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UBE2QL1 Gene

protein-coding   GIFtS: 37

GC05P006448
ubiquitin-conjugating enzyme E2Q family-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
ubiquitin-conjugating enzyme E2Q family-like 11 2
FLJ250761 2
ubiquitin-conjugating enzyme E2Q-like protein 12
FLJ392932
EC 6.3.2.193

External Ids:    HGNC: 372691   Entrez Gene: 1341112   Ensembl: ENSG000002152187   UniProtKB: A1L1673   

Export aliases for UBE2QL1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167
Function: Catalyzes the covalent attachment of ubiquitin to other proteins (Potential)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for UBE2QL1
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for UBE2QL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UBE2QL1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.31   Ensembl cytogenetic band:  5p15.31   HGNC cytogenetic band: 5p15.31

UBE2QL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2QL1 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P006448:  view genomic region     (about GC identifiers)

Start:
6,448,736 bp from pter
End:
6,495,022 bp from pter
Size:
46,287 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2Q-like protein 1  
Size: 161 amino acids; 18338 Da
Sequence caution: Sequence=AAI27724.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI50555.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Explore the universe of human proteins at neXtProt for UBE2QL1: NX_A1L167 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001138633.1  

    ENSEMBL proteins: 
    ENSP00000382713 


    Human Recombinant Proteins 
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    Browse antibodies at Epitomics

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    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UBE2QL1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugat/RWD-like

    Graphical View of Domain Structure for InterPro Entry A1L167

    ProtoNet protein and cluster: A1L167

    UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins (Potential)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Enzyme Number (IUBMB): EC 6.3.2.19 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for UBE2QL1
    Sigma-Aldrich shRNA for UBE2QL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): UBE2QL1
    OriGene shRNA RFP (see all 3): UBE2QL1
    OriGene basic RS shRNA (see all 3): UBE2QL1
    OriGene siRNA (see all 3): UBE2QL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UBE2QL1 
    miRNA:Sigma-Aldrich microRNA Mimics for UBE2QL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UBE2QL1 
    Search SABiosciences for Assays for microRNAs that regulate UBE2QL1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): UBE2QL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): UBE2QL1
    OriGene untagged cDNA clones in CMV expression vector: UBE2QL1
    OriGene 3'-UTR clone: UBE2QL1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for UBE2QL1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for UBE2QL1 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004842 ubiquitin-protein ligase activity IEA--
    GO:0005524 ATP binding IEA--
    GO:0016874 ligase activity IEA--
    GO:0019787 small conjugating protein ligase activity ----
    About this table

    UBE2QL1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    UBE2QL1 for pathways           About GeneDecksing

    1 Kegg Pathway  (Kegg details for UBE2QL1):
        hsa04120 Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167
    Pathway: Protein modification; protein ubiquitination

        SABiosciences Custom Pathway-Focused PCR Arrays for UBE2QL1 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2QL1

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043687 post-translational protein modification IEA--
    GO:0051246 regulation of protein metabolic process IEA--
    About this table

    UBE2QL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2QL1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for UBE2QL1
    Sigma-Aldrich shRNA for UBE2QL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): UBE2QL1
    OriGene shRNA RFP (see all 3): UBE2QL1
    OriGene basic RS shRNA (see all 3): UBE2QL1
    OriGene siRNA (see all 3): UBE2QL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UBE2QL1 
    miRNA: Sigma-Aldrich microRNA Mimics for UBE2QL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UBE2QL1 
    Search SABiosciences for Assays for microRNAs that regulate UBE2QL1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): UBE2QL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): UBE2QL1
    OriGene untagged cDNA clones in CMV expression vector: UBE2QL1
    OriGene 3'-UTR Clone: UBE2QL1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for UBE2QL1 
    Primers: OriGene genome-wide validated SYBR primer pairs: UBE2QL1
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for UBE2QL1

    REFSEQ mRNAs for UBE2QL1 gene: 

    NM_001145161.2  

    Additional cDNA sequence: 

    AB188494.1 AK057805.1 AK096612.1 AK308577.1 BC127723.1 BC150554.1 

    3 DOTS entries:

    DT.115035  DT.99994154  DT.95159567 

    24/66 AceView cDNA sequences (see all 66):

    T16575 BE048820 F02655 F10145 Z45266 AK096612 AI264863 BE502530 
    BU727576 F04161 CK004421 AW594171 AI867447 Z43784 AA449241 BF056928 
    BG911906 AW004030 BM714666 T87230 AI366013 AI651825 AI953735 BM728118 

    Unigene Cluster for UBE2QL1:

    Ubiquitin-conjugating enzyme E2Q family-like 1
    Hs.126856  [show with all ESTs]
    Unigene Representative Sequence: AK096612


