Aliases &
Descriptions
for UBE2R2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin-conjugating enzyme E2R 21 2 | | Ubiquitin carrier protein R22 3 | | UBC3B1 2 3 5 | | Ubiquitin-protein ligase R22 3 | | CDC34B1 2 3 | | ubiquitin-conjugating enzyme UBC3B2 | | FLJ204191 2 | | ubiquitin-conjugating enzyme E2 R22 | | MGC104811 2 | | E2-CDC34B2 | | Ubiquitin-conjugating enzyme E2-CDC34B2 3 | | EC 6.3.2.193 |
Export aliases for UBE2R2 gene to outside databasesPrevious GC identifers: GC09P033987 GC09P033807 |
Summaries
for UBE2R2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2R2:
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation.This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest thatCK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substraterecognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. (provided by RefSeq)
UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin
Gene Wiki entry for UBE2R2 |
Genomic Views
for UBE2R2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2R2 gene promoter:
ER-alpha YY1 RORalpha2 Bach1 STAT3 Egr-1 MRF-2 Bach2 POU2F1 RORalpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2R2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UBE2R2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2UBE2R2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P033774: view genomic region
(about GC identifiers)
Start:
|
33,774,994 bp from pter |
End:
|
33,920,402 bp from pter |
Size:
|
145,409 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000009.11 NT_008413.18
|
Proteins
for UBE2R2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 R2 Size: 238 amino acids; 27166 Da
Subunit: When phosphorylated, interacts with beta-TrCP (BTRC)
Secondary accessions: Q9NX64Explore the universe of human proteins at neXtProt for UBE2R2: NX_Q712K3
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060281.2
ENSEMBL proteins: ENSP00000263228
Human Recombinant Proteins
Antibodies for UBE2R2:
Assays for UBE2R2: |
Protein
Domains/
Families
for UBE2R2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2R2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q712K3ProtoNet protein and cluster: Q712K3 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Gene Function
for UBE2R2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of kateninCatalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19
5 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
UBE2R2 for ontologies About GeneDecksing
|
Pathways & Interactions
for UBE2R2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UBE2R2 for pathways About GeneDecksing
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for UBE2R2
1  Kegg Pathway (Kegg details for UBE2R2):
UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Pathway: Protein modification; protein ubiquitination SABiosciences Pathway-Focused PCR Array including UBE2R2: PAHS-079A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UBE2R2
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2R2
2 Interacting proteins for UBE2R2 (ENSP000002632283) via UniProtKB, MINT, and/or STRING About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006513 | protein monoubiquitination |
IDA | -- | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | | GO:0070936 | protein K48-linked ubiquitination |
IDA | -- |
About this table
UBE2R2 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2R2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UBE2R2
|
Transcripts
for UBE2R2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UBE2R2 gene: NM_017811.3 Additional cDNA sequence: AJ240087.1 AK000426.1 AK225880.1 BC004862.2 BC047584.1 CR457233.1 CR592127.1 CR606642.1 CR626708.1 14 DOTS entries: DT.100825430 DT.454119 DT.420317 DT.100825439 DT.100825442 DT.95150382 DT.100825431 DT.100036350 DT.92433223 DT.100825441 DT.121211030 DT.95368200 DT.100825434 DT.100825440 24/414 AceView cDNA sequences (see all 414): AA063147 BI820998 CR592127 T40487 BI061548 BU146449 T87855 AI350363 AA740851 W76225 AI650476 AA477832 BQ653355 BF351857 BE739827 AA397839 AA835694 CD243112 BU625506 N34206 AA321134 AA044888 AA286768 BQ448284
 highest scoring ESTs for UBE2R2:Z78377 AA010793 AA029820 AA029821 AA043373 AA044661 AA044888 AA084062 AA084172 AA147324 Unigene Cluster for UBE2R2: Ubiquitin-conjugating enzyme E2R 2 Hs.725177 [show with all ESTs]Unigene Representative Sequence: NM_017811
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000263228(uc003ztm.2)
|
Expression
for UBE2R2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UBE2R2 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching UBE2R2 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 56479_at2, 3
|
U95-B |
1 |
0.88 |
1.00 |
0.84 |
1.11 |
Z78377 |
1.00 |
1.00 |
1.00 |
1 |
| 46616_at2, 3
|
U95-B |
1 |
0.75 |
1.00 |
0.75 |
0.89 |
AI969737 |
0.40 |
1.00 |
0.76 |
1 |
| 223014_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
BC004862 |
0.80 |
0.83 |
0.82 |
1 |
| 226954_at2, 3
|
U133-B |
1 |
0.55 |
1.00 |
-- |
-- |
BE221883 |
0.60 |
1.00 |
0.82 |
1 |
| 223014_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 226954_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UBE2R2 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GAGGCCTCAG
SOURCE GeneReport for Unigene cluster: Hs.725177
SABiosciences Expression via Pathway-Focused PCR Array including UBE2R2: PAHS-079A
|
Orthologs
for UBE2R2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2R2 gene from 5/17 species (see all 17)
About this table Species with no ortholog for UBE2R2
ENSEMBL Gene Tree for UBE2R2 (if available) |
Paralogs
for UBE2R2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UBE2R2 gene
- CDC342
UBE2R2 for paralogs About GeneDecksing
|
Genomic Variants
for UBE2R2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 9 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UBE2R2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UBE2R2
1 CNV: 2815
1 Indel: 70539 | | QIAGEN SeqTarget long-range PCR primers for resequencing UBE2R2 |
|
Disorders & Mutations
for UBE2R2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2R2 for disorders About GeneDecksing
OMIM: 612506
Human Genome Epidemiology (HuGE) Navigator: UBE2R2 (3 documents)
Export disorders and mutations for UBE2R2 gene to outside databases
|
Medical News
for UBE2R2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UBE2R2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/15 PubMed articles for UBE2R2 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with UBE2R2)- CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. (PubMed id 12037680)1, 2, 3 Semplici F.... Oliviero S. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The E2 ubiquitin-conjugating enzymes direct polyubiqu itination to preferred lysines. (PubMed id 20061386)2 David Y....Navon A. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
|
External Searches for UBE2R2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2R2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2R2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2R2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBE2R2 gene:
Search GeneIP for patents involving UBE2R2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2R2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for UBE2R2 (UBC3B) |
| | | | Search Tocris compounds for UBE2R2 |
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