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USF1 Gene

protein-coding GIFtS: 58

GC01M132366

upstream transcription factor 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
upstream transcription factor 1¹ ²		FCHL1²
bHLHb11¹ ² ³		OTTHUMP00000029695²
UEF¹ ²		MLTF²
MLTFI¹ ²		FCHL²
Class B basic helix-loop-helix protein 11² ³		upstream stimulatory factor 1²
Major late transcription factor 1² ³		BHLHB11³
HYPLIP1² ⁵		USF³

External Ids:	HGNC: 12593¹	Entrez Gene: 7391²	Ensembl: ENSG00000158773⁷	UniProtKB: P22415³

Export aliases for USF1 gene to outside databases

Previous GC identifers: GC01M158720 GC01M156741 GC01M157786 GC01M158225 GC01M158208 GC01M157822 GC01M159275 GC01M161009

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for USF1:

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular

transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements

and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants

encoding distinct isoforms have been identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: USF1_HUMAN, P22415

Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a

variety of viral and cellular promoters

Gene Wiki entry for USF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the USF1 gene promoter:
         c-Myc   Max1   Max   GATA-1   SREBP-1c   SREBP-1b   SREBP-1a   Sp1   AP-1   ATF
         Other transcription factors

Search SABiosciences Chromatin IP Primers for USF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for USF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23 Ensembl cytogenetic band: 1q23.3 HGNC cytogenetic band: 1q22-q23

USF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
USF1 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M132366: view genomic region (about GC identifiers)

Start:	132,366,984 bp from pter
End:	132,373,689 bp from pter
Size:	6,706 bases
Orientation:	minus strand

1 alternative location:

Chr1- 161,009,041-161,015,767

RefSeq DNA sequence:

NC_000001.10 NT_004487.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: USF1_HUMAN, P22415 (See protein sequence)

Recommended Name: Upstream stimulatory factor 1

Size: 310 amino acids; 33538 Da

Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as an homodimer or a

heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1AN4 (3D)

Secondary accessions: B2RBZ4 Q5SY46

Explore the universe of human proteins at neXtProt for USF1: NX_P22415

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_009053.1 NP_996888.1

ENSEMBL proteins:

ENSP00000357000 ENSP00000356999 ENSP00000356998 ENSP00000412790 ENSP00000390109

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: USF1 OriGene Protein Over-expression Lysate (see all 2): USF1
	GenScript Custom Purified and Recombinant Proteins Services for USF1
	Novus Biologicals Proteins for USF1
	Novus Biologicals Lysates for USF1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11256614
GO:0005667	transcription factor complex	IDA	19303849

About this table

USF1 for ontologies About GeneDecksing

Antibodies for USF1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for USF1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for USF1
	Novus Biologicals Antibodies for USF1
	Browse antibodies at Epitomics

Assays for USF1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for USF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for USF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

USF1 for domains About GeneDecksing

2 InterPro domains/families:

IPR001092 HLH_DNA-bd_dom

IPR011598 HLH_DNA-bd

Graphical View of Domain Structure for InterPro Entry P22415

ProtoNet protein and cluster: P22415

1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

UniProtKB/Swiss-Prot: USF1_HUMAN, P22415

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: USF1_HUMAN, P22415

Function: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a

variety of viral and cellular promoters

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for USF1 Sigma-Aldrich shRNA for USF1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): USF1 OriGene shRNA RFP (see all 2): USF1 OriGene basic RS shRNA (see all 2): USF1 OriGene siRNA (see all 2): USF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of USF1

miRNA:		Sigma-Aldrich microRNA Mimics for USF1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of USF1
		Search SABiosciences for Assays for microRNAs that regulate USF1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): USF1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): USF1 OriGene untagged cDNA clones in CMV expression vector (see all 3): USF1 OriGene 3'-UTR clone (see all 2): USF1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): USF1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for USF1

Genatlas biochemistry entry for USF1:

upstream stimulatory transcription factor,ubiquitous (43 kDa),binding the AP-1/AP-4 site on the APP promoter

5/14 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 14):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	--	--
GO:0003690	double-stranded DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	IMP	8576131
GO:0005515	protein binding	IPI	19303849

About this table

USF1 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Usf1):

behavior/neurological

lethality-prenatal/perinatal

nervous system

normal

USF1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Pathway-Focused PCR Array including USF1: PAHS-039A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for USF1

5 Interacting proteins for USF1 (ENSP00000356999³ P22415¹) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
USF2	Q15853¹	STRING: ENSP00000222305 EBI-1054489,EBI-1055994
KAT2B	Q92831¹	EBI-1054489,EBI-477430
MAPK11	ENSP00000333685³	STRING: ENSP00000333685
MAPK14	ENSP00000229794³	STRING: ENSP00000229794
GTF2I	ENSP00000322542³	STRING: ENSP00000322542

About this table

5/18 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 18):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose	IC	8576131
GO:0000432	positive regulation of transcription from RNA polymerase II promoter by glucose	ISS	--
GO:0001666	response to hypoxia	IMP	12917334
GO:0006006	glucose metabolic process	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--

