Aliases &
Descriptions
for USP53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin specific peptidase 531 2 | | inactive ubiquitin carboxyl-terminal hydrolase 532 | | ubiquitin specific protease 531 2 | | DKFZp781E14172 | | KIAA13501 3 | | ubiquitin specific proteinase 532 | | Inactive ubiquitin-specific peptidase 532 3 | | |
Export aliases for USP53 gene to outside databasesPrevious GC identifers: GC04P120590 GC04P120619 GC04P120518 GC04P120380 GC04P120354 GC04P120133 |
Summaries
for USP53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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|
UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8Function: Has no peptidase activity
Gene Wiki entry for USP53 |
Genomic Views
for USP53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP53 gene promoter:
AREB6 MRF-2 GATA-1 MZF-1 POU2F1 Cdc5 FOXJ2 (long isoform) p53 Nkx2-2 ATF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP53
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q26 Ensembl cytogenetic band: 4q26 HGNC cytogenetic band: 4q26USP53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P115855: view genomic region
(about GC identifiers)
Start:
|
115,855,506 bp from pter |
End:
|
115,938,506 bp from pter |
Size:
|
83,001 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr4+ 120,133,742-120,216,672 |
RefSeq DNA sequence:- NC_000004.11 NT_016354.19
|
Proteins
for USP53 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8 (See
protein sequence)Recommended Name: Inactive ubiquitin carboxyl-terminal hydrolase 53 Size: 1073 amino acids; 120806 Da
Caution: Although the active site residues are conserved, lacks the conserved His residue which is normally found 9residues before the catalytic His
Sequence caution: Sequence=AAH17382.1; Type=Erroneous initiation;
Secondary accessions: Q68DA5 Q8WVQ5 Q9P2J7Explore the universe of human proteins at neXtProt for USP53: NX_Q70EK8
REFSEQ proteins: NP_061923.2
ENSEMBL proteins: ENSP00000274030 ENSP00000426628 ENSP00000421729 ENSP00000409906
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
About this table
USP53 for ontologies About GeneDecksing
Antibodies for USP53:
Assays for USP53: |
Protein
Domains/
Families
for USP53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP53 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q70EK8ProtoNet protein and cluster: Q70EK8 1 Blocks protein family: IPB001394 Ubiquitin thiolesterase
UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8Similarity: Belongs to the peptidase C19 family |
Gene Function
for USP53 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8Function: Has no peptidase activity
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004221 | NOT ubiquitin thiolesterase activity |
IDA | 14715245 |
About this table
USP53 for ontologies About GeneDecksing
|
Pathways & Interactions
for USP53 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
USP53 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for USP53
SABiosciences Custom Pathway-Focused PCR Arrays for USP53
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for USP53
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for USP53
1 Interacting protein for USP53 (Q70EK82) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
About this table
USP53 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for USP53
|
Transcripts
for USP53 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for USP53 gene: NM_019050.2 Additional cDNA sequence: AF085848.1 14 DOTS entries: DT.111329 DT.306580 DT.92018936 DT.70104947 DT.97773968 DT.121219552 DT.70101570 DT.100677745 DT.100711131 DT.100672396 DT.121219505 DT.75137146 DT.91808629 DT.91951234 24/124 AceView cDNA sequences (see all 124): AI382521 BX648339 AI918463 AA398081 BQ694947 BM978590 BM699374 AA299360 AA653470 BM670031 AB037771 AJ583824 BX095809 R70063 AI276062 AI567034 AW264205 AA394189 AA319736 CD244970 BX496884 BX108691 BU568370 BX113891
 highest scoring ESTs for USP53:AA299360 AA394189 AA398081 AB037771 AI276062 AK022799 AK025233 AU126986 BC017382 BE005079 Unigene Clusters for USP53: Ubiquitin specific peptidase 53 Hs.431081 [show with all ESTs], Hs.595368 [show with all ESTs]Unigene Representative Sequences: NM_019050, BX113891
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for USP53
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | |
About this scheme
ECgene alternative splicing isoforms for USP53
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514665 ENST00000274030 ENST00000507597 ENST00000514305 ENST00000510737
ENST00000509769 ENST00000507906 ENST00000510852(uc003ict.2) ENST00000450251(uc003ics.3 uc003icr.3 uc003icu.3)
|
Expression
for USP53 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| USP53 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching USP53 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 58414_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.95 |
1.30 |
AI276062 |
0.80 |
1.00 |
0.91 |
1 |
| 58003_at2, 3
|
U95-B |
1 |
0.81 |
1.00 |
0.97 |
1.47 |
AA504253 |
0.20 |
1.00 |
0.72 |
1 |
| 49919_at2, 3
|
U95-C |
1 |
0.50 |
1.00 |
0.77 |
0.37 |
AI201014 |
0.60 |
1.00 |
0.82 |
1 |
| 82370_at2, 3
|
U95-E |
1 |
0.38 |
1.00 |
0.87 |
0.92 |
AI081118 |
0.40 |
0.50 |
0.45 |
1 |
| 231817_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
H25097 |
0.60 |
1.00 |
0.82 |
1 |
| 230083_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AW188464 |
0.20 |
1.00 |
0.72 |
1 |
| 231817_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 230083_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
USP53 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGAAATCAAT
SOURCE GeneReport for Unigene clusters: Hs.431081 Hs.595368
UniProtKB/Swiss-Prot: UBP53_HUMAN, Q70EK8Tissue specificity: Expressed predominantly in skeletal muscle and heart
SABiosciences Custom PCR Arrays for USP53
|
Orthologs
for USP53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for USP53 gene from 5/7 species (see all 7)
About this table Species with no ortholog for USP53
ENSEMBL Gene Tree for USP53 (if available) |
Paralogs
for USP53 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for USP53 gene
- USP542
USP53 for paralogs About GeneDecksing
|
Genomic Variants
for USP53 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 4 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for USP53 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for USP53
1 Indel: 46496 |
Disorders & Mutations
for USP53 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP53 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: USP53 (1 document)
Export disorders and mutations for USP53 gene to outside databases
|
Medical News
for USP53 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for USP53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for USP53 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with USP53)- Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. (PubMed id 14715245)1, 2, 3 Quesada V.... Lopez-Otin C. (2004)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
- A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts. (PubMed id 15851553)1 Ozyildirim A.M....Laurie G.W. (2005)
|
External Searches for USP53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP53 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP53 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for USP53 gene:
Search GeneIP for patents involving USP53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP53 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for USP53 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for USP53 |
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