UBE2G1 Gene
protein-coding GIFtS: 53
GC17M004061
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ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)
(Previous names: ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7), ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: UBE2G)
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Aliases &
Descriptions
for UBE2G1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)1 2 | | Ubiquitin-protein ligase G12 3 | | UBE2G2 3 5 | | UBC72 3 | | ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7)1 2 | | E217K2 3 | | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)1 2 | | ubiquitin-conjugating enzyme E2 G12 | | Ubiquitin carrier protein G12 3 | | EC 6.3.2.193 |
Export aliases for UBE2G1 gene to outside databasesPrevious GC identifers: GC17M004492 GC17M004124 GC17M004380 GC17M004120 |
Summaries
for UBE2G1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2G1:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of theE2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. Theprotein may be involved in degradation of muscle-specific proteins. (provided by RefSeq)
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specificproteins. Mediates polyubiquitination of CYP3A4
Gene Wiki entry for UBE2G1 |
Genomic Views
for UBE2G1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2G1 gene promoter:
MZF-1 Egr-1 MEF-2A Pax-5 Max c-Myc USF1 Sox9 c-Myb RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2G1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UBE2G1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42|17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2UBE2G1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M004061: view genomic region
(about GC identifiers)
Start:
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4,061,449 bp from pter |
End:
|
4,158,493 bp from pter |
Size:
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97,045 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr17- 4,172,512-4,269,969 |
RefSeq DNA sequence:- NC_000017.10 NT_010718.16
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Proteins
for UBE2G1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 G1 Size: 170 amino acids; 19509 Da
Sequence caution: Sequence=AAH26288.2; Type=Erroneous initiation;
PDB structures from  and Proteopedia  :2AWF (3D)
Secondary accessions: B2R7P2 Q99462Explore the universe of human proteins at neXtProt for UBE2G1: NX_P62253
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003333.1
ENSEMBL proteins: ENSP00000380178
Human Recombinant Proteins
Antibodies for UBE2G1:
Assays for UBE2G1: |
Protein
Domains/
Families
for UBE2G1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2G1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62253ProtoNet protein and cluster: P62253 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Gene Function
for UBE2G1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specificproteins. Mediates polyubiquitination of CYP3A4Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19
Genatlas biochemistry entry for UBE2G1:ubiquitin conjugating enzyme E2G,highly homolog to C elegans UBC7,highly expressed in skeletal muscle5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
UBE2G1 for ontologies About GeneDecksing
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Pathways & Interactions
for UBE2G1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UBE2G1 for pathways About GeneDecksing
1  Millipore Pathway for UBE2G1
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for UBE2G1
3  Kegg Pathways (Kegg details for UBE2G1):  | hsa04120 Ubiquitin mediated proteolysis | | hsa04141 Protein processing in endoplasmic reticulum | | hsa05012 Parkinson's disease |
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Pathway: Protein modification; protein ubiquitination SABiosciences Pathway-Focused PCR Array including UBE2G1: PAHS-079A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UBE2G1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2G1
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
TAS | 8893823 | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | | GO:0070534 | protein K63-linked ubiquitination |
IDA | -- | | GO:0070936 | protein K48-linked ubiquitination |
IDA | -- |
About this table
UBE2G1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2G1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UBE2G1
|
Transcripts
for UBE2G1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UBE2G1 gene: NM_003342.4 Additional cDNA sequence: AK313059.1 BC002775.2 BC017006.1 BC026288.1 BT007416.1 CR622319.1 CR623407.1 D78514.1 10 DOTS entries: DT.444928 DT.97847027 DT.95333171 DT.100789880 DT.100789882 DT.91751363 DT.120910165 DT.445070 DT.75172367 DT.91742715 24/350 AceView cDNA sequences (see all 350): CB048652 CB215969 Z42296 BG676464 AA149306 BQ924413 BX280781 AA551383 CB051447 BI858725 BM142249 Z38893 BG681901 AI364886 AI358757 AI091026 AA721173 BM715491 AA125858 AI655468 CK820173 AA814632 BC002775 AW499792
 highest scoring ESTs for UBE2G1:D78514 AA113903 AU137034 BE396516 BE898059 BF981447 BG112905 BG115232 BG116490 BG289576 Unigene Cluster for UBE2G1: Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) Hs.727591 [show with all ESTs]Unigene Representative Sequence: NM_003342
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G1 (see all 6)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UBE2G1
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000396981(uc002fxs.2)
|
Expression
for UBE2G1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UBE2G1 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching UBE2G1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1423_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.95 |
0.94 |
D78514 |
1.00 |
0.90 |
0.95 |
1 |
| 37662_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
0.95 |
0.86 |
AI701164 |
0.80 |
0.80 |
0.80 |
1 |
| 49474_at2, 3
|
U95-B |
1 |
0.38 |
1.00 |
0.86 |
1.21 |
AI191413 |
0.40 |
1.00 |
0.76 |
1 |
| 209142_s_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
BC002775 |
0.80 |
0.88 |
0.84 |
1 |
| 209141_at2, 3
|
U133-A |
1 |
0.64 |
1.00 |
-- |
-- |
AW299555 |
0.60 |
1.00 |
0.82 |
1 |
| 209142_s_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 209141_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UBE2G1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGATGAGTGC
SOURCE GeneReport for Unigene cluster: Hs.727591
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Tissue specificity: Widely expressed, mainly in skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including UBE2G1: PAHS-079A
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Orthologs
for UBE2G1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2G1 gene from 5/21 species (see all 21)
About this table Species with no ortholog for UBE2G1
ENSEMBL Gene Tree for UBE2G1 (if available) |
Paralogs
for UBE2G1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UBE2G1 gene
- UBE2G22
UBE2G1 for paralogs About GeneDecksing
|
Genomic Variants
for UBE2G1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 17 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UBE2G1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for UBE2G1
3 CNVs: 49862 49863 4984 | | QIAGEN SeqTarget long-range PCR primers for resequencing UBE2G1 |
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Disorders & Mutations
for UBE2G1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2G1 for disorders About GeneDecksing
OMIM: 601569
Export disorders and mutations for UBE2G1 gene to outside databases
|
Medical News
for UBE2G1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UBE2G1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/20 PubMed articles for UBE2G1 gene, integrated from 7 sources (see all 20):
(articles sorted by number of sources associating them with UBE2G1)- Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. (PubMed id 8893823)1, 2, 3 Watanabe T.K.... Takahashi E. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. (PubMed id 12933904)1, 7 Kim B.W....Bianco A.C. (2003)
- The E2 ubiquitin-conjugating enzymes direct polyubiqu itination to preferred lysines. (PubMed id 20061386)2 David Y....Navon A. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. (PubMed id 19103148)2 Pabarcus M.K....Correia M.A. (2009)
- Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity. (PubMed id 17452445)1 Sagar G.D....Bianco A.C. (2007)
- TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. (PubMed id 15673284)1 Hassink G.... Wiertz E. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for UBE2G1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2G1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2G1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2G1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBE2G1 gene:
Search GeneIP for patents involving UBE2G1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2G1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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