Aliases &
Descriptions
for UBQLN3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquilin 31 2 | | TUP-11 2 | | OTTHUMP000000698062 | | ubiquilin-32 |
Export aliases for UBQLN3 gene to outside databasesPrevious GC identifers: GC11M006276 GC11M005830 GC11M005487 GC11M005492 GC11M005485 |
Summaries
for UBQLN3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBQLN3:
Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with relatedproducts in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminalubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thoughtto functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This geneis specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis.(provided by RefSeq)
|
Genomic Views
for UBQLN3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBQLN3 gene promoter:
SREBP-1b SREBP-1c SREBP-1a RP58 NRSF form 2 NRSF form 1 NF-E2 p45 NF-E2 MIF-1 AP-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBQLN3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15UBQLN3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M005188: view genomic region
(about GC identifiers)
Start:
|
5,186,337 bp from pter |
End:
|
5,188,960 bp from pter |
Size:
|
2,624 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr11- 5,528,530-5,531,215 |
RefSeq DNA sequence:- NC_000011.9 NT_009237.18
|
Proteins
for UBQLN3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UBQL3_HUMAN, Q9H347 (See
protein sequence)Recommended Name: Ubiquilin-3 Size: 655 amino acids; 70841 Da
Sequence caution: Sequence=AAG41675.1; Type=Erroneous gene model prediction;
PDB structures from  and Proteopedia  :1WX7 (3D)
1YQB (3D)
2DAH (3D)
Secondary accessions: Q9NRE0Explore the universe of human proteins at neXtProt for UBQLN3: NX_Q9H347
REFSEQ proteins: NP_059509.1
ENSEMBL proteins: ENSP00000412561 ENSP00000347997
Human Recombinant Proteins
Antibodies for UBQLN3:
Assays for UBQLN3: |
Protein
Domains/
Families
for UBQLN3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBQLN3 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9H347ProtoNet protein and cluster: Q9H347 2 Blocks protein families: IPB000449 Ubiquitin-associated domain IPB000626 Ubiquitin domain
UniProtKB/Swiss-Prot: UBQL3_HUMAN, Q9H347Similarity: Contains 1 UBA domainSimilarity: Contains 1 ubiquitin-like domain |
Gene Function
for UBQLN3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
UBQLN3 for ontologies About GeneDecksing
|
Pathways & Interactions
for UBQLN3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UBQLN3 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for UBQLN3):  | hsa04141 Protein processing in endoplasmic reticulum |
SABiosciences Custom Pathway-Focused PCR Arrays for UBQLN3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBQLN3
|
Drugs & Compounds
for UBQLN3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UBQLN3
|
Transcripts
for UBQLN3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UBQLN3 gene: NM_017481.2 Additional cDNA sequence: AF230481.1 BC036743.1 2 DOTS entries: DT.100686157 DT.40264831 24/31 AceView cDNA sequences (see all 31): BX098900 NM_017481 BC036743 BP370850 BM554226 BF979648 CD360011 BI520124 BI828244 AF230481 BG723394 AA628294 CD358097 BM559772 AI990809 BI831995 BG720868 BP371381 BG719475 BI559998 BI830050 BI559461 BI562365 BF980366
 highest scoring ESTs for UBQLN3:AA628294 AF230481 AI990809 BC036743 BF979417 BF979648 BG719475 BG720868 BG723394 BI464540 Unigene Cluster for UBQLN3: Ubiquilin 3 Hs.189184 [show with all ESTs]Unigene Representative Sequence: BC036743
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for UBQLN3
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c |
|---|
|
| SP1: | | | | | - | | | | | | |
| SP2: | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UBQLN3
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445998 ENST00000311659(uc001may.1)
|
Expression
for UBQLN3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UBQLN3 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching UBQLN3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 68024_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AI990809 |
0.80 |
1.00 |
0.91 |
1 |
| 220422_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_017481 |
0.60 |
1.00 |
0.82 |
1 |
| 220422_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UBQLN3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGCTTTCTGA
SOURCE GeneReport for Unigene cluster: Hs.189184
UniProtKB/Swiss-Prot: UBQL3_HUMAN, Q9H347Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for UBQLN3
|
Orthologs
for UBQLN3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBQLN3 gene from 4 species
About this table Species with no ortholog for UBQLN3
ENSEMBL Gene Tree for UBQLN3 (if available) |
Paralogs
for UBQLN3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UBQLN3 gene
- UBQLN22 UBQLN42 UBQLN12 UBQLNL2
UBQLN3 for paralogs About GeneDecksing
|
Genomic Variants
for UBQLN3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UBQLN3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBQLN3
1 CNV: 34458 | | QIAGEN SeqTarget long-range PCR primers for resequencing UBQLN3 |
|
Disorders & Mutations
for UBQLN3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBQLN3 for disorders About GeneDecksing
OMIM: 605473
Export disorders and mutations for UBQLN3 gene to outside databases
|
Medical News
for UBQLN3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UBQLN3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
6 PubMed articles for UBQLN3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with UBQLN3)- Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain. (PubMed id 10831842)1, 2, 3, 7 Conklin D.... Feldhaus A.L. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters. (PubMed id 11121057)1, 2 Bulger M.... Hardison R. (2000)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)1 Suzuki Y.... Sugano S. (1997)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
|
External Searches for UBQLN3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBQLN3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBQLN3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBQLN3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBQLN3 gene:
Search GeneIP for patents involving UBQLN3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBQLN3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for UBQLN3 |
| |  |  |  |  | | | | |
 | | |
|
|
