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VIL1 Gene

protein-coding GIFtS: 53

GC02P211136

villin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: VIL)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
villin 1¹ ²
D2S1471¹ ²
VIL² ³
OTTHUMP00000207159²
villin-1²

External Ids:	HGNC: 12690¹	Entrez Gene: 7429²	Ensembl: ENSG00000127831⁷	UniProtKB: P09327³

Export aliases for VIL1 gene to outside databases

Previous GC identifers: GC02P217304 GC02P218009 GC02P219247 GC02P219491 GC02P219113 GC02P218992 GC02P219285

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VIL1:

This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant

part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two

mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals

present in the terminal exon. (provided by RefSeq)

UniProtKB/Swiss-Prot: VILI_HUMAN, P09327

Function: Ca(2+)-regulated actin-binding protein

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VIL1 gene promoter:
         SRF   MRF-2   Max1   c-Myc   AhR   LUN-1   GATA-2   GATA-1   GATA-3   ZID
         Other transcription factors

Search SABiosciences Chromatin IP Primers for VIL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35

VIL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VIL1 gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P211136: view genomic region (about GC identifiers)

Start:	211,136,728 bp from pter
End:	211,167,137 bp from pter
Size:	30,410 bases
Orientation:	plus strand

1 alternative location:

Chr2+ 219,283,815-219,318,018

RefSeq DNA sequence:

NC_000002.11 NT_005403.17

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: VILI_HUMAN, P09327 (See protein sequence)

Recommended Name: Villin-1

Size: 827 amino acids; 92695 Da

Subunit: Monomer

Subcellular location: Cytoplasm, cytoskeleton

PDB structure from and Proteopedia :

1UNC (3D)

3FG7 (3D)

Secondary accessions: B2R9A7

Explore the universe of human proteins at neXtProt for VIL1: NX_P09327

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_009058.2

ENSEMBL proteins:

ENSP00000412657 ENSP00000409270 ENSP00000375962 ENSP00000402688 ENSP00000248444 ENSP00000394030

Human Recombinant Proteins

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	Novus Biologicals Lysate for VIL1
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	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18029348
GO:0005856	cytoskeleton	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IDA	18029348

About this table

VIL1 for ontologies About GeneDecksing

Antibodies for VIL1:

	Millipore Mono- and Polyclonal Antibodies for the study of VIL1
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	Novus Biologicals Antibodies for VIL1
	Epitomics antibodies for VIL1

Assays for VIL1:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VIL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VIL1 for domains About GeneDecksing

4 InterPro domains/families:

IPR015627 Villin

IPR007122 Gelsolin

IPR003128 Villin_headpiece

IPR007123 Gelsolin_dom

Graphical View of Domain Structure for InterPro Entry P09327

ProtoNet protein and cluster: P09327

3 Blocks protein families:

IPB003128 Villin headpiece

IPB007122 Gelsolin family signature

IPB007123 Gelsolin region

UniProtKB/Swiss-Prot: VILI_HUMAN, P09327

Domain: Consists of a large core fragment, the N-terminal portion, and a small headpiece, the C-terminal portion. The

headpiece binds F-actin strongly in both the presence and absence of calcium

Similarity: Belongs to the villin/gelsolin family

Similarity: Contains 6 gelsolin-like repeats

Similarity: Contains 1 HP (headpiece) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: VILI_HUMAN, P09327

Function: Ca(2+)-regulated actin-binding protein

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Browse siRNA at Sigma-Aldrich Browse shRNA at Sigma-Aldrich
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): VIL1 OriGene shRNA RFP (see all 2): VIL1 OriGene basic RS shRNA (see all 2): VIL1 OriGene siRNA (see all 2): VIL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VIL1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VIL1
		Search SABiosciences for Assays for microRNAs that regulate VIL1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: VIL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VIL1 OriGene untagged cDNA clones in CMV expression vector (see all 2): VIL1 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for VIL1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for VIL1

Genatlas biochemistry entry for VIL1:

villin 1 (95kDa),component of intestinal brush border cytoskeleton,actin binding protein

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	17353931

About this table

VIL1 for ontologies About GeneDecksing

Animal Models: 2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Vil1):

homeostasis/metabolism

normal

VIL1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for VIL1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for VIL1

2 Interacting proteins for VIL1 (P09327^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPM1B	O75688¹	EBI-1047253,EBI-1047039
TEX11	Q8IYF3²	MINT-66955

About this table

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006461	protein complex assembly	TAS	2846586
GO:0007010	cytoskeleton organization	IEA	--
GO:0051014	actin filament severing	TAS	2846586
GO:0051693	actin filament capping	IEA	--

About this table

VIL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VIL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Browse siRNA at Sigma-Aldrich Browse shRNA at Sigma-Aldrich
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): VIL1 OriGene shRNA RFP (see all 2): VIL1 OriGene basic RS shRNA (see all 2): VIL1 OriGene siRNA (see all 2): VIL1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VIL1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VIL1
		Search SABiosciences for Assays for microRNAs that regulate VIL1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: VIL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VIL1 OriGene untagged cDNA clones in CMV expression vector (see all 2): VIL1 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for VIL1

