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UCKL1 Gene

protein-coding   GIFtS: 56

GC20M059304
uridine-cytidine kinase 1-like 1
(Previous name: uridine kinase-like 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: URKL1)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
uridine-cytidine kinase 1-like 11 2     FLJ205171
URKL12 3 5     UCK1-LIKE2
uridine kinase-like 11 2     uridine-cytidine kinase-like 12
UCK1L2 5     EC 2.7.1.483

External Ids:    HGNC: 159381   Entrez Gene: 549632   Ensembl: ENSG000001982767   UniProtKB: Q9NWZ53   

Export aliases for UCKL1 gene to outside databases

Previous GC identifers: GC20M062041 GC20M062571


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
Function: May contribute to UTP accumulation needed for blast transformation and proliferation

Gene Wiki entry for UCKL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UCKL1 gene promoter:
         NF-kappaB   NF-kappaB1   GR-alpha   GR-beta   c-Myb   HOXA9B   Meis-1   FOXC1   C/EBPalpha   CHOP-10   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for UCKL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UCKL1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC chromosome: 20

UCKL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UCKL1 gene location

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M059304:  view genomic region     (about GC identifiers)

Start:
59,304,567 bp from pter
End:
59,323,105 bp from pter
Size:
18,539 bases
Orientation:
minus strand

1 alternative location:
Chr20- 62,571,186-62,587,769     
RefSeq DNA sequence:
NC_000020.10  NT_011333.6  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5 (See protein sequence)
Recommended Name: Uridine-cytidine kinase-like 1  
Size: 548 amino acids; 61141 Da
Subunit: Interacts with RNF19B and EBV EBNA3
Subcellular location: Cytoplasm. Nucleus. Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does
change isoform 3 location
Secondary accessions: Q5JWV0 Q70AQ5 Q8N524 Q9H3Z2
Alternative splicing: 3 isoforms:  Q9NWZ5-1   Q9NWZ5-2   Q9NWZ5-3   

Explore the universe of human proteins at neXtProt for UCKL1: NX_Q9NWZ5 

Post-translational modifications:

  • Ubiquitinated by RNF19B; which induces proteasomal degradation1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001180308.1  NP_060329.2  


    ENSEMBL proteins: 
    ENSP00000358908 ENSP00000402994 ENSP00000346155 ENSP00000358924 ENSP00000404474 ENSP00000351546 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: UCKL1
    GenScript Custom Purified and Recombinant Proteins Services for UCKL1 
    Novus Biologicals Proteins for UCKL1
    Novus Biologicals Lysate for UCKL1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005783 endoplasmic reticulum IDA18029348
    About this table

    UCKL1 for ontologies           About GeneDecksing



    Antibodies for UCKL1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for UCKL1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for UCKL1 
    Novus Biologicals Antibodies for UCKL1
    Epitomics antibodies for UCKL1

    Assays for UCKL1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UCKL1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for UCKL1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UCKL1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000764 Uridine_kinase
     IPR006083 PRK/URK

    Graphical View of Domain Structure for InterPro Entry Q9NWZ5

    ProtoNet protein and cluster: Q9NWZ5

    1 Blocks protein family: IPB000764 Uridine kinase signature

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Similarity: Belongs to the uridine kinase family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Function: May contribute to UTP accumulation needed for blast transformation and proliferation
    Catalytic activity: ATP + uridine = ADP + UMP
    Catalytic activity: ATP + cytidine = ADP + CMP
    Enzyme Number (IUBMB): EC 2.7.1.48 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for UCKL1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for UCKL1
    Sigma-Aldrich shRNA Panels and shRNA for UCKL1
    OriGene 29mer shRNA kits in GFP-retroviral vector: UCKL1
    OriGene shRNA RFP: UCKL1
    OriGene basic RS shRNA: UCKL1
    OriGene siRNA: UCKL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UCKL1 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Sigma-Aldrich microRNA target validation systems for UCKL1 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UCKL1 
    Search SABiosciences for Assays for microRNAs that regulate UCKL1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: UCKL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: UCKL1
    OriGene untagged cDNA clones in CMV expression vector: UCKL1
    OriGene 3'-UTR clone: UCKL1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for UCKL1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for UCKL1 

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004849 uridine kinase activity IEA--
    GO:0005515 protein binding IPI16709802
    GO:0005524 ATP binding IEA--
    GO:0016301 kinase activity IEA--
    About this table

    UCKL1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    UCKL1 for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  UCKL1
        Pyrimidine Metabolism

    3 Kegg Pathways  (Kegg details for UCKL1):
        hsa00240 Pyrimidine metabolism
    hsa00983 Drug metabolism - other enzymes
    hsa01100 Metabolic pathways

