Aliases &
Descriptions
for VGF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| VGF nerve growth factor inducible1 2 | | neuro-endocrine specific protein VGF2 | | neurosecretory protein VGF2 | | OTTHUMP000002114822 |
Export aliases for VGF gene to outside databasesPrevious GC identifers: GC07M099289 GC07M100352 GC07M100365 GC07M100401 GC07M100592 GC07M100805 |
Summaries
for VGF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for VGF:
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growthfactor. The structural organization of this gene is similar to that of the rat gene, and both the translated and theuntranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein alsoshares similarities with the secretogranin/chromogranin family, however, its exact function is not known. (provided byRefSeq)
UniProtKB/Swiss-Prot: VGF_HUMAN, O15240Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of thenervous system (By similarity)
|
Genomic Views
for VGF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VGF gene promoter:
STAT3 NRSF form 2 NRSF form 1 deltaCREB CREB Bach2 Arnt STAT1beta STAT1alpha STAT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for VGF
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for VGF  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q22.1 Ensembl cytogenetic band: 7q22.1 HGNC cytogenetic band: 7q22VGF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M095398: view genomic region
(about GC identifiers)
Start:
|
95,398,955 bp from pter |
End:
|
95,401,959 bp from pter |
Size:
|
3,005 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7- 100,805,790-100,808,874 |
RefSeq DNA sequence:- NC_000007.13 NT_007933.15 NT_079596.2
|
Proteins
for VGF gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: VGF_HUMAN, O15240 (See
protein sequence)Recommended Name: Neurosecretory protein VGF precursor Size: 615 amino acids; 67258 Da
Subcellular location: Secreted (By similarity). Cytoplasmic vesicle, secretory vesicle (By similarity). Note=Stored insecretory vesicles and then secreted (By similarity)
Secondary accessions: Q9UDW8Explore the universe of human proteins at neXtProt for VGF: NX_O15240
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003369.2
ENSEMBL proteins: ENSP00000249330 ENSP00000400884 ENSP00000406116
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
VGF for ontologies About GeneDecksing
Antibodies for VGF:
Assays for VGF: |
Protein
Domains/
Families
for VGF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O15240 |
Gene Function
for VGF gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: VGF_HUMAN, O15240Function: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of thenervous system (By similarity)
Genatlas biochemistry entry for VGF:neurotrophin responsive factor,70kDa,expressed in the brain,with a C terminal region encoding posttranslationalyprocessed peptides3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0005184 | neuropeptide hormone activity |
IEA | -- | | GO:0008083 | growth factor activity |
IEA | -- |
About this table
VGF for ontologies About GeneDecksing
Animal Models: 8 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Vgf):
VGF for phenotypes About GeneDecksing
|
Pathways & Interactions
for VGF gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including VGF: PAHS-031A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VGF
5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001541 | ovarian follicle development |
IEA | -- | | GO:0002021 | response to dietary excess |
IEA | -- | | GO:0006091 | generation of precursor metabolites and energy |
IEA | -- | | GO:0009409 | response to cold |
IEA | -- | | GO:0019953 | sexual reproduction |
IEA | -- |
About this table
VGF for ontologies About GeneDecksing
|
Drugs & Compounds
for VGF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
VGF for compounds About GeneDecksing
 Browse Tocris compounds for VGF
5  Novoseek chemical compound relationships for VGF gene
About this table
|
Transcripts
for VGF gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for VGF gene: NM_003378.3 Additional cDNA sequence: AK225839.1 BC006217.2 BC036537.1 BC044212.1 BC063835.1 5 DOTS entries: DT.91892495 DT.97794502 DT.101984471 DT.300806 DT.75102021 24/86 AceView cDNA sequences (see all 86): BC036537 BM142488 BC006217 NM_003378 AI636497 BM052867 CK904657 BM126861 BI963104 BM726762 BM142297 BC044212 BU784525 BM263198 BM911486 BU166517 BM718178 BQ637569 CD108874 BC063835 CK904961 AW207250 BM068821 BE855486
