Aliases &
Descriptions
for UBXN2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| UBX domain protein 2B1 2 | | p371 2 5 | | p97 cofactor p372 3 | | NSFL1 cofactor p372 3 | | UBX domain-containing protein 2B2 | | LOC1378865 |
Export aliases for UBXN2B gene to outside databasesPrevious GC identifers: GC08P059487 GC08P059323 |
Summaries
for UBXN2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmicreticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP hasmembrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required,but not its deubiquitinating activity
|
Genomic Views
for UBXN2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for UBXN2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBXN2B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q12.1 Ensembl cytogenetic band: 8q12.1 HGNC cytogenetic band: 8q12.1UBXN2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P054812: view genomic region
(about GC identifiers)
Start:
|
54,811,019 bp from pter |
End:
|
54,851,280 bp from pter |
Size:
|
40,262 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr8+ 59,323,823-59,364,060 |
RefSeq DNA sequence:- NC_000008.10 NT_008183.19
|
Proteins
for UBXN2B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0 (See
protein sequence)Recommended Name: UBX domain-containing protein 2B Size: 331 amino acids; 37077 Da
Subunit: Interacts with VCP. Does not bind ubiquitin (By similarity)
Subcellular location: Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (Bysimilarity). Golgi apparatus (By similarity)
Secondary accessions: B3KWZ3Explore the universe of human proteins at neXtProt for UBXN2B: NX_Q14CS0
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001071087.1
ENSEMBL proteins: ENSP00000428314 ENSP00000428241 ENSP00000382507 ENSP00000427759
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
UBXN2B for ontologies About GeneDecksing
Antibodies for UBXN2B:
Assays for UBXN2B: |
Protein
Domains/
Families
for UBXN2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBXN2B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14CS0ProtoNet protein and cluster: Q14CS0 2 Blocks protein families: IPB001012 UBX domain IPB012989 SEP
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0Similarity: Belongs to the NSFL1C familySimilarity: Contains 1 SEP domainSimilarity: Contains 1 UBX domain |
Gene Function
for UBXN2B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UBX2B_HUMAN, Q14CS0Function: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmicreticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP hasmembrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required,but not its deubiquitinating activity
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- |
About this table
UBXN2B for ontologies About GeneDecksing
|
Pathways & Interactions
for UBXN2B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for UBXN2B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBXN2B
|
Drugs & Compounds
for UBXN2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UBXN2B
|
Transcripts
for UBXN2B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UBXN2B gene: NM_001077619.1 Additional cDNA sequence: AK054658.1 AK091561.1 AK126300.1 AL831990.2 AL833075.2 BC070386.1 BC113645.1 BX647876.2 U79282.1 7 DOTS entries: DT.214492 DT.100813407 DT.75119746 DT.91712440 DT.92056703 DT.40229368 DT.40258251 24/131 AceView cDNA sequences (see all 131): BM781756 BM557875 AL138274 CA422938 AI471953 BQ027160 CA951114 BI492758 BM818193 BF508075 AA593630 BU622593 AK126300 BQ937602 CB155575 AA012939 AI090885 BU146383 BU616960 CA941488 BM464311 AI307158 AA489698 AK054658 Unigene Cluster for UBXN2B: UBX domain protein 2B Hs.155572 [show with all ESTs]Unigene Representative Sequence: NM_001077619
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000522978 ENST00000523409 ENST00000521796 ENST00000520932 ENST00000399598(uc003xtl.2)
ENST00000520732
|
Expression
for UBXN2B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UBXN2B expression in normal and diseased human tissues
1 / 2 6 probe-sets matching UBXN2B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 32059_at2
|
U95-A |
1 |
0.88 |
1.00 |
0.28 |
1.20 |
-- |
-- |
-- |
-- |
-- |
| 60225_at2
|
U95-C |
3 |
0.31 |
0.87 |
0.95 |
0.81 |
-- |
-- |
-- |
-- |
-- |
| 212934_at2
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 238903_at2
|
U133-B |
2 |
0.36 |
0.88 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 212934_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 238903_at2
|
U133Plus2 |
2 |
0.36 |
0.88 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UBXN2B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: ATGTATGTAA
SOURCE GeneReport for Unigene cluster: Hs.155572
SABiosciences Custom PCR Arrays for UBXN2B
|
Orthologs
for UBXN2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBXN2B gene from 5/9 species (see all 9)
About this table Species with no ortholog for UBXN2B
ENSEMBL Gene Tree for UBXN2B (if available) |
Paralogs
for UBXN2B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UBXN2B gene
- UBXN2A2 NSFL1C2
UBXN2B for paralogs About GeneDecksing
|
Genomic Variants
for UBXN2B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 8 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UBXN2B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for UBXN2B
3 CNVs: 2756 82620 95456 | | QIAGEN SeqTarget long-range PCR primers for resequencing UBXN2B |
|
Disorders & Mutations
for UBXN2B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBXN2B for disorders About GeneDecksing
OMIM: 610686
Human Genome Epidemiology (HuGE) Navigator: UBXN2B (1 document)
Export disorders and mutations for UBXN2B gene to outside databases
|
Medical News
for UBXN2B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UBXN2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for UBXN2B gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with UBXN2B)- p37 is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis. (PubMed id 17141156)1, 2 Uchiyama K.... Kondo H. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Phosphorylation of p37 is important for Golgi disasse mbly at mitosis. (PubMed id 20875789)1 Kaneko Y....Kondo H. (2010 Nov 5)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for UBXN2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBXN2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBXN2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBXN2B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBXN2B gene:
Search GeneIP for patents involving UBXN2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBXN2B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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