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Aliases & Descriptionsfor USP29 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions ubiquitin specific peptidase 291 2 HOM-TES-84/862 Deubiquitinating enzyme 292 3 ubiquitin-specific processing protease2 Ubiquitin thiolesterase 292 3 ubiquitin thioesterase 292 Ubiquitin-specific-processing protease 292 3 MGC1632662 ubiquitin specific protease 291 MGC1632702 ubiquitin carboxyl-terminal hydrolase 292 EC 3.4.19.123
Export aliases for USP29 gene to outside databases Previous GC identifers: GC19P058538 GC19P058094 GC19P062316 GC19P062331 GC19P057631
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Summariesfor USP29 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor USP29 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the USP29 gene promoter: p53 SRF HNF-1A FOXD3 Other transcription factors Search SABiosciences Chromatin IP Primers for USP29 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for USP29
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.4 USP29 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P053944: view genomic region
(about GC identifiers )
Start:
53,944,257 bp from pter
End:
53,956,044 bp from pter
Size:
11,788 bases
Orientation:
plus strand
1 alternative location : Chr 19+ 57,633,693-57,643,294
RefSeq DNA sequence: NC_000019.9 NT_011109.16
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Proteinsfor USP29 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: UBP29_HUMAN, Q9HBJ7 (See
protein sequence )Recommended Name: Ubiquitin carboxyl-terminal hydrolase 29 Size : 922 amino acids; 104156 DaExplore the universe of human proteins at neXtProt for USP29: NX_Q9HBJ7 Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_065954.1 ENSEMBL proteins: ENSP00000254181 Human Recombinant Proteins 1 Gene Ontology (GO) cellular component term (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND --
About this table
USP29 for ontologies About GeneDecksing Antibodies for USP29: Assays for USP29:
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Protein
Domains/ Familiesfor USP29 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
USP29 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q9HBJ7 ProtoNet protein and cluster: Q9HBJ7
1 Blocks protein family : IPB001394 Ubiquitin thiolesterase UniProtKB/Swiss-Prot: UBP29_HUMAN, Q9HBJ7 Similarity : Belongs to the peptidase C19 family
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Gene Functionfor USP29 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: UBP29_HUMAN, Q9HBJ7 Catalytic activity : Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) Enzyme Number (IUBMB): EC 3.4.19.12
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
About this table
USP29 for ontologies About GeneDecksing Animal Models: 3 MGI phenotypic alleles for Usp29 (no phenotypes)
USP29 for phenotypes About GeneDecksing
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Pathways & Interactionsfor USP29 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
USP29 for pathways About GeneDecksing 1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for USP29 SABiosciences Custom Pathway-Focused PCR Arrays for USP29 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for USP29 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP29 1 Interacting protein for USP29 (Q9HBJ7 1 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006464 protein modification process
NAS -- GO:0006511 ubiquitin-dependent protein catabolic process
IEA --
About this table
USP29 for ontologies About GeneDecksing
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Drugs & Compoundsfor USP29 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for USP29
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Transcriptsfor USP29 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for USP29 gene: NM_020903.2
Additional cDNA sequence: AF124433.1 AF229438.1 AK308285.1 BC130394.1 BC130398.1
1 DOTS entry : DT.40129292
6 AceView cDNA sequences :
NM_020903 AF229438 BX112459 AF124433 AA909508 BU569620
highest scoring ESTs for USP29 :AA909508 AF124433 AF229438 BX112459 BU569620 NM_020903 BC130394 BC130398 DR007229 DB060668 Unigene Cluster for USP29:
Ubiquitin specific peptidase 29 Hs.515632 [show with all ESTs ] Unigene Representative Sequence: NM_020903 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000254181 (uc002qny.2 )
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Expression for USP29 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section USP29 expression in normal and diseased human tissues 1 / 2 / 3
2 probe-sets matching USP29 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
220895_at2 , 3
U133-A
1
0.73
1.00
--
--
NM_020903
0.60
1.00
0.82
1
220895_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
About this table Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAAGTTTGAA SOURCE GeneReport for Unigene cluster: Hs.515632 SABiosciences Custom PCR Arrays for USP29
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Orthologsfor USP29 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for USP29 gene from 3 species
About this table Species with no ortholog for USP29 ENSEMBL Gene Tree for USP29 (if available)
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Paralogsfor USP29 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for USP29 gene USP37 2 USP26 2
USP29 for paralogs About GeneDecksing
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Genomic Variantsfor USP29 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 19 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for USP29 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for USP29: --
QIAGEN SeqTarget long-range PCR primers for resequencing USP29
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Disorders & Mutationsfor USP29 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
USP29 for disorders About GeneDecksing
OMIM: 609546 Export disorders and mutations for USP29 gene to outside databases
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Medical Newsfor USP29 gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor USP29 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 10/19 PubMed articles for USP29 gene, integrated from 7 sources (see all 19 ): (articles sorted by number of sources associating them with USP29) Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. (PubMed id 10958632) 1 , 2 , 7 Kim J.... Stubbs L. (2000) Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346) 1 , 3 Puente X.S.... Lopez-Otin C. (2003) Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732) 1 Sowa M.E....Harper J.W. (2009) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription. (PubMed id 19068137) 7 Kim J.D....Kim J. (2008) Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. (PubMed id 11739384) 7 Li Z.... Wu G. (2002) Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain. (PubMed id 11543637) 7 Kim J.... Stubbs L. (2001) Zinc-finger UBPs: regulators of deubiquitylation. (PubMed id 18603431) 7 Bonnet J....Devys D. (2008) Gender specific differences in levels of DNA methylation at selected loci from human total blood: a tendency toward higher methylation levels in males. (PubMed id 17851693) 7 El-Maarri O....Oldenburg J. (2007) Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway. (PubMed id 16402859) 7 Hu M.... Shi Y. (2006)
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External Searches for USP29 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing USP29 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing USP29 gene
(According to HUGE )
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Specialized Databases showing USP29 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for USP29 gene: Search GeneIP for patents involving USP29 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor USP29 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for USP29
ELISAs and CLIAs for USP29
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