Aliases &
Descriptions
for UCKL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| uridine-cytidine kinase 1-like 11 2 | | FLJ205171 | | URKL12 3 5 | | UCK1-LIKE2 | | uridine kinase-like 11 2 | | uridine-cytidine kinase-like 12 | | UCK1L2 5 | | EC 2.7.1.483 |
Export aliases for UCKL1 gene to outside databasesPrevious GC identifers: GC20M062041 GC20M062571 |
Summaries
for UCKL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5Function: May contribute to UTP accumulation needed for blast transformation and proliferation
Gene Wiki entry for UCKL1 |
Genomic Views
for UCKL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UCKL1 gene promoter:
NF-kappaB NF-kappaB1 GR-alpha GR-beta c-Myb HOXA9B Meis-1 FOXC1 C/EBPalpha CHOP-10
Other transcription factors
Search SABiosciences Chromatin IP Primers for UCKL1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UCKL1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC chromosome: 20UCKL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M059304: view genomic region
(about GC identifiers)
Start:
|
59,304,567 bp from pter |
End:
|
59,323,105 bp from pter |
Size:
|
18,539 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr20- 62,571,186-62,587,769 |
RefSeq DNA sequence:- NC_000020.10 NT_011333.6
|
Proteins
for UCKL1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5 (See
protein sequence)Recommended Name: Uridine-cytidine kinase-like 1 Size: 548 amino acids; 61141 Da
Subunit: Interacts with RNF19B and EBV EBNA3
Subcellular location: Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it doeschange isoform 3 location
Secondary accessions: Q5JWV0 Q70AQ5 Q8N524 Q9H3Z2Alternative splicing: 3 isoforms: Q9NWZ5-1 Q9NWZ5-2 Q9NWZ5-3 Explore the universe of human proteins at neXtProt for UCKL1: NX_Q9NWZ5
Post-translational modifications:
Ubiquitinated by RNF19B; which induces proteasomal degradation1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_001180308.1 NP_060329.2
ENSEMBL proteins: ENSP00000358908 ENSP00000402994 ENSP00000346155 ENSP00000358924 ENSP00000404474 ENSP00000351546
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
UCKL1 for ontologies About GeneDecksing
Antibodies for UCKL1:
Assays for UCKL1: |
Protein
Domains/
Families
for UCKL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UCKL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NWZ5ProtoNet protein and cluster: Q9NWZ5 1 Blocks protein family: IPB000764 Uridine kinase signature
UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5Similarity: Belongs to the uridine kinase family |
Gene Function
for UCKL1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5Function: May contribute to UTP accumulation needed for blast transformation and proliferationCatalytic activity: ATP + uridine = ADP + UMPCatalytic activity: ATP + cytidine = ADP + CMPEnzyme Number (IUBMB): EC 2.7.1.48
5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8): About this table
UCKL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for UCKL1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UCKL1 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for UCKL1
3  Kegg Pathways (Kegg details for UCKL1):
UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1 SABiosciences Custom Pathway-Focused PCR Arrays for UCKL1
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UCKL1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UCKL1
5 Interacting proteins for UCKL1 (ENSP000003461553 Q9NWZ51) via UniProtKB, MINT, and/or STRING About this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008152 | metabolic process |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
IEA | -- |
About this table
UCKL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UCKL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UCKL1
|
Transcripts
for UCKL1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UCKL1 gene (2 alternative transcripts): NM_001193379.1 NM_017859.3 Additional cDNA sequence: AJ605558.1 AK000524.1 AK128082.1 AK222559.1 AK223220.1 AK301602.1 AK303688.1 BC033078.1 CR594251.1 22 DOTS entries: DT.97817341 DT.95204026 DT.211623 DT.120803977 DT.75109769 DT.75102038 DT.95173576 DT.95114287 DT.209710 DT.120803978 DT.120803982 DT.100709734 DT.95173580 DT.100811435 DT.75118267 DT.100786530 DT.65287100 DT.95140900 DT.209709 DT.95256609 DT.120804018 DT.91741721 24/172 AceView cDNA sequences (see all 172): BM127708 BM702108 F27242 AI953030 AI343518 BQ640057 AI744038 BI772135 BQ637053 AW236555 CK429822 BQ641615 BE746017 BU730779 BM693202 AI364501 CR594251 AI478287 AA020997 BE552310 AW079506 BF001641 AL134381 AI979128
