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VNN1 Gene

protein-coding   GIFtS: 59

GC06M130576
vanin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
vanin 11 2     MGC1169312
Tiff661 2 3     pantetheinase2
Vascular non-inflammatory molecule 12 3     MGC1169332
Pantetheine hydrolase2 3     MGC1169322
HDLCQ82 5     MGC1169302
vannin 12     Vanin-13
vanin-12     EC 3.5.1.923

External Ids:    HGNC: 127051   Entrez Gene: 88762   Ensembl: ENSG000001122997   UniProtKB: O954973   

Export aliases for VNN1 gene to outside databases

Previous GC identifers: GC06M132625 GC06M132849 GC06M132938 GC06M132983 GC06M133044


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VNN1:
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other,
and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been
reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of
the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response.
This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed
by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies
in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.
(provided by RefSeq)

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497
Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling
pantothenic acid (vitamin B5) and releasing cysteamine

Gene Wiki entry for VNN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VNN1 gene promoter:
         PPAR-gamma2   PPAR-gamma1   HNF-1A   FAC1   ISGF-3   MRF-2   HNF-4alpha2   COUP-TF1   HSF1 (long)   HSF2   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for VNN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24   Ensembl cytogenetic band:  6q23.2   HGNC cytogenetic band: 6q23-q24

VNN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VNN1 gene location

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M130576:  view genomic region     (about GC identifiers)

Start:
130,576,916 bp from pter
End:
130,610,106 bp from pter
Size:
33,191 bases
Orientation:
minus strand

1 alternative location:
Chr6- 133,002,729-133,035,188     
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497 (See protein sequence)
Recommended Name: Pantetheinase precursor  
Size: 513 amino acids; 57012 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
Secondary accessions: A8K310 Q4JFW6 Q4VAS7 Q4VAS8 Q4VAS9 Q9UF16 Q9UJF4

Explore the universe of human proteins at neXtProt for VNN1: NX_O95497 

REFSEQ proteins: NP_004657.2  

ENSEMBL proteins: 
ENSP00000356905 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: VNN1
GenScript Custom Purified and Recombinant Proteins Services for VNN1 
Novus Biologicals Proteins for VNN1
Novus Biologicals Lysates for VNN1
Sino Biological Recombinant Protein for VNN1
Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0016021 integral to membrane TAS17145956
GO:0031225 anchored to membrane IEA--
About this table

VNN1 for ontologies           About GeneDecksing



Antibodies for VNN1: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for VNN1
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for VNN1 
Novus Biologicals Antibodies for VNN1
Epitomics antibodies for VNN1

Assays for VNN1: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for VNN1 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for VNN1 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VNN1 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR003010 Ntlse/CNhydtse
 IPR012101 Biotinidase_euk

Graphical View of Domain Structure for InterPro Entry O95497

ProtoNet protein and cluster: O95497

1 Blocks protein family: IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497
Similarity: Belongs to the CN hydrolase family. BTD/VNN subfamily
Similarity: Contains 1 CN hydrolase domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497
Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling
pantothenic acid (vitamin B5) and releasing cysteamine
Catalytic activity: (R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol
Induction: By Th17/Th1 type cytokines, but not by Th2-type
Enzyme Number (IUBMB): EC 3.5.1.92 

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VNN1
Sigma-Aldrich shRNA for VNN1
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): VNN1
OriGene shRNA RFP (see all 2): VNN1
OriGene basic RS shRNA (see all 2): VNN1
OriGene siRNA: VNN1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VNN1 
miRNA:Sigma-Aldrich microRNA Mimics for VNN1
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VNN1 
Search SABiosciences for Assays for microRNAs that regulate VNN1

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: VNN1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VNN1
OriGene untagged cDNA clones in CMV expression vector (see all 2): VNN1
OriGene 3'-UTR clone: VNN1 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for VNN1 
Sino Biological Human cDNA Clone for VNN1

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for VNN1 

Genatlas biochemistry entry for VNN1:
vanin 1,55kDa,expressed in spleen,thymus,peripheral blood lymphocytes,small intestine with homology to
biotinidase,homolog to mouse VNN1,involved in lymphocyte migration in cell adhesion and in the colonization of the
thymus by hematopoietic precursor cells

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds ----
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ----
GO:0017159 pantetheine hydrolase activity IDA11491533
GO:0034235 GPI anchor binding TAS17145956
About this table

