Aliases &
Descriptions
for USP8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| ubiquitin specific peptidase 81 2 | | Ubiquitin isopeptidase Y2 3 | | KIAA00551 2 3 | | hUBPy2 3 | | UBPY1 2 3 | | ubiquitin carboxyl-terminal hydrolase 82 | | ubiquitin specific protease 81 2 | | FLJ344562 | | HumORF81 2 | | ubiquitin thioesterase 82 | | Ubiquitin thiolesterase 82 3 | | MGC1297182 | | Deubiquitinating enzyme 82 3 | | EC 3.4.19.123 | | Ubiquitin-specific-processing protease 82 3 | | |
Export aliases for USP8 gene to outside databasesPrevious GC identifers: GC15P046273 GC15P043762 GC15P048295 GC15P048432 GC15P048503 GC15P050716 |
Summaries
for USP8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818Function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory roleat the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitinchains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phasein response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complexcontaining RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitindynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level ofprotein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. DeubiquitinatesEPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradationand downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complexand microtubules
Gene Wiki entry for USP8 |
Genomic Views
for USP8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the USP8 gene promoter:
CUTL1 Pax-2 Pax-6 POU2F1 Cart-1 p53 GATA-1 ER-alpha XBP-1 ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for USP8
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for USP8  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q21.2 Ensembl cytogenetic band: 15q21.2 HGNC cytogenetic band: 15q21.1USP8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P027548: view genomic region
(about GC identifiers)
Start:
|
27,547,372 bp from pter |
End:
|
27,623,683 bp from pter |
Size:
|
76,312 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr15+ 50,716,579-50,793,280 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for USP8 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818 (See
protein sequence)Recommended Name: Ubiquitin carboxyl-terminal hydrolase 8 Size: 1118 amino acids; 127523 Da
Subunit: Forms a ternary complex with RNF128 and OTUB1. Interacts (via C-terminal UCH catalytic domain) with OTUB1isoform 1. Interacts with STAM2 (via SH3 domain). Interacts with DNAJB3, EGFR, EPS15, RASGRF1, RNF41, YWHAE, YWHAG andYWHAZ (By similarity). Interacts with NBR1, RASGRF1, RNF41 and IST1. Associates with the ESCRT-0 complex and withmicrotubules (By similarity)
Subcellular location: Cytoplasm. Nucleus (By similarity). Endosome membrane; Peripheral membrane protein. Cellmembrane; Peripheral membrane protein
Sequence caution: Sequence=AAH38801.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAH51345.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
PDB structures from  and Proteopedia  :1WHB (3D)
2A9U (3D)
2GFO (3D)
2GWF (3D)
3N3K (3D)
Secondary accessions: Q2TB31 Q7Z3U2 Q86VA0 Q8IWI7Explore the universe of human proteins at neXtProt for USP8: NX_P40818
Post-translational modifications:
Phosphorylation of Ser-718 is essential for interaction with YWHAE and for cytosol localization (By similarity).Undergoes dephosphorylation at Ser-718 in the M phase (By similarity). Tyrosine-phosphorylated in its N-terminal halfin an EGFR-dependent manner (By similarity)1
Ubiquitinated. Inactive form is mostly monoubiquitinated, but polyubiquitination happens too. Ubiquitination isincreased in EGF-stimulated cells. Ubiquitination of active form is undetectable, suggesting a possibility that USP8deubiquitinates itself, thereby regulating its own function (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001122082.1 NP_001122083.1 NP_005145.3
ENSEMBL proteins: ENSP00000379721 ENSP00000408491 ENSP00000302239 ENSP00000379717 ENSP00000405537 ENSP00000412682
Human Recombinant Proteins
5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8): About this table
USP8 for ontologies About GeneDecksing
Antibodies for USP8:
Assays for USP8: |
Protein
Domains/
Families
for USP8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
USP8 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P40818ProtoNet protein and cluster: P40818 3 Blocks protein families: IPB001394 Ubiquitin thiolesterase IPB001448 Small acid-soluble spore protein IPB001763 Rhodanese-like