About this table

USF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

USF1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for USF1
10/18 Novoseek chemical compound relationships for USF1 gene (see all 18)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	56.9	24	8306960 (2), 7642609 (2), 17827227 (2), 16010690 (1) (see all 16)
oligonucleotide	30.6	9	10527831 (2), 7983715 (1), 15684402 (1), 1869565 (1) (see all 8)
glucose	25.1	39	12200434 (4), 7852331 (4), 16376850 (3), 15175273 (3) (see all 20)
lipid	21.4	35	18593823 (3), 19910639 (3), 15175273 (3), 15310455 (1) (see all 21)
deoxycytidine	17	2	14514691 (1), 15729384 (1)
cholesterol	16.6	10	18593823 (4), 17065663 (1), 15959806 (1), 18230803 (1) (see all 5)
3-methylcholanthrene	13.5	4	9388470 (1)
sterol	12.8	3	15814457 (1), 17493856 (1), 17313375 (1)
chloramphenicol	12.5	2	7499336 (1), 9731700 (1)
fatty acid	5.84	3	15814457 (1), 10103003 (1), 17313375 (1)

About this table

1 PharmGKB drug compound relationship for USF1 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
gemcitabine	FA	14514691

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for USF1 Sigma-Aldrich shRNA for USF1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): USF1 OriGene shRNA RFP (see all 2): USF1 OriGene basic RS shRNA (see all 2): USF1 OriGene siRNA (see all 2): USF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of USF1

miRNA:		Sigma-Aldrich microRNA Mimics for USF1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of USF1
		Search SABiosciences for Assays for microRNAs that regulate USF1

Clones:		Sigma-Aldrich FLAG tag genes for USF1
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): USF1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): USF1 OriGene untagged cDNA clones in CMV expression vector (see all 3): USF1 OriGene 3'-UTR Clone (see all 2): USF1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): USF1

Primers:		OriGene genome-wide validated SYBR primer pairs: USF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for USF1: PPH02649A

REFSEQ mRNAs for USF1 gene (2 alternative transcripts):

NM_007122.3 NM_207005.1

Additional cDNA sequence:

AB098540.1 AK314876.1 AL832119.1 BC035505.2 X55666.1

7 DOTS entries:

DT.433299 DT.91708168 DT.91708167 DT.95172988 DT.100751470 DT.95172983 DT.100689001

24/44 AceView cDNA sequences (see all 44):

BI910596 BG743195 AB098540 NM_207005 NM_007122 AW607964 BX284104 BM837168

T28080 BX400480 X55666 BX400481 AL558282 BI768672 BC035505 BI907062

BG696772 BX327387 BQ951602 BG323427 AL832119 AA449938 BQ688770 BP362349

highest scoring ESTs for USF1:

AL832119 BC035505 BF751497 BG323427 BG696772 BI912256 BQ951602 AA449938 AB098540 AL558282

Unigene Cluster for USF1:

Upstream transcription factor 1

Hs.414880 [show with all ESTs]

Unigene Representative Sequence: AL832119

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for USF1 (see all 7)

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10a	·	10b	^	11a	·	11b	·	11c
SP1:									-												-										-
SP2:															-						-										-
SP3:									-
SP4:									-						-
SP5:									-								-

About this scheme

ECgene alternative splicing isoforms for USF1
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368021(uc001fxi.2 uc001fxj.2) ENST00000368020 ENST00000472217

ENST00000368019 ENST00000473969 ENST00000496363 ENST00000491629 ENST00000442467

ENST00000435396

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

USF1 expression in normal and diseased human tissues

¹ / ² / ³

2 probe-sets matching USF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
231768_at²^{, 3}	U133-B	1	1.00	1.00	--	--	X55666	0.60	1.00	0.82	1
231768_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

USF1 gene electronic northern expression

About these images

CGAP SAGE TAG: AAGAGGAGAT

SOURCE GeneReport for Unigene cluster: Hs.414880

Primers:		OriGene genome-wide validated SYBR primer pairs: USF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for USF1: PPH02649A

SABiosciences Expression via Pathway-Focused PCR Array including USF1: PAHS-039A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for USF1 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	USF1¹	--	upstream transcription factor 1	94.41(n) 99.68(a)	488646 XM_545763.2 XP_545763.2
cow (Bos taurus)	USF1¹	--	upstream transcription factor 1	94.52(n) 99.35(a)	407239 NM_001001161.2 NP_001001161.1
rat (Rattus norvegicus)	Usf1¹	--	upstream transcription factor 1	90.32(n) 98.39(a)	83586 NM_031777.2 NP_113965.1
mouse (Mus musculus)	Usf1^{1 , 5}	1 (79.40 cM)⁵	upstream transcription factor 1^{1, 5}	90.43(n)¹ 98.39(a)¹	22278¹ NM_009480.2¹ NP_033506.1¹ AF479773⁵ AK142437⁵ (see all 10)
chicken (Gallus gallus)	USF1¹	--	upstream transcription factor 1	78.57(n) 87.99(a)	425126 NM_001007485.1 NP_001007486.1