VNN1 for ontologies           About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Vnn1):

growth/sizehomeostasis/metabolismimmune system

VNN1 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


VNN1 for pathways           About GeneDecksing

5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  VNN1
    Nitrogen Metabolism
Sphingolipid Metabolism
Arginine and Proline Metabolism
Nicotinate and Nicotinamide Metabolism
Lysine Biosynthesis

1 Kegg Pathway  (Kegg details for VNN1):
    hsa00770 Pantothenate and CoA biosynthesis

    SABiosciences Custom Pathway-Focused PCR Arrays for VNN1 

    Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for VNN1
    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VNN1

2 Interacting proteins for VNN1 (ENSP000003569053) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PANK3ENSP000002392313STRING: ENSP00000239231
PANK4ENSP000003677273STRING: ENSP00000367727
About this table

5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11):

GO IDQualified GO termEvidencePubMed IDs
GO:0002526 acute inflammatory response ISS14966568
GO:0002544 chronic inflammatory response ISS14966568
GO:0006807 nitrogen compound metabolic process IEA--
GO:0006916 anti-apoptosis ISS15282320
GO:0006928 cellular component movement TAS9790769
About this table

VNN1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

VNN1 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VNN1
2 Novoseek chemical compound relationships for VNN1 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pantetheine 94 6 10691189 (3), 8590605 (2), 20018163 (1)
guanidine hydrochloride 47.8 5 10691189 (2), 8590605 (2)
About this table



(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VNN1
Sigma-Aldrich shRNA for VNN1
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): VNN1
OriGene shRNA RFP (see all 2): VNN1
OriGene basic RS shRNA (see all 2): VNN1
OriGene siRNA: VNN1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VNN1 
miRNA: Sigma-Aldrich microRNA Mimics for VNN1
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VNN1 
Search SABiosciences for Assays for microRNAs that regulate VNN1
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: VNN1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VNN1
OriGene untagged cDNA clones in CMV expression vector (see all 2): VNN1
OriGene 3'-UTR Clone: VNN1 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for VNN1 
Primers: OriGene genome-wide validated SYBR primer pairs: VNN1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for VNN1: PPH07829A

REFSEQ mRNAs for VNN1 gene: 

NM_004666.2  

Additional cDNA sequence: AK095461.1 

4 DOTS entries:

DT.407202  DT.91687534  DT.121389503  DT.95091209 

24/47 AceView cDNA sequences (see all 47):

AI762340 AI985105 AI625852 AI253190 AI793191 AA983530 AI700952 AI863511 
AK095461 AI640361 CA415661 AW264804 BU683071 AW614263 AW192400 AA377003 
NM_004666 AI732613 BM146356 U39664 BX329034 AA074379 AI081684 AA166710 

highest scoring ESTs for VNN1:

AJ132099 BE241644 T72215 U39664 AA166710 AA377003 AA904048 AA983530 AI433356 AI478364 

Unigene Clusters for VNN1:

Vanin 1
Hs.12114  [show with all ESTs], Hs.720659  [show with all ESTs]
Unigene Representative Sequences: NM_004666, AK095461


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for VNN1

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1:                                -     -     -                           
SP2:                                                                        
SP3:                                            -                           

About this scheme

ECgene alternative splicing isoforms for VNN1
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000367928(uc003qdn.2 uc003qdo.2)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

VNN1 expression in normal and diseased human tissues

1  / 2  / 3

6 probe-sets matching VNN1 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
37526_at2, 3 U95-A 1 0.44 1.00 0.98 0.78 AJ132099 1.00 1.00 1.00 1
52192_r_at2, 3 U95-C 1 0.31 1.00 0.86 0.56 AI793191 0.40 1.00 0.76 1
52189_s_at2, 3 U95-C 1 0.31 1.00 0.30 1.83 AI793191 0.40 1.00 0.76 1
205844_at2, 3 U133-A 1 0.73 1.00 -- -- NM_004666 0.60 1.00 0.82 1
1558549_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
205844_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
About this table

VNN1 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
VNN1 gene expression
VNN1 gene electronic northern expression
VNN1 gene sage expression
About these images

CGAP SAGE TAG: CCCTTCTGCA TTGAAGCACC

SOURCE GeneReport for Unigene clusters: Hs.12114 Hs.720659

Expression variation in blood from EXPOLDB for VNN1

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497
Tissue specificity: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional
psoriatic skin