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818Domain: The MIT domain is required for endosomal localization, CHMP1B-binding, maintenance of ESCRT-0 stability andEGFR degradationDomain: The rhodanese domain is sufficent for RNF41-binding (By similarity)Similarity: Belongs to the peptidase C19 familySimilarity: Contains 1 MIT domainSimilarity: Contains 1 rhodanese domain |
Gene Function
for USP8 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UBP8_HUMAN, P40818Function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory roleat the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitinchains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phasein response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complexcontaining RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitindynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level ofprotein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. DeubiquitinatesEPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradationand downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complexand microtubulesCatalytic activity: Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by theC-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)Induction: Upon growth stimulation in starved human fibroblasts. Decreases in response to growth arrest induced bycell-cell contactEnzyme Number (IUBMB): EC 3.4.19.12
Genatlas biochemistry entry for USP8:ubiquitin specific protease 8,similar to the tre oncogene,with homology to ubiquitin carboxy-terminalhydrolase,deubiquitin enzyme family5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7): About this table
USP8 for ontologies About GeneDecksing
Animal Models: 7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Usp8):
USP8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for USP8 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
USP8 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for USP8
1  Kegg Pathway (Kegg details for USP8):
SABiosciences Custom Pathway-Focused PCR Arrays for USP8
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for USP8
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for USP8
5/20 Interacting proteins for USP8 (P408181, 2 ENSP000003022393) via UniProtKB, MINT, and/or STRING (see all 20)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| YWHAZ | P631041, 2 | EBI-1050865,EBI-347088 MINT-3318133 MINT-51011 | | CHMP1A | Q9HD421, 2 | EBI-1050865,EBI-1057156 MINT-6946783 | | CHMP1B | Q7LBR11, 2 | EBI-1050865,EBI-2118090 MINT-6946799 | | CHMP4C | Q96CF21, 2 | EBI-1050865,EBI-1221015 MINT-6946888 | | YWHAB | P319461, 2 | EBI-1050865,EBI-359815 MINT-50951 |
About this table
5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8): About this table
USP8 for ontologies About GeneDecksing
|
Drugs & Compounds
for USP8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
USP8 for compounds About GeneDecksing
 Browse Tocris compounds for USP8
1  Novoseek chemical compound relationship for USP8 gene
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
26.7 |
1 |
14646586 (1) |
About this table
|
Transcripts
for USP8 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for USP8 gene (3 alternative transcripts): NM_001128610.1 NM_001128611.1 NM_005154.3 Additional cDNA sequence: AK090830.1 AK292400.1 AK296480.1 AK300590.1 BC015545.1 BC026954.1 BC038801.1 BC051345.1 BC062694.1 BC092443.1 BC110590.2 BX537420.1 D29956.1 17 DOTS entries: DT.101983565 DT.117668 DT.444526 DT.121045161 DT.95276438 DT.95276444 DT.121045139 DT.102841822 DT.95290024 DT.92437210 DT.100795148 DT.121045147 DT.121045187 DT.121045207 DT.121310784 DT.95276440 DT.95276443 24/277 AceView cDNA sequences (see all 277): AA291439 BI256314 BQ232715 AA149437 AA453876 AI222503 BC051345 AI915940 AK091775 AI973154 BQ008106 AI812012 CN481560 AA446489 AA773709 AI479489 AI655860 AA235847 CB143520 BQ425745 AA773713 BP379003 BQ943006 BF435143
 highest scoring ESTs for USP8:D29956 AA149437 AA250865 AA401886 AA421355 AA443908 AA444094 AA446309 AA446489 AA496689 Unigene Cluster for USP8: Ubiquitin specific peptidase 8 Hs.443731 [show with all ESTs]Unigene Representative Sequence: NM_001128611
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for USP8 (see all 9)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19 | ^ | 20 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for USP8
