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UBE2DNL Gene

pseudogene   GIFtS: 27

GC0XP084193
ubiquitin-conjugating enzyme E2D N-terminal like (pseudogene)
(Previous names: ubiquitin-conjugating enzyme E2D N-terminal like, ubiquitin-conjugating enzyme E2D N-terminal like pseudogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for UBE2DNL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
ubiquitin-conjugating enzyme E2D N-terminal like (pseudogene)1 2     UBE2D2L3
MGC426381 2     Ubiquitin-protein ligase D2-like3
ubiquitin-conjugating enzyme E2D N-terminal like pseudogene1     Ubiquitin-conjugating enzyme E2D N-terminal-like3
ubiquitin-conjugating enzyme E2D N-terminal like1     Ubiquitin carrier protein D2-like3

External Ids:    HGNC: 286561   Entrez Gene: 1001318162   UniProtKB: Q8IWF73   

Export aliases for UBE2DNL gene to outside databases

Previous GC identifers: GC0XU900848 GC0XP084077 GC0XP084190 GC0XP084191


Summaries
for UBE2DNL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for UBE2DNL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for UBE2DNL
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for UBE2DNL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.1   HGNC cytogenetic band: Xq21.1

UBE2DNL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2DNL gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP084193:  view genomic region     (about GC identifiers)

Start:
 84,189,157 bp from pter
End:
 84,189,896 bp from pter
Size:
 740 bases
Orientation:
 plus strand
UBE2DNL has overlapping exons with:
 ENSG00000242846

1 alternative location:
ChrX+ 77,763,448-77,764,187     
RefSeq DNA sequence:
NC_000023.10  NT_011651.17  

Proteins
for UBE2DNL gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: U2D2L_HUMAN, Q8IWF7 (See protein sequence)
Recommended Name: Putative ubiquitin-conjugating enzyme E2 D2-like protein  
Size: 75 amino acids; 8761 Da
Caution: Could be the product of a pseudogene. Probably inactive as a ubiquitin-conjugating enzyme since it lacks the
essential active site cysteine

Explore the universe of human proteins at neXtProt for UBE2DNL: NX_Q8IWF7 


Human Recombinant Proteins 

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Protein Domains/
Families
for UBE2DNL gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
UBE2DNL for domains           About GeneDecksing

2 InterPro domains/families:
 IPR000608 UBQ-conjugat_E2
 IPR016135 UBQ-conjugat/RWD-like

Graphical View of Domain Structure for InterPro Entry Q8IWF7

ProtoNet protein and cluster: Q8IWF7

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: U2D2L_HUMAN, Q8IWF7
Similarity: Belongs to the ubiquitin-conjugating enzyme family


Gene Function
for UBE2DNL gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
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Search SABiosciences for Assays for microRNAs that regulate UBE2DNL

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for UBE2DNL 

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0019787 small conjugating protein ligase activity IEA--
About this table

UBE2DNL for ontologies           About GeneDecksing


Pathways & Interactions
for UBE2DNL gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for UBE2DNL 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2DNL

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0043687 post-translational protein modification IEA--
GO:0051246 regulation of protein metabolic process IEA--
About this table

UBE2DNL for ontologies           About GeneDecksing



Drugs & Compounds
for UBE2DNL gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
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Browse Tocris compounds for UBE2DNL


Transcripts
for UBE2DNL gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
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miRNA: Browse microRNA Mimics at Sigma-Aldrich
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UBE2DNL 
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Clones: Browse FLAG tag genes at Sigma-Aldrich
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Primers:Browse OriGene genome-wide validated SYBR primer pairs
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SABiosciences RT2 qPCR Primer Assay for UBE2DNL: PPH19153A

Additional cDNA sequence: BC040290.1 

1 DOTS entry:

DT.40218494 

highest scoring ESTs for UBE2DNL:

NM_178567 AA535530 AW009213 AW082719 BC040290 AA620648 AA770080 AI223087 AI341772 BG717914 

Unigene Cluster for UBE2DNL:

Ubiquitin-conjugating enzyme E2D N-terminal like (pseudogene)
Hs.460809  [show with all ESTs]
Unigene Representative Sequence: BG717914


GeneLoc Exon Structure


Expression
for UBE2DNL gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

UBE2DNL expression in normal and diseased human tissues

1  / 2  / 3

1 probe-set matching UBE2DNL gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
1554763_at2 U133Plus2 2 0.73 0.75 -- -- -- -- -- -- --
About this table
Data from Genenote  (Publications) and GNF BioGPS
    About these images
UBE2DNL gene expression
UBE2DNL gene electronic northern expression
UBE2DNL gene sage expression
About these images

CGAP SAGE TAG: TAATTTCAAA

SOURCE GeneReport for Unigene cluster: Hs.460809
Primers:Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for UBE2DNL: PPH19153A
    SABiosciences Custom PCR Arrays for UBE2DNL 


Orthologs
for UBE2DNL gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for UBE2DNL gene from 1 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
mouse
(Mus musculus)		 Ube2dnl5 X (49.47 cM) ubiquitin-conjugating enzyme E2D N-terminal like   -- BC048523 
About this table        Species with no ortholog for UBE2DNL

Paralogs
for UBE2DNL gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

Genomic Variants
for UBE2DNL gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
Search QIAGEN SeqTarget long-range PCR primers for resequencing for UBE2DNL 

Disorders & Mutations
for UBE2DNL gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for UBE2DNL gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for UBE2DNL gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

3 PubMed articles for UBE2DNL gene integrated from 7 sources:
(articles sorted by number of sources associating them with UBE2DNL)
  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  3. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)

External Searches for UBE2DNL gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing UBE2DNL gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 100131816 HGNC: 28656 euGenes: HUgn100131816 ECgene: UBE2DNL H-InvDB: UBE2DNL

Other Databases showing UBE2DNL gene

(According to HUGE)
About This Section
   --

Specialized Databases showing UBE2DNL gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
   --

Intellectual Property
for UBE2DNL gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for UBE2DNL gene:
Search GeneIP for patents involving UBE2DNL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for UBE2DNL gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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