Aliases &
Descriptions
for USP35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin specific peptidase 351 2 | | Ubiquitin thiolesterase 352 3 | | ubiquitin specific protease 351 2 | | ubiquitin carboxyl-terminal hydrolase 352 | | KIAA13721 3 | | ubiquitin thioesterase 352 | | Deubiquitinating enzyme 352 3 | | USP343 | | Ubiquitin-specific-processing protease 352 3 | | EC 3.4.19.123 |
Export aliases for USP35 gene to outside databasesPrevious GC identifers: GC11P078122 GC11P077636 GC11P077626 GC11P077577 GC11P077899 |
Summaries
for USP35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for USP35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP35 gene promoter:
Egr-1 Egr-2 Egr-3 AhR Arnt AP-4 SRF deltaCREB CREB RFX1
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP35
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for USP35  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q13.4USP35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P074197: view genomic region
(about GC identifiers)
Start:
|
74,197,805 bp from pter |
End:
|
74,244,613 bp from pter |
Size:
|
46,809 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr11+ 77,899,958-77,925,753 |
RefSeq DNA sequence:- NC_000011.9 NT_167190.1
|
Proteins
for USP35 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 35 Size: 1018 amino acids; 113405 Da
Sequence caution: Sequence=BAA92610.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Alternative splicing: 2 isoforms: Q9P2H5-1 Q9P2H5-2 Explore the universe of human proteins at neXtProt for USP35: NX_Q9P2H5
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_065849.1
ENSEMBL proteins: ENSP00000263311 ENSP00000400825
Human Recombinant Proteins
Antibodies for USP35:
Assays for USP35: |
Protein
Domains/
Families
for USP35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP35 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P2H5ProtoNet protein and cluster: Q9P2H5 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5Similarity: Belongs to the peptidase C19 family |
Gene Function
for USP35 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5Catalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Enzyme Number (IUBMB): EC 3.4.19.12
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
USP35 for ontologies About GeneDecksing
|
Pathways & Interactions
for USP35 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
USP35 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for USP35
SABiosciences Custom Pathway-Focused PCR Arrays for USP35
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for USP35
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP35
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- |
About this table
USP35 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for USP35
|
Transcripts
for USP35 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for USP35 gene: NM_020798.2 Additional cDNA sequence: AB037793.1 AJ586137.1 AK056231.1 AK301048.1 AK307875.1 BC131489.1 3 DOTS entries: DT.430726 DT.95366881 DT.91896906 24/37 AceView cDNA sequences (see all 37): BQ948121 CA389703 AJ586137 AB037793 BU741911 AA977762 AK056231 AA403190 BU632442 R50743 CA445653 CK904610 BM718319 BM147701 BM068765 AI000900 BM149991 AI694095 BX104206 BE867644 BX478131 CB129491 AI826092 CK904609
 highest scoring ESTs for USP35:AI499814 AA403190 AA977762 AB037793 AI000900 AI694095 AI826092 AI885653 AJ586137 AK056231 Unigene Cluster for USP35: Ubiquitin specific peptidase 35 Hs.531249 [show with all ESTs]Unigene Representative Sequence: NM_020798
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263311(uc001oze.2 uc001ozc.2 uc010rsp.1 uc009yva.1 uc001ozd.2 uc001ozf.2)
ENST00000441408
|
Expression
for USP35 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| USP35 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching USP35 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 74373_at2, 3
|
U95-E |
1 |
0.88 |
1.00 |
1.00 |
1.00 |
AI499814 |
1.00 |
1.00 |
1.00 |
1 |
| 229198_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
AB037793 |
0.80 |
1.00 |
0.91 |
1 |
| 229198_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
USP35 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTCATAAATA
SOURCE GeneReport for Unigene cluster: Hs.531249
UniProtKB/Swiss-Prot: UBP35_HUMAN, Q9P2H5Tissue specificity: Expressed in testis, pancreas and skeletal muscle
SABiosciences Custom PCR Arrays for USP35
|
Orthologs
for USP35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for USP35 gene from 5/6 species (see all 6)
About this table Species with no ortholog for USP35
ENSEMBL Gene Tree for USP35 (if available) |
Paralogs
for USP35 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for USP35 gene
- USP122 USP382 USP12 USP462
USP35 for paralogs About GeneDecksing
|
Genomic Variants
for USP35 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 11 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for USP35 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for USP35
2 CNVs: 6942 48885 | | QIAGEN SeqTarget long-range PCR primers for resequencing USP35 |
|
Disorders & Mutations
for USP35 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP35 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: USP35 (3 documents)
Export disorders and mutations for USP35 gene to outside databases
|
Medical News
for USP35 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for USP35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for USP35 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with USP35)- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2 Quesada V.... Lopez-Otin C. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for USP35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP35 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP35 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for USP35 gene:
Search GeneIP for patents involving USP35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP35 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for USP35 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for USP35 |
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