Aliases &
Descriptions
for TYSND1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| trypsin domain containing 11 2 | | MGC1319342 | | NET411 2 | | FLJ403782 | | MGC346951 2 | | peroxisomal leader peptide-processing protease2 | | Trypsin domain-containing protein 12 3 | | EC 3.4.21.-3 |
Export aliases for TYSND1 gene to outside databasesPrevious GC identifers: GC10M071244 GC10M071567 GC10M071897 |
Summaries
for TYSND1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TYSND1:
All peroxisomal proteins are synthesized in the cytosol, and 2 distinct peroxisomal targeting signals (PTSs), theC-terminal PTS1 and N-terminal PTS2, are used for transport of these proteins into peroxisomes. Proteolytic cleavageof the N-terminal targeting sequence of PTS2 proteins accompanies import into peroxisomes, and many PTS1 proteinsundergo C-terminal processing once in the peroxisomal matrix. TYSND1 processes both PTS1 and PTS2 proteins involved inbeta-oxidation of fatty acids (Kurochkin et al., 2007 (PubMed 17255948)).(supplied by OMIM)
UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2target sequence and the specific processing of PTS1 proteins. May participate to a regulatory mechanism that controlthe peroxisomal beta-oxidation of fatty acids (By similarity)
|
Genomic Views
for TYSND1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TYSND1 gene promoter:
AP-1 NF-kappaB1 Pax-6 Meis-1 HOXA9B LCR-F1 c-Myc Max1 MIF-1 RP58
Other transcription factors
Search SABiosciences Chromatin IP Primers for TYSND1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TYSND1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.1TYSND1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M065890: view genomic region
(about GC identifiers)
Start:
|
65,890,225 bp from pter |
End:
|
65,898,970 bp from pter |
Size:
|
8,746 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr10- 71,897,737-71,906,432 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
|
Proteins
for TYSND1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0 (See
protein sequence)Recommended Name: Peroxisomal leader peptide-processing protease Size: 566 amino acids; 59309 Da
Subcellular location: Peroxisome (By similarity)
Secondary accessions: Q5SQT4 Q5SQU1 Q8N6H2 Q96AR5Alternative splicing: 2 isoforms: Q2T9J0-1 Q2T9J0-2 Explore the universe of human proteins at neXtProt for TYSND1: NX_Q2T9J0
Post-translational modifications:
Processed into the 49 kDa and the 10 kDa forms upon import into the peroxisomes. The 49 kDa form probably correspondsto the mature enzyme, while the 10 kDa form may represent an inhibitory N-terminal fragment which prevents proteaseactivity until it reaches the peroxisomes (By similarity)1
REFSEQ proteins (2 alternative transcripts):
NP_001035363.1 NP_775826.2
ENSEMBL proteins: ENSP00000287078 ENSP00000335673
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005777 | peroxisome |
IEA | -- |
About this table
TYSND1 for ontologies About GeneDecksing
Antibodies for TYSND1:
Assays for TYSND1: |
Protein
Domains/
Families
for TYSND1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TYSND1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2T9J0ProtoNet protein and cluster: Q2T9J0 UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0Similarity: Belongs to the peptidase S1B family |
Gene Function
for TYSND1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2target sequence and the specific processing of PTS1 proteins. May participate to a regulatory mechanism that controlthe peroxisomal beta-oxidation of fatty acids (By similarity)Enzyme Number (IUBMB): EC 3.4.21.-
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
-- | -- | | GO:0004252 | serine-type endopeptidase activity |
IEA | -- | | GO:0008233 | peptidase activity |
IEA | -- |
About this table
TYSND1 for ontologies About GeneDecksing
|
Pathways & Interactions
for TYSND1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for TYSND1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TYSND1
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
About this table
TYSND1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TYSND1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TYSND1
|
Transcripts
for TYSND1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for TYSND1 gene (2 alternative transcripts): NM_001040273.1 NM_173555.2 Additional cDNA sequence: AK074968.1 AK097697.1 BC016840.1 BC030242.1 BC042629.1 BC047424.1 BC111501.1 16 DOTS entries: DT.95171726 DT.455072 DT.95171724 DT.100776127 DT.75110654 DT.95171723 DT.92422395 DT.121261108 DT.121261164 DT.92001575 DT.121261040 DT.100776128 DT.100776130 DT.121261117 DT.75171099 DT.91740825 24/150 AceView cDNA sequences (see all 150): BM553590 AK097697 AW188353 BI829894 BI766480 AI382207 BF724663 AI563945 AA918067 AA953270 BX340786 BX282686 AI024441 BM975929 BC016840 CD671353 BM670951 BM664638 BM693889 BM703137 BU183732 CA442516 AI377960 AL713282
 highest scoring ESTs for TYSND1:AA147213 AA593528 BQ961990 AW206205 BI160553 BI766480 BI831245 F02516 BF326541 BM551377 Unigene Cluster for TYSND1: Trypsin domain containing 1 Hs.533655 [show with all ESTs]Unigene Representative Sequence: NM_173555
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TYSND1 (see all 9)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for TYSND1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479086(uc001jqq.2 uc001jqt.2) ENST00000494143 ENST00000287078(uc001jqr.2)
ENST00000335494(uc001jqs.2)
|
Expression
for TYSND1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| TYSND1 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching TYSND1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 53896_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.82 |
1.08 |
AA147213 |
0.60 |
1.00 |
0.82 |
1 |
| 57823_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.86 |
1.10 |
H18472 |
0.60 |
0.75 |
0.68 |
1 |
| 46481_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.84 |
0.87 |
AA470128 |
0.60 |
0.75 |
0.68 |
1 |
| 77773_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
0.80 |
0.95 |
AA593528 |
0.60 |
1.00 |
0.82 |
1 |
| 225877_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BG389635 |
0.40 |
0.67 |
0.55 |
1 |
| 238802_at2, 3
|
U133-B |
1 |
0.82 |
1.00 |
-- |
-- |
AA470128 |
0.60 |
0.75 |
0.68 |
1 |
| 225877_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 238802_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
TYSND1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ATCTATTGAA
SOURCE GeneReport for Unigene cluster: Hs.533655
SABiosciences Custom PCR Arrays for TYSND1
|
Orthologs
for TYSND1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TYSND1 gene from 5/8 species (see all 8)
About this table Species with no ortholog for TYSND1
ENSEMBL Gene Tree for TYSND1 (if available) |
Paralogs
for TYSND1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for TYSND1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for TYSND1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TYSND1
1 CNV: 6879 | | QIAGEN SeqTarget long-range PCR primers for resequencing TYSND1 |
|
Disorders & Mutations
for TYSND1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TYSND1 for disorders About GeneDecksing
OMIM: 611017
Human Genome Epidemiology (HuGE) Navigator: TYSND1 (2 documents)
Export disorders and mutations for TYSND1 gene to outside databases
|
Medical News
for TYSND1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TYSND1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for TYSND1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with TYSND1)- Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids. (PubMed id 17255948)1, 3 Kurochkin I.V....Okazaki Y. (2007)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TYSND1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TYSND1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TYSND1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TYSND1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TYSND1 gene:
Search GeneIP for patents involving TYSND1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TYSND1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for TYSND1 |
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