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TYSND1 Gene

protein-coding   GIFtS: 44

GC10M065890
trypsin domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
trypsin domain containing 11 2     MGC1319342
NET411 2     FLJ403782
MGC346951 2     peroxisomal leader peptide-processing protease2
Trypsin domain-containing protein 12 3     EC 3.4.21.-3

External Ids:    HGNC: 285311   Entrez Gene: 2197432   Ensembl: ENSG000001565217   UniProtKB: Q2T9J03   

Export aliases for TYSND1 gene to outside databases

Previous GC identifers: GC10M071244 GC10M071567 GC10M071897


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TYSND1:
All peroxisomal proteins are synthesized in the cytosol, and 2 distinct peroxisomal targeting signals (PTSs), the
C-terminal PTS1 and N-terminal PTS2, are used for transport of these proteins into peroxisomes. Proteolytic cleavage
of the N-terminal targeting sequence of PTS2 proteins accompanies import into peroxisomes, and many PTS1 proteins
undergo C-terminal processing once in the peroxisomal matrix. TYSND1 processes both PTS1 and PTS2 proteins involved in
beta-oxidation of fatty acids (Kurochkin et al., 2007 (PubMed 17255948)).(supplied by OMIM)

UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0
Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2
target sequence and the specific processing of PTS1 proteins. May participate to a regulatory mechanism that control
the peroxisomal beta-oxidation of fatty acids (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TYSND1 gene promoter:
         AP-1   NF-kappaB1   Pax-6   Meis-1   HOXA9B   LCR-F1   c-Myc   Max1   MIF-1   RP58   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for TYSND1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TYSND1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.1   Ensembl cytogenetic band:  10q22.1   HGNC cytogenetic band: 10q22.1

TYSND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TYSND1 gene location

GeneLoc gene densities for chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M065890:  view genomic region     (about GC identifiers)

Start:
65,890,225 bp from pter
End:
65,898,970 bp from pter
Size:
8,746 bases
Orientation:
minus strand

1 alternative location:
Chr10- 71,897,737-71,906,432     
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0 (See protein sequence)
Recommended Name: Peroxisomal leader peptide-processing protease  
Size: 566 amino acids; 59309 Da
Subcellular location: Peroxisome (By similarity)
Secondary accessions: Q5SQT4 Q5SQU1 Q8N6H2 Q96AR5
Alternative splicing: 2 isoforms:  Q2T9J0-1   Q2T9J0-2   

Explore the universe of human proteins at neXtProt for TYSND1: NX_Q2T9J0 

Post-translational modifications:

  • Processed into the 49 kDa and the 10 kDa forms upon import into the peroxisomes. The 49 kDa form probably corresponds
  • to the mature enzyme, while the 10 kDa form may represent an inhibitory N-terminal fragment which prevents protease
    activity until it reaches the peroxisomes (By similarity)1


    REFSEQ proteins (2 alternative transcripts): 
    NP_001035363.1  NP_775826.2  


    ENSEMBL proteins: 
    ENSP00000287078 ENSP00000335673 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for TYSND1 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777 peroxisome IEA--
    About this table

    TYSND1 for ontologies           About GeneDecksing



    Antibodies for TYSND1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TYSND1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for TYSND1 
    Browse antibodies at Epitomics

    Assays for TYSND1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TYSND1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TYSND1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TYSND1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR017345 Pept_S1A_Tysnd1
     IPR001254 Peptidase_S1_S6
     IPR009003 Ser/Cys_Pept_Trypsin-like

    Graphical View of Domain Structure for InterPro Entry Q2T9J0

    ProtoNet protein and cluster: Q2T9J0

    UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0
    Similarity: Belongs to the peptidase S1B family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TYSD1_HUMAN, Q2T9J0
    Function: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2
    target sequence and the specific processing of PTS1 proteins. May participate to a regulatory mechanism that control
    the peroxisomal beta-oxidation of fatty acids (By similarity)
    Enzyme Number (IUBMB): EC 3.4.21.- 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TYSND1
    Sigma-Aldrich shRNA for TYSND1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TYSND1
    OriGene shRNA RFP (see all 3): TYSND1
    OriGene basic RS shRNA (see all 3): TYSND1
    OriGene siRNA (see all 2): TYSND1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TYSND1 
    miRNA:Sigma-Aldrich microRNA Mimics for TYSND1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TYSND1 
    3 SABiosciences Assays for microRNAs that regulate TYSND1:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-1291