About this table Species with no ortholog for USF1

ENSEMBL Gene Tree for USF1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for USF1 gene

USF2²

USF1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1556259^1,2	C,F,O,A,	161014649(-)	`TTGTGT/CTGGGA`	2	--	int¹		18		NS NA EA WA	1442
rs1556260^1,2	C,F,O,A,	161014446(-)	`TTGGAG/ATTGTC`	2	--	int¹		25		NA PA NS EA WA	1956
rs2073653^1,2	C,F,O,A,H,	161012760(-)	`TGCCAA/GTGAGT`	2	--	int¹		13		NS EA NA WA	862
rs2073654^1,2	C	161012591(-)	`TAAGAA/CCCCAT`	2	--	int¹		0	--	--	--	--
rs2073655^1,2	C,F,	161012590(-)	`AAGAAC/TCCATC`	2	--	int¹		9		NS EA NA	676
rs2073656^1,2	C,F,	161011355(-)	`CATGAC/GTCTTA`	2	--	int¹		10		EA NS NA	2174
rs2073657^1,2	C,F,A,H	161010791(-)	`tacagG/Atgtga`	2	--	int¹		6		NS NA	102
rs2516837^1,2	C,F,O,A,	161014727(-)	`ATCCAC/TTGAAA`	2	--	int¹		22		EA NS NA WA	1596
rs2516838^1,2	C,F,O,	161014370(-)	`GAAGAG/CGATCC`	2	--	int¹		22		EA NS NA WA	1598
rs2516839^1,2	C,F,O,A,	161013121(-)	`CAGGAA/GATACA`	2	--	ut5¹		19		EU NS EA NA WA	1977

About this table

HapMap Linkage Disequilibrium images for USF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for USF1: --

QIAGEN SeqTarget long-range PCR primers for resequencing USF1

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

USF1 for disorders About GeneDecksing

OMIM: 191523 disorders: 602491

UniProtKB/Swiss-Prot: USF1_HUMAN, P22415

Genetic variations in USF1 are associated with hyperlipidemia combined type 1 (HYPLIP1) [MIM:602491]; also

known as familial combined hyperlipidemia type 1 (FCHL1). HYPLIP1 is characterized by elevated levels of serum total

cholesterol, triglycerides or both, and is observed in about 20% of individuals with premature coronary heart disease

10/17 Novoseek disease relationships for USF1 gene (see all 17)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperlipidemia familial combined	87	48	16531745 (6), 17065663 (2), 15959806 (2), 15976322 (2) (see all 21)
dyslipidemia	38.1	16	20031629 (4), 19910639 (1), 16680034 (1), 19750004 (1) (see all 6)
glioblastoma	21.7	3	12444925 (2), 11776974 (1)
coronary heart disease	17.4	6	18276913 (2), 20031629 (1), 18577828 (1)
immunodeficiency	12	5	7824954 (1), 15767439 (1), 2251256 (1), 11153081 (1) (see all 5)
metabolic disorder	11.9	5	18303204 (1)
carcinoma	2.78	1	17379962 (1)
cardiovascular diseases	0	7	16699592 (2), 15310455 (1), 17885212 (1), 19403457 (1)
niddm	0	3	18593823 (2), 16531745 (1)
cancer lung	0	2	12403649 (2)

About this table

Human Gene Mutation Database (HGMD): USF1
Genetic Association Database (GAD): USF1
Human Genome Epidemiology (HuGE) Navigator: USF1 (26 documents)

Export disorders and mutations for USF1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/315 PubMed articles for USF1 gene, integrated from 7 sources (see all 315):
(articles sorted by number of sources associating them with USF1)

Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity. (PubMed id 14514691)^{1, 5, 7} Ge Y....Taub J.W. (2003)
Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians. (PubMed id 16186412)^{1, 4, 7} Gibson F....Froguel P. (2005)
The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. (PubMed id 16132950)^{1, 4, 7} Ng M.C....Chan J.C. (2005)
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). (PubMed id 14991056)^{1, 2, 7} Pajukanta P.... Peltonen L. (2004)
Upstream transcription factor-1 gene polymorphism is associated with increased adipocyte lipolysis. (PubMed id 15985485)^{1, 4, 7} Hoffstedt J....Arner P. (2005)
Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II. (PubMed id 15175273)^{1, 4, 7} Putt W....Talmud P.J. (2004)
Structure and function of the b/HLH/Z domain of USF. (PubMed id 8306960)^{1, 2, 7} Ferre-D'Amare A.R.... Burley S.K. (1994)
Localization of the gene-encoding upstream stimulatory factor (USF) to human chromosome 1q22-q23. (PubMed id 8486371)^{1, 3, 7} Shieh B.H....Lusis A.J. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Transcription factor USF, expressed during the entire phase of Varicella-zoster virus infection, interacts physically with the major viral transactivator IE62 and plays a significant role in virus replication. (PubMed id 14573800)^{1, 2} Rahaus M.... Wolff M.H. (2003)

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Entrez Gene: 7391	HGNC: 12593	AceView: USF1	Ensembl:ENSG00000158773	euGenes: HUgn7391
ECgene: USF1	H-InvDB: USF1

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