Primers: OriGene genome-wide validated SYBR primer pairs: VNN1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for VNN1: PPH07829A
    SABiosciences Custom PCR Arrays for VNN1 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VNN1 gene from 5/7 species (see all 7)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
VNN11   -- vanin 1 84.8(n)
79.73(a)
442973  NM_001003372.1  NP_001003372.1 
chimpanzee
(Pan troglodytes)
VNN11   -- vanin 1 99.74(n)
99.61(a)
746544  XM_001169280.1  XP_001169280.1 
cow
(Bos taurus)
VNN11   -- vanin 1 85.49(n)
83.4(a)
526704  NM_001024556.1  NP_001019727.1 
rat
(Rattus norvegicus)
Vnn11   -- vanin 1 80.55(n)
78.67(a)
29142  NM_001025623.1  NP_001020794.1 
mouse
(Mus musculus)
Vnn11 , 5 10 (11.33 cM)5
vanin 11, 5 79.97(n)1
78(a)1
223611  NM_011704.11  NP_035834.11 
 AI6444835  AJ1320985  (see all 14)
About this table        Species with no ortholog for VNN1

ENSEMBL Gene Tree for VNN1 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for VNN1 gene
BTD2  VNN22  

VNN1 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/483 NCBI SNPs in VNN1 are shown (see all 483)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs7425161,2
C,F,O,A,133014623(+) CTAAAC/TTGGGC 1 -- int132Minor allele frequency- T:0.50NS EA NA WA 2244
rs7527761,2
--133014485(+) AAAAAA/TTTATT 1 -- int1 trp30--------
rs9099751,2
C,F,O,A,133014991(+) TCCACG/ACTTTA 1 -- int124Minor allele frequency- A:0.48NA NS EA WA 1392
rs9099761,2
C,F,133015018(+) TTTGCC/GCCTAC 1 -- int115Minor allele frequency- G:0.05NS EA WA 1080
rs9099771,2
C,F,O,A,H,133015041(+) GTGTGC/TTTATC 1 -- int122Minor allele frequency- T:0.38NA NS EA WA 1386
rs9633481,2
C,F,A,H,133036822(+) AGGCAG/ACAGAG 1 -- ng5112Minor allele frequency- A:0.02MN NS EA NA WA 702
rs9904991,2
C,F,O,133022468(+) CACCCT/ACAAGG 1 -- int119Minor allele frequency- A:0.49NS EA NA WA 1194
rs9905001,2
C,F,A,133022761(+) ccagcA/Gattgt 1 -- int115Minor allele frequency- G:0.49NS EA NA WA 1060
rs10445931,2
C,F,A,133003865(-) CTTTTT/AGTTTT 1 -- ut3119Minor allele frequency- A:0.41NS EA NA WA 962
rs10739541,2
C,F,133026689(-) catggG/Atctgt 1 -- int17Minor allele frequency- A:0.42NA EA WA 348
About this table

HapMap Linkage Disequilibrium images for VNN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for VNN1: --

QIAGEN SeqTarget long-range PCR primers for resequencing VNN1 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VNN1 for disorders           About GeneDecksing

OMIM: 603570

Human Gene Mutation Database (HGMD): VNN1
Human Genome Epidemiology (HuGE) Navigator: VNN1 (2 documents)

Export disorders and mutations for VNN1 gene to outside databases


(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/31 PubMed articles for VNN1 gene, integrated from 7 sources (see all 31):
(articles sorted by number of sources associating them with VNN1)
  1. Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PubMed id 9790769)1, 2, 3, 7 Galland F.... Naquet P. (1998)
  2. Is pantetheinase the actual identity of mouse and human vanin-1 proteins? (PubMed id 10567687)1, 2, 7 Maras B.... Pitari G. (1999)
  3. Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PubMed id 19322213)1, 2, 7 Jansen P.A.M.... Schalkwijk J. (2009)
  4. Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PubMed id 11491533)1, 2, 7 Martin F....Galland F. (2001)
  5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
  6. A proteomic analysis of human bile. (PubMed id 15084671)1, 2 Kristiansen T.Z.... Pandey A. (2004)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  9. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
  10. Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. (PubMed id 17145956)1, 7 Berruyer C....Galland F. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 8876 HGNC: 12705 AceView: VNN1 Ensembl:ENSG00000112299 euGenes: HUgn8876
ECgene: VNN1 Kegg: 8876 H-InvDB: VNN1

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
NIEHS-SNPshttp://egp.gs.washington.edu/data/vnn1/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
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Patent Information for VNN1 gene:
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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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 Regulatory tfbs in VNN1 promoter
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 SABiosciences Custom PCR Arrays for VNN1
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 ELISAs and CLIAs for VNN1
       

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