Primers:		OriGene genome-wide validated SYBR primer pairs: VIL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for VIL1: PPH23365A

REFSEQ mRNAs for VIL1 gene:

NM_007127.2

Additional cDNA sequence:

AK223398.1 AK300965.1 AK313709.1 BC017303.2 X04657.1 X12901.1

8 DOTS entries:

DT.86839119 DT.416827 DT.95360700 DT.92429189 DT.95366402 DT.100788777 DT.40106351 DT.102823347

24/125 AceView cDNA sequences (see all 125):

AI910841 AA887782 AW139085 BC017303 BX483099 AA502293 AA128234 AI304462

AA305307 BQ084461 BM783461 AA876039 N74218 CB133386 BM852368 AW273255

AW444781 CA429743 BX505818 AV697342 BM823478 AI355117 AA527320 AI304550

highest scoring ESTs for VIL1:

X12901 AA527320 AI346370 AI355117 AI433336 AV697342 AW242356 AW269183 AW951431 BF063361

Unigene Cluster for VIL1:

Villin 1

Hs.654595 [show with all ESTs]

Unigene Representative Sequence: NM_007127

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for VIL1

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20
SP1:																									-						-
SP2:
SP3:							-		-		-		-
SP4:
SP5:									-

About this scheme

ECgene alternative splicing isoforms for VIL1
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000454069 ENST00000440053(uc002vic.1) ENST00000392114 ENST00000441734

ENST00000248444(uc002via.2 uc010zke.1 uc002vib.2) ENST00000419986

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

VIL1 expression in normal and diseased human tissues

¹ / ² / ³

8 probe-sets matching VIL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35415_at²^{, 3}	U95-A	1	0.88	1.00	0.93	0.97	X12901	1.00	1.00	1.00	1
61664_r_at²^{, 3}	U95-C	1	0.38	1.00	0.77	1.21	AI859398	0.40	1.00	0.76	1
205506_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_007127	0.60	1.00	0.82	1
228912_at²^{, 3}	U133-B	1	0.27	1.00	--	--	AI436136	0.20	0.50	0.38	1
205506_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554943_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
1554945_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
228912_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

About this table

VIL1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

VIL1 gene electronic northern expression

About these images

CGAP SAGE TAG: CCAACGAGGA

SOURCE GeneReport for Unigene cluster: Hs.654595

Expression variation in blood from EXPOLDB for VIL1

UniProtKB/Swiss-Prot: VILI_HUMAN, P09327

Tissue specificity: Major component of microvilli of intestinal epithelial cells and kidney proximal tubule cells

Primers:		OriGene genome-wide validated SYBR primer pairs: VIL1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for VIL1: PPH23365A

SABiosciences Custom PCR Arrays for VIL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VIL1 gene from 5/12 species (see all 12)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VIL1¹	--	villin 1	87.34(n) 88.39(a)	488522 XM_545642.2 XP_545642.2
chimpanzee (Pan troglodytes)	VIL1¹	--	villin 1	99.27(n) 99.4(a)	470646 XM_526028.2 XP_526028.2
cow (Bos taurus)	VIL1¹	--	villin 1	88.92(n) 89.48(a)	281573 NM_001013591.1 NP_001013609.1
rat (Rattus norvegicus)	Vil1¹	--	villin 1	87.06(n) 89.72(a)	316521 XM_237288.4 XP_237288.3
mouse (Mus musculus)	Vil1^{1 , 5}	1 (38.54 cM)⁵	villin 1^{1, 5}	86.54(n)¹ 89.84(a)¹	22349¹ NM_009509.1¹ NP_033535.1¹ AI663456⁵ AK027908⁵ (see all 12)

About this table Species with no ortholog for VIL1

ENSEMBL Gene Tree for VIL1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VIL1 gene

FLII² SVIL² VILL² AVIL² GSN² SCIN² CAPG²

VIL1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs733925^1,2	C,F,A,	219302466(+)	`TAAAGG/AACTGA`	1	--	int¹		5		NA EA WA	214
rs1000879^1,2	C,F,	219304130(-)	`AACTAC/TATGAA`	1	--	int¹		8		NS EA NA WA	610
rs1563599^1,2	C,A,H,	219302452(+)	`AAACAT/CGTTGG`	1	--	int¹		10		NA WA	204
rs2004348^1,2		219289386(+)	`tttttA/Taaatt`	1	--	int¹		0	--	--	--	--
rs2004349^1,2	C,H	219289643(+)	`ctcccG/Aaaatg`	1	--	int¹		2		WA NA	4
rs2305833^1,2	C,F,A,H,	219305404(+)	`GCTGTC/GCACCA`	1	--	int¹		13		NS EA NA WA	906
rs2384807^1,2	C,F,A	219308144(-)	`CAGGAA/GTTTGA`	1	--	int¹		4		NA	8
rs2384948^1,2	C,F,	219286366(-)	`TGAGAC/TGTGGC`	1	--	int¹		10		NS EA NA WA	430
rs3217689^1,2	C	219299822(+)	`ACTCT-/CTAGTTT`	1	--	int¹		0	--	--	--	--
rs3731866^1,2	C,F,	219288899(+)	`GGGCCC/TGGCTC`	1	--	int¹		8		EA NS WA NA	2050

