Aliases &
Descriptions
for UBE2W gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin-conjugating enzyme E2W (putative)1 2 | | ubiquitin-conjugating enzyme 162 | | FLJ110111 2 | | probable ubiquitin-conjugating enzyme E2 W2 | | Ubiquitin-protein ligase W2 3 | | hUBC-162 | | Ubiquitin carrier protein W2 3 | | EC 6.3.2.193 |
Export aliases for UBE2W gene to outside databasesPrevious GC identifers: GC08M074866 GC08M074702 |
Summaries
for UBE2W gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes monoubiquitination and 'Lys-11'-linked polyubiquitination
|
Genomic Views
for UBE2W gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2W gene promoter:
Egr-3 Egr-2 Egr-1 Arnt AhR MEF-2A RFX1 HSF1 (long) E47 deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2W
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UBE2W  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q21.11UBE2W Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M070193: view genomic region
(about GC identifiers)
Start:
|
70,193,719 bp from pter |
End:
|
70,282,251 bp from pter |
Size:
|
88,533 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr8- 74,692,332-74,791,145 |
|
Proteins
for UBE2W gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02 (See
protein sequence)Recommended Name: Probable ubiquitin-conjugating enzyme E2 W Size: 151 amino acids; 17331 Da
Subunit: Homodimer
PDB structures from  and Proteopedia  :2A7L (3D)
Secondary accessions: Q9H823 Q9HAG6 Q9NV07Alternative splicing: 2 isoforms: Q96B02-1 Q96B02-2 Explore the universe of human proteins at neXtProt for UBE2W: NX_Q96B02
REFSEQ proteins (2 alternative transcripts):
NP_001001481.1 NP_060769.3
ENSEMBL proteins: ENSP00000403764 ENSP00000430254 ENSP00000351607 ENSP00000429136 ENSP00000414771 ENSP00000428813 ENSP00000382398 ENSP00000428835 ENSP00000397453
Human Recombinant Proteins
Antibodies for UBE2W:
Assays for UBE2W: |
Protein
Domains/
Families
for UBE2W gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2W for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96B02ProtoNet protein and cluster: Q96B02 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Gene Function
for UBE2W gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes monoubiquitination and 'Lys-11'-linked polyubiquitinationCatalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
UBE2W for ontologies About GeneDecksing
|
Pathways & Interactions
for UBE2W gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UBE2W for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for UBE2W):
UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02Pathway: Protein modification; protein ubiquitination SABiosciences Pathway-Focused PCR Array including UBE2W: PAHS-079A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2W
3 Interacting proteins for UBE2W (Q96B021, 2) via UniProtKB, MINT, and/or STRING About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006513 | protein monoubiquitination |
IDA | -- | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | | GO:0070979 | protein K11-linked ubiquitination |
IDA | -- |
About this table
UBE2W for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2W gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UBE2W
|
Transcripts
for UBE2W gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UBE2W gene (2 alternative transcripts): NM_001001481.1 NM_018299.3 24/446 AceView cDNA sequences (see all 446): BQ067641 H11522 AW471368 AW305281 D25755 BU754116 NM_014393 AI351764 AL705155 BI792408 F09321 BM818932 AU143505 AI768561 CA313094 CB851654 BM723081 AA441931 AI581093 AW192087 BQ082747 BM836010 AL708648 CA312778
 highest scoring ESTs for UBE2W:AA620611 AI625741 AK001873 AK021735 AK024050 AL710166 AU143505 BC016326 BG426710 BI547963
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2W
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UBE2W
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000453587 ENST00000519277 ENST00000358757 ENST00000519255 ENST00000422906
ENST00000517608 ENST00000399473 ENST00000523278 ENST00000419880(uc003xzt.2 uc003xzu.2 uc003xzv.2 uc003xzw.2)
|
Expression
for UBE2W gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UBE2W expression in normal and diseased human tissues
1 / 2 / 3 11 probe-sets matching UBE2W gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 46903_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.77 |
1.11 |
AA620611 |
0.80 |
0.88 |
0.84 |
1 |
| 60791_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.42 |
1.17 |
AI828160 |
0.60 |
0.83 |
0.73 |
1 |
| 60199_at2, 3
|
U95-C |
1 |
0.94 |
1.00 |
0.68 |
0.74 |
AA453924 |
0.60 |
0.83 |
0.73 |
1 |
| 59735_at2, 3
|
U95-B |
1 |
0.81 |
1.00 |
0.86 |
0.99 |
AI625741 |
0.80 |
0.88 |
0.84 |
1 |
| 218521_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_018299 |
0.60 |
0.83 |
0.73 |
1 |
| 222657_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AK024050 |
0.80 |
0.75 |
0.78 |
1 |
| 222656_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
AI625741 |
0.80 |
0.88 |
0.84 |
1 |
| 218521_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 222657_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 222656_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1555217_at2
|
U133Plus2 |
1 |
0.36 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UBE2W for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SABiosciences Expression via Pathway-Focused PCR Array including UBE2W: PAHS-079A
|
Orthologs
for UBE2W gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2W gene from 5/12 species (see all 12)
About this table Species with no ortholog for UBE2W
ENSEMBL Gene Tree for UBE2W (if available) |
Paralogs
for UBE2W gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UBE2W gene
- UBE2L62 UBE2L32
UBE2W for paralogs About GeneDecksing
|
Genomic Variants
for UBE2W gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 8 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UBE2W (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBE2W
1 Indel: 10914 | | QIAGEN SeqTarget long-range PCR primers for resequencing UBE2W |
|
Disorders & Mutations
for UBE2W gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for UBE2W gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UBE2W gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for UBE2W gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with UBE2W)- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- The E2 ubiquitin-conjugating enzymes direct polyubiqu itination to preferred lysines. (PubMed id 20061386)2 David Y....Navon A. (2010)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Cloning, characterization and subcellular localization of a gene encoding a human Ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product. (PubMed id 16368532)1 Yin G....Mao Y. (2006)
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)2 Nusbaum C....Lander E.S. (2006)
- A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)1 Suzuki Y.... Sugano S. (1997)
|
External Searches for UBE2W gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2W gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2W gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2W gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBE2W gene:
Search GeneIP for patents involving UBE2W
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2W gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for UBE2W |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for UBE2W |
| |
|
|
