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UBE2C Gene

protein-coding   GIFtS: 62

GC20P041183
ubiquitin-conjugating enzyme E2C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ubiquitin-conjugating enzyme E2C1 2     ubiquitin carrier protein E2-C2
UBCH101 2 3 5     mitotic-specific ubiquitin-conjugating enzyme2
Ubiquitin carrier protein C2 3     ubiquitin-conjugating enzyme E2 C2
Ubiquitin-protein ligase C2 3     UbcH103
dJ447F3.22     EC 6.3.2.193
cyclin-selective ubiquitin carrier protein2     

External Ids:    HGNC: 159371   Entrez Gene: 110652   Ensembl: ENSG000001750637   UniProtKB: O007623   

Export aliases for UBE2C gene to outside databases

Previous GC identifers: GC20P044169 GC20P045079 GC20P045126 GC20P043874 GC20P044442


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2C:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or
E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the
E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell
cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. (provided
by RefSeq)

UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting
complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by
initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by
the proteasome and promoting mitotic exit

Gene Wiki entry for UBE2C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2C gene promoter:
         SRF   TGIF   Lmo2   Meis-1   HOXA9B   POU3F2   AP-2rep   NF-1   GR-alpha   AhR   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for UBE2C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UBE2C 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

UBE2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2C gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P041183:  view genomic region     (about GC identifiers)

Start:
41,183,027 bp from pter
End:
41,187,357 bp from pter
Size:
4,331 bases
Orientation:
plus strand

1 alternative location:
Chr20+ 44,441,215-44,445,596     
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 C  
Size: 179 amino acids; 19652 Da
Subunit: Component of the APC/C complex
PDB structures from and Proteopedia :
1I7K (3D)    

Explore the universe of human proteins at neXtProt for UBE2C: NX_O00762 

Post-translational modifications:

  • Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central
  • role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the
    autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have
    been destroyed1


    REFSEQ proteins (6 alternative transcripts): 
    NP_008950.1  NP_861515.1  NP_861516.1  NP_861517.1  NP_861518.1  NP_861519.1  


    ENSEMBL proteins: 
    ENSP00000333975 ENSP00000348838 ENSP00000243893 ENSP00000385878 ENSP00000335674 ENSP00000361649 
    ENSP00000361660 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant UBE2C Protein
    Sigma-Aldrich Proteins and AQUA Peptides for UBE2C
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for UBE2C
    OriGene Purified Proteins (see all 2): UBE2C
    OriGene Protein Over-expression Lysate (see all 2): UBE2C
    GenScript Custom Purified and Recombinant Proteins Services for UBE2C 
    Novus Biologicals Proteins for UBE2C
    Novus Biologicals Lysates for UBE2C
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for UBE2C

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654 nucleoplasm TAS--
    GO:0005680 anaphase-promoting complex IDA18485873
    GO:0005829 cytosol TAS--
    About this table

    UBE2C for ontologies           About GeneDecksing



    Antibodies for UBE2C: 
    Millipore Mono- and Polyclonal Antibodies for the study of UBE2C
    Sigma-Aldrich Antibodies for UBE2C
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for UBE2C 
    Novus Biologicals Antibodies for UBE2C
    Browse antibodies at Epitomics

    Assays for UBE2C: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2C 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UBE2C 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UBE2C for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR015582 Ubiquitin-conj_enz_E2_H10
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugat/RWD-like

    Graphical View of Domain Structure for InterPro Entry O00762

    ProtoNet protein and cluster: O00762

    1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting
    complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by
    initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by
    the proteasome and promoting mitotic exit
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Enzyme Number (IUBMB): EC 6.3.2.19 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for UBE2C
    Sigma-Aldrich shRNA Panels and shRNA for UBE2C
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): UBE2C
    OriGene shRNA RFP (see all 6): UBE2C
    OriGene basic RS shRNA (see all 6): UBE2C
    OriGene siRNA (see all 6): UBE2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UBE2C 
    miRNA:Sigma-Aldrich microRNA Mimics for UBE2C
    Sigma-Aldrich microRNA target validation systems for UBE2C 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UBE2C 
    Search SABiosciences for Assays for microRNAs that regulate UBE2C

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): UBE2C
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): UBE2C
    OriGene untagged cDNA clones in CMV expression vector (see all 7): UBE2C
    OriGene 3'-UTR clone (see all 5): UBE2C 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 5): UBE2C 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for UBE2C 

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004842contributes to ubiquitin-protein ligase activity IDA18485873
    GO:0005515 protein binding IPI19822757
    GO:0005524 ATP binding IEA--
    GO:0016874 ligase activity IEA--
    About this table

    UBE2C for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    UBE2C for pathways           About GeneDecksing

    1 Millipore Pathway for UBE2C
        Common schema of ubiquitination

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  UBE2C
        Hypoxia Signaling in the Cardiovascular System
    Protein Ubiquitination Pathway

