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VAV1 Gene

protein-coding   GIFtS: 68

GC19P006535
vav 1 guanine nucleotide exchange factor
(Previous name: vav 1 oncogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: VAV)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
vav 1 guanine nucleotide exchange factor1 2
VAV2 3 5
vav 1 oncogene1 2
oncogene vav2
vav proto-oncogene2
proto-oncogene vav2

External Ids:    HGNC: 126571   Entrez Gene: 74092   Ensembl: ENSG000001419687   UniProtKB: P154983   

Export aliases for VAV1 gene to outside databases

Previous GC identifers: GC19P006867 GC19P006712 GC19P006723


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VAV1:
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF)
for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and
B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef
proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal
rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
(provided by RefSeq)

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell
differentiation and/or proliferation

Gene Wiki entry for VAV1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VAV1 gene promoter:
         AP-1   NF-kappaB1   C/EBPbeta   STAT1   STAT1alpha   STAT1beta   NF-kappaB   c-Jun   c-Fos   IRF-7A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for VAV1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.2

VAV1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VAV1 gene location

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006535:  view genomic region     (about GC identifiers)

Start:
6,535,196 bp from pter
End:
6,619,802 bp from pter
Size:
84,607 bases
Orientation:
plus strand

1 alternative location:
Chr19+ 6,772,722-6,857,371     
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: VAV_HUMAN, P15498 (See protein sequence)
Recommended Name: Proto-oncogene vav  
Size: 845 amino acids; 98314 Da
Subunit: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK.
Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell
antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates
activity. Interacts with SHB and CLNK (By similarity). Interacts with THEMIS2 (By similarity)
Miscellaneous: 'Vav' stands for the sixth letter of the Hebrew alphabet
Sequence caution: Sequence=CAA34383.1; Type=Frameshift; Positions=322, 355;
PDB structures from and Proteopedia :
2CRH (3D)    2ROR (3D)    3BJI (3D)    3KY9 (3D)    
Secondary accessions: Q15860

Explore the universe of human proteins at neXtProt for VAV1: NX_P15498 

Post-translational modifications:

  • Phosphorylated on tyrosine residues1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005419.2  

    ENSEMBL proteins: 
    ENSP00000302269 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: VAV1
    OriGene Protein Over-expression Lysate: VAV1
    GenScript Custom Purified and Recombinant Proteins Services for VAV1 
    Novus Biologicals Protein for VAV1
    Novus Biologicals Lysate for VAV1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005829 cytosol TAS--
    GO:0005886 plasma membrane TAS--
    About this table

    VAV1 for ontologies           About GeneDecksing



    Antibodies for VAV1: 
    Millipore Mono- and Polyclonal Antibodies for the study of VAV1
    Sigma-Aldrich Antibodies for VAV1
    R&D Systems Antibodies for VAV1 (Vav-1)
    Cell Signaling Technology (CST) Antibodies for VAV1 
    OriGene Antibodies (see all 2): VAV1
    GenScript Custom Superior Antibodies Services for VAV1 
    Novus Biologicals Antibodies for VAV1
    Epitomics antibodies for VAV1

    Assays for VAV1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VAV1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for VAV1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    VAV1 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_type
     IPR001331 GDS_CDC24_CS

    Graphical View of Domain Structure for InterPro Entry P15498

    ProtoNet protein and cluster: P15498

    5/6 Blocks protein families (see all 6):
    IPB000219 DH domain
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
    Domain: The DH domain is involved in interaction with CCPG1 (By similarity)
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 2 SH3 domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
    Function: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell
    differentiation and/or proliferation

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for VAV1
    Sigma-Aldrich shRNA Panels and shRNA for VAV1
    OriGene 29mer shRNA kits in GFP-retroviral vector: VAV1
    OriGene shRNA RFP: VAV1
    OriGene basic RS shRNA: VAV1
    OriGene siRNA: VAV1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VAV1 
    miRNA:Sigma-Aldrich microRNA Mimics for VAV1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VAV1 
    Search SABiosciences for Assays for microRNAs that regulate VAV1

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for VAV1 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: VAV1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VAV1
    OriGene untagged cDNA clones in CMV expression vector: VAV1
    OriGene 3'-UTR clone: VAV1 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: VAV1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for VAV1 

    Genatlas biochemistry entry for VAV1:
    VAV proto-oncogene 1,homolog,expressed in hematopoietic cells,critical transducer of T cell receptor signals to the
    calcium,ERK and FNKB pathways

