Aliases &
Descriptions
for UNC5B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| unc-5 homolog B (C. elegans)1 2 | | unc5 (C.elegans homolog) b1 | | UNC5H21 2 3 5 | | transmembrane receptor Unc5H22 | | p53RDL11 2 | | unc-5 homolog 22 | | Protein unc-5 homolog 22 3 | | netrin receptor UNC5B2 | | Protein unc-5 homolog B2 3 | | P53RDL13 | | p53-regulated receptor for death and life protein 12 3 | | |
Export aliases for UNC5B gene to outside databasesPrevious GC identifers: GC00U990539 GC10P072864 GC10P072316 GC10P072642 GC10P072972 |
Summaries
for UNC5B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UNC5B:
UNC5B belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).(supplied by OMIM)
UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in thedeveloping nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association withDCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis inductionwhen not associated with netrin ligand
|
Genomic Views
for UNC5B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UNC5B gene promoter:
p53 AP-4 Arnt IRF-7A GATA-1 Nkx6-1 Cart-1 MAZR POU2F1 Tal-1beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for UNC5B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UNC5B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2UNC5B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P066966: view genomic region
(about GC identifiers)
Start:
|
66,966,135 bp from pter |
End:
|
67,054,784 bp from pter |
Size:
|
88,650 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr10+ 72,972,327-73,062,621 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
|
Proteins
for UNC5B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1 (See
protein sequence)Recommended Name: Netrin receptor UNC5B precursor Size: 945 amino acids; 103638 Da
Subunit: Interacts with the cytoplasmic part of DCC (By similarity). Interacts with GNAI2 via its cytoplasmic part
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Miscellaneous: Down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidneycancers
Sequence caution: Sequence=BAB14276.1; Type=Erroneous initiation; Sequence=BAC04382.1; Type=Erroneous initiation;
Secondary accessions: Q5T3R9 Q5T3S0 Q86SN3 Q8N1Y2 Q9H9F3Alternative splicing: 2 isoforms: Q8IZJ1-1 Q8IZJ1-2 Explore the universe of human proteins at neXtProt for UNC5B: NX_Q8IZJ1
Post-translational modifications:
Phosphorylated on cytoplasmic tyrosine residues (By similarity)1
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associatedwith netrin ligand. Its cleavage by caspases is required to induce apoptosis1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_734465.2
ENSEMBL proteins: ENSP00000334329 ENSP00000362288
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
UNC5B for ontologies About GeneDecksing
Antibodies for UNC5B:
Assays for UNC5B: |
Protein
Domains/
Families
for UNC5B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UNC5B for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q8IZJ1ProtoNet protein and cluster: Q8IZJ1 4 Blocks protein families: IPB000488 Death domain IPB003598 Immunoglobulin C-2 type IPB003599 Immunoglobulin subtype IPB008085 Thrombospondin type 1 repeat signature
UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1Similarity: Belongs to the unc-5 familySimilarity: Contains 1 death domainSimilarity: Contains 1 Ig-like (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 2 TSP type-1 domainsSimilarity: Contains 1 ZU5 domain |
Gene Function
for UNC5B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in thedeveloping nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association withDCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis inductionwhen not associated with netrin ligandInduction: By TP53/p53
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
UNC5B for ontologies About GeneDecksing
Animal Models: 6 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Unc5b):
UNC5B for phenotypes About GeneDecksing
|
Pathways & Interactions
for UNC5B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UNC5B for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for UNC5B
1  Kegg Pathway (Kegg details for UNC5B):
SABiosciences Custom Pathway-Focused PCR Arrays for UNC5B
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UNC5B
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UNC5B
5 Interacting proteins for UNC5B (ENSP000003343293) via UniProtKB, MINT, and/or STRINGAbout this table
5 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
UNC5B for ontologies About GeneDecksing
|
Drugs & Compounds
for UNC5B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UNC5B
|
Transcripts
for UNC5B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UNC5B gene: NM_170744.3 Additional cDNA sequence: AB096256.1 AK022859.1 AK094595.1 AK128132.1 AL049370.1 AY358351.1 CR617227.1 CR623022.1 6 DOTS entries: DT.91908160 DT.100774251 DT.75129932 DT.121221609 DT.121221632 DT.97843475 24/158 AceView cDNA sequences (see all 158): BM696085 AL528394 CB306604 AA897641 CB529414 CA421928 F07655 AK128132 CA776404 CA421154 F05244 BQ182589 AA911800 BQ447630 AL049370 AK094595 AA873508 BQ448491 AA330282 AI344433 CA439546 AK022859 AW054966 BM987430
