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TTPAL Gene

protein-coding   GIFtS: 38

GC20P039846
tocopherol (alpha) transfer protein-like
(Previous name: chromosome 20 open reading frame 121 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf121)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
tocopherol (alpha) transfer protein-like1 2     MGC24702
C20orf1212 3     OTTHUMP000000632212
dJ179M20.31     alpha-tocopherol transfer protein-like2
chromosome 20 open reading frame 1211     DKFZp686E08702

External Ids:    HGNC: 161141   Entrez Gene: 791832   Ensembl: ENSG000001241207   UniProtKB: Q9BTX73   

Export aliases for TTPAL gene to outside databases

Previous GC identifers: GC20P042538 GC20P043104


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7
Function: May act as a protein that binds a hydrophobic ligand (Potential)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TTPAL
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TTPAL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

TTPAL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TTPAL gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P039846:  view genomic region     (about GC identifiers)

Start:
39,846,021 bp from pter
End:
39,864,717 bp from pter
Size:
18,697 bases
Orientation:
plus strand

1 alternative location:
Chr20+ 43,104,526-43,123,244     
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7 (See protein sequence)
Recommended Name: Alpha-tocopherol transfer protein-like  
Size: 342 amino acids; 38515 Da
Secondary accessions: Q5QPC1 Q9H1G2 Q9NQG8

Explore the universe of human proteins at neXtProt for TTPAL: NX_Q9BTX7 

REFSEQ proteins (2 alternative transcripts): 
NP_001034288.1  NP_077307.2  


ENSEMBL proteins: 
ENSP00000396346 ENSP00000412720 ENSP00000361997 ENSP00000361995 ENSP00000262605 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
OriGene Purified Protein: TTPAL
OriGene Protein Over-expression Lysate: TTPAL
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Novus Biologicals Lysate for TTPAL
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005622 intracellular IEA--
About this table

TTPAL for ontologies           About GeneDecksing



Antibodies for TTPAL: 
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Assays for TTPAL: 
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Browse ELISAs at Sigma-Aldrich
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Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for TTPAL 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TTPAL for domains           About GeneDecksing

4 InterPro domains/families:
 IPR001071 CRAL-bd_toc_tran
 IPR001251 CRAL-bd_TRIO_C
 IPR011074 Sec14p-like_N
 IPR008273 CRAL-bd_TRIO_N

Graphical View of Domain Structure for InterPro Entry Q9BTX7

ProtoNet protein and cluster: Q9BTX7

3 Blocks protein families:
IPB001071 Cellular retinaldehyde-binding protein signature
IPB001251 Cellular retinaldehyde-binding (CRAL)/Triple function domain (TRIO)
IPB008273 Cellular retinaldehyde-binding/triple function


UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7
Similarity: Contains 1 CRAL-TRIO domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: TTPAL_HUMAN, Q9BTX7
Function: May act as a protein that binds a hydrophobic ligand (Potential)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for TTPAL
Sigma-Aldrich shRNA for TTPAL
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TTPAL
OriGene shRNA RFP (see all 2): TTPAL
OriGene basic RS shRNA (see all 2): TTPAL
OriGene siRNA (see all 2): TTPAL
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TTPAL 
miRNA:Sigma-Aldrich microRNA Mimics for TTPAL
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TTPAL 
8/28 SABiosciences Assays for microRNAs that regulate TTPAL (see all 28):
hsa-miR-520e hsa-miR-106a hsa-miR-197 hsa-miR-512-3p hsa-miR-1297 hsa-miR-372 hsa-miR-133a hsa-miR-93

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TTPAL
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TTPAL
OriGene untagged cDNA clones in CMV expression vector (see all 3): TTPAL
OriGene 3'-UTR clone (see all 2): TTPAL 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for TTPAL 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for TTPAL 

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005215 transporter activity IEA--
About this table

TTPAL for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for TTPAL 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TTPAL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TTPAL


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for TTPAL
Sigma-Aldrich shRNA for TTPAL
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): TTPAL
OriGene shRNA RFP (see all 2): TTPAL
OriGene basic RS shRNA (see all 2): TTPAL
OriGene siRNA (see all 2): TTPAL
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TTPAL 
miRNA: Sigma-Aldrich microRNA Mimics for TTPAL
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TTPAL 
8/28 SABiosciences Assays for microRNAs that regulate TTPAL (see all 28):
hsa-miR-520e hsa-miR-106a hsa-miR-197 hsa-miR-512-3p hsa-miR-1297 hsa-miR-372 hsa-miR-133a hsa-miR-93
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TTPAL
OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TTPAL
OriGene untagged cDNA clones in CMV expression vector (see all 3): TTPAL
OriGene 3'-UTR Clone (see all 2): TTPAL 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for TTPAL 
Primers: OriGene genome-wide validated SYBR primer pairs: TTPAL
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TTPAL: PPH15955A

REFSEQ mRNAs for TTPAL gene (2 alternative transcripts): 

NM_001039199.1  NM_024331.3  

Additional cDNA sequence: 

AK056178.1 AK307236.1 AK314045.1 BC003071.2 CR936621.1 

9 DOTS entries:

DT.40314550  DT.425475  DT.95161462  DT.95270572  DT.100024331  DT.440699  DT.120837456  DT.120837486 
DT.95256850 

24/95 AceView cDNA sequences (see all 95):