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Pathway: Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3
    Pathway: Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1

        SABiosciences Custom Pathway-Focused PCR Arrays for UCKL1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UCKL1
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UCKL1

    5 Interacting proteins for UCKL1 (ENSP000003461553 Q9NWZ51) via UniProtKB, MINT, and/or STRING

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF19BQ6ZMZ01EBI-2466660,EBI-2466594
    CMPK1ENSP000003609393STRING: ENSP00000360939
    UCK1ENSP000003612853STRING: ENSP00000361285
    UCK2ENSP000003568533STRING: ENSP00000356853
    UPP2ENSP000000057563STRING: ENSP00000005756
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152 metabolic process IEA--
    GO:0044419 interspecies interaction between organisms IEA--
    About this table

    UCKL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UCKL1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for UCKL1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for UCKL1
    Sigma-Aldrich shRNA Panels and shRNA for UCKL1
    OriGene 29mer shRNA kits in GFP-retroviral vector: UCKL1
    OriGene shRNA RFP: UCKL1
    OriGene basic RS shRNA: UCKL1
    OriGene siRNA: UCKL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UCKL1 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Sigma-Aldrich microRNA target validation systems for UCKL1 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UCKL1 
    Search SABiosciences for Assays for microRNAs that regulate UCKL1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: UCKL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: UCKL1
    OriGene untagged cDNA clones in CMV expression vector: UCKL1
    OriGene 3'-UTR Clone: UCKL1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for UCKL1 
    Primers: OriGene genome-wide validated SYBR primer pairs: UCKL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for UCKL1: PPH22760A

    REFSEQ mRNAs for UCKL1 gene (2 alternative transcripts): 

    NM_001193379.1  NM_017859.3  

    Additional cDNA sequence: 

    AJ605558.1 AK000524.1 AK128082.1 AK222559.1 AK223220.1 AK301602.1 AK303688.1 BC033078.1 
    CR594251.1 

    22 DOTS entries:

    DT.97817341  DT.95204026  DT.211623  DT.120803977  DT.75109769  DT.75102038  DT.95173576  DT.95114287 
    DT.209710  DT.120803978  DT.120803982  DT.100709734  DT.95173580  DT.100811435  DT.75118267  DT.100786530 
    DT.65287100  DT.95140900  DT.209709  DT.95256609  DT.120804018  DT.91741721 

    24/172 AceView cDNA sequences (see all 172):

    BM127708 BM702108 F27242 AI953030 AI343518 BQ640057 AI744038 BI772135 
    BQ637053 AW236555 CK429822 BQ641615 BE746017 BU730779 BM693202 AI364501 
    CR594251 AI478287 AA020997 BE552310 AW079506 BF001641 AL134381 AI979128 

    highest scoring ESTs for UCKL1:

    AI478287 AI249721 AI343518 AI654629 AW291947 BE293963 BE304354 BE746017 BE794780 BF203267 

    Unigene Cluster for UCKL1:

    Uridine-cytidine kinase 1-like 1
    Hs.504998  [show with all ESTs]
    Unigene Representative Sequence: AK128082


    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for UCKL1 (see all 17)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ·
    SP1:                    -     -                                         -     -     -     -                                                           -     -   
    SP2:                                                                                                                                                  -     -   
    SP3:                    -     -                                         -     -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                    -     -                                         -     -     -                                                                           

    ExUns: 11c · 11d · 11e ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:  -                                                         
    SP2:  -           -                                             
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            

    About this scheme

    ECgene alternative splicing isoforms for UCKL1
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369892(uc011abm.1) ENST00000430743(uc002yhj.2) ENST00000492660
    ENST00000354216(uc010gkn.2 uc011abn.1 uc011abo.1) ENST00000369908
    ENST00000418992 ENST00000358711 ENST00000483710

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    UCKL1 expression in normal and diseased human tissues

    1  / 2  / 3

    10 probe-sets matching UCKL1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35727_at2, 3 U95-A 1 1.00 1.00 0.37 1.06 AI249721 0.80 1.00 0.91 1
    65045_f_at2, 3 U95-C 1 0.69 1.00 0.79 1.11 AI440329 0.40 1.00 0.76 1
    54221_at2, 3 U95-C 1 0.50 1.00 0.31 1.19 AA021081 0.40 1.00 0.76 1
    67286_r_at2, 3 U95-E 1 0.50 1.00 0.50 0.74 AI478287 1.00 1.00 1.00 1
    52209_at2, 3 U95-B 1 0.44 1.00 0.70 0.85 AI953030 0.60 1.00 0.82 1
    44945_at2, 3 U95-B 1 0.38 1.00 0.42 1.06 AA398841 0.40 1.00 0.76 1
    218533_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_017859 0.60 1.00 0.82 1
    232675_s_at2, 3 U133-B 1 0.91 1.00 -- -- BG149850 0.40 1.00 0.76 1
    218533_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    232675_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    About this table