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 sequence-specific DNA binding transcription factor activity TAS2477241
    GO:0005085 guanyl-nucleotide exchange factor activity TAS--
    GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS--
    GO:0005515 protein binding IPI15558030
    GO:0046872 metal ion binding IEA--
    About this table

    VAV1 for ontologies           About GeneDecksing

    Animal Models: 8 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Vav1):

    digestive/alimentaryembryogenesishematopoietic systemhomeostasis/metabolismimmune system
    lethality-prenatal/perinatalnormalreproductive system

    VAV1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    VAV1 for pathways           About GeneDecksing

    5/20 Millipore Pathways for VAV1 (see all 20)
        Chemotaxis CXCR4 signaling pathway
    Immune response CD16 signaling in NK cells
    Cytoskeleton remodeling Role of PDGFs in cell migration
    Immune response Role of integrins in NK cells cytotoxicity
    Development Prolactin receptor signaling

    5/14 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  VAV1 (see all 14)
        PKCθ Signaling in T Lymphocytes
    Natural Killer Cell Signaling
    CD28 Signaling in T Helper Cells
    T Cell Receptor Signaling
    iCOS-iCOSL Signaling in T Helper Cells

    3 Cell Signaling Technology (CST) Pathways for VAV1
        T Cell Receptor Signaling
    Cytoskeletal Signaling
    B Cell Receptor Signaling

    5/9 Kegg Pathways  (Kegg details for VAV1) (see all 9):
        hsa04062 Chemokine signaling pathway
    hsa04510 Focal adhesion
    hsa04650 Natural killer cell mediated cytotoxicity
    hsa04660 T cell receptor signaling pathway
    hsa04662 B cell receptor signaling pathway

        SABiosciences Pathway-Focused PCR Array including VAV1: PAHS-054A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for VAV1
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VAV1

    5/176 Interacting proteins for VAV1 (ENSP000003022693 P154981, 2) via UniProtKB, MINT, and/or STRING (see all 176)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZNF655Q8N7201, 2EBI-625518,EBI-625509 MINT-50591 MINT-50593 MINT-50590
    GRB2P629931STRING: ENSP00000339007 EBI-625518,EBI-401755
    LCP2Q130942STRING: ENSP00000046794 MINT-8037365 MINT-8029636 MINT-8029651 MINT-8029682 MINT-8037411 MINT-8037350 MINT-8037380 MINT-8029621
    SH3BP2P783142STRING: ENSP00000348685 MINT-4563411 MINT-4549720 MINT-7301369 MINT-7301313 MINT-7301258 MINT-7301359 MINT-8026718 MINT-7301343
    LCKP062392STRING: ENSP00000328213 MINT-8028153 MINT-8025628
    About this table

    5/10 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915 apoptosis EXP12376548
    GO:0007264 small GTPase mediated signal transduction TAS--
    GO:0007596 blood coagulation TAS--
    GO:0008624 induction of apoptosis by extracellular signals EXP12787561
    GO:0023034 intracellular signaling pathway IEA--
    About this table

    VAV1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    VAV1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VAV1
    10/37 Novoseek chemical compound relationships for VAV1 gene (see all 37)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 80.5 346 11331248 (6), 9108397 (6), 7489739 (6), 8809042 (5) (see all 99)
    gdp 75.6 41 8133029 (5), 10664460 (3), 8036025 (2), 8554611 (1) (see all 26)
    gtp 65.5 39 8133029 (5), 8036025 (4), 10664460 (2), 12920122 (1) (see all 26)
    phosphatidylinositol 61 22 9488489 (3), 9190913 (3), 7692230 (2), 11087752 (2) (see all 16)
    phosphoinositide 53.6 20 11331248 (3), 9438848 (3), 9891995 (2), 11994416 (2) (see all 12)
    guanine 50.8 12 12496381 (4), 20147552 (2), 19801678 (1), 9444953 (1) (see all 8)
    guanosine 49.6 5 9671484 (1), 16365460 (1), 9438848 (1), 15514010 (1)
    piceatannol 39.1 1 11331248 (1)
    herbimycin a 36.4 5 8133029 (2), 8809042 (1)
    threonine 33.8 12 8809042 (3), 16493040 (1), 7592945 (1), 15618286 (1) (see all 6)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for VAV1
    Sigma-Aldrich shRNA Panels and shRNA for VAV1
    OriGene 29mer shRNA kits in GFP-retroviral vector: VAV1
    OriGene shRNA RFP: VAV1
    OriGene basic RS shRNA: VAV1
    OriGene siRNA: VAV1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VAV1 
    miRNA: Sigma-Aldrich microRNA Mimics for VAV1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VAV1 
    Search SABiosciences for Assays for microRNAs that regulate VAV1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: VAV1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VAV1
    OriGene untagged cDNA clones in CMV expression vector: VAV1
    OriGene 3'-UTR Clone: VAV1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: VAV1 
    Primers: OriGene genome-wide validated SYBR primer pairs: VAV1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for VAV1: PPH01499A

