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VCP Gene

protein-coding   GIFtS: 67

GC09M035011
valosin-containing protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for VCP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
valosin-containing protein1 2 3     MGC85602
IBMPFD1 2 5     transitional endoplasmic reticulum ATPase2
p971 2     TERA2
15S Mg(2+)-ATPase p97 subunit2 3     yeast Cdc48p homolog2
TER ATPase2 3     MGC1319972
MGC1480922     

External Ids:    HGNC: 126661   Entrez Gene: 74152   Ensembl: ENSG000001652807   UniProtKB: P550723   

Export aliases for VCP gene to outside databases

Previous GC identifers: GC09M035368 GC09M035225 GC09M035046


Summaries
for VCP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VCP:
The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in
vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural
protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a
number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body
function, and ubiquitin-dependent protein degradation. (provided by RefSeq)

UniProtKB/Swiss-Prot: TERA_HUMAN, P55072
Function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis.
Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the
endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough,
part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent
process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the
export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The
NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a
closed nuclear envelope (By similarity). Regulates E3 ubiquitin-protein ligase activity of RNF19A

Gene Wiki entry for VCP (Valosin-containing protein)

Genomic Views
for VCP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VCP gene promoter:
         GATA-1   CREB   deltaCREB   NF-kappaB   NF-kappaB1   GATA-3   GATA-2   ATF6   AhR   Arnt   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for VCP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for VCP 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13

VCP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VCP gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M035011:  view genomic region     (about GC identifiers)

Start:
 35,011,651 bp from pter
End:
 35,028,327 bp from pter
Size:
 16,677 bases
Orientation:
 minus strand

1 alternative location:
Chr9- 35,056,061-35,073,246     
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  

Proteins
for VCP gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: TERA_HUMAN, P55072 (See protein sequence)
Recommended Name: Transitional endoplasmic reticulum ATPase  
Size: 806 amino acids; 89322 Da
Subunit: Homohexamer. Forms a ring-shaped particle of 12.5 nm diameter, that displays 6-fold radial symmetry. Part of a
ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP
homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi
membrane fusion. Binds to a heterodimer of NPLOC4 and UFD1L, binding to this heterodimer inhibits Golgi-membrane
fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Part of a ternary
complex containing NPLOC4, UFD1L and VCP. Interacts with NSFL1C-like protein p37; the complex has membrane fusion
activity and is required for Golgi and endoplasmic reticulum biogenesis (By similarity). Interacts with SELS/VIMP and
SYVN1, as well as with DERL1, DERL2 and DERL3; which probably transfer misfolded proteins from the ER to VCP.
Interacts with SVIP. Component of a complex required to couple retrotranslocation, ubiquitination and deglycosylation
composed of NGLY1, SAKS1, AMFR, VCP and RAD23B. Directly interacts with UBXD2 and RNF19A. Interacts with CASR.
Interacts with UBXN6, UBE4B and YOD1. Interacts with clathrin. Interacts with RNF103. Interacts with TRIM13 and TRIM21
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Present in the neuronal hyaline inclusion bodies specifically
found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in
neurons from Parkinson disease patients
PDB structures from and Proteopedia :
3EBB (3D)    3HU1 (3D)    3HU2 (3D)    3HU3 (3D)    
Secondary accessions: B2R5T8 Q0V924 Q2TAI5 Q969G7 Q9UCD5

Explore the universe of human proteins at neXtProt for VCP: NX_P55072 

Post-translational modifications:

  • Phosphorylated by tyrosine kinases in response to T-cell antigen receptor activation (By similarity). Phosphorylated
    • upon DNA damage, probably by ATM or ATR1
  • ISGylated1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_009057.1  

    ENSEMBL proteins: 
    ENSP00000392088 ENSP00000399456 ENSP00000351777 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: VCP
    OriGene Protein Over-expression Lysate: VCP
    GenScript Custom Purified and Recombinant Proteins Services for VCP 
    Novus Biologicals Proteins for VCP
    Novus Biologicals Lysate for VCP
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502 proteasome complex IDA9452483
    GO:0005634 nucleus TAS16130169
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    GO:0005783 endoplasmic reticulum IDA15215856
    About this table