    UCKL1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    UCKL1 gene expression
    UCKL1 gene electronic northern expression
    UCKL1 gene sage expression
    About these images

    CGAP SAGE TAG: GCAGAGATGG

    SOURCE GeneReport for Unigene cluster: Hs.504998

    Expression variation in blood from EXPOLDB for UCKL1

    UniProtKB/Swiss-Prot: UCKL1_HUMAN, Q9NWZ5
    Tissue specificity: Ubiquitous

    Primers: OriGene genome-wide validated SYBR primer pairs: UCKL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for UCKL1: PPH22760A
        SABiosciences Custom PCR Arrays for UCKL1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for UCKL1 gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UCKL11   -- uridine-cytidine kinase 1-like 1 85.9(n)
    89.67(a)
    612562  XM_850293.1  XP_855386.1 
    chimpanzee
    (Pan troglodytes)
    UCKL11   -- uridine-cytidine kinase 1-like 1 93.25(n)
    92.22(a)
    458424  XM_514792.2  XP_514792.2 
    cow
    (Bos taurus)
    UCKL11   -- uridine-cytidine kinase 1-like 1 87.45(n)
    95.8(a)
    534046  XM_865607.2  XP_870700.1 
    rat
    (Rattus norvegicus)
    Uckl11   -- uridine-cytidine kinase 1-like 1 86.8(n)
    94.34(a)
    499956  XM_001070413.1  XP_001070413.1 
    mouse
    (Mus musculus)
    Uckl11 , 5 2 (103.66 cM)5
    uridine-cytidine kinase 1-like 11, 5 85.83(n)1
    94.89(a)1
    685561  NM_026765.31  NP_081041.21 
     AI8512385  AK0035415  (see all 7)
    About this table        Species with no ortholog for UCKL1

    ENSEMBL Gene Tree for UCKL1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for UCKL1 gene
    UCK22  UCK12  

    UCKL1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    9 NCBI SNPs in UCKL1 are shown
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 20 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs7513271,2
    C,F,62577613(+) CCGCCT/CCCCAA 2 /G ref1 syn110Minor allele frequency- C:0.08EA NA MN NS WA 696
    rs60112341,2
    --62577514(+) CCCACC/TTTGTA 2 K syn1 ref1 ese30--------
    rs60625921,2
    --62571982(+) GATGAA/GGATGG 2 L F ref1 mis10--------
    rs114766111,2
    --62572560(+) CGCAG-/CCCTGG 2 A fra1 ref10--------
    rs178531561,2
    --62575795(+) ATGGCC/GACCGT 2 V syn1 ref1 ese30--------
    rs285791841,2
    --62571341(+) GTGTAA/GGCCAC 2 A ref1 syn1 ese30--------
    rs355955841,2
    --62577941(-) GCTCTC/TCCCGG 2 P S ref1 mis11Minor allele frequency- T:0.02NA 44
    rs617435061,2
    --62577179(+) CTGTGC/TGTGGT 2 T syn1 ref10--------
    rs750777771,2
    --62571547(+) TGTCCA/CCCGCC 2 G V mis1 ref10--------
    About this table

    HapMap Linkage Disequilibrium images for UCKL1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for UCKL1
         1 CNV: 2252
         1 Indel: 73575

    QIAGEN SeqTarget long-range PCR primers for resequencing UCKL1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UCKL1 for disorders           About GeneDecksing

    OMIM: 610866


    Export disorders and mutations for UCKL1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/14 PubMed articles for UCKL1 gene, integrated from 7 sources (see all 14):
    (articles sorted by number of sources associating them with UCKL1)
    1. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1, 2, 7 Fortier J.M. and Kornbluth J. (2006)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase. (PubMed id 12199906)1, 2 Kashuba E.... Szekely L. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Downregulation of uridine-cytidine kinase like-1 decr eases proliferation and enhances tumor susceptibility to lysis by apoptotic age nts and natural killer cells. (PubMed id 19653100)1, 7 Ambrose E.C. and Kornbluth J. (2009)
    8. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
    9. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54963 HGNC: 15938 AceView: UCKL1 Ensembl:ENSG00000198276 euGenes: HUgn54963
    ECgene: UCKL1 Kegg: 54963 H-InvDB: UCKL1

    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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