Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



TXN2 Gene

protein-coding   GIFtS: 58

GC22M019831
thioredoxin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
thioredoxin 21 2     thioredoxin, mitochondrial2
MT-TRX1 2     mitochondrial thioredoxin2
TRX22 3     Thioredoxin-23
MTRX2 3     Mt-Trx3
thioredoxin-22     

External Ids:    HGNC: 177721   Entrez Gene: 258282   Ensembl: ENSG000001003487   UniProtKB: Q997573   

Export aliases for TXN2 gene to outside databases

Previous GC identifers: GC22M033477 GC22M035105 GC22M035106 GC22M035187 GC22M036863


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TXN2:
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional
redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane
potential and in protection against oxidant-induced apoptosis. (provided by RefSeq)

UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757
Function: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane
potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity

Gene Wiki entry for TXN2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TXN2 gene promoter:
         ISGF-3   AREB6   STAT3   LCR-F1   LUN-1   Arnt   AhR   MEF-2A   GR-alpha   ZID   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TXN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TXN2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q12.3   HGNC cytogenetic band: 22q13.1

TXN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXN2 gene location

GeneLoc gene densities for chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M019831:  view genomic region     (about GC identifiers)

Start:
19,831,327 bp from pter
End:
19,845,504 bp from pter
Size:
14,178 bases
Orientation:
minus strand

1 alternative location:
Chr22- 36,863,083-36,878,077     
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757 (See protein sequence)
Recommended Name: Thioredoxin, mitochondrial precursor  
Size: 166 amino acids; 18383 Da
Subunit: Monomer
Subcellular location: Mitochondrion
PDB structures from and Proteopedia :
1UVZ (3D)    1W4V (3D)    1W89 (3D)    
Secondary accessions: Q5JZA0 Q6FH60 Q9UH29

Explore the universe of human proteins at neXtProt for TXN2: NX_Q99757 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_036605.2  

    ENSEMBL proteins: 
    ENSP00000385393 ENSP00000409407 ENSP00000216185 ENSP00000399188 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: TXN2
    GenScript Custom Purified and Recombinant Proteins Services for TXN2 
    Novus Biologicals Protein for TXN2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730 nucleolus IDA18029348
    GO:0005739 mitochondrion IDA18029348
    About this table

    TXN2 for ontologies           About GeneDecksing



    Antibodies for TXN2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TXN2
    R&D Systems Antibodies for TXN2 (Thioredoxin-2)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for TXN2 
    Novus Biologicals Antibody for TXN2
    Browse antibodies at Epitomics

    Assays for TXN2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TXN2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TXN2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TXN2 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR005746 Thioredoxin
     IPR012336 Thioredoxin-like_fold
     IPR012335 Thioredoxin_fold
     IPR013766 Thioredoxin_domain
     IPR017937 Thioredoxin_CS

    Graphical View of Domain Structure for InterPro Entry Q99757

    ProtoNet protein and cluster: Q99757

    1 Blocks protein family: IPB006662 Thioredoxin type domain

    UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757
    Similarity: Belongs to the thioredoxin family
    Similarity: Contains 1 thioredoxin domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757
    Function: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane
    potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TXN2
    Sigma-Aldrich shRNA for TXN2
    OriGene 29mer shRNA kits in GFP-retroviral vector: TXN2
    OriGene shRNA RFP: TXN2
    OriGene basic RS shRNA: TXN2
    OriGene siRNA: TXN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TXN2 
    miRNA:Sigma-Aldrich microRNA Mimics for TXN2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TXN2 
    Search SABiosciences for Assays for microRNAs that regulate TXN2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TXN2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TXN2
    OriGene untagged cDNA clones in CMV expression vector: TXN2
    OriGene 3'-UTR clone: TXN2 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: TXN2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TXN2 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding ----
    GO:0008113 peptide-methionine-(S)-S-oxide reductase activity IEA--
    GO:0009055 electron carrier activity IEA--
    GO:0015035 protein disulfide oxidoreductase activity IEA--
    GO:0032403 protein complex binding IEA--
    About this table

    TXN2 for ontologies           About GeneDecksing

    Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Txn2):

    cellularembryogenesisgrowth/sizelethality-prenatal/perinatalnervous system
    no phenotypic analysis

    TXN2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    TXN2 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  TXN2
        Mitochondrial Dysfunction

        SABiosciences Custom Pathway-Focused PCR Arrays for TXN2 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TXN2
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TXN2

    5/13 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 13):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666 response to hypoxia IEA--
    GO:0006662 glycerol ether metabolic process IEA--
    GO:0006810 transport IEA--
    GO:0006979 response to oxidative stress IEA--
    GO:0007584 response to nutrient IEA--
    About this table