    VCP for ontologies           About GeneDecksing



    Antibodies for VCP: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for VCP
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for VCP 
    OriGene Antibodies (see all 2): VCP
    GenScript Custom Superior Antibodies Services for VCP 
    Novus Biologicals Antibodies for VCP
    Epitomics antibodies for VCP

    Assays for VCP: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VCP 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for VCP 

    Protein Domains/
    Families
    for VCP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VCP for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR003959 ATPase_AAA_core
     IPR015415 Vps4_C
     IPR003338 ATPase_AAA_VAT_N
     IPR003960 ATPase_AAA_CS
     IPR004201 Cell_division_protein_CDC48_2

    Graphical View of Domain Structure for InterPro Entry P55072

    ProtoNet protein and cluster: P55072

    2 Blocks protein families:
    IPB003338 AAA ATPase VAT
    IPB003960 AAA-protein subdomain


    UniProtKB/Swiss-Prot: TERA_HUMAN, P55072
    Similarity: Belongs to the AAA ATPase family


    Gene Function
    for VCP gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: TERA_HUMAN, P55072
    Function: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis.
    Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the
    endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough,
    part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent
    process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the
    export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The
    NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a
    closed nuclear envelope (By similarity). Regulates E3 ubiquitin-protein ligase activity of RNF19A

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VCP
    Sigma-Aldrich shRNA Panels and shRNA for VCP
    OriGene 29mer shRNA kits in GFP-retroviral vector: VCP
    OriGene shRNA RFP: VCP
    OriGene basic RS shRNA: VCP
    OriGene siRNA: VCP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VCP 
    miRNA:Sigma-Aldrich microRNA Mimics for VCP
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VCP 
    8 SABiosciences Assays for microRNAs that regulate VCP:
    hsa-miR-1274a hsa-miR-198 hsa-miR-663b hsa-miR-1274b hsa-miR-339-5p hsa-miR-484 hsa-miR-659 hsa-miR-450b-5p

    Gene
    Editing:    		Sigma-Aldrich CompoZr Knockout ZFN for VCP 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: VCP
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VCP
    OriGene untagged cDNA clones in CMV expression vector: VCP
    OriGene 3'-UTR clone: VCP 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for VCP 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for VCP 

    Genatlas biochemistry entry for VCP:
    valosin-containing protein,bound with high affinity to clathrin

    5/12 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 12):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005488 binding ----
    GO:0005515 protein binding IPI15215856
    GO:0005524 ATP binding IEA--
    GO:0008289 lipid binding IEA--
    About this table

    VCP for ontologies           About GeneDecksing

    Animal Models: 2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Vcp):

    lethality-postnatallethality-prenatal/perinatal

    VCP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VCP gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    VCP for pathways           About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  VCP
        NRF2-mediated Oxidative Stress Response
    Purine Metabolism

    1 Kegg Pathway  (Kegg details for VCP):
        hsa04141 Protein processing in endoplasmic reticulum

        SABiosciences Pathway-Focused PCR Arrays including VCP (see all 3): PAHS-089A PAHS-3012A  

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for VCP
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VCP

    5/32 Interacting proteins for VCP (ENSP000003517773 P550721, 2) via UniProtKB, MINT, and/or STRING (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN3P542521, 2STRING: ENSP00000352872 EBI-355164,EBI-946046 MINT-2837662 MINT-2837891 MINT-2837871 MINT-2837641 MINT-2838376 MINT-2837835 MINT-7903973 MINT-2838443 MINT-7904025 MINT-2838413 MINT-2837781 MINT-50296 MINT-2837757 MINT-7904005 MINT-50299
    NSFL1CQ9UNZ21, 2EBI-355164,EBI-721577 MINT-7903948 MINT-7903973
    UBXN6Q9BZV11STRING: ENSP00000301281 EBI-355164,EBI-1993899
    UFD1LQ928902STRING: ENSP00000263202 MINT-7903922 MINT-7903948 MINT-2837686
    CANXP278242STRING: ENSP00000247461 MINT-6176482
    About this table

    5/18 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 18):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281 DNA repair NAS16140914
    GO:0006302 double-strand break repair IDA10855792
    GO:0006511 ubiquitin-dependent protein catabolic process ----
    GO:0006810 transport IEA--
    GO:0006888 ER to Golgi vesicle-mediated transport IEA--
    About this table