    REFSEQ mRNAs for VAV1 gene: 

    NM_005428.2  

    Additional cDNA sequence: 

    AK225710.1 AK301128.1 AK313307.1 BC013361.2 X16316.1 X83931.1 

    8 DOTS entries:

    DT.121501823  DT.100021082  DT.200575  DT.97838137  DT.91692965  DT.121501814  DT.40221170  DT.40237954 

    24/56 AceView cDNA sequences (see all 56):

    AW316763 BQ688696 BC013361 BM916915 BU196930 BG284436 BQ958817 BM807186 
    NM_005428 BM829321 AW402629 CD742670 BX374047 BM713574 BE394716 BX362424 
    AA484949 BX101430 BQ685450 BQ051816 AI886795 CA425579 X16316 BQ928720 

    highest scoring ESTs for VAV1:

    X16316 AA628345 AI586976 AI886722 AI886795 AW105491 AW316763 AW575217 BC013361 BE049420 

    Unigene Cluster for VAV1:

    Vav 1 guanine nucleotide exchange factor
    Hs.116237  [show with all ESTs]
    Unigene Representative Sequence: NM_005428


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for VAV1 (see all 6)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                                                                          -                                                                                 
    SP2:              -                                                                                                                                             
    SP3:              -                             -     -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:                                          
    SP5:                                          

    About this scheme

    ECgene alternative splicing isoforms for VAV1
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000304076(uc002mfu.1 uc010xjh.1 uc010dva.1 uc002mfv.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    VAV1 expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching VAV1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    34481_at2, 3 U95-A 1 0.69 1.00 0.99 1.16 AF030227 0.20 1.00 0.72 1
    1919_at2, 3 U95-A 1 0.50 1.00 0.99 0.85 X16316 1.00 1.00 1.00 1
    206219_s_at2, 3 U133-A 1 0.64 1.00 -- -- NM_005428 0.60 1.00 0.82 1
    206219_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    VAV1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    VAV1 gene expression
    VAV1 gene electronic northern expression
    VAV1 gene sage expression
    About these images

    CGAP SAGE TAG: GTTAATTTAT

    SOURCE GeneReport for Unigene cluster: Hs.116237

    Expression variation in blood from EXPOLDB for VAV1

    UniProtKB/Swiss-Prot: VAV_HUMAN, P15498
    Tissue specificity: Widely expressed in hematopoietic cells but not in other cell types

    Primers: OriGene genome-wide validated SYBR primer pairs: VAV1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for VAV1: PPH01499A
        SABiosciences Expression via Pathway-Focused PCR Array including VAV1: PAHS-054A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for VAV1 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    VAV11   -- vav 1 guanine nucleotide exchange factor 91.24(n)
    96.21(a)
    485016  XM_542134.2  XP_542134.2 
    chimpanzee
    (Pan troglodytes)
    VAV11   -- vav 1 guanine nucleotide exchange factor 99.53(n)
    99.74(a)
    455647  XM_512321.2  XP_512321.2 
    rat
    (Rattus norvegicus)
    Vav11   -- vav 1 guanine nucleotide exchange factor 86.04(n)
    93.12(a)
    25156  NM_012759.1  NP_036891.1 
    mouse
    (Mus musculus)
    Vav11 , 5 17 (29.76 cM)5
    vav 1 oncogene1, 5 85.68(n)1
    93.02(a)1
    223241  NM_011691.31  NP_035821.21 
     AF0316515  AK0885865  (see all 29)
    zebrafish
    (Danio rerio)
    Dr.172852   -- Transcribed sequence with weak similarity to protein more 74.2(n)  AL922920.1 
    About this table        Species with no ortholog for VAV1

    ENSEMBL Gene Tree for VAV1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for VAV1 gene
    SPATA132  PREX22  ARHGEF92  VAV32  VAV22  PREX12  

