Aliases &
Descriptions
for TXN2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| thioredoxin 21 2 | | thioredoxin, mitochondrial2 | | MT-TRX1 2 | | mitochondrial thioredoxin2 | | TRX22 3 | | Thioredoxin-23 | | MTRX2 3 | | Mt-Trx3 | | thioredoxin-22 | | |
Export aliases for TXN2 gene to outside databasesPrevious GC identifers: GC22M033477 GC22M035105 GC22M035106 GC22M035187 GC22M036863 |
Summaries
for TXN2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TXN2:
This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctionalredox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membranepotential and in protection against oxidant-induced apoptosis. (provided by RefSeq)
UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757Function: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membranepotential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity
Gene Wiki entry for TXN2 |
Genomic Views
for TXN2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TXN2 gene promoter:
ISGF-3 AREB6 STAT3 LCR-F1 LUN-1 Arnt AhR MEF-2A GR-alpha ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for TXN2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TXN2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q12.3 HGNC cytogenetic band: 22q13.1TXN2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M019831: view genomic region
(about GC identifiers)
Start:
|
19,831,327 bp from pter |
End:
|
19,845,504 bp from pter |
Size:
|
14,178 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr22- 36,863,083-36,878,077 |
RefSeq DNA sequence:- NC_000022.10 NT_011520.12
|
Proteins
for TXN2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757 (See
protein sequence)Recommended Name: Thioredoxin, mitochondrial precursor Size: 166 amino acids; 18383 Da
Subunit: Monomer
Subcellular location: Mitochondrion
PDB structures from  and Proteopedia  :1UVZ (3D)
1W4V (3D)
1W89 (3D)
Secondary accessions: Q5JZA0 Q6FH60 Q9UH29Explore the universe of human proteins at neXtProt for TXN2: NX_Q99757
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_036605.2
ENSEMBL proteins: ENSP00000385393 ENSP00000409407 ENSP00000216185 ENSP00000399188
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
TXN2 for ontologies About GeneDecksing
Antibodies for TXN2:
Assays for TXN2: |
Protein
Domains/
Families
for TXN2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TXN2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q99757ProtoNet protein and cluster: Q99757 1 Blocks protein family: IPB006662 Thioredoxin type domain
UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757Similarity: Belongs to the thioredoxin familySimilarity: Contains 1 thioredoxin domain |
Gene Function
for TXN2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757Function: Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membranepotential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0008113 | peptide-methionine-(S)-S-oxide reductase activity |
IEA | -- | | GO:0009055 | electron carrier activity |
IEA | -- | | GO:0015035 | protein disulfide oxidoreductase activity |
IEA | -- | | GO:0032403 | protein complex binding |
IEA | -- |
About this table
TXN2 for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Txn2):
TXN2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TXN2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
TXN2 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for TXN2
SABiosciences Custom Pathway-Focused PCR Arrays for TXN2
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for TXN2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TXN2
5/13 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 13): About this table
TXN2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TXN2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
TXN2 for compounds About GeneDecksing
 Browse Tocris compounds for TXN2
10/22  Novoseek chemical compound relationships for TXN2 gene (see all 22)
About this table
|
Transcripts
for TXN2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TXN2 gene: NM_012473.3 Additional cDNA sequence: AF276920.1 AF480262.1 AK123361.1 AK130187.1 AK301837.1 BC013726.1 BC050610.1 CR456601.2 CR541896.1 CR541917.1 CR593318.1 CR617907.1 U78678.1 17 DOTS entries: DT.102840739 DT.447659 DT.97816348 DT.318223 DT.120643634 DT.100817631 DT.120643560 DT.120643611 DT.97795103 DT.100817625 DT.97844963 DT.100029033 DT.100817626 DT.100817633 DT.120643636 DT.120643662 DT.92435426 24/536 AceView cDNA sequences (see all 536): BC050610 BQ688422 AI523674 BQ639422 BM931185 BM850651 BG421975 AI862181 AA425729 BM662529 BQ691048 BU174841 CN481396 AI741767 AW515413 BQ880539 AF480262 BQ689596 BQ691767 BC013726 AI202286 BX446119 BX341512 BQ691701
 highest scoring ESTs for TXN2:AF480262 AK130187 AV734020 BC013726 BC050610 BE549196 BE748099 BE777637 BE972524 BF032015 Unigene Cluster for TXN2: Thioredoxin 2 Hs.211929 [show with all ESTs]Unigene Representative Sequence: AK123361
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TXN2 (see all 7)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TXN2
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487725 ENST00000403313 ENST00000416967 ENST00000411915 ENST00000216185(uc003apk.1 uc003apl.1)
ENST00000429495
|
Expression
for TXN2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TXN2 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching TXN2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 32852_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
U78678 |
0.80 |
1.00 |
0.91 |
1 |
| 209077_at2
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 209078_s_at2, 3
|
U133-A |
2 |
0.91 |
0.90 |
-- |
-- |
AF276920 |
0.60 |
1.00 |
0.82 |
1 |
| 209077_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 209078_s_at2
|
U133Plus2 |
2 |
0.91 |
0.90 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TXN2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTTAGAGCCC
SOURCE GeneReport for Unigene cluster: Hs.211929
Expression variation in blood from EXPOLDB for TXN2 UniProtKB/Swiss-Prot: THIOM_HUMAN, Q99757Tissue specificity: Widely expressed in adult (at protein level) and fetal tissues
SABiosciences Custom PCR Arrays for TXN2
|
Orthologs
for TXN2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TXN2 gene from 5/11 species (see all 11)
About this table Species with no ortholog for TXN2
ENSEMBL Gene Tree for TXN2 (if available) |
Paralogs
for TXN2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for TXN2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 22 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TXN2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TXN2
1 CNV: 5183 | | QIAGEN SeqTarget long-range PCR primers for resequencing TXN2 |
|
Disorders & Mutations
for TXN2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TXN2 for disorders About GeneDecksing
OMIM: 609063
1 Novoseek disease relationship for TXN2 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
4.6 |
1 |
12215208 (1) |
About this table
Human Gene Mutation Database (HGMD): TXN2
Human Genome Epidemiology (HuGE) Navigator: TXN2 (9 documents)
Export disorders and mutations for TXN2 gene to outside databases
|
Medical News
for TXN2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TXN2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/86 PubMed articles for TXN2 gene, integrated from 7 sources (see all 86):
(articles sorted by number of sources associating them with TXN2)- Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells. (PubMed id 12032145)1, 2, 7 Chen Y.... Jones D.P. (2002)
- Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death. (PubMed id 12080052)1, 2, 7 Damdimopoulos A.E.... Spyrou G. (2002)
- Thioredoxin 1 and thioredoxin 2 have opposed regulato ry functions on hypoxia-inducible factor-1alpha. (PubMed id 17220299)1, 3, 7 Zhou J....BrA1ne B. (2007)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I....O'Brien K.P. (1999)
- Interaction of mitochondrial thioredoxin with glucoco rticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. (PubMed id 19570036)1, 7 Psarra A.M....Spyrou G. (2009)
- Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress. (PubMed id 17548047)1, 7 Zhang H....Jones D.P. (2007)
- Thioredoxin2 enhances the damaged DNA binding activit y of mtTFA through direct interaction. (PubMed id 19885567)1, 7 Kidani A....Kohno K. (2009)
- Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2. (PubMed id 16195549)2, 7 Smeets A....Declercq J.P. (2005)
|
External Searches for TXN2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TXN2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TXN2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TXN2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TXN2 gene:
Search GeneIP for patents involving TXN2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TXN2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for TXN2 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for TXN2 |
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