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VAPA Gene

protein-coding GIFtS: 62

GC18P009904

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
(Previous name: VAMP (vesicle-associated membrane protein)-associated protein A (33kD) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa¹ ²		33 kDa VAMP-associated protein² ³
VAP-A¹ ² ³		VAP-33² ³
VAP33² ³ ⁵		VAMP (vesicle-associated membrane protein)-associated protein A (33kD)¹
hVAP-33¹ ²		vesicle-associated membrane protein-associated protein A²
VAMP-A² ³		MGC3745²
VAMP-associated protein A² ³

External Ids:	HGNC: 12648¹	Entrez Gene: 9218²	Ensembl: ENSG00000101558⁷	UniProtKB: Q9P0L0³

Export aliases for VAPA gene to outside databases

Previous GC identifers: GC18P010047 GC18P009903

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAPA:

The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular

vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane

fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript

variants encoding distinct isoforms have been identified. (provided by RefSeq)

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0

Function: May play a role in vesicle trafficking

Gene Wiki entry for VAPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VAPA gene promoter:
         Fra-1   c-Fos   JunB   JunD   c-Jun   AP-1   Arnt   AhR   NF-E2 p45   NF-E2
         Other transcription factors

Search SABiosciences Chromatin IP Primers for VAPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for VAPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.22 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.2

VAPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAPA gene location

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P009904: view genomic region (about GC identifiers)

Start:	9,893,891 bp from pter
End:	9,960,018 bp from pter
Size:	66,128 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.9 NT_010859.14

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0 (See protein sequence)

Recommended Name: Vesicle-associated membrane protein-associated protein A

Size: 249 amino acids; 27893 Da

Subunit: Homodimer, and heterodimer with VAPB. Interacts with VAMP1, VAMP2, STX1A, BET1, SEC22C and with the C-terminal

domain of OCLN. Interacts with OSBPL1A

Subcellular location: Cell membrane; Single-pass type IV membrane protein. Endomembrane system; Single-pass type IV

membrane protein. Note=Present in the plasma membrane and in intracellular vesicles, together with SNARE proteins. May

also associate with the cytoskeleton. Colocalizes with OCLN at the tight junction in polarized epithelial cells

Sequence caution: Sequence=AAD09742.1; Type=Erroneous initiation; Sequence=AAF72105.1; Type=Erroneous initiation;

Sequence=BG488667; Type=Frameshift; Positions=72, 207, 241;

PDB structures from and Proteopedia :

2RR3 (3D)

Secondary accessions: A6NDZ0 O75453 Q5U0E7 Q9UBZ2

Alternative splicing: 2 isoforms: Q9P0L0-1 Q9P0L0-2

Explore the universe of human proteins at neXtProt for VAPA: NX_Q9P0L0

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_003565.4 NP_919415.2

ENSEMBL proteins:

ENSP00000345656 ENSP00000382880

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: VAPA OriGene Protein Over-expression Lysate: VAPA
	GenScript Custom Purified and Recombinant Proteins Services for VAPA
	Novus Biologicals Proteins for VAPA
	Novus Biologicals Lysates for VAPA
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for VAPA

5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005783	endoplasmic reticulum	IDA	18029348
GO:0005789	endoplasmic reticulum membrane	TAS	--
GO:0005874	microtubule	--	--
GO:0005886	plasma membrane	IDA	10523508

About this table

VAPA for ontologies About GeneDecksing

Antibodies for VAPA:

	Millipore Mono- and Polyclonal Antibodies for the study of VAPA
	Sigma-Aldrich Antibodies for VAPA
	R&D Systems Antibodies for VAPA (VAP-A)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for VAPA
	Novus Biologicals Antibodies for VAPA
	Epitomics antibodies for VAPA

Assays for VAPA:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VAPA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VAPA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VAPA for domains About GeneDecksing

3 InterPro domains/families:

IPR008962 PapD-like

IPR000535 Major_sperm

IPR016763 Vesicle-associated_membrane

Graphical View of Domain Structure for InterPro Entry Q9P0L0

ProtoNet protein and cluster: Q9P0L0

1 Blocks protein family: IPB000535 Major sperm protein (MSP) domain

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0

Similarity: Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family

Similarity: Contains 1 MSP domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0