    VCP for ontologies           About GeneDecksing



    Drugs & Compounds
    for VCP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    VCP for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VCP
    10/14 Novoseek chemical compound relationships for VCP gene (see all 14)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ptdins(3)p 45.2 1 12650639 (1)
    atp 40.1 29 12504076 (2), 12473691 (2), 12807884 (2), 12747802 (2) (see all 15)
    glutamine 38.3 10 18208395 (2), 17584300 (2), 11859409 (1), 17935506 (1) (see all 7)
    n-ethylmaleimide 33.1 7 7553850 (1), 10402460 (1), 14630332 (1)
    adp 32.4 6 12807884 (2), 12504076 (1), 10715114 (1), 18174159 (1)
    bortezomib 26.2 6 16966435 (4)
    thapsigargin 24.8 4 9405427 (1), 15306153 (1), 19302589 (1), 8672553 (1)
    calcium 8.85 8 9405427 (1), 8648106 (1), 15306153 (1), 8672553 (1)
    tyrosine 0.209 16 11087817 (4), 12509440 (2), 11086075 (1), 17166906 (1) (see all 7)
    lipid 0 1 10205162 (1)
    About this table



    Transcripts
    for VCP gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VCP
    Sigma-Aldrich shRNA Panels and shRNA for VCP
    OriGene 29mer shRNA kits in GFP-retroviral vector: VCP
    OriGene shRNA RFP: VCP
    OriGene basic RS shRNA: VCP
    OriGene siRNA: VCP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VCP 
    miRNA: Sigma-Aldrich microRNA Mimics for VCP
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VCP 
    8 SABiosciences Assays for microRNAs that regulate VCP:
    hsa-miR-1274a hsa-miR-198 hsa-miR-663b hsa-miR-1274b hsa-miR-339-5p hsa-miR-484 hsa-miR-659 hsa-miR-450b-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: VCP
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VCP
    OriGene untagged cDNA clones in CMV expression vector: VCP
    OriGene 3'-UTR Clone: VCP 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for VCP 
    Primers: OriGene genome-wide validated SYBR primer pairs: VCP
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for VCP: PPH19422A

    REFSEQ mRNAs for VCP gene: 

    NM_007126.3  

    Additional cDNA sequence: 

    AF100752.1 AF313486.1 AK307735.1 AK312310.1 AL137377.1 BC007562.1 BC096751.1 BC110913.1 
    BC121794.1 BC122550.1 CR606334.1 Z70768.1 

    24/57 DOTS entries (see all 57):

    DT.92461598  DT.100878430  DT.100061017  DT.100878429  DT.121145904  DT.100878422  DT.92475957  DT.92017855 
    DT.91827473  DT.100878435  DT.100878436  DT.121146017  DT.100840391  DT.100878441  DT.92461619  DT.121145929 
    DT.121145989  DT.100716087  DT.99980507  DT.100039142  DT.121145950  DT.95186348  DT.92461603  DT.100878427 

    24/1276 AceView cDNA sequences (see all 1276):

    BE390023 BQ653128 BX439775 AI040593 BU632341 BM791666 CB242315 BQ899010 
    BM471718 BM667680 BM310118 BQ894739 BQ927608 BM717236 AU125829 BU192233 
    BM818313 BE731292 CA434404 BU683460 AA620399 BQ685642 F03550 AA337700 

    highest scoring ESTs for VCP:

    AA172312 AF100752 AI017298 AL045207 AL520921 AL540610 AL554534 AW732580 AW732949 BE241601 

    Unigene Cluster for VCP:

    Valosin-containing protein
    Hs.529782  [show with all ESTs]
    Unigene Representative Sequence: NM_007126


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for VCP (see all 7)

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
    SP1:                    -     -     -     -                                                                                                                     
    SP2:                                                                                                                                                            
    SP3:              -     -     -     -     -                                                                                                                     
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -                                                                                                               

    ExUns: 16 ^ 17 ^ 18 ^ 19
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for VCP
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448530 ENST00000417448 ENST00000466100 ENST00000358901(uc003zvy.2 uc003zvz.2 uc010mkh.1 uc010mki.1)
    ENST00000479300 ENST00000493886 ENST00000480327

