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UPF0639 Gene

protein-coding   GIFtS: 25

GC14P050120

symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).
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Aliases &
Descriptions
for UPF0639 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
hypothetical protein LOC4002242
UPF0639 protein2
FLJ448172

External Ids:    Entrez Gene: 4002242   Ensembl: ENSG000001759857   UniProtKB: A6NEE13   

Export aliases for UPF0639 gene to outside databases

Previous GC identifer: GC14P069951


Summaries
for UPF0639 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for UPF0639 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for UPF0639
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for UPF0639

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UPF0639 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.1   Ensembl cytogenetic band:  14q24.1   

UPF0639 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UPF0639 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P050120:  view genomic region     (about GC identifiers)

Start:
 50,120,506 bp from pter
End:
 50,164,233 bp from pter
Size:
 43,728 bases
Orientation:
 plus strand

1 alternative location:
Chr14+ 69,951,566-69,995,166     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

Proteins
for UPF0639 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: U639_HUMAN, A6NEE1 (See protein sequence)
Recommended Name: UPF0639 protein  
Size: 506 amino acids; 59171 Da

Explore the universe of human proteins at neXtProt for UPF0639: NX_A6NEE1 

REFSEQ proteins: NP_001154970.1  

ENSEMBL proteins: 
ENSP00000317175 


Human Recombinant Proteins 
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Protein Domains/
Families
for UPF0639 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
UPF0639 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR001849 Pleckstrin_homology
 IPR011993 PH_type

Graphical View of Domain Structure for InterPro Entry A6NEE1

ProtoNet protein and cluster: A6NEE1

UniProtKB/Swiss-Prot: U639_HUMAN, A6NEE1
Similarity: Belongs to the UPF0639 family
Similarity: Contains 1 PH domain


Gene Function
for UPF0639 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI ,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section
Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for UPF0639
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 10): UPF0639
OriGene shRNA RFP (see all 10): UPF0639
OriGene basic RS shRNA (see all 10): UPF0639
OriGene siRNA (see all 5): UPF0639
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UPF0639 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UPF0639 
Search SABiosciences for Assays for microRNAs that regulate UPF0639

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: UPF0639
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: UPF0639
OriGene untagged cDNA clones in CMV expression vector (see all 3): UPF0639
OriGene 3'-UTR clone: UPF0639 
Browse MicroRNA Expression Plasmids 
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Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for UPF0639 


Pathways & Interactions
for UPF0639 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for UPF0639 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UPF0639

Drugs & Compounds
for UPF0639 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UPF0639


Transcripts
for UPF0639 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build ; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for UPF0639
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 10): UPF0639
OriGene shRNA RFP (see all 10): UPF0639
OriGene basic RS shRNA (see all 10): UPF0639
OriGene siRNA (see all 5): UPF0639
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of UPF0639 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UPF0639 
Search SABiosciences for Assays for microRNAs that regulate UPF0639
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: UPF0639
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: UPF0639
OriGene untagged cDNA clones in CMV expression vector (see all 3): UPF0639
OriGene 3'-UTR Clone: UPF0639 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for UPF0639 
Primers: OriGene genome-wide validated SYBR primer pairs: UPF0639
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for UPF0639

REFSEQ mRNAs for UPF0639 gene: 

NM_001161498.1  

Additional cDNA sequence: 

AK126770.1 BC146872.1 

3 DOTS entries:

DT.101974338  DT.120776339  DT.120753523 

1 AceView cDNA sequence:

AK126770 

Unigene Cluster for UPF0639:

UPF0639 protein
Hs.509796  [show with all ESTs]
Unigene Representative Sequence:


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000322564(uc001xli.2 uc010ttf.1)

Expression
for UPF0639 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build ), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

UPF0639 expression in normal and diseased human tissues

Data from GNF BioGPS
    About these images

UPF0639 gene expression
UPF0639 gene electronic northern expression
UPF0639 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.509796
Primers: OriGene genome-wide validated SYBR primer pairs: UPF0639
Browse OriGene validated miRNA SYBR primer pairs 
Search SABiosciences RT2 qPCR Primer Assays for UPF0639
    SABiosciences Custom PCR Arrays for UPF0639 