 highest scoring ESTs for VGF:BC036537 BC063835 BI712777 AA224159 AI811072 AI951596 AL523909 AW248251 BI552988 BM023247 Unigene Cluster for VGF: VGF nerve growth factor inducible Hs.587325 [show with all ESTs]Unigene Representative Sequence: BC063835
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000249330(uc003uxx.3) ENST00000445482 ENST00000448792
|
Expression
for VGF gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| VGF expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching VGF gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 59503_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
0.98 |
1.01 |
AI811072 |
0.60 |
1.00 |
0.82 |
1 |
| 32969_r_at2, 3
|
U95-A |
1 |
0.81 |
1.00 |
0.97 |
1.00 |
Y12661 |
0.20 |
1.00 |
0.72 |
1 |
| 205586_x_at2, 3
|
U133-A |
1 |
0.73 |
1.00 |
-- |
-- |
NM_003378 |
0.60 |
1.00 |
0.82 |
1 |
| 205586_x_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
VGF for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CGCCCCGGCC
SOURCE GeneReport for Unigene cluster: Hs.587325
Expression variation in blood from EXPOLDB for VGF UniProtKB/Swiss-Prot: VGF_HUMAN, O15240Tissue specificity: Expressed in brain
SABiosciences Expression via Pathway-Focused PCR Array including VGF: PAHS-031A
|
Orthologs
for VGF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VGF gene from 5 species
About this table Species with no ortholog for VGF
ENSEMBL Gene Tree for VGF (if available) |
Paralogs
for VGF gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for VGF gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for VGF (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for VGF
2 CNVs: 8576 5245 | | QIAGEN SeqTarget long-range PCR primers for resequencing VGF |
|
Disorders & Mutations
for VGF gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VGF for disorders About GeneDecksing
OMIM: 602186
2 Novoseek disease relationships for VGF gene
About this table
Human Genome Epidemiology (HuGE) Navigator: VGF (3 documents)
Export disorders and mutations for VGF gene to outside databases
|
Medical News
for VGF gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for VGF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/69 PubMed articles for VGF gene, integrated from 7 sources (see all 69):
(articles sorted by number of sources associating them with VGF)- Cloning, structural organization analysis and chromosomal assignment of the human gene for neurosecretory protein VGF. (PubMed id 9344675)1, 2, 3, 7 Canu N.... Levi A. (1997)
- The expression of VGF is reduced in leukocytes of dep ressed patients and it is restored by effective antidepressant treatment. (PubMed id 20164831)1, 7 Cattaneo A....Gennarelli M. (2010)
- Molecular cloning and characterization of the human VGF promoter region. (PubMed id 9084409)1, 7 Canu N....Levi A. (1997)
- Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase. (PubMed id 10381005)1, 7 Nagasaki K....Yamaguchi K. (1999)
- Replication of linkage on chromosome 7q22 and association of the regional Reelin gene with working memory in schizophrenia families. (PubMed id 17684500)1, 7 Wedenoja J....Peltonen L. (2008)
- The neuropeptide VGF is reduced in human bipolar post mortem brain and contributes to some of the behavioral and molecular effects of lithium. (PubMed id 20631166)1 Thakker-Varia S....Alder J. (2010)
- Genes related to sex steroids, neural growth, and soc ial-emotional behavior are associated with autistic traits, empathy, and Asperg er syndrome. (PubMed id 19598235)1 Chakrabarti B....Baron-Cohen S. (2009)
- Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis. (PubMed id 18432310)1 Zhao Z....Pasinetti G.M. (2008)
- Peptide products of the neurotrophin-inducible gene vgf are produced in human neuroendocrine cells from early development and increase in hyperplasia and neoplasia. (PubMed id 17440014)1 Rindi G....Ferri G.L. (2007)
- Identification of potential CSF biomarkers in ALS. (PubMed id 16481598)1 Pasinetti G.M....Ho L. (2006)
|
External Searches for VGF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VGF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VGF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VGF gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for VGF gene:
Search GeneIP for patents involving VGF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VGF gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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