    Expression
    for VCP gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    VCP expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching VCP gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33818_at2, 3 U95-A 1 1.00 1.00 0.84 0.98 AC004472 0.20 0.25 0.23 1
    56348_at2, 3 U95-B 1 0.94 1.00 0.93 1.18 AI017298 0.80 1.00 0.91 1
    44058_at2, 3 U95-B 1 0.50 1.00 0.66 0.83 W60953 0.60 1.00 0.82 1
    208649_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF100752 0.80 1.00 0.91 1
    208648_at2, 3 U133-A 1 0.27 1.00 -- -- W60953 0.60 1.00 0.82 1
    208649_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    208648_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    About this table

    VCP for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    VCP gene expression
    VCP gene electronic northern expression
    VCP gene sage expression
    About these images

    CGAP SAGE TAG: TTGTAAAAGG

    SOURCE GeneReport for Unigene cluster: Hs.529782

    Expression variation in blood from EXPOLDB for VCP

    Primers: OriGene genome-wide validated SYBR primer pairs: VCP
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for VCP: PPH19422A
        SABiosciences Expression via Pathway-Focused PCR Arrays including VCP (see all 3): PAHS-089A PAHS-3012A  


    Orthologs
    for VCP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for VCP gene from 5/27 species (see all 27)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 VCP1   -- valosin-containing protein 93.51(n)
    99.88(a)    		 481590  XM_861098.1  XP_866191.1 
    cow
    (Bos taurus)    		 VCP1   -- valosin-containing protein 92.8(n)
    99.75(a)    		 507345  NM_001034294.1  NP_001029466.1 
    rat
    (Rattus norvegicus)    		 Vcp1   -- valosin-containing protein 91.73(n)
    99.88(a)    		 116643  NM_053864.2  NP_446316.1 
    mouse
    (Mus musculus)    		 Vcp1 , 5 4 (22.95 cM)5
    		 valosin containing protein1, 5 91.4(n)1
    99.88(a)1    		 2695231  NM_009503.31  NP_033529.21 
     AC0052595  AI1952255  (see all 79)
    chicken
    (Gallus gallus)    		 VCP1   -- valosin-containing protein 84(n)
    99.01(a)    		 427410  NM_001044664.1  NP_001038129.1 
    About this table        Species with no ortholog for VCP

    ENSEMBL Gene Tree for VCP (if available)

    Paralogs
    for VCP gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    		  --

    Genomic Variants
    for VCP gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/168 NCBI SNPs in VCP are shown (see all 168)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ----------
    rs4899221,2
    		C,F,A,H35069608(+) ccacaA/Cctggc 1 -- int15Minor allele frequency- C:0.33NA 12
    rs4954171,2
    		C35070204(+) TTCCAA/CAAGTC 1 -- int10--------
    rs5144921,2
    		C,F,O,A,H,35062972(+) TATCTT/CACCAT 1 -- int120Minor allele frequency- C:0.36NA EA NS WA 1146
    rs5623811,2
    		C,F,A,35060746(+) CCCAGA/GTCAAT 1 -- int110Minor allele frequency- G:0.44NS EA NA 586
    rs5954291,2
    		C,F,A,H,35055669(+) tcgtgT/Cagtgg 1 -- ng3113Minor allele frequency- C:0.48NS EA NA WA 640
    rs6076711,2
    		C,F,O,A,H,35062613(+) GAGCAG/AGAGAG 1 -- int117Minor allele frequency- A:0.37NA EA MN NS WA 1162
    rs6229451,2
    		C,F,A,H,35063724(+) GACCAA/GTAGTT 1 -- int114Minor allele frequency- G:0.33NA NS EA WA 784
    rs6233181,2
    		C,F,35063789(+) CTTACT/GTCTAC 1 -- int116Minor allele frequency- G:0.08NS EA NA 1344
    rs6378851,2
    		C,F,O,35064788(+) AATCCA/GAGAAA 1 -- int118Minor allele frequency- G:0.30NS EA NA MN WA 1032
    rs6845621,2
    		C,F,A,H,35060302(+) TATTGT/CAGCTC 1 -- int115Minor allele frequency- C:0.15EA NA NS WA 2286
    About this table

    HapMap Linkage Disequilibrium images for VCP (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for VCP: --

    QIAGEN SeqTarget long-range PCR primers for resequencing VCP 

    Disorders & Mutations
    for VCP gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VCP for disorders           About GeneDecksing