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TYSND1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TYSND1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): TYSND1
    OriGene 3'-UTR clone (see all 2): TYSND1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TYSND1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for TYSND1 

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824 catalytic activity ----
    GO:0004252 serine-type endopeptidase activity IEA--
    GO:0008233 peptidase activity IEA--
    About this table

    TYSND1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for TYSND1 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TYSND1

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508 proteolysis IEA--
    About this table

    TYSND1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TYSND1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for TYSND1
    Sigma-Aldrich shRNA for TYSND1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): TYSND1
    OriGene shRNA RFP (see all 3): TYSND1
    OriGene basic RS shRNA (see all 3): TYSND1
    OriGene siRNA (see all 2): TYSND1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TYSND1 
    miRNA: Sigma-Aldrich microRNA Mimics for TYSND1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TYSND1 
    3 SABiosciences Assays for microRNAs that regulate TYSND1:
    hsa-miR-125a-5p hsa-miR-125b hsa-miR-1291
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): TYSND1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): TYSND1
    OriGene untagged cDNA clones in CMV expression vector (see all 3): TYSND1
    OriGene 3'-UTR Clone (see all 2): TYSND1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for TYSND1 
    Primers: OriGene genome-wide validated SYBR primer pairs: TYSND1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TYSND1: PPH08034A

    REFSEQ mRNAs for TYSND1 gene (2 alternative transcripts): 

    NM_001040273.1  NM_173555.2  

    Additional cDNA sequence: 

    AK074968.1 AK097697.1 BC016840.1 BC030242.1 BC042629.1 BC047424.1 BC111501.1 

    16 DOTS entries:

    DT.95171726  DT.455072  DT.95171724  DT.100776127  DT.75110654  DT.95171723  DT.92422395  DT.121261108 
    DT.121261164  DT.92001575  DT.121261040  DT.100776128  DT.100776130  DT.121261117  DT.75171099  DT.91740825 

    24/150 AceView cDNA sequences (see all 150):

    BM553590 AK097697 AW188353 BI829894 BI766480 AI382207 BF724663 AI563945 
    AA918067 AA953270 BX340786 BX282686 AI024441 BM975929 BC016840 CD671353 
    BM670951 BM664638 BM693889 BM703137 BU183732 CA442516 AI377960 AL713282 

    highest scoring ESTs for TYSND1:

    AA147213 AA593528 BQ961990 AW206205 BI160553 BI766480 BI831245 F02516 BF326541 BM551377 

    Unigene Cluster for TYSND1:

    Trypsin domain containing 1
    Hs.533655  [show with all ESTs]
    Unigene Representative Sequence: NM_173555


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TYSND1 (see all 9)

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                    -     -     -     -           -                                                   
    SP2:                    -     -     -     -                                                               
    SP3:                          -     -     -                 -                                             
    SP4:                          -     -     -                                                               
    SP5:                                -     -                                                               

    About this scheme

    ECgene alternative splicing isoforms for TYSND1
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000479086(uc001jqq.2 uc001jqt.2) ENST00000494143 ENST00000287078(uc001jqr.2)
    ENST00000335494(uc001jqs.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    TYSND1 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching TYSND1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    53896_at2, 3 U95-B 1 1.00 1.00 0.82 1.08 AA147213 0.60 1.00 0.82 1
    57823_at2, 3 U95-B 1 0.94 1.00 0.86 1.10 H18472 0.60 0.75 0.68 1
    46481_at2, 3 U95-B 1 0.94 1.00 0.84 0.87 AA470128 0.60 0.75 0.68 1
    77773_at2, 3 U95-E 1 0.88 1.00 0.80 0.95 AA593528 0.60 1.00 0.82 1
    225877_at2, 3 U133-B 1 1.00 1.00 -- -- BG389635 0.40 0.67 0.55 1
    238802_at2, 3 U133-B 1 0.82 1.00 -- -- AA470128 0.60 0.75 0.68 1
    225877_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    238802_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    About this table

    TYSND1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    TYSND1 gene expression
    TYSND1 gene electronic northern expression
    TYSND1 gene sage expression
    About these images