Function: May play a role in vesicle trafficking

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VAPA Sigma-Aldrich shRNA for VAPA
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): VAPA OriGene shRNA RFP (see all 3): VAPA OriGene basic RS shRNA (see all 3): VAPA OriGene siRNA (see all 2): VAPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VAPA

miRNA:		Sigma-Aldrich microRNA Mimics for VAPA Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VAPA
		8/36 SABiosciences Assays for microRNAs that regulate VAPA (see all 36):
		hsa-miR-300 hsa-miR-485-3p hsa-miR-519a hsa-miR-508-3p hsa-miR-548m hsa-miR-23a hsa-miR-520g hsa-miR-330-3p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): VAPA OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): VAPA OriGene untagged cDNA clones in CMV expression vector (see all 5): VAPA OriGene 3'-UTR clone (see all 2): VAPA Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for VAPA
		Sino Biological Human cDNA Clone for VAPA

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for VAPA

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004871	signal transducer activity	IMP	12761501
GO:0005198	structural molecule activity	IEA	--
GO:0005515	protein binding	IPI	16895911
GO:0046982	protein heterodimerization activity	IPI	9920726

About this table

VAPA for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

VAPA for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for VAPA

Tight Junction Signaling

1 Kegg Pathway (Kegg details for VAPA):

hsa04530 Tight junction

SABiosciences Pathway-Focused PCR Array including VAPA: PAHS-023A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for VAPA

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VAPA

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006665	sphingolipid metabolic process	TAS	--
GO:0006944	cellular membrane fusion	TAS	9657962
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IMP	12761501

About this table

VAPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

VAPA for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VAPA
2 Novoseek chemical compound relationships for VAPA gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
lipid	12.5	3	16691359 (1), 19515777 (1), 15212954 (1)
cholesterol	2.65	3	16173481 (1), 20178991 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VAPA Sigma-Aldrich shRNA for VAPA
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): VAPA OriGene shRNA RFP (see all 3): VAPA OriGene basic RS shRNA (see all 3): VAPA OriGene siRNA (see all 2): VAPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VAPA

miRNA:		Sigma-Aldrich microRNA Mimics for VAPA Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VAPA
		8/36 SABiosciences Assays for microRNAs that regulate VAPA (see all 36):
		hsa-miR-300 hsa-miR-485-3p hsa-miR-519a hsa-miR-508-3p hsa-miR-548m hsa-miR-23a hsa-miR-520g hsa-miR-330-3p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): VAPA OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): VAPA OriGene untagged cDNA clones in CMV expression vector (see all 5): VAPA OriGene 3'-UTR Clone (see all 2): VAPA Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for VAPA

Primers:		OriGene genome-wide validated SYBR primer pairs: VAPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for VAPA: PPH06290A

REFSEQ mRNAs for VAPA gene (2 alternative transcripts):

NM_003574.5 NM_194434.2

Additional cDNA sequence:

AF044670.1 AF057358.1 AF086627.1 AF154847.1 AK024299.1 AK096868.1 AK292948.1 AK315577.1

BC002992.1 BC033947.2 BC042860.1 BT019618.1 CR592788.1 CR595148.1 CR607357.1 CR610939.1

CR615746.1 CR616989.1 CR624715.1 CR626025.1 CR626388.1

24 DOTS entries:

DT.442809 DT.439881 DT.95168871 DT.91964878 DT.95168881 DT.40316651 DT.418692 DT.441566

DT.100881374 DT.91665525 DT.100682134 DT.121089512 DT.91765601 DT.100741929 DT.111436 DT.121089546

DT.121089547 DT.121089558 DT.75154841 DT.85105060 DT.95168872 DT.100881377 DT.121089561 DT.95168883

24/598 AceView cDNA sequences (see all 598):

CA421447 CD171781 BM847176 AA724285 CR615746 CR626025 CR624715 AA553414

Z42683 AA969237 AI276053 AA910010 BF447534 AA897496 CR610939 CR592788

AI469498 BM802464 BC033947 AW275936 AA887602 CR616989 CA419557 CF272527

highest scoring ESTs for VAPA:

