Aliases &
Descriptions
for UBE2J1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)1 2 | | Ubc6p2 | | NCUBE11 2 3 | | HSUBC6e2 | | HSPC1531 2 | | ubiquitin-conjugating enzyme E2 J12 | | Non-canonical ubiquitin-conjugating enzyme 12 3 | | MGC125552 | | Yeast ubiquitin-conjugating enzyme UBC6 homolog E2 3 | | non-canonical ubquitin conjugating enzyme 12 | | NCUBE-12 3 | | HSPC2052 | | CGI-761 | | HsUBC6e3 | | HSU932432 | | EC 6.3.2.193 |
Export aliases for UBE2J1 gene to outside databasesPrevious GC identifers: GC06M090003 GC06M090032 GC06M090031 GC06M090093 |
Summaries
for UBE2J1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2J1:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of theE2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) andmay contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. (provided by RefSeq)
UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selectivedegradation of misfolded membrane proteins from the endoplasmic reticulum
Gene Wiki entry for UBE2J1 |
Genomic Views
for UBE2J1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2J1 gene promoter:
oct-B2 POU2F1 oct-B3 POU2F2 (Oct-2.1) Oct-B1 POU2F2B POU2F2C POU2F2 c-Myb ZID
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2J1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q15 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q16.1UBE2J1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M087253: view genomic region
(about GC identifiers)
Start:
|
87,253,169 bp from pter |
End:
|
87,279,755 bp from pter |
Size:
|
26,587 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr6- 90,036,344-90,039,278 |
RefSeq DNA sequence:- NC_000006.11 NT_007299.13
|
Proteins
for UBE2J1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 J1 Size: 318 amino acids; 35199 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein
Sequence caution: Sequence=AAD34071.1; Type=Erroneous initiation; Sequence=AAF36125.1; Type=Frameshift; Positions=119;
Secondary accessions: A8K3F9 Q5W0N4 Q9BZ32 Q9NQL3 Q9NY66 Q9P011 Q9P0S0 Q9UF10Explore the universe of human proteins at neXtProt for UBE2J1: NX_Q9Y385
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_057105.2
Human Recombinant Proteins
4 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
UBE2J1 for ontologies About GeneDecksing
Antibodies for UBE2J1:
Assays for UBE2J1: |
Protein
Domains/
Families
for UBE2J1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2J1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y385ProtoNet protein and cluster: Q9Y385 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Gene Function
for UBE2J1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selectivedegradation of misfolded membrane proteins from the endoplasmic reticulumCatalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
UBE2J1 for ontologies About GeneDecksing
|
Pathways & Interactions
for UBE2J1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UBE2J1 for pathways About GeneDecksing
1  Millipore Pathway for UBE2J1
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for UBE2J1
3  Kegg Pathways (Kegg details for UBE2J1):  | hsa04120 Ubiquitin mediated proteolysis | | hsa04141 Protein processing in endoplasmic reticulum | | hsa05012 Parkinson's disease |
UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385Pathway: Protein modification; protein ubiquitination SABiosciences Pathway-Focused PCR Array including UBE2J1: PAHS-079A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UBE2J1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2J1
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- |
About this table
UBE2J1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2J1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UBE2J1
|
Transcripts
for UBE2J1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UBE2J1 gene: NM_016021.2 Additional cDNA sequence: AB075487.1 AF151039.1 AF151834.1 AF161502.1 AJ245898.1 AJ420479.1 AJ420522.1 AJ420578.1 AJ420600.1 AK223464.1 AK290574.1 AK300629.1 BC013973.1 CR593056.1 CR608832.1 CR618158.1 U93243.1 13 DOTS entries: DT.452520 DT.91754919 DT.91754932 DT.92035712 DT.100726380 DT.100645848 DT.100645843 DT.91754923 DT.87001128 DT.95224761 DT.101976909 DT.121383951 DT.95141421 24/349 AceView cDNA sequences (see all 349): AL562528 AA504141 AW118565 AA435533 CA941012 AA811362 AA676862 AL121463 BU688929 AL538922 AA622355 AA165621 BM453083 CB216761 NM_016021 CB997305 BU154273 AI222553 BM686728 AW296841 BI830194 BQ009872 BG566075 BU509302
 highest scoring ESTs for UBE2J1:AA018130 AA044667 AA156816 AA211896 AA371039 AA478628 AA491236 AA574142 AA614686 AA631316 Unigene Cluster for UBE2J1: Ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) Hs.163776 [show with all ESTs]Unigene Representative Sequence: NM_016021