    CGAP SAGE TAG: ATCTATTGAA

    SOURCE GeneReport for Unigene cluster: Hs.533655
    Primers: OriGene genome-wide validated SYBR primer pairs: TYSND1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for TYSND1: PPH08034A
        SABiosciences Custom PCR Arrays for TYSND1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for TYSND1 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    TYSND11   -- trypsin domain containing 1 98.65(n)
    98.06(a)
    746962  XM_001170770.1  XP_001170770.1 
    rat
    (Rattus norvegicus)
    Tysnd11   -- trypsin domain containing 1 80.12(n)
    80.53(a)
    365571  XM_345106.2  XP_345107.1 
    mouse
    (Mus musculus)
    Tysnd11 , 5 10 (32.26 cM)5
    trypsin domain containing 11, 5 80.53(n)1
    80(a)1
    717671  XM_125636.31  XP_125636.31 
     AK0050695  AK1545135  (see all 15)
    chicken
    (Gallus gallus)
    TYSND11   -- trypsin domain containing 1 59.75(n)
    47.25(a)
    769373  XM_001232632.1  XP_001232633.1 
    zebrafish
    (Danio rerio)
    tysnd11   -- trypsin domain containing 1 47.72(n)
    42.97(a)
    561667  XM_685076.2  XP_690168.1 
    About this table        Species with no ortholog for TYSND1

    ENSEMBL Gene Tree for TYSND1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/122 NCBI SNPs in TYSND1 are shown (see all 122)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 10 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10531051,2
    C,F,O,A,H,71897998(-) TCACAG/ATGGGT 1 -- ut31 ese316Minor allele frequency- A:0.18MN NS EA NA 1230
    rs22927221,2
    C,F,71902413(+) CCAAAG/CAGCTG 1 -- int15Minor allele frequency- C:0.05EA NA 1614
    rs23946471,2
    C,H,71898355(+) GGGGGA/C/G/
            
    TGCCC
    1 -- ut31 ese39NS NA WA 208
    rs23946481,2
    C,F,A,71904306(+) CTCCCA/GGGgag 1 -- int111Minor allele frequency- G:0.27NA EA WA 306
    rs37507741,2
    C,F,71905569(+) CCGGGA/CAGGCA 2 L ref1 syn16Minor allele frequency- C:0.45EA NS NA 1132
    rs37637351,2
    C,F,71903995(+) TAGTGC/TTTTGT 1 -- int118Minor allele frequency- T:0.24NS EA NA WA 1062
    rs42930191,2
    C,F,A,71897517(+) GCCGGG/TTGTCC 1 -- ng314Minor allele frequency- T:0.37NA WA 126
    rs47460211,2
    C,A,H,71903179(+) taataA/Ggtggc 1 -- int110Minor allele frequency- G:0.30NA EA WA 228
    rs47460221,2
    C,A,H,71903186(+) tggcaG/Taggaa 1 -- int110Minor allele frequency- T:0.32NA EA WA 226
    rs47469691,2
    C,F,A,H,71900189(+) tttgaT/Ggtttt 1 -- int126Minor allele frequency- G:0.22NS EA NA WA 1626
    About this table

    HapMap Linkage Disequilibrium images for TYSND1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TYSND1
         1 CNV: 6879

    QIAGEN SeqTarget long-range PCR primers for resequencing TYSND1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TYSND1 for disorders           About GeneDecksing

    OMIM: 611017

    Human Genome Epidemiology (HuGE) Navigator: TYSND1 (2 documents)

    Export disorders and mutations for TYSND1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    8 PubMed articles for TYSND1 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with TYSND1)
    1. Novel peroxisomal protease Tysnd1 processes PTS1- and PTS2-containing enzymes involved in beta-oxidation of fatty acids. (PubMed id 17255948)1, 3 Kurochkin I.V....Okazaki Y. (2007)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    3. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    7. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219743 HGNC: 28531 AceView: TYSND1 Ensembl:ENSG00000156521 euGenes: HUgn219743
    ECgene: TYSND1 H-InvDB: TYSND1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for TYSND1 gene:
    Search GeneIP for patents involving TYSND1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for TYSND1 Antibodies for TYSND1
     Super-pooled esiRNAs for TYSND1 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TYSND1 microRNA Mimics for TYSND1
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of TYSND1
     SeqTarget long-range PCR primers for resequencing TYSND1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for TYSND1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of TYSND1
     GenScript Custom Purified and Recombinant Proteins Services for TYSND1 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for TYSND1
     GenScript Custom Assay Services for TYSND1 GenScript Custom Superior Antibodies Services for TYSND1
     GenScript Custom overexpressing Cell Line Services for TYSND1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TYSND1 promoter
     Search Chromatin IP Primers for TYSND1
     RT2 qPCR Primer Assay for TYSND1
     Search GNC Networks for TYSND1
     Assays for microRNAs that regulate TYSND1
     SABiosciences Custom PCR Arrays for TYSND1
     Search Tocris compounds for TYSND1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for TYSND1
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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