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VNN1 Gene

protein-coding GIFtS: 59

GC06M130576

vanin 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
vanin 1¹ ²		MGC116931²
Tiff66¹ ² ³		pantetheinase²
Vascular non-inflammatory molecule 1² ³		MGC116933²
Pantetheine hydrolase² ³		MGC116932²
HDLCQ8² ⁵		MGC116930²
vannin 1²		Vanin-1³
vanin-1²		EC 3.5.1.92³

External Ids:	HGNC: 12705¹	Entrez Gene: 8876²	Ensembl: ENSG00000112299⁷	UniProtKB: O95497³

Export aliases for VNN1 gene to outside databases

Previous GC identifers: GC06M132625 GC06M132849 GC06M132938 GC06M132983 GC06M133044

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for VNN1:

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other,

and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been

reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of

the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response.

This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed

by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies

in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24.

(provided by RefSeq)

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497

Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling

pantothenic acid (vitamin B5) and releasing cysteamine

Gene Wiki entry for VNN1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the VNN1 gene promoter:
         PPAR-gamma2   PPAR-gamma1   HNF-1A   FAC1   ISGF-3   MRF-2   HNF-4alpha2   COUP-TF1   HSF1 (long)   HSF2
         Other transcription factors

Search SABiosciences Chromatin IP Primers for VNN1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23-q24 Ensembl cytogenetic band: 6q23.2 HGNC cytogenetic band: 6q23-q24

VNN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VNN1 gene location

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M130576: view genomic region (about GC identifiers)

Start:	130,576,916 bp from pter
End:	130,610,106 bp from pter
Size:	33,191 bases
Orientation:	minus strand

1 alternative location:

Chr6- 133,002,729-133,035,188

RefSeq DNA sequence:

NC_000006.11 NT_025741.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497 (See protein sequence)

Recommended Name: Pantetheinase precursor

Size: 513 amino acids; 57012 Da

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)

Secondary accessions: A8K310 Q4JFW6 Q4VAS7 Q4VAS8 Q4VAS9 Q9UF16 Q9UJF4

Explore the universe of human proteins at neXtProt for VNN1: NX_O95497

REFSEQ proteins: NP_004657.2

ENSEMBL proteins:

ENSP00000356905

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: VNN1
	GenScript Custom Purified and Recombinant Proteins Services for VNN1
	Novus Biologicals Proteins for VNN1
	Novus Biologicals Lysates for VNN1
	Sino Biological Recombinant Protein for VNN1
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	TAS	17145956
GO:0031225	anchored to membrane	IEA	--

About this table

VNN1 for ontologies About GeneDecksing

Antibodies for VNN1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for VNN1
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for VNN1
	Novus Biologicals Antibodies for VNN1
	Epitomics antibodies for VNN1

Assays for VNN1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for VNN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for VNN1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

VNN1 for domains About GeneDecksing

2 InterPro domains/families:

IPR003010 Ntlse/CNhydtse

IPR012101 Biotinidase_euk

Graphical View of Domain Structure for InterPro Entry O95497

ProtoNet protein and cluster: O95497

1 Blocks protein family: IPB003010 Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497

Similarity: Belongs to the CN hydrolase family. BTD/VNN subfamily

Similarity: Contains 1 CN hydrolase domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497

Function: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling

pantothenic acid (vitamin B5) and releasing cysteamine

Catalytic activity: (R)-pantetheine + H(2)O = (R)-pantothenate + 2-aminoethanethiol

Induction: By Th17/Th1 type cytokines, but not by Th2-type

Enzyme Number (IUBMB): EC 3.5.1.92

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VNN1 Sigma-Aldrich shRNA for VNN1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): VNN1 OriGene shRNA RFP (see all 2): VNN1 OriGene basic RS shRNA (see all 2): VNN1 OriGene siRNA: VNN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VNN1

miRNA:		Sigma-Aldrich microRNA Mimics for VNN1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VNN1
		Search SABiosciences for Assays for microRNAs that regulate VNN1