 highest scoring ESTs for UCKL1:AI478287 AI249721 AI343518 AI654629 AW291947 BE293963 BE304354 BE746017 BE794780 BF203267 Unigene Cluster for UCKL1: Uridine-cytidine kinase 1-like 1 Hs.504998 [show with all ESTs]Unigene Representative Sequence: AK128082
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 (see all 17)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 11c | · | 11d | · | 11e | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UCKL1
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369892(uc011abm.1) ENST00000430743(uc002yhj.2) ENST00000492660
ENST00000354216(uc010gkn.2 uc011abn.1 uc011abo.1) ENST00000369908
ENST00000418992 ENST00000358711 ENST00000483710
|
Expression
for UCKL1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UCKL1 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching UCKL1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 35727_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.37 |
1.06 |
AI249721 |
0.80 |
1.00 |
0.91 |
1 |
| 65045_f_at2, 3
|
U95-C |
1 |
0.69 |
1.00 |
0.79 |
1.11 |
AI440329 |
0.40 |
1.00 |
0.76 |
1 |
| 54221_at2, 3
|
U95-C |
1 |
0.50 |
1.00 |
0.31 |
1.19 |
AA021081 |
0.40 |
1.00 |
0.76 |
1 |
| 67286_r_at2, 3
|
U95-E |
1 |
0.50 |
1.00 |
0.50 |
0.74 |
AI478287 |
1.00 |
1.00 |
1.00 |
1 |
| 52209_at2, 3
|
U95-B |
1 |
0.44 |
1.00 |
0.70 |
0.85 |
AI953030 |
0.60 |
1.00 |
0.82 |
1 |
| 44945_at2, 3
|
U95-B |
1 |
0.38 |
1.00 |
0.42 |
1.06 |
AA398841 |
0.40 |
1.00 |
0.76 |
1 |
| 218533_s_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_017859 |
0.60 |
1.00 |
0.82 |
1 |
| 232675_s_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
BG149850 |
0.40 |
1.00 |
0.76 |
1 |
| 218533_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 232675_s_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UCKL1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCAGAGATGG
SOURCE GeneReport for Unigene cluster: Hs.504998
Expression variation in blood from EXPOLDB for UCKL1 UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for UCKL1
|
Orthologs
for UCKL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UCKL1 gene from 5/13 species (see all 13)
About this table Species with no ortholog for UCKL1
ENSEMBL Gene Tree for UCKL1 (if available) |
Paralogs
for UCKL1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UCKL1 gene
- UCK22 UCK12
UCKL1 for paralogs About GeneDecksing
|
Genomic Variants
for UCKL1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 20 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UCKL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for UCKL1
1 CNV: 2252
1 Indel: 73575 | | QIAGEN SeqTarget long-range PCR primers for resequencing UCKL1 |
|
Disorders & Mutations
for UCKL1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UCKL1 for disorders About GeneDecksing
OMIM: 610866
Export disorders and mutations for UCKL1 gene to outside databases
|
Medical News
for UCKL1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UCKL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/14 PubMed articles for UCKL1 gene, integrated from 7 sources (see all 14):
(articles sorted by number of sources associating them with UCKL1)- NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1, 2, 7 Fortier J.M. and Kornbluth J. (2006)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. (PubMed id 12199906)1, 2 Kashuba E.... Szekely L. (2002)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- Downregulation of uridine-cytidine kinase like-1 decr eases proliferation and enhances tumor susceptibility to lysis by apoptotic age nts and natural killer cells. (PubMed id 19653100)1, 7 Ambrose E.C. and Kornbluth J. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for UCKL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UCKL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UCKL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UCKL1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UCKL1 gene:
Search GeneIP for patents involving UCKL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UCKL1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for UCKL1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for UCKL1 |
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