    TXN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    TXN2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TXN2
    10/22 Novoseek chemical compound relationships for TXN2 gene (see all 22)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    imexon 86.5 1 16321833 (1)
    dihydrolipoic acid 63 1 12631263 (1)
    2-oxo acid 62.2 1 12631263 (1)
    tert-butylhydroperoxide 55.1 4 16797630 (3)
    gssg 49.9 1 16337887 (1)
    diamide 48.3 2 17113580 (2)
    selenocysteine 46 1 15901730 (1)
    cysteine 42.1 1 18267127 (1)
    oxygen 38.5 3 15082714 (1), 19506101 (1), 16407224 (1)
    manganese superoxide 35.8 1 11990504 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TXN2
    Sigma-Aldrich shRNA for TXN2
    OriGene 29mer shRNA kits in GFP-retroviral vector: TXN2
    OriGene shRNA RFP: TXN2
    OriGene basic RS shRNA: TXN2
    OriGene siRNA: TXN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TXN2 
    miRNA: Sigma-Aldrich microRNA Mimics for TXN2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TXN2 
    Search SABiosciences for Assays for microRNAs that regulate TXN2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: TXN2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: TXN2
    OriGene untagged cDNA clones in CMV expression vector: TXN2
    OriGene 3'-UTR Clone: TXN2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: TXN2 
    Primers: OriGene genome-wide validated SYBR primer pairs: TXN2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TXN2: PPH06073A

    REFSEQ mRNAs for TXN2 gene: 

    NM_012473.3  

    Additional cDNA sequence: 

    AF276920.1 AF480262.1 AK123361.1 AK130187.1 AK301837.1 BC013726.1 BC050610.1 CR456601.2 
    CR541896.1 CR541917.1 CR593318.1 CR617907.1 U78678.1 

    17 DOTS entries:

    DT.102840739  DT.447659  DT.97816348  DT.318223  DT.120643634  DT.100817631  DT.120643560  DT.120643611 
    DT.97795103  DT.100817625  DT.97844963  DT.100029033  DT.100817626  DT.100817633  DT.120643636  DT.120643662 
    DT.92435426 

    24/536 AceView cDNA sequences (see all 536):

    BC050610 BQ688422 AI523674 BQ639422 BM931185 BM850651 BG421975 AI862181 
    AA425729 BM662529 BQ691048 BU174841 CN481396 AI741767 AW515413 BQ880539 
    AF480262 BQ689596 BQ691767 BC013726 AI202286 BX446119 BX341512 BQ691701 

    highest scoring ESTs for TXN2:

    AF480262 AK130187 AV734020 BC013726 BC050610 BE549196 BE748099 BE777637 BE972524 BF032015 

    Unigene Cluster for TXN2:

    Thioredoxin 2
    Hs.211929  [show with all ESTs]
    Unigene Representative Sequence: AK123361


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TXN2 (see all 7)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                    -                             -                                       
    SP2:                    -     -                       -                                       
    SP3:                    -     -     -                 -                                       
    SP4:                                                  -                                       
    SP5:                                                                                          

    About this scheme

    ECgene alternative splicing isoforms for TXN2
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000487725 ENST00000403313 ENST00000416967 ENST00000411915 ENST00000216185(uc003apk.1 uc003apl.1)
    ENST00000429495

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TXN2 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching TXN2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32852_at2, 3 U95-A 1 0.94 1.00 1.00 1.00 U78678 0.80 1.00 0.91 1
    209077_at2 U133-A 1 0.91 1.00 -- -- -- -- -- -- --
    209078_s_at2, 3 U133-A 2 0.91 0.90 -- -- AF276920 0.60 1.00 0.82 1
    209077_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    209078_s_at2 U133Plus2 2 0.91 0.90 -- -- -- -- -- -- --
    About this table

    TXN2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TXN2 gene expression
    TXN2 gene electronic northern expression
    TXN2 gene sage expression
    About these images

    CGAP SAGE TAG: CTTAGAGCCC

    SOURCE GeneReport for Unigene cluster: Hs.211929

    Expression variation in blood from EXPOLDB for TXN2

    UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757
    Tissue specificity: Widely expressed in adult (at protein level) and fetal tissues

    Primers: OriGene genome-wide validated SYBR primer pairs: TXN2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TXN2: PPH06073A
        SABiosciences Custom PCR Arrays for TXN2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TXN2 gene from 5/11 species (see all 11)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TXN21   -- thioredoxin 2 89.37(n)
    90.18(a)
    474519  XM_531748.2  XP_531748.2 
    cow
    (Bos taurus)
    TXN21   -- thioredoxin 2 88.55(n)
    88.55(a)
    281557  NM_174208.2  NP_776633.1 
    rat
    (Rattus norvegicus)
    Txn21   -- thioredoxin 2 85.34(n)
    87.95(a)
    79462  NM_053331.1  NP_445783.1 
    mouse
    (Mus musculus)
    Txn21 , 5 15 (36.92 cM)5
    thioredoxin 21, 5 85.94(n)1
    88.55(a)1
    565511  NM_019913.41  NP_064297.11 
     AI7888735  AK0023585  (see all 20)
    chicken
    (Gallus gallus)
    TXN21   -- thioredoxin 2 72.18(n)
    76.69(a)
    426978  NM_001031410.1  NP_001026581.1 
    About this table        Species with no ortholog for TXN2

