Aliases &
Descriptions
for UTF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| undifferentiated embryonic cell transcription factor 11 2 |
Export aliases for UTF1 gene to outside databasesPrevious GC identifers: GC10P133958 GC10P134173 GC10P134959 GC10P134517 GC10P134932 GC10P135043 |
Summaries
for UTF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230Function: Acts as a transcriptional coactivator of ATF2
|
Genomic Views
for UTF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UTF1 gene promoter:
AhR Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for UTF1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for UTF1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26UTF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P128590: view genomic region
(about GC identifiers)
Start:
|
128,590,264 bp from pter |
End:
|
128,591,548 bp from pter |
Size:
|
1,285 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr10+ 135,043,778-135,045,062 |
RefSeq DNA sequence:- NC_000010.10 NT_008818.16
|
Proteins
for UTF1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230 (See
protein sequence)Recommended Name: Undifferentiated embryonic cell transcription factor 1 Size: 341 amino acids; 36439 Da
Subunit: Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAT38949.1; Type=Erroneous initiation;
Secondary accessions: O75833 Q6J1H3Explore the universe of human proteins at neXtProt for UTF1: NX_Q5T230
Post-translational modifications:
Phosphorylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003568.2
ENSEMBL proteins: ENSP00000305906
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): About this table
UTF1 for ontologies About GeneDecksing
Antibodies for UTF1:
Assays for UTF1: |
Protein
Domains/
Families
for UTF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5T230 UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230Domain: The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein isable to stimulate transcription from a number of gene promoters (By similarity) |
Gene Function
for UTF1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: UTF1_HUMAN, Q5T230Function: Acts as a transcriptional coactivator of ATF2
Genatlas biochemistry entry for UTF1:undifferentiated embryonic cell transcription factor 1 from the mouse F9 teratocarcinoma cell line,homolog,potentiatingATF-2 (activating transcription factor)-2 activity3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
UTF1 for ontologies About GeneDecksing
|
Pathways & Interactions
for UTF1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
UTF1 for pathways About GeneDecksing
1  Millipore Pathway for UTF1
2  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for UTF1
SABiosciences Pathway-Focused PCR Array including UTF1: PAHS-081A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for UTF1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UTF1
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
UTF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for UTF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for UTF1
|
Transcripts
for UTF1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for UTF1 gene: NM_003577.2 Additional cDNA sequence: AB011076.2 AY606112.1 1 DOTS entry: DT.91745164 3 AceView cDNA sequences: AY606112 NM_003577 AB011076
 highest scoring ESTs for UTF1:AB011076 AY606112 NM_003577 Unigene Cluster for UTF1: Undifferentiated embryonic cell transcription factor 1 Hs.458406 Unigene Representative Sequence: AB011076
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000304477(uc001lmc.2)
|
Expression
for UTF1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| UTF1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching UTF1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 31393_r_at2, 3
|
U95-A |
1 |
0.31 |
1.00 |
1.00 |
1.00 |
AB011076 |
1.00 |
1.00 |
1.00 |
1 |
| 208275_x_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
NM_003577 |
0.60 |
1.00 |
0.82 |
1 |
| 208275_x_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
UTF1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGGCTGCTGG
SOURCE GeneReport for Unigene cluster: Hs.458406
Expression variation in blood from EXPOLDB for UTF1 SABiosciences Expression via Pathway-Focused PCR Array including UTF1: PAHS-081A
|
Orthologs
for UTF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UTF1 gene from 1 species
About this table Species with no ortholog for UTF1
ENSEMBL Gene Tree for UTF1 (if available) |
Paralogs
for UTF1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for UTF1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for UTF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for UTF1
9 CNVs: 2896 4723 4721 30525 5272 29879 4722 5273 3829 | | QIAGEN SeqTarget long-range PCR primers for resequencing UTF1 |
|
Disorders & Mutations
for UTF1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UTF1 for disorders About GeneDecksing
OMIM: 604130
Human Gene Mutation Database (HGMD): UTF1
Export disorders and mutations for UTF1 gene to outside databases
|
Medical News
for UTF1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for UTF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
9 PubMed articles for UTF1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with UTF1)- Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. (PubMed id 9748258)1, 2, 3 Fukushima A....Muramatsu M. (1998)
- Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. (PubMed id 18281244)1, 3 Kristensen D.M....Leffers H. (2008)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- Expression of UTF1 in primary and metastatic testicul ar germ cell tumors. (PubMed id 20855642)1 Wang P....Cao D. (2010)
- Functional characterization of single-nucleotide poly morphisms in the human undifferentiated embryonic-cell transcription factor 1 g ene. (PubMed id 20218897)1 Thummer R.P....Eggen B.J. (2010)
- Two supporting factors greatly improve the efficiency of human iPSC generation. (PubMed id 18983962)1 Zhao Y....Deng H. (2008)
- The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. (PubMed id 16582099)1 Wissmuller S....Wegner M. (2006)
- Structural analyses of the UTF1 gene encoding a transcriptional coactivator expressed in pluripotent embryonic stem cells. (PubMed id 11467843)1 Nishimoto M....Okuda A. (2001)
- UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. (PubMed id 9524124)1 Okuda A....Muramatsu M. (1998)
|
External Searches for UTF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UTF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UTF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UTF1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UTF1 gene:
Search GeneIP for patents involving UTF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UTF1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 | Antibodies & Assays for UTF1 |
| | | | Search Tocris compounds for UTF1 |
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 | | | ELISAs and CLIAs for UTF1 |
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