AI742846 W95894 AA033624 AA127848 AA136130 AA166921 AA169201 AA169658 AA287076 AA287077

Unigene Cluster for VAPA:

VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa

Hs.165195 [show with all ESTs]

Unigene Representative Sequence: NM_003574

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for VAPA (see all 8)

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9a	·	9b	·	9c	·	9d
SP1:									-		-		-				-						-				-
SP2:									-		-		-				-						-
SP3:											-		-				-						-				-
SP4:																	-						-				-
SP5:									-				-				-

About this scheme

ECgene alternative splicing isoforms for VAPA
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340541 ENST00000400000(uc002koj.2 uc002kok.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

VAPA expression in normal and diseased human tissues

¹ / ² / ³

17 probe-sets matching VAPA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
89329_at²^{, 3}	U95-E	1	1.00	1.00	0.83	1.38	AI985653	0.80	1.00	0.91	1
54663_at²^{, 3}	U95-B	1	0.88	1.00	0.73	1.32	H17359	0.80	1.00	0.91	1
63624_at²^{, 3}	U95-C	1	0.75	1.00	0.77	0.91	AI253177	0.80	1.00	0.91	1
38801_at²^{, 3}	U95-A	1	0.62	1.00	0.49	1.51	AI742846	1.00	1.00	1.00	1
88498_at²^{, 3}	U95-E	1	0.62	1.00	0.84	0.72	W95894	1.00	1.00	1.00	1
46029_r_at²^{, 3}	U95-B	1	0.56	1.00	0.50	0.39	AI671488	0.80	1.00	0.91	1
80694_at*²^{, 3}	U95-D	1	--	--	0.47	0.89	AI332536	0.60	1.00	0.82	1
225198_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AL571942	0.60	1.00	0.82	1
228480_at²^{, 3}	U133-B	1	0.64	1.00	--	--	AW296039	0.60	1.00	0.82	1
208780_x_at²^{, 3}	U133-A	1	0.64	1.00	--	--	AF154847	0.80	0.88	0.84	1
239750_x_at²^{, 3}	U133-B	1	0.55	1.00	--	--	AI671488	0.80	1.00	0.91	1
242780_at*²^{, 3}	U133-B	NULL	0.00	0.00	--	--	AI332536	0.60	1.00	0.82	1
225198_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228480_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
208780_x_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
239750_x_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--
242780_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

VAPA for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

VAPA gene electronic northern expression

About these images

CGAP SAGE TAG: GTATTTAACA

SOURCE GeneReport for Unigene cluster: Hs.165195

Expression variation in blood from EXPOLDB for VAPA

UniProtKB/Swiss-Prot: VAPA_HUMAN, Q9P0L0

Tissue specificity: Ubiquitous

Primers:		OriGene genome-wide validated SYBR primer pairs: VAPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for VAPA: PPH06290A

SABiosciences Expression via Pathway-Focused PCR Array including VAPA: PAHS-023A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VAPA gene from 5/11 species (see all 11)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VAPA¹	--	VAMP (vesicle-associated membrane protein)-associated more	93.88(n) 95.58(a)	480208 XM_537332.2 XP_537332.1
chimpanzee (Pan troglodytes)	VAPA¹	--	VAMP (vesicle-associated membrane protein)-associated more	99.77(n) 100(a)	455288 XM_512022.2 XP_512022.2
cow (Bos taurus)	VAPA¹	--	VAMP (vesicle-associated membrane protein)-associated more	88.49(n) 95.18(a)	516024 NM_001075733.1 NP_001069201.1
rat (Rattus norvegicus)	Vapa¹	--	VAMP (vesicle-associated membrane protein)-associated more	91.74(n) 96.69(a)	58857 NM_031631.2 NP_113819.2
mouse (Mus musculus)	Vapa^{1 , 5}	17 (34.90 cM)⁵	vesicle-associated membrane protein, associated protein more^{1, 5}	93.71(n)¹ 97.19(a)¹	30960¹ NM_013933.2¹ NP_038961.2¹ AA608327⁵ AF115503⁵ (see all 16)

