Aliases &
Descriptions
for UBE2D4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin-conjugating enzyme E2D 4 (putative)1 2 | | OTTHUMP000002075762 | | HBUCE11 2 3 | | ubiquitin-conjugating enzyme HBUCE12 | | Ubiquitin carrier protein D42 3 | | ubiquitin-conjugating enzyme E2 D42 | | Ubiquitin-protein ligase D42 3 | | EC 6.3.2.193 | | FLJ320042 | | UBCH5D3 |
Export aliases for UBE2D4 gene to outside databasesPrevious GC identifers: GC07P043740 GC07P043966 |
Summaries
for UBE2D4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UB2D4_HUMAN, Q9Y2X8Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro ableto promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linkedpolyubiquitination
|
Genomic Views
for UBE2D4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2D4 gene promoter:
ZID Nkx3-1 v1 Nkx3-1 v4 Nkx3-1 v3 Nkx3-1 v2 Nkx3-1 Pax-5 p53 MEF-2A LCR-F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2D4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UBE2D4  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13UBE2D4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P043932: view genomic region
(about GC identifiers)
Start:
|
43,850,744 bp from pter |
End:
|
43,880,447 bp from pter |
Size:
|
29,704 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+ 43,966,037-43,993,166 |
RefSeq DNA sequence:- NC_000007.13 NT_007819.17 NT_079592.2
|
Proteins
for UBE2D4 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UB2D4_HUMAN, Q9Y2X8 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 D4 Size: 147 amino acids; 16649 Da
Secondary accessions: A4D1V0Explore the universe of human proteins at neXtProt for UBE2D4: NX_Q9Y2X8
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057067.1
ENSEMBL proteins: ENSP00000391678 ENSP00000406583 ENSP00000401824 ENSP00000222402 ENSP00000414331 ENSP00000410897 ENSP00000397406 ENSP00000411738 ENSP00000407196
Human Recombinant Proteins
Antibodies for UBE2D4:
Assays for UBE2D4: |
Protein
Domains/
Families
for UBE2D4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2D4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2X8ProtoNet protein and cluster: Q9Y2X8 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2D4_HUMAN, Q9Y2X8Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Gene Function
for UBE2D4 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UB2D4_HUMAN, Q9Y2X8Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro ableto promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linkedpolyubiquitinationCatalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
UBE2D4 for ontologies About GeneDecksing
|
Pathways & Interactions
for UBE2D4 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UBE2D4 for pathways About GeneDecksing
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for UBE2D4
2  Kegg Pathways (Kegg details for UBE2D4):  | hsa04120 Ubiquitin mediated proteolysis | | hsa04141 Protein processing in endoplasmic reticulum |
UniProtKB/Swiss-Prot: UB2D4_HUMAN, Q9Y2X8Pathway: Protein modification; protein ubiquitination SABiosciences Custom Pathway-Focused PCR Arrays for UBE2D4
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UBE2D4
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2D4
5/26 Interacting proteins for UBE2D4 (Q9Y2X81, 2 ENSP000002224023) via UniProtKB, MINT, and/or STRING (see all 26) About this table
5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035519 | protein K29-linked ubiquitination |
IDA | -- | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0044314 | protein K27-linked ubiquitination |
IDA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | | GO:0070534 | protein K63-linked ubiquitination |
IDA | -- |
About this table
UBE2D4 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2D4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UBE2D4
|
Transcripts
for UBE2D4 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UBE2D4 gene: NM_015983.3 Additional cDNA sequence: AF125044.1 AF125045.1 AK001446.1 AK056566.1 BC004104.2 CR608137.1 16 DOTS entries: DT.100019767 DT.80102034 DT.91830044 DT.100776196 DT.121041056 DT.100776192 DT.100776194 DT.405831 DT.114072 DT.100776195 DT.95370728 DT.91691670 DT.97847498 DT.100804099 DT.114726 DT.91746835 24/199 AceView cDNA sequences (see all 199): AI025707 BI962825 AA737986 BM808115 AW612621 BM681664 BE467880 AA366525 BC004104 BQ708956 Z41304 BU933711 BM674974 F26606 BQ183706 AI434404 BX093978 AK001446 CR608137 AI911590 BQ226554 BI966681 AA317388 AA350152
 highest scoring ESTs for UBE2D4:AA045185 AA056016 AA190487 AA350151 AA350152 AA514438 AA527399 AA527790 AA569028 AA643161 Unigene Cluster for UBE2D4: Ubiquitin-conjugating enzyme E2D 4 (putative) Hs.19196 [show with all ESTs]Unigene Representative Sequence: NM_015983
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D4 (see all 7)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UBE2D4
11 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000450743 ENST00000440652 ENST00000454350 ENST00000491770 ENST00000222402(uc003tja.1 uc003tjb.1)
ENST00000415051 ENST00000440899 ENST00000446008 ENST00000473007 ENST00000454428
ENST00000443780
|
Expression
for UBE2D4 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UBE2D4 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching UBE2D4 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 65521_at2, 3
|
U133-C |
1 |
0.81 |
1.00 |
0.86 |
1.36 |
W74577 |
0.80 |
1.00 |
0.91 |
1 |
| 46425_at2, 3
|
U95-B |
1 |
0.56 |
1.00 |
0.53 |
0.89 |
AI346497 |
0.20 |
1.00 |
0.72 |
1 |
| 57309_f_at2, 3
|
U95-C |
1 |
0.50 |
1.00 |
0.94 |
0.78 |
AA045185 |
1.00 |
1.00 |
1.00 |
1 |
| 218837_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_015983 |
0.60 |
1.00 |
0.82 |
1 |
| 65521_at2, 3
|
U133-A |
1 |
0.81 |
1.00 |
-- |
-- |
W74577 |
0.80 |
1.00 |
0.91 |
1 |
| 218837_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 65521_at2
|
U133Plus2 |
1 |
0.81 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UBE2D4 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTACTCCATT
SOURCE GeneReport for Unigene cluster: Hs.19196
SABiosciences Custom PCR Arrays for UBE2D4
|
Orthologs
for UBE2D4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2D4 gene from 5/14 species (see all 14)
About this table Species with no ortholog for UBE2D4
ENSEMBL Gene Tree for UBE2D4 (if available) |
Paralogs
for UBE2D4 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UBE2D4 gene
- UBE2D32 UBE2E32 UBE2D12 UBE2E12 UBE2D22 UBE2E22
UBE2D4 for paralogs About GeneDecksing
Pseudogenes
- 3 related pseudogenes
|
Genomic Variants
for UBE2D4 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UBE2D4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for UBE2D4
4 CNVs: 3677 94462 4531 81922 |
Disorders & Mutations
for UBE2D4 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for UBE2D4 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UBE2D4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for UBE2D4 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with UBE2D4)- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2, 3 Scherer S.W.... Tsui L.-C. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The E2 ubiquitin-conjugating enzymes direct polyubiqu itination to preferred lysines. (PubMed id 20061386)2 David Y....Navon A. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Functional proteomics mapping of a human signaling pathway. (PubMed id 15231748)1 Colland F....Gauthier J.M. (2004)
|
External Searches for UBE2D4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2D4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2D4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2D4 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBE2D4 gene:
Search GeneIP for patents involving UBE2D4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2D4 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for UBE2D4 |
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