEN SeqTarget long-range PCR primers for resequencing TTC12
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Disorders & Mutationsfor TTC12 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TTC12 for disorders About GeneDecksing
OMIM: 610732 Human Genome Epidemiology (HuGE) Navigator: TTC12 (5 documents) Export disorders and mutations for TTC12 gene to outside databases
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Medical Newsfor TTC12 gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor TTC12 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/13 PubMed articles for TTC12 gene, integrated from 7 sources (see all 13 ): (articles sorted by number of sources associating them with TTC12) Identification and characterization of TPARM gene in silico. (PubMed id 12964006) 1 , 3, 7 Katoh M. and Katoh M. (2003) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Sex differences in TTC12/ANKK1 haplotype associations with daily tobacco smoking in Black and White Americans. (PubMed id 20133381) 1 David S.P....Eaton W.W. (2010) Haplotypic Variants in DRD2, ANKK1, TTC12, and NCAM1 are Associated With Comorbid Alcohol and Drug Dependence. (PubMed id 18828801) 1 Yang B.Z....Gelernter J. (2008) Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples. (PubMed id 17761687) 1 Yang B.Z....Gelernter J. (2007) Hypermethylation of TTC12 gene in acute lymphoblastic leukemia. (PubMed id 17657212) 1 Wattanawaraporn R....Mutirangura A. (2007) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. (PubMed id 17085484) 1 Gelernter J....Farrer L. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TTC12 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TTC12 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TTC12 gene
(According to HUGE )
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Specialized Databases showing TTC12 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for TTC12 gene: Search GeneIP for patents involving TTC12 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TTC12 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for TTC12
ELISAs and CLIAs for TTC12
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