About this table

HapMap Linkage Disequilibrium images for VIL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VIL1: --

QIAGEN SeqTarget long-range PCR primers for resequencing VIL1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VIL1 for disorders About GeneDecksing

OMIM: 193040

Export disorders and mutations for VIL1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/39 PubMed articles for VIL1 gene, integrated from 7 sources (see all 39):
(articles sorted by number of sources associating them with VIL1)

Sequence of human villin: a large duplicated domain homologous with other actin-severing proteins and a unique small carboxy-terminal domain related to villin specificity. (PubMed id 2846586)^{1, 2, 3} Arpin M.... van de Kerckhove B. (1988)
A human villin cDNA clone to investigate the differentiation of intestinal and kidney cells in vivo and in culture. (PubMed id 3453110)^{1, 2} Pringault E.... Louvard D. (1986)
Villin1, a novel diagnostic marker for cervical adeno carcinoma. (PubMed id 19377296)¹ Nakamura E....Imai T. (2009)
Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. (PubMed id 19371634)¹ Yamamichi N....Iba H. (2009)
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia. (PubMed id 18054784)¹ Khurana S....Mathew S. (2008)
Regulation of cell structure and function by actin-binding proteins: villin's perspective. (PubMed id 18307996)¹ Khurana S. and George S.P. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Janus kinase 3 regulates interleukin 2-induced mucosal wound repair through tyrosine phosphorylation of villin. (PubMed id 17537734)¹ Kumar N....Waters C.M. (2007)
Villin severing activity enhances actin-based motility in vivo. (PubMed id 17182858)¹ Revenu C....Robine S. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7429	HGNC: 12690	AceView: VIL1	Ensembl:ENSG00000127831	euGenes: HUgn7429
ECgene: VIL1	H-InvDB: VIL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for VIL1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for VIL1 gene:
Search GeneIP for patents involving VIL1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VIL1
	SeqTarget long-range PCR primers for resequencing VIL1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VIL1

	GenScript Custom Purified and Recombinant Proteins Services for VIL1		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for VIL1
	GenScript Custom Assay Services for VIL1		GenScript Custom Superior Antibodies Services for VIL1
	GenScript Custom overexpressing Cell Line Services for VIL1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for VIL1 (Villin-1)

	Regulatory tfbs in VIL1 promoter
	Search Chromatin IP Primers for VIL1
	RT² qPCR Primer Assay for VIL1
	GNC Network for VIL1
	Search for Assays for microRNAs that regulate VIL1
	SABiosciences Custom PCR Arrays for VIL1

Search Tocris compounds for VIL1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for VIL1
	Proteins for VIL1
	Lysates for VIL1

Antibodies for VIL1

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for VIL1

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

VIL1 gene at Home site.

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VIL1 Gene

protein-coding GIFtS: 53

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Export list of displayed genes

VIL1 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor VIL1 gene

Summariesfor VIL1 gene

Genomic Viewsfor VIL1 gene

Proteinsfor VIL1 gene

Protein Domains/Familiesfor VIL1 gene

Gene Functionfor VIL1 gene

Pathways & Interactionsfor VIL1 gene

Drugs & Compoundsfor VIL1 gene

Transcriptsfor VIL1 gene

Expression for VIL1 gene

Orthologsfor VIL1 gene

Paralogsfor VIL1 gene

Genomic Variantsfor VIL1 gene

Disorders & Mutationsfor VIL1 gene

Medical Newsfor VIL1 gene

Publicationsfor VIL1 gene

External Searches for VIL1 gene

Genome Databases showing VIL1 gene

Other Databases showing VIL1 gene

Specialized Databases showing VIL1 gene

Intellectual Propertyfor VIL1 gene

Productsfor VIL1 gene

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Aliases &
Descriptions
for VIL1 gene

Summaries
for VIL1 gene

Genomic Views
for VIL1 gene

Proteins
for VIL1 gene

Protein Domains/
Families
for VIL1 gene

Gene Function
for VIL1 gene

Pathways & Interactions
for VIL1 gene

Drugs & Compounds
for VIL1 gene

Transcripts
for VIL1 gene

Expression
for VIL1 gene

Orthologs
for VIL1 gene

Paralogs
for VIL1 gene

Genomic Variants
for VIL1 gene

Disorders & Mutations
for VIL1 gene

Medical News
for VIL1 gene

Publications
for VIL1 gene

Intellectual Property
for VIL1 gene

Products
for VIL1 gene