Aliases &
Descriptions
for UNC5A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| unc-5 homolog A (C. elegans)1 2 | | Protein unc-5 homolog 12 3 | | UNC5H11 2 3 5 | | netrin receptor Unc5h12 | | KIAA19761 2 3 | | netrin receptor UNC5A2 | | unc5 (C.elegans homolog) a1 2 | | FLJ164492 | | Protein unc-5 homolog A2 3 | | unc-5 homolog 12 |
Export aliases for UNC5A gene to outside databasesPrevious GC identifers: GC00U990540 GC05P176270 GC05P176170 |
Summaries
for UNC5A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UNC5A:
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).(supplied by OMIM)
UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in thedeveloping nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association withDCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis inductionwhen not associated with netrin ligand
Gene Wiki entry for UNC5A |
Genomic Views
for UNC5A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UNC5A gene promoter:
LUN-1 GR-beta GR-alpha c-Myc Max PPAR-gamma2 PPAR-gamma1 GCNF-1 GCNF-2 Pax-6
Other transcription factors
Search SABiosciences Chromatin IP Primers for UNC5A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UNC5A  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.3UNC5A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P171160: view genomic region
(about GC identifiers)
Start:
|
171,160,941 bp from pter |
End:
|
171,230,624 bp from pter |
Size:
|
69,684 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr5+ 176,237,478-176,307,897 |
RefSeq DNA sequence:- NC_000005.9 NT_023133.13
|
Proteins
for UNC5A gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44 (See
protein sequence)Recommended Name: Netrin receptor UNC5A precursor Size: 842 amino acids; 92932 Da
Subunit: Interacts with the cytoplasmic part of DCC. Interacts with MAGED1. Interacts with PRKCABP, possibly mediatingsome interaction with PKC (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity). Note=The interaction withPRKCABP regulates its surface expression and leads to its removal from surface of neurons and growth cones (Bysimilarity)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidneycancers
Sequence caution: Sequence=BAB85562.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: B2RXE6 Q8TF26 Q96GP4Alternative splicing: 3 isoforms: Q6ZN44-1 Q6ZN44-2 Q6ZN44-3 Explore the universe of human proteins at neXtProt for UNC5A: NX_Q6ZN44
Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues. Phosphorylated by PKC in vitro (By similarity)1
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associatedwith netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_588610.2
ENSEMBL proteins: ENSP00000421795 ENSP00000261961 ENSP00000332737 ENSP00000424067
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
UNC5A for ontologies About GeneDecksing
Antibodies for UNC5A:
Assays for UNC5A: |
Protein
Domains/
Families
for UNC5A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UNC5A for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q6ZN44ProtoNet protein and cluster: Q6ZN44 3 Blocks protein families: IPB000488 Death domain IPB000884 Thrombospondin IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44Domain: The ZU5 domain mediates the interaction with MAGED1, which participates in the induction of apoptosis (Bysimilarity)Similarity: Belongs to the unc-5 familySimilarity: Contains 1 death domainSimilarity: Contains 1 Ig-like (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 TSP type-1 domainSimilarity: Contains 1 ZU5 domain |
Gene Function
for UNC5A gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UNC5A_HUMAN, Q6ZN44Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in thedeveloping nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association withDCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis inductionwhen not associated with netrin ligandInduction: By TP53/p53
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
UNC5A for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Unc5a):
UNC5A for phenotypes About GeneDecksing
|
Pathways & Interactions
for UNC5A gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UNC5A for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for UNC5A
1  Kegg Pathway (Kegg details for UNC5A):
SABiosciences Custom Pathway-Focused PCR Arrays for UNC5A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UNC5A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5A
5 Interacting proteins for UNC5A (ENSP000003327373) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
UNC5A for ontologies About GeneDecksing
|
Drugs & Compounds
for UNC5A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UNC5A
|
Transcripts
for UNC5A gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UNC5A gene: NM_133369.2 Additional cDNA sequence: AK131380.1 BC009333.2 BC033727.1 BC122556.1 BC157824.1 CR598115.1 8 DOTS entries: DT.303017 DT.440944 DT.91996076 DT.100021845 DT.100743049 DT.99996360 DT.120818188 DT.95360734 24/67 AceView cDNA sequences (see all 67): BX282095 CR598115 BC009333 BM271771 BQ689148 BU195807 BM479478 AB075856 BI818609 BU729492 CK824949 BQ691915 BG329812 BC033727 BM272095 BF311804 BF311896 AA400943 BX453456 BM668454 AI334729 BI758231 BX348193 R19123
 highest scoring ESTs for UNC5A:R67163 AA400877 AA400943 AA428837 AA478321 AA496285 AL516579 AW872760 BC009333 BG329812 Unigene Cluster for UNC5A: Unc-5 homolog A (C. elegans) Hs.33191 [show with all ESTs]Unigene Representative Sequence: NM_133369
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5A (see all 7)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UNC5A
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000509580 ENST00000261961 ENST00000329542(uc003mex.1 uc003mey.2)
ENST00000513890(uc010jkg.1)
|
Expression
for UNC5A gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UNC5A expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching UNC5A gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 47437_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.96 |
1.00 |
R37358 |
0.60 |
1.00 |
0.82 |
1 |
| 88651_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
0.78 |
1.01 |
R67163 |
1.00 |
1.00 |
1.00 |
1 |
| 236448_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
R37358 |
0.60 |
1.00 |
0.82 |
1 |
| 236448_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UNC5A for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGAAGCTCGT
SOURCE GeneReport for Unigene cluster: Hs.33191
SABiosciences Custom PCR Arrays for UNC5A
|
Orthologs
for UNC5A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UNC5A gene from 5/7 species (see all 7)
About this table Species with no ortholog for UNC5A
ENSEMBL Gene Tree for UNC5A (if available) |
Paralogs
for UNC5A gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UNC5A gene
- UNC5B2 UNC5C2 CFP2 UNC5D2
UNC5A for paralogs About GeneDecksing
|
Genomic Variants
for UNC5A gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 5 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UNC5A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for UNC5A
3 CNVs: 51637 53250 51636
4 Indels: 27871 69250 27872 34345 | | QIAGEN SeqTarget long-range PCR primers for resequencing UNC5A |
|
Disorders & Mutations
for UNC5A gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UNC5A for disorders About GeneDecksing
OMIM: 607869
Human Genome Epidemiology (HuGE) Navigator: UNC5A (2 documents)
Export disorders and mutations for UNC5A gene to outside databases
|
Medical News
for UNC5A gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UNC5A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/23 PubMed articles for UNC5A gene, integrated from 7 sources (see all 23):
(articles sorted by number of sources associating them with UNC5A)- The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 7 Thiebault K.... Mehlen P. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- p53RDL1 regulates of p53-dependent apoptosis. (PubMed id 12598906)1, 2 Tanikawa C.... Arakawa H. (2003)
- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
- Identification of UNC5A as a novel transcriptional ta rget of tumor suppressor p53 and a regulator of apoptosis. (PubMed id 20372800)1 Miyamoto Y....Arakawa H. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. (PubMed id 17174565)1 Qin S....Zhang C. (2007)
- The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. (PubMed id 15729359)1 Llambi F....Mehlen P. (2005)
|
External Searches for UNC5A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UNC5A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UNC5A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing UNC5A gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UNC5A gene:
Search GeneIP for patents involving UNC5A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UNC5A gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for UNC5A |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for UNC5A |
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