    1 Kegg Pathway  (Kegg details for UBE2C):
        hsa04120 Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762
    Pathway: Protein modification; protein ubiquitination

        SABiosciences Pathway-Focused PCR Array including UBE2C: PAHS-079A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UBE2C
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2C

    5/69 Interacting proteins for UBE2C (ENSP000003488383) via UniProtKB, MINT, and/or STRING (see all 69)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC11ENSP000003499573STRING: ENSP00000349957
    BUB1BENSP000002875983STRING: ENSP00000287598
    BUB3ENSP000003578583STRING: ENSP00000357858
    CDC27ENSP000000665443STRING: ENSP00000066544
    CDK2ENSP000002669703STRING: ENSP00000266970
    About this table

    5/23 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 23):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075 cell cycle checkpoint TAS--
    GO:0000278 mitotic cell cycle TAS--
    GO:0006511 ubiquitin-dependent protein catabolic process IDA9122200
    GO:0007049 cell cycle NAS15504738
    GO:0007051 spindle organization NAS15504738
    About this table

    UBE2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    UBE2C for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2C
    2 Novoseek chemical compound relationships for UBE2C gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 19.1 1 14732013 (1)
    oligonucleotide 11.8 1 17217624 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for UBE2C
    Sigma-Aldrich shRNA Panels and shRNA for UBE2C
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): UBE2C
    OriGene shRNA RFP (see all 6): UBE2C
    OriGene basic RS shRNA (see all 6): UBE2C
    OriGene siRNA (see all 6): UBE2C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UBE2C 
    miRNA: Sigma-Aldrich microRNA Mimics for UBE2C
    Sigma-Aldrich microRNA target validation systems for UBE2C 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UBE2C 
    Search SABiosciences for Assays for microRNAs that regulate UBE2C
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): UBE2C
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): UBE2C
    OriGene untagged cDNA clones in CMV expression vector (see all 7): UBE2C
    OriGene 3'-UTR Clone (see all 5): UBE2C 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 5): UBE2C 
    Primers: OriGene genome-wide validated SYBR primer pairs: UBE2C
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for UBE2C: PPH10508A

    REFSEQ mRNAs for UBE2C gene (6 alternative transcripts): 

    NM_007019.2  NM_181799.1  NM_181800.1  NM_181801.2  NM_181802.1  NM_181803.1  

    Additional cDNA sequence: 

    AK311949.1 BC007656.2 BC016292.1 BC028161.1 BC032677.2 BC050736.1 BT007300.1 BT020165.1 
    BT020166.1 CR456988.1 CR593952.1 CR610834.1 U73379.1 

    17 DOTS entries:

    DT.455083  DT.446076  DT.101984847  DT.91766689  DT.95092516  DT.101984846  DT.100822418  DT.120817240 
    DT.120817711  DT.102842123  DT.102842126  DT.120817606  DT.102842114  DT.120817859  DT.95189185  DT.95245584 
    DT.100038110 

    24/252 AceView cDNA sequences (see all 252):

    AA315182 BE268039 NM_181802 BM758823 BU844974 AI650374 NM_181799 BE797203 
    BC016292 BM556795 BM423477 BC007656 AA596035 NM_181800 BU509336 BI870709 
    BU506804 BM557700 NM_181801 BC050736 BU625723 BC028161 BM549174 CR610834 

    highest scoring ESTs for UBE2C:

    U73379 AA136118 AA149943 AA160710 AA305922 AA382274 AA401483 AA403150 AA430504 AA554943 

    Unigene Cluster for UBE2C:

    Ubiquitin-conjugating enzyme E2C
    Hs.93002  [show with all ESTs]
    Unigene Representative Sequence: BC032677


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2C (see all 8)

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                    -     -           -                           
    SP2:                    -     -                 -                     
    SP3:                    -     -           -     -                     
    SP4:                    -     -     -           -                     
    SP5:                    -     -     -     -                           

    About this scheme

    ECgene alternative splicing isoforms for UBE2C
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352551 ENST00000356455(uc002xpm.2 uc002xpo.2 uc002xpp.2)
    ENST00000496085 ENST00000243893 ENST00000405520(uc002xpn.2) ENST00000335046(uc002xpl.2)
    ENST00000372568(uc002xpq.2) ENST00000372579

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    UBE2C expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching UBE2C gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    1651_at2, 3 U95-A 3 1.00 0.96 1.00 1.00 U73379 1.00 1.00 1.00 1
    202954_at2, 3 U133-A 3 1.00 0.91 -- -- NM_007019 0.60 1.00 0.82 1
    202954_at2 U133Plus2 3 1.00 0.91 -- -- -- -- -- -- --
    About this table

    UBE2C for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    UBE2C gene expression
    UBE2C gene electronic northern expression
    UBE2C gene sage expression
    About these images