 highest scoring ESTs for UNC5B:AA846091 AA233833 AA604346 AA665740 AA913567 AB096256 AI690475 AI818200 AK022859 AK094595 Unigene Cluster for UNC5B: Unc-5 homolog B (C. elegans) Hs.522997 [show with all ESTs]Unigene Representative Sequence: NM_170744
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UNC5B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b |
|---|
|
| SP1: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for UNC5B
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335350(uc001jro.2 uc001jrp.2 uc001jrq.1) ENST00000373192
|
Expression
for UNC5B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UNC5B expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching UNC5B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 90745_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.97 |
0.91 |
AA846091 |
1.00 |
1.00 |
1.00 |
1 |
| 41856_at2, 3
|
U133-A |
1 |
0.56 |
1.00 |
0.71 |
1.10 |
AL049370 |
0.60 |
1.00 |
0.82 |
1 |
| 226899_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AK022859 |
0.80 |
1.00 |
0.91 |
1 |
| 213100_at2, 3
|
U133-A |
1 |
0.82 |
1.00 |
-- |
-- |
AA127885 |
0.40 |
1.00 |
0.76 |
1 |
| 41856_at2, 3
|
U133-A |
1 |
0.56 |
1.00 |
-- |
-- |
AL049370 |
0.60 |
1.00 |
0.82 |
1 |
| 226899_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 213100_at2
|
U133Plus2 |
1 |
0.82 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 41856_at2
|
U133Plus2 |
1 |
0.56 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UNC5B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGTTTTAGTT
SOURCE GeneReport for Unigene cluster: Hs.522997
Expression variation in blood from EXPOLDB for UNC5B UniProtKB/Swiss-Prot: UNC5B_HUMAN, Q8IZJ1Tissue specificity: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney andhematopoietic and immune tissues
SABiosciences Custom PCR Arrays for UNC5B
|
Orthologs
for UNC5B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UNC5B gene from 5/7 species (see all 7)
About this table Species with no ortholog for UNC5B
ENSEMBL Gene Tree for UNC5B (if available) |
Paralogs
for UNC5B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for UNC5B gene
- UNC5C2 CFP2 UNC5A2 UNC5D2
UNC5B for paralogs About GeneDecksing
|
Genomic Variants
for UNC5B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UNC5B
1 Indel: 39760 | | QIAGEN SeqTarget long-range PCR primers for resequencing UNC5B |
|
Disorders & Mutations
for UNC5B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UNC5B for disorders About GeneDecksing
OMIM: 607870
1  Novoseek disease relationship for UNC5B gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0 |
3 |
12655055 (2), 18582460 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: UNC5B (2 documents)
Export disorders and mutations for UNC5B gene to outside databases
|
Medical News
for UNC5B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UNC5B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/31 PubMed articles for UNC5B gene, integrated from 7 sources (see all 31):
(articles sorted by number of sources associating them with UNC5B)- The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. (PubMed id 12655055)1, 2, 7 Thiebault K.... Mehlen P. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- p53RDL1 regulates of p53-dependent apoptosis. (PubMed id 12598906)1, 2 Tanikawa C.... Arakawa H. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Modulation of G(ialpha(2)) signaling by the axonal guidance molecule UNC5H2. (PubMed id 12359238)1, 2 Komatsuzaki K.... Kinane T.B. (2002)
- Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. (PubMed id 18719102)1, 7 Lejmi E....Plouet J. (2008)
- Role of the netrin system of repellent factors on syn ovial fibroblasts in rheumatoid arthritis and osteoarthritis. (PubMed id 19822088)1, 7 Schubert T....Bosserhoff A.K. (2009)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Characterization and expression of netrin-1 and its r eceptors UNC5B and DCC in human placenta. (PubMed id 19826074)1 Dakouane-Giudicelli M....de Mazancourt P. (2010)
- [Down-regulated expression of UNC5b related to hepato cellular carcinoma angiogenesis]. (PubMed id 20092749)1 Zhang H....Yang L.Y. (2009 Oct 15)
|
External Searches for UNC5B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UNC5B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UNC5B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UNC5B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UNC5B gene:
Search GeneIP for patents involving UNC5B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UNC5B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for UNC5B |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for UNC5B |
| |
|
|