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000396444 ENST00000419830 ENST00000307179 ENST00000396440 ENST00000433963(uc001zyk.1 uc001zym.3 uc001zyl.3 uc001zyn.3 uc010ufh.1 uc010bev.1 uc001zyp.3)
ENST00000425032
|
Expression
for USP8 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| USP8 expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching USP8 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 43467_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.61 |
0.91 |
N23022 |
0.40 |
1.00 |
0.76 |
1 |
| 50904_g_at2
|
U95-C |
1 |
1.00 |
1.00 |
0.87 |
0.92 |
-- |
-- |
-- |
-- |
-- |
| 39794_at2, 3
|
U95-A |
1 |
1.00 |
1.00 |
0.67 |
1.19 |
D29956 |
1.00 |
0.90 |
0.95 |
1 |
| 229501_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AI393759 |
0.40 |
1.00 |
0.76 |
1 |
| 202745_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_005154 |
0.60 |
1.00 |
0.82 |
1 |
| 229501_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 202745_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
USP8 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CATATAGCCT
SOURCE GeneReport for Unigene cluster: Hs.443731
Expression variation in blood from EXPOLDB for USP8 SABiosciences Custom PCR Arrays for USP8
|
Orthologs
for USP8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for USP8 gene from 5/14 species (see all 14)
About this table Species with no ortholog for USP8
ENSEMBL Gene Tree for USP8 (if available) |
Paralogs
for USP8 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for USP8 gene
- LOC7283792 ENSG000002509132 USP17L6P2 USP422 LOC7283932 LOC7284052 LOC1002872052 USP17L32
- LOC1002871442 USP22 LOC1002874412 LOC1002873642 USP17L82 USP17L22 LOC1002874782 LOC7284002
- USP172 LOC1002875132 USP502 USP17L1P2 LOC1002885202 LOC7284192 LOC1002874042 USP17L72
- USP17L42 LOC1002871782 LOC1002873272 USP362 USP212 LOC1002872382 LOC7283692 USP17L52
USP8 for paralogs About GeneDecksing
Pseudogenes
- 1 related pseudogene
|
Genomic Variants
for USP8 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for USP8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for USP8
2 CNVs: 53349 29644
1 Indel: 25526 | | QIAGEN SeqTarget long-range PCR primers for resequencing USP8 |
|
Disorders & Mutations
for USP8 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
USP8 for disorders About GeneDecksing
OMIM: 603158
Export disorders and mutations for USP8 gene to outside databases
|
Medical News
for USP8 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for USP8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/44 PubMed articles for USP8 gene, integrated from 7 sources (see all 44):
(articles sorted by number of sources associating them with USP8)- Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). (PubMed id 17035239)1, 2, 7 Avvakumov G.V.... Dhe-Paganon S. (2006)
- The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. (PubMed id 17711858)1, 2 Row P.E....Urbe S. (2007)
- The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. (PubMed id 16520378)1, 2 Row P.E....Urbe S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human and mouse proteases: a comparative genomic approach. (PubMed id 12838346)1, 3 Puente X.S.... Lopez-Otin C. (2003)
- UBPY: a growth-regulated human ubiquitin isopeptidase. (PubMed id 9628861)1, 2 Naviglio S.... Draetta G.F. (1998)
- An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme. (PubMed id 9582025)1, 3 Janssen J.W.G.... Schulz A.S. (1998)
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
- 14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase. (PubMed id 17720156)1, 7 Mizuno E....Komada M. (2007)
- Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. (PubMed id 15314180)1, 7 Wu X....Carraway K.L. (2004)
|
External Searches for USP8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing USP8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing USP8 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing USP8 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for USP8 gene:
Search GeneIP for patents involving USP8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for USP8 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
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| | |
 |  |  |  | |
| |  | Search Tocris compounds for USP8 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for USP8 |
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