    CGAP SAGE TAG: CTGCCGAGCT

    SOURCE GeneReport for Unigene cluster: Hs.93002

    Expression variation in blood from EXPOLDB for UBE2C

    Primers: OriGene genome-wide validated SYBR primer pairs: UBE2C
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for UBE2C: PPH10508A
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2C: PAHS-079A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for UBE2C gene from 5/20 species (see all 20)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UBE2C1   -- ubiquitin-conjugating enzyme E2C 93.11(n)
    97.77(a)
    485898  XM_543022.2  XP_543022.2 
    cow
    (Bos taurus)
    UBE2C1   -- ubiquitin-conjugating enzyme E2C 91.43(n)
    97.21(a)
    506962  NM_001037449.1  NP_001032526.1 
    rat
    (Rattus norvegicus)
    Ube2c1   -- ubiquitin-conjugating enzyme E2C 89.76(n)
    96.09(a)
    296368  XM_215924.3  XP_215924.1 
    mouse
    (Mus musculus)
    Ube2c1 , 5 2 (85.27 cM)5
    ubiquitin-conjugating enzyme E2C1, 5 87.52(n)1
    95.53(a)1
    686121  NM_026785.21  NP_081061.11 
     AK0037225  AK1361865  (see all 13)
    zebrafish
    (Danio rerio)
    zgc:1231901   -- zgc:123190 68.64(n)
    76.92(a)
    566441  NM_001037691.1  NP_001032780.1 
    About this table        Species with no ortholog for UBE2C

    ENSEMBL Gene Tree for UBE2C (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for UBE2C gene
    UBE2U2  

    UBE2C for paralogs           About GeneDecksing


    Pseudogenes
    3 related pseudogenes



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/89 NCBI SNPs in UBE2C are shown (see all 89)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs3686221,2
    C,A,H,44440690(-) acgtcT/Cgtaat 6 -- ng5111Minor allele frequency- C:0.05NS EA NA WA 502
    rs3824941,2
    C,F,44444760(-) AAATTA/GTTTAT 6 -- int16Minor allele frequency- G:0.02MN NS EA WA 654
    rs4407891,2
    C,F44441493(+) ACCCAG/CAGCAA 6 -- int1 ut51 ng51 ese313Minor allele frequency- C:0.06MN NS EA NA 1092
    rs4455031,2
    C,F,A,44446069(-) TCCACC/AGGGGA 6 -- ng319Minor allele frequency- A:0.50EA NA NS WA 346
    rs9103961,2
    C,A,H44443766(-) GGGCGC/TGGTGG 6 -- int17Minor allele frequency- T:0.21NA WA 14
    rs17111931,2
    --44442909(-) tatatA/Gcccac 6 -- int10--------
    rs17111941,2
    C,44442908(-) tatgcC/Tcacat 6 -- int11Minor allele frequency- T:0.00NA 2
    rs18047441,2
    --44442103(+) CTCATG/TATGTC 12 M I ref1 mis10--------
    rs30801051,2
    --44442902(+) tgtgt-/GTatgtg 6 -- int10--------
    rs30801071,2
    --44442939(+) atata-/TATATA
            
    aAATT
    6 -- int10--------
    About this table

    HapMap Linkage Disequilibrium images for UBE2C (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UBE2C: --

    QIAGEN SeqTarget long-range PCR primers for resequencing UBE2C 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UBE2C for disorders           About GeneDecksing

    OMIM: 605574

    3 Novoseek disease relationships for UBE2C gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    primary tumor 15.8 2 16772118 (1)
    tumors 6.27 15 20065091 (4), 20099376 (4), 18331723 (1), 17217624 (1) (see all 6)
    metastasis 0 1 16772118 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: UBE2C (2 documents)

    Export disorders and mutations for UBE2C gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
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    10/71 PubMed articles for UBE2C gene, integrated from 7 sources (see all 71):
    (articles sorted by number of sources associating them with UBE2C)
    1. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PubMed id 9122200)1, 2, 3, 7 Townsley F.M.... Ruderman J.V. (1997)
    2. Identification of a physiological E2 module for the human anaphase- promoting complex. (PubMed id 19822757)1, 2 Williamson A....Rape M. (2009)
    3. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PubMed id 19820702)1, 2 Garnett M.J.... Venkitaraman A.R. (2009)
    4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)1, 2 Jin L....Rape M. (2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. (PubMed id 11927573)1, 2 Lin Y.... Basavappa R. (2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. (PubMed id 17354233)1, 7 Ieta K....Mori M. (2007)
    9. Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. (PubMed id 17217624)1, 7 Lin J....Lin L. (2006)
    10. Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. (PubMed id 16772118)1, 7 Takahashi Y....Asai S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11065 HGNC: 15937 AceView: UBE2C Ensembl:ENSG00000175063 euGenes: HUgn11065
    ECgene: UBE2C Kegg: 11065 H-InvDB: UBE2C

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for UBE2C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for UBE2C gene:
    Search GeneIP for patents involving UBE2C

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