Orthologs
for UPF0639 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI , with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for UPF0639 gene from 5 species
Organism Gene Locus Description Human
Similarity		 NCBI accessions
chimpanzee
(Pan troglodytes)		 LOC4674891   -- hypothetical LOC467489 99.73(n)
100(a)		 467489  XM_522886.2  XP_522886.2 
rat
(Rattus norvegicus)		 RGD15661121   -- similar to pleckstrin homology domain protein (5V327) 87.13(n)
91.8(a)		 500685  XM_576067.2  XP_576067.2 
mouse
(Mus musculus)		 3830431G21Rik1   -- RIKEN cDNA 3830431G21 gene 89.38(n)
95.42(a)		 217682  XM_126991.8  XP_126991.2 
chicken
(Gallus gallus)		 LOC4232601   -- hypothetical LOC423260 78.4(n)
82.09(a)		 423260  XM_421181.2  XP_421181.2 
worm
(Caenorhabditis elegans)		 F31D4.51   -- hypothetical protein 45.26(n)
34.6(a)		 180373  NM_075628.1  NP_508029.1 
About this table        Species with no ortholog for UPF0639

ENSEMBL Gene Tree for UPF0639 (if available)

Paralogs
for UPF0639 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

Genomic Variants
for UPF0639 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/415 NCBI SNPs in UPF0639 are shown (see all 415)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 14 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs8858021,2
C,F,O,69964425(+) GTGGGA/CAGAGG 1 -- int19Minor allele frequency- C:0.34NA EA WA 356
rs9326421,2
F,A,69962007(+) GgcaaC/Tatccc 1 -- int14Minor allele frequency- T:0.08NS EA 418
rs9929311,2
C,69963613(+) gggccC/Ttaccc 1 -- int11Minor allele frequency- T:0.02WA 50
rs9946251,2
C,F,69960129(+) agtttC/Actctc 1 -- int15Minor allele frequency- A:0.06NS EA WA 468
rs12757211,2
C,F,O,A,H,69955918(+) AGTTCA/GGCTTC 1 -- int110Minor allele frequency- G:0.07NS EA NA WA 614
rs12757221,2
C,A,H,69956872(+) gagccC/AccTGT 1 -- int15Minor allele frequency- A:0.40NA WA 80
rs12757231,2
C,F,A,H,69957542(+) GAGGGA/CAGTCC 1 -- int113Minor allele frequency- C:0.46NA EA WA 500
rs12757241,2
C,F,A,69958960(+) tctgtC/Gtggaa 1 -- int15Minor allele frequency- G:0.03NS EA WA 468
rs12757251,2
C,F,A,69962627(+) tattcG/Atcatc 1 -- int110Minor allele frequency- A:0.05NS EA NA WA 898
rs12757261,2
C,F,A,69962984(+) GTGGGT/AGGGGC 1 -- int11Minor allele frequency- A:0.16WA 50
About this table

HapMap Linkage Disequilibrium images for UPF0639 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for UPF0639: --

QIAGEN SeqTarget long-range PCR primers for resequencing UPF0639 

Disorders & Mutations
for UPF0639 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Medical News
for UPF0639 gene

(Possibly Related Articles in Doctor's Guide)
About This Section
   --

Publications
for UPF0639 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

3 PubMed articles for UPF0639 gene integrated from 7 sources:
(articles sorted by number of sources associating them with UPF0639)
  1. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

External Searches for UPF0639 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing UPF0639 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 400224 AceView: LOC400224 Ensembl:ENSG00000175985 euGenes: HUgn400224

Other Databases showing UPF0639 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing UPF0639 gene

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
   --

Intellectual Property
for UPF0639 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for UPF0639 gene:
Search GeneIP for patents involving UPF0639

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for UPF0639 gene

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

 Millipore Custom Antibody & Bulk Services
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 Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
 Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of UPF0639
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