BQ128334 AW874112 BU621308 AA074871 BM810916 AA325298 NM_024331 BQ646722 
BE383204 BU902299 BM454474 BG680428 AL707926 BM915194 AI360302 BC003071 
BU735733 BM461853 AI690985 BG030377 BM019004 BP351602 AI674166 BQ048944 

Unigene Cluster for TTPAL:

Tocopherol (alpha) transfer protein-like
Hs.283869  [show with all ESTs]
Unigene Representative Sequence: NM_024331


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TTPAL (see all 6)

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1:                    -                       -                     
SP2:                    -                                             
SP3:                                                                  
SP4:                                            -                     
SP5:                                                                  

About this scheme

ECgene alternative splicing isoforms for TTPAL
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000443145 ENST00000461134 ENST00000456317 ENST00000372906 ENST00000372904(uc002xmc.1)
ENST00000262605(uc002xmd.1 uc010ggr.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

TTPAL expression in normal and diseased human tissues

1  / 2

4 probe-sets matching TTPAL gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
219633_at2 U133-A 1 0.82 1.00 -- -- -- -- -- -- --
228031_at2 U133-B 1 0.64 1.00 -- -- -- -- -- -- --
219633_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
228031_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
TTPAL gene expression
TTPAL gene electronic northern expression
TTPAL gene sage expression
About these images

CGAP SAGE TAG: ACTCAGTCTG

SOURCE GeneReport for Unigene cluster: Hs.283869
Primers: OriGene genome-wide validated SYBR primer pairs: TTPAL
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for TTPAL: PPH15955A
    SABiosciences Custom PCR Arrays for TTPAL 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TTPAL gene from 5/8 species (see all 8)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TTPAL1   -- tocopherol (alpha) transfer protein-like 90.45(n)
94.74(a)
477234  XM_534426.2  XP_534426.1 
chimpanzee
(Pan troglodytes)
TTPAL1   -- tocopherol (alpha) transfer protein-like 99.42(n)
99.71(a)
458270  XM_514665.2  XP_514665.2 
cow
(Bos taurus)
TTPAL1   -- tocopherol (alpha) transfer protein-like 87.52(n)
91.81(a)
526582  XM_604955.3  XP_604955.2 
rat
(Rattus norvegicus)
Ttpal1   -- tocopherol (alpha) transfer protein-like 86.26(n)
93.27(a)
296349  XM_230830.4  XP_230830.2 
mouse
(Mus musculus)
Ttpal1 , 5 2 (84.37 cM)5
tocopherol (alpha) transfer protein-like1, 5 87.91(n)1
94.44(a)1
760801  NM_029512.21  NP_083788.21 
 AA3871015  AK0142625  (see all 19)
About this table        Species with no ortholog for TTPAL

ENSEMBL Gene Tree for TTPAL (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for TTPAL gene
RLBP12  CLVS22  CLVS12  TTPA2  

TTPAL for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/181 NCBI SNPs in TTPAL are shown (see all 181)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs19831,2
C,F,O,A,H,43123028(+) AGCTTG/AGGGCA 2 -- ut3115Minor allele frequency- A:0.34MN NS EA NA 1282
rs30915051,2
--43121209(+) TCTCT-/CTTTTTA 2 -- ut310--------
rs30915631,2
C43117537(+) GTGAT-/TCTGAG 2 -- int11Minor allele frequency- T:0.00NA 2
rs30917491,2
C43114844(+) gcctc-/Tccaag 2 -- int11Minor allele frequency- T:0.00NA 2
rs30921181,2
C,F,O,A,43119938(+) TTAGAC/TGGTTC 2 -- ut31 ese318Minor allele frequency- T:0.22NA NS EA WA 1136
rs37465771,2
C,F,43109261(+) GGATTC/TAGTCG 2 -- int19Minor allele frequency- N:0.00EA NA NS 2130
rs37465781,2
C,43117969(+) CCCAAG/AGAGTA 4 /K syn1 ref1 ese33Minor allele frequency- A:0.01EA NS 266
rs58415551,2
--43120418(+) GAGAA-/ACTGGG 2 -- ut310--------
rs60173521,2
--43107019(+) GAGTCC/GTATGT 2 -- int10--------
rs60173531,2
--43110031(+) aatttA/TaaaaA 2 -- int10--------
About this table

HapMap Linkage Disequilibrium images for TTPAL (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TTPAL: --

QIAGEN SeqTarget long-range PCR primers for resequencing TTPAL 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

5 PubMed articles for TTPAL gene integrated from 7 sources:
(articles sorted by number of sources associating them with TTPAL)
  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
  3. High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79183 HGNC: 16114 AceView: C20orf121 Ensembl:ENSG00000124120 euGenes: HUgn79183
ECgene: TTPAL H-InvDB: TTPAL

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for TTPAL gene:
Search GeneIP for patents involving TTPAL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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 Predesigned and custom siRNAs for TTPAL Antibodies for TTPAL
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 "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TTPAL
 SeqTarget long-range PCR primers for resequencing TTPAL
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TTPAL
 GenScript Custom Purified and Recombinant Proteins Services for TTPAL GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TTPAL
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