    OMIM: 601023   disorders: 167320  

    UniProtKB/Swiss-Prot: TERA_HUMAN, P55072

  • Defects in VCP are the cause of inclusion body myopathy with early-onset Paget disease and frontotemporal
    • dementia (IBMPFD) [MIM:167320]; also known as muscular dystrophy, limb-girdle, with Paget disease of bone or pagetoid
    amyotrophic lateral sclerosis or pagetoid neuroskeletal syndrome or lower motor neuron degeneration with Paget-like
    bone disease. IBMPFD features adult-onset proximal and distal muscle weakness (clinically resembling limb girdle
    muscular dystrophy), early-onset Paget disease of bone in most cases and premature frontotemporal dementia

    10/30 Novoseek disease relationships for VCP gene (see all 30)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inclusion body myopathy 95.9 56 17935506 (2), 19380227 (2), 17457594 (2), 17889967 (2) (see all 31)
    frontotemporal dementia 89.3 76 17279000 (3), 17457594 (3), 17618707 (3), 15732117 (3) (see all 34)
    myopathy 66.6 25 17763460 (3), 19208399 (2), 16822868 (1), 16199218 (1) (see all 11)
    machado-joseph disease 65.4 5 12351637 (1), 20414249 (1)
    limb girdle 59.9 1 20116073 (1)
    neurodegenerative diseases 55.2 7 18208395 (2), 12759168 (1), 16317258 (1), 18798739 (1) (see all 6)
    motor neuron disease 54.8 2 12759168 (1)
    dementia 51.1 20 19380227 (2), 12759168 (1), 16932700 (1), 16199218 (1) (see all 13)
    neurodegeneration 47.2 5 11859409 (3), 19237541 (1)
    amyotrophic lateral sclerosis 46.7 2 20496755 (1)
    About this table

    GeneTests: VCP
    Inclusion Body Myopathy with Paget Disease of Bone and/or Frontotemporal Dementia

    Locus Specific Mutation Databases (LSDB): VCP
    Human Gene Mutation Database (HGMD): VCP
    Human Genome Epidemiology (HuGE) Navigator: VCP (3 documents)

    Export disorders and mutations for VCP gene to outside databases

    Medical News
    for VCP gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    Publications
    for VCP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/252 PubMed articles for VCP gene, integrated from 7 sources (see all 252):
    (articles sorted by number of sources associating them with VCP)
    1. Ubxd1 is a novel co-factor of the human p97 ATPase. (PubMed id 18656546)1, 2, 7 Madsen L....Hartmann-Petersen R. (2008)
    2. A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. (PubMed id 15362974)1, 2, 7 McNeill H.... Cohen P. (2004)
    3. Physical and functional interaction between dorfin and valosin- containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. (PubMed id 15456787)1, 2, 7 Ishigaki S.... Sobue G. (2004)
    4. Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein. (PubMed id 8413590)1, 2, 7 Pleasure I.T.... Keen J.H. (1993)
    5. Inclusion body myopathy and Paget disease is linked to a novel mutation in the VCP gene. (PubMed id 16247064)1, 2, 7 Haubenberger D.... Zimprich A. (2005)
    6. Mutant valosin-containing protein causes a novel type of frontotemporal dementia. (PubMed id 15732117)1, 2, 7 Schroeder R.... Thal D.R. (2005)
    7. Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP. (PubMed id 8595912)1, 3, 7 Druck T....Keen J.H. (1995)
    8. Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein. (PubMed id 15034582)1, 2, 7 Watts G.D.J.... Kimonis V.E. (2004)
    9. An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments. (PubMed id 7553851)1, 3, 7 Rabouille C....Warren G. (1995)
    10. Ubiquitin ligase Kf-1 is involved in the endoplasmic reticulum-associated degradation pathway. (PubMed id 18675248)1, 2, 7 Maruyama Y....Yamada M. (2008)

    External Searches for VCP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing VCP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7415 HGNC: 12666 AceView: VCP Ensembl:ENSG00000165280 euGenes: HUgn7415
    ECgene: VCP Kegg: 7415 H-InvDB: VCP

    Other Databases showing VCP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VCP gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for VCP Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/VCP

    Intellectual Property
    for VCP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for VCP gene:
    Search GeneIP for patents involving VCP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for VCP gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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     ELISAs and CLIAs for VCP
           

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