    ENSEMBL Gene Tree for TXN2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/219 NCBI SNPs in TXN2 are shown (see all 219)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 22 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs84871,2
    --36863265(+) GAGGCA/CGCTCC 1 -- ut31 ese30--------
    rs1399991,2
    C,F,36863375(+) CAGACC/ATACAA 1 -- ut31 ese317Minor allele frequency- A:0.07MN NS EA NA 1590
    rs10620551,2
    F36863435(-) AAAAAA/GAAAAA 1 -- ut311Minor allele frequency- G:0.10MN 184
    rs22673371,2
    C,F,O,A,H,36870471(+) CTTGCC/TGCAGG 1 -- int115Minor allele frequency- T:0.44NS EA NA WA 848
    rs22810821,2
    C,F,O,A,H,36872750(+) TGGCTT/GCCCTG 1 -- int120Minor allele frequency- G:0.42EA NS NA WA 2634
    rs22810831,2
    C,F,36873285(+) agtctC/Ggctct 1 -- int12Minor allele frequency- G:0.18EA NA 1314
    rs22839651,2
    C,F,A,H,36869013(+) CAtgtT/Cggctc 1 -- int19Minor allele frequency- C:0.42NS EA NA WA 498
    rs22839661,2
    C,F,A,H,36869039(+) ggcatC/Tacctg 1 -- int19Minor allele frequency- T:0.41NS EA NA WA 498
    rs48214941,2
    C,F,A,H,36878160(+) CCGTCG/TGGGAA 1 -- ng5113Minor allele frequency- T:0.43NS EA NA WA 798
    rs57502591,2
    H36864407(+) cctttC/Gtgagc 1 -- int14Minor allele frequency- G:0.00NS EA 420
    About this table

    HapMap Linkage Disequilibrium images for TXN2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TXN2
         1 CNV: 5183

    QIAGEN SeqTarget long-range PCR primers for resequencing TXN2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TXN2 for disorders           About GeneDecksing

    OMIM: 609063

    1 Novoseek disease relationship for TXN2 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 4.6 1 12215208 (1)
    About this table

    Human Gene Mutation Database (HGMD): TXN2
    Human Genome Epidemiology (HuGE) Navigator: TXN2 (9 documents)

    Export disorders and mutations for TXN2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/86 PubMed articles for TXN2 gene, integrated from 7 sources (see all 86):
    (articles sorted by number of sources associating them with TXN2)
    1. Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. (PubMed id 12032145)1, 2, 7 Chen Y.... Jones D.P. (2002)
    2. Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. (PubMed id 12080052)1, 2, 7 Damdimopoulos A.E.... Spyrou G. (2002)
    3. Thioredoxin 1 and thioredoxin 2 have opposed regulato ry functions on hypoxia-inducible factor-1alpha. (PubMed id 17220299)1, 3, 7 Zhou J....BrA1ne B. (2007)
    4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
    7. Interaction of mitochondrial thioredoxin with glucoco rticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. (PubMed id 19570036)1, 7 Psarra A.M....Spyrou G. (2009)
    8. Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress. (PubMed id 17548047)1, 7 Zhang H....Jones D.P. (2007)
    9. Thioredoxin2 enhances the damaged DNA binding activit y of mtTFA through direct interaction. (PubMed id 19885567)1, 7 Kidani A....Kohno K. (2009)
    10. Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2. (PubMed id 16195549)2, 7 Smeets A....Declercq J.P. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25828 HGNC: 17772 AceView: TXN2andFLJ23322 Ensembl:ENSG00000100348 euGenes: HUgn25828
    ECgene: TXN2 H-InvDB: TXN2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TXN2 gene:
    Search GeneIP for patents involving TXN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for TXN2 Antibodies for TXN2
     Super-pooled esiRNAs for TXN2 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TXN2 microRNA Mimics for TXN2
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies for TXN2 (Thioredoxin-2)   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TXN2
     SeqTarget long-range PCR primers for resequencing TXN2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TXN2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TXN2
     GenScript Custom Purified and Recombinant Proteins Services for TXN2 GenScript cDNA clones with any tag delivered in your preferred vector for TXN2
     GenScript Custom Assay Services for TXN2 GenScript Custom Superior Antibodies Services for TXN2
     GenScript Custom overexpressing Cell Line Services for TXN2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TXN2 promoter
     Search Chromatin IP Primers for TXN2
     RT2 qPCR Primer Assay for TXN2
     GNC Network for TXN2
     Search for Assays for microRNAs that regulate TXN2
     SABiosciences Custom PCR Arrays for TXN2
     Search Tocris compounds for TXN2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for TXN2
     Proteins for TXN2
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for TXN2
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    TXN2 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4