About this table Species with no ortholog for VAPA

ENSEMBL Gene Tree for VAPA (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VAPA gene

VAPB²

VAPA for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs3069^1,2	C,F,A,	9959493(+)	`AACCTA/GCAAGA`	2	--	ut3¹ ese³		23	NA EA MN NS WA	1694
rs3070^1,2	C,F,A,	9958522(-)	`caattA/Ttcttt`	2	--	ut3¹		12	MN NS EA NA WA	818
rs28212^1,2	C,F,A,	9959882(-)	`TTTTGA/GATTAA`	2	--	ut3¹		21	NA MN NS EA WA	1619
rs28804^1,2	C,F,O,A,	9950744(-)	`CAGCAA/GTGAGA`	2	--	int¹		15	NS EA NA WA	1190
rs29066^1,2	C,F,A,	9959635(+)	`TGTTAT/CGTACT`	2	--	ut3¹		13	NA EA MN NS WA	798
rs29067^1,2	C,F,O,A,	9957918(-)	`CGAAGA/CAGCGT`	2	--	ut3¹ ese³		22	NS EA NA WA	2868
rs29068^1,2	C,F,A,H,	9957573(-)	`CCCTCT/GAATAA`	2	--	ut3¹ ese³		22	EA NA MN NS WA	1170
rs29069^1,2	C,F,O,A,	9955960(-)	`CTGCAC/TTTATG`	2	--	ut3¹		20	EA NA NS WA	1254
rs29070^1,2	C,F,H,	9949382(-)	`GTGATT/CTGATT`	2	--	int¹		13	NS EA NA WA	1052
rs29071^1,2	C,F,O,A,H,	9949113(-)	`TATTTC/TACCCT`	2	--	int¹		11	EA NA WA	438

About this table

HapMap Linkage Disequilibrium images for VAPA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for VAPA
1 CNV: 73103
2 Indels: 41368 45722

QIAGEN SeqTarget long-range PCR primers for resequencing VAPA

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VAPA for disorders About GeneDecksing

OMIM: 605703

3 Novoseek disease relationships for VAPA gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis c	40.8	1	19515777 (1)
pneumonia	26.6	1	16173481 (1)
aids	15.9	1	9041424 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: VAPA (2 documents)

Export disorders and mutations for VAPA gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/45 PubMed articles for VAPA gene, integrated from 7 sources (see all 45):
(articles sorted by number of sources associating them with VAPA)

Identification of a human homologue of the vesicle-associated membrane protein (VAMP)-associated protein of 33 kDa (VAP-33): a broadly expressed protein that binds to VAMP. (PubMed id 9657962)^{1, 2, 3, 7} Weir M.L.... Trimble W.S. (1998)
Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. (PubMed id 9920726)^{1, 2, 3, 7} Nishimura Y.... Tanaka T. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
VAP-A binds promiscuously to both v- and tSNAREs. (PubMed id 11511104)^{1, 2} Weir M.L.... Trimble W.S. (2001)
VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction. (PubMed id 10523508)^{1, 2} Lapierre L.A.... Anderson J.M. (1999)
Association between polymorphisms in the vesicle-associated membrane protein-associated protein A (VAPA) gene on chromosome 18p and bipolar disorder. (PubMed id 18665321)^{1, 7} Lohoff F.W....Berrettini W.H. (2008)
Hepatitis C virus RNA polymerase and NS5A complex with a SNARE-like protein. (PubMed id 10544080)^{1, 7} Tu H....Lai M.M. (1999)
Promotion of Neurite Extension by Protrudin Requires Its Interaction with Vesicle-associated Membrane Protein-associated Protein. (PubMed id 19289470)^{1, 7} Saita S....Nakayama K.I. (2009)
Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes. (PubMed id 18165232)^{1, 7} Saito S....Kobayashi T. (2008)
Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft. (PubMed id 15016871)^{1, 7} Gao L....Lai M.M. (2004)

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Entrez Gene: 9218	HGNC: 12648	AceView: VAPA	Ensembl:ENSG00000101558	euGenes: HUgn9218
ECgene: VAPA	Kegg: 9218	H-InvDB: VAPA

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