    VAV1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1173 NCBI SNPs in VAV1 are shown (see all 1173)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs1627251,2
    C,F,6819728(-) CCACAA/GCCCCC 1 -- int13Minor allele frequency- G:0.11MN NA 165
    rs1627261,2
    C,A,H,6845470(-) AATTAC/AAAGGT 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1627271,2
    C,H,6845006(-) atcaaA/Catttt 1 -- int17Minor allele frequency- C:0.30NA EA WA 220
    rs1640141,2
    C,F6848572(+) ccatgC/Accagc 1 -- int11Minor allele frequency- A:0.15MN 184
    rs1640151,2
    C,H6821188(+) TGGGCG/AGATCA 1 -- int17Minor allele frequency- A:0.00NA WA 16
    rs1640161,2
    C,F,O,A,6820951(+) CAAGAT/CGCAAA 1 -- int122Minor allele frequency- C:0.31NA NS EA WA 1490
    rs1640171,2
    C,F,A,6820412(+) tagtaT/Cgaatc 1 -- int16Minor allele frequency- C:0.16NS EA WA 488
    rs1640181,2
    C,A,6820208(+) gactgA/Tagtcc 1 -- int13Minor allele frequency- T:0.14NA WA 76
    rs1640191,2
    C,F,A,6819533(+) catgtT/Cgtagt 1 -- int17Minor allele frequency- C:0.31NA EA WA 218
    rs1640201,2
    C,F,A,H,6818628(+) gtggcA/Tgtatt 1 -- int18Minor allele frequency- T:0.41NS EA NA WA 630
    About this table

    HapMap Linkage Disequilibrium images for VAV1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for VAV1
         9 CNVs: 5341 78049 8862 67449 78048 5340 5077 5342 37710
         2 Indels: 78047 89046

    QIAGEN SeqTarget long-range PCR primers for resequencing VAV1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    VAV1 for disorders           About GeneDecksing

    OMIM: 164875

    10/15 Novoseek disease relationships for VAV1 gene (see all 15)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 40 2 10706671 (1), 16493040 (1)
    leukemia t-cell 35.6 4 10849438 (1), 9465094 (1), 11274147 (1), 12496421 (1)
    leukemia 25.6 7 2253939 (1), 8677749 (1), 11684286 (1), 1531699 (1) (see all 6)
    hematopoietic malignancies 21.3 1 8608221 (1)
    myeloproliferative disorders 14.1 2 15878332 (1)
    leukaemia lymphocytic 12 3 16704440 (3)
    tumors 5.09 5 9109498 (1), 17590270 (1), 16685433 (1), 10092764 (1)
    lymphoma 2.21 3 15964830 (1), 9178638 (1), 14586401 (1)
    dysplasia 0 2 8994827 (2)
    myeloma 0 3 9013873 (1), 10673353 (1)
    About this table

    1 PharmGKB disease relationship for VAV1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Human Genome Epidemiology (HuGE) Navigator: VAV1 (3 documents)
    Tumor Gene Database (TGDB): VAV1

    Export disorders and mutations for VAV1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/441 PubMed articles for VAV1 gene, integrated from 7 sources (see all 441):
    (articles sorted by number of sources associating them with VAV1)
    1. Genomic organization and regulation of the vav proto-oncogene. (PubMed id 10760587)1, 2, 7 Denkinger D.J.... Kawahara R.S. (2000)
    2. Mechanism of activation of the vav protooncogene. (PubMed id 2069873)1, 2, 7 Coppola J.... Barbacid M. (1991)
    3. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. (PubMed id 1565462)1, 2, 7 Adams J.M.... Harvey R. (1992)
    4. Loss of the amino-terminal helix-loop-helix domain of the vav proto- oncogene activates its transforming potential. (PubMed id 2005887)1, 2, 7 Katzav S.... Pulido D. (1991)
    5. Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. (PubMed id 15558030)1, 2, 7 Houlard M....Varin-Blank N. (2005)
    6. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. (PubMed id 12393632)1, 2, 7 Nishihara H....Tanaka S. (2002)
    7. Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. (PubMed id 12400014)1, 2, 7 Yabana N. and Shibuya M. (2002)
    8. hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways. (PubMed id 10207103)1, 2, 7 Germani A.... Varin-Blank N. (1999)
    9. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. (PubMed id 9438848)1, 3, 7 Han J....Broek D. (1998)
    10. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7409 HGNC: 12657 AceView: VAV1 Ensembl:ENSG00000141968 euGenes: HUgn7409
    ECgene: VAV1 Kegg: 7409 H-InvDB: VAV1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for VAV1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for VAV1 gene:
    Search GeneIP for patents involving VAV1

    GeneCards and IP:
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