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000399816(uc003jdp.3)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    UBE2QL1 expression in normal and diseased human tissues

    1  / 2

    5 probe-sets matching UBE2QL1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    54043_at2 U95-B 1 0.69 1.00 1.00 1.00 -- -- -- -- --
    226618_at2 U133-B 1 0.55 1.00 -- -- -- -- -- -- --
    226612_at2 U133-B 1 0.55 1.00 -- -- -- -- -- -- --
    226618_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    226612_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    UBE2QL1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    UBE2QL1 gene expression
    UBE2QL1 gene electronic northern expression
    UBE2QL1 gene sage expression
    About these images

    CGAP SAGE TAG: CATACCTGAA

    SOURCE GeneReport for Unigene cluster: Hs.126856
    Primers: OriGene genome-wide validated SYBR primer pairs: UBE2QL1
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for UBE2QL1
        SABiosciences Custom PCR Arrays for UBE2QL1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for UBE2QL1 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    mouse
    (Mus musculus)
    Ube2ql15 13 (35.55 cM) ubiquitin-conjugating enzyme E2Q family-like 1   -- BF467553 
    zebrafish
    (Danio rerio)
    wufj55b042   -- Transcribed sequence with weak similarity to protein refNP_492764.1 (C.elegans) F25H2.8.p [Caenorhabditis elegans] less 83.91(n)  BG306414.1 
    African clawed frog
    (Xenopus laevis)
    Xl.74152   -- Xenopus laevis transcribed sequence with weak similarity to protein refNP_492764.1 (C.elegans) F25H2.8.p [Caenorhabditis elegans] less 82.32(n)  BX854059.1 
    tropical clawed frog
    (Silurana tropicalis)
    Str.156712   -- Transcribed sequences 79.46(n)  BX733045.1 
    rainbow trout
    (Oncorhynchus mykiss)
    Omy.36612   -- Oncorhynchus mykiss transcribed sequence with weak similarity to protein refNP_492764.1 (C.elegans) F25H2.8.p [Caenorhabditis elegans] less 80.12(n)  BX074490.1 
    About this table        Species with no ortholog for UBE2QL1

    ENSEMBL Gene Tree for UBE2QL1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for UBE2QL1 gene
    UBE2Q22  UBE2Q12  UBE2Q2P22  UBE2Q2P32  

    UBE2QL1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/536 NCBI SNPs in UBE2QL1 are shown (see all 536)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 5 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1666251,2
    C,F,A,6461513(+) ACAGCT/GAACTG 1 -- int17Minor allele frequency- G:0.39NA EA WA 218
    rs1692501,2
    C,F,6450203(+) GACCCA/CCCCCC 1 -- int14Minor allele frequency- C:0.19NS EA NA 296
    rs1692511,2
    C,F,A,6461429(+) CTGACC/TAGCTA 1 -- int115Minor allele frequency- T:0.33NS EA NA WA 1058
    rs1720591,2
    C,A,6466220(+) TGGAGG/AGGCTG 1 -- int18Minor allele frequency- A:0.41NA EA WA 172
    rs1821191,2
    C,F,O,6485363(-) AGCTGG/CATCTA 1 -- int111Minor allele frequency- C:0.23NS EA NA 716
    rs1856541,2
    C,F,H,6460043(+) tacccC/Ggagga 1 -- int111Minor allele frequency- G:0.08NS EA NA WA 476
    rs2724521,2
    C,A,6484545(-) GGCACC/TGCAGA 1 -- int16Minor allele frequency- T:0.35NA EA WA 216
    rs2724531,2
    C,F,A,6484530(-) CATGCG/ATGTGG 1 -- int110Minor allele frequency- A:0.33NS EA NA WA 634
    rs2724541,2
    C,6484467(-) GCCTGC/AGGAGG 1 -- int14Minor allele frequency- A:0.00NA WA 8
    rs2724551,2
    C,F,6484456(-) GGCCCA/CGAATC 1 -- int18Minor allele frequency- C:0.23NS EA NA 462
    About this table

    HapMap Linkage Disequilibrium images for UBE2QL1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UBE2QL1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing UBE2QL1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    4 PubMed articles for UBE2QL1 gene integrated from 7 sources:
    (articles sorted by number of sources associating them with UBE2QL1)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 134111 HGNC: 37269 AceView: LOC134111 Ensembl:ENSG00000215218 euGenes: HUgn134111
    ECgene: UBE2QL1 Kegg: 134111 H-InvDB: UBE2QL1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for UBE2QL1 gene:
    Search GeneIP for patents involving UBE2QL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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    About This Section

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     SeqTarget long-range PCR primers for resequencing UBE2QL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UBE2QL1
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