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | · | 8d |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | - | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UBE2J1
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000435041(uc010kcb.2 uc003pnc.2)
|
Expression
for UBE2J1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UBE2J1 expression in normal and diseased human tissues
1 / 2 / 3 14 probe-sets matching UBE2J1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 57081_at2, 3
|
U95-B |
2 |
0.94 |
0.90 |
0.76 |
1.13 |
AA044667 |
0.80 |
1.00 |
0.91 |
1 |
| 39040_at2, 3
|
U95-A |
1 |
0.75 |
1.00 |
0.84 |
0.93 |
W28360 |
0.80 |
1.00 |
0.91 |
1 |
| 57780_at2, 3
|
U95-C |
1 |
0.69 |
1.00 |
0.64 |
0.73 |
N57554 |
0.80 |
1.00 |
0.91 |
1 |
| 39039_s_at2, 3
|
U95-A |
1 |
0.56 |
1.00 |
0.93 |
1.22 |
AI557497 |
0.60 |
1.00 |
0.82 |
1 |
| 222435_s_at2, 3
|
U133-B |
2 |
1.00 |
0.82 |
-- |
-- |
AF161502 |
0.80 |
1.00 |
0.91 |
1 |
| 217826_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_016021 |
0.60 |
1.00 |
0.82 |
1 |
| 217825_s_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
AF151039 |
0.60 |
1.00 |
0.82 |
1 |
| 217824_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AW500009 |
0.40 |
1.00 |
0.76 |
1 |
| 217823_s_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
AL562528 |
0.40 |
1.00 |
0.76 |
1 |
| 222435_s_at2
|
U133Plus2 |
2 |
1.00 |
0.82 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217826_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217825_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217824_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 217823_s_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UBE2J1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.163776
Expression variation in blood from EXPOLDB for UBE2J1 SABiosciences Expression via Pathway-Focused PCR Array including UBE2J1: PAHS-079A
|
Orthologs
for UBE2J1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2J1 gene from 5/13 species (see all 13)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
dog
(Canis familiaris) |
UBE2J11 |
-- |
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, more |
92.19(n)
94.39(a) |
474993 XM_532230.2 XP_532230.2 |
chimpanzee
(Pan troglodytes) |
UBE2J11 |
-- |
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, more |
99.69(n)
99.69(a) |
462883 XM_518636.2 XP_518636.2 |
cow
(Bos taurus) |
UBE2J11 |
-- |
ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, more |
93.19(n)
95.6(a) |
539754 XM_866344.2 XP_871437.2 |
rat
(Rattus norvegicus) |
Ube2j11 |
-- |
ubiquitin-conjugating enzyme E2, J1 |
88.68(n)
93.28(a) |
297961 XM_216362.4 XP_216362.3 |
mouse
(Mus musculus) |
Ube2j11 , 5 |
4 (14.61 cM)5
|
ubiquitin-conjugating enzyme E2, J11, 5 |
88.16(n)1
92.45(a)1 |
562281 NM_019586.31 NP_062532.21
AA7268025 AI8485275 (see all 18) |
About this table Species with no ortholog for UBE2J1
ENSEMBL Gene Tree for UBE2J1 (if available) |
Paralogs
for UBE2J1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for UBE2J1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UBE2J1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBE2J1
1 Indel: 69564 |
Disorders & Mutations
for UBE2J1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2J1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: UBE2J1 (1 document)
Export disorders and mutations for UBE2J1 gene to outside databases
|
Medical News
for UBE2J1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UBE2J1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/23 PubMed articles for UBE2J1 gene, integrated from 7 sources (see all 23):
(articles sorted by number of sources associating them with UBE2J1)- Identification of a family of non-canonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. (PubMed id 10708578)1, 2, 3, 7 Lester D.H.... Houston B. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- A role for mammalian Ubc6 homologues in ER-associated protein degradation. (PubMed id 12082160)1, 2 Lenk U....Sommer T. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- A meta-analysis of genome-wide data from five Europea n isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creat inine level. (PubMed id 20222955)1, 7 Pattaro C....Pramstaller P.P. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for UBE2J1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2J1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2J1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2J1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBE2J1 gene:
Search GeneIP for patents involving UBE2J1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2J1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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