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: VNN1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VNN1 OriGene untagged cDNA clones in CMV expression vector (see all 2): VNN1 OriGene 3'-UTR clone: VNN1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for VNN1
		Sino Biological Human cDNA Clone for VNN1

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for VNN1

Genatlas biochemistry entry for VNN1:

vanin 1,55kDa,expressed in spleen,thymus,peripheral blood lymphocytes,small intestine with homology to

biotinidase,homolog to mouse VNN1,involved in lymphocyte migration in cell adhesion and in the colonization of the

thymus by hematopoietic precursor cells

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	--	--
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	--	--
GO:0017159	pantetheine hydrolase activity	IDA	11491533
GO:0034235	GPI anchor binding	TAS	17145956

About this table

VNN1 for ontologies About GeneDecksing

Animal Models: 3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Vnn1):

growth/size

homeostasis/metabolism

immune system

VNN1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

VNN1 for pathways About GeneDecksing

5 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for VNN1

	Nitrogen Metabolism
	Sphingolipid Metabolism
	Arginine and Proline Metabolism
	Nicotinate and Nicotinamide Metabolism
	Lysine Biosynthesis

1 Kegg Pathway (Kegg details for VNN1):

hsa00770 Pantothenate and CoA biosynthesis

SABiosciences Custom Pathway-Focused PCR Arrays for VNN1

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for VNN1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for VNN1

2 Interacting proteins for VNN1 (ENSP00000356905³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PANK3	ENSP00000239231³	STRING: ENSP00000239231
PANK4	ENSP00000367727³	STRING: ENSP00000367727

About this table

5/11 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 11):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002526	acute inflammatory response	ISS	14966568
GO:0002544	chronic inflammatory response	ISS	14966568
GO:0006807	nitrogen compound metabolic process	IEA	--
GO:0006916	anti-apoptosis	ISS	15282320
GO:0006928	cellular component movement	TAS	9790769

About this table

VNN1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

VNN1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for VNN1
2 Novoseek chemical compound relationships for VNN1 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pantetheine	94	6	10691189 (3), 8590605 (2), 20018163 (1)
guanidine hydrochloride	47.8	5	10691189 (2), 8590605 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VNN1 Sigma-Aldrich shRNA for VNN1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): VNN1 OriGene shRNA RFP (see all 2): VNN1 OriGene basic RS shRNA (see all 2): VNN1 OriGene siRNA: VNN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VNN1

miRNA:		Sigma-Aldrich microRNA Mimics for VNN1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VNN1
		Search SABiosciences for Assays for microRNAs that regulate VNN1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: VNN1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VNN1 OriGene untagged cDNA clones in CMV expression vector (see all 2): VNN1 OriGene 3'-UTR Clone: VNN1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for VNN1

Primers:		OriGene genome-wide validated SYBR primer pairs: VNN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for VNN1: PPH07829A

REFSEQ mRNAs for VNN1 gene:

NM_004666.2

Additional cDNA sequence: AK095461.1

4 DOTS entries:

DT.407202 DT.91687534 DT.121389503 DT.95091209

24/47 AceView cDNA sequences (see all 47):

AI762340 AI985105 AI625852 AI253190 AI793191 AA983530 AI700952 AI863511

AK095461 AI640361 CA415661 AW264804 BU683071 AW614263 AW192400 AA377003

NM_004666 AI732613 BM146356 U39664 BX329034 AA074379 AI081684 AA166710

highest scoring ESTs for VNN1:

AJ132099 BE241644 T72215 U39664 AA166710 AA377003 AA904048 AA983530 AI433356 AI478364

Unigene Clusters for VNN1:

Vanin 1

Hs.12114 [show with all ESTs], Hs.720659 [show with all ESTs]

Unigene Representative Sequences: NM_004666, AK095461

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for VNN1

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9a	·	9b	·	9c
SP1:											-		-		-
SP2:
SP3:															-

About this scheme

ECgene alternative splicing isoforms for VNN1
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000367928(uc003qdn.2 uc003qdo.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

VNN1 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching VNN1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37526_at²^{, 3}	U95-A	1	0.44	1.00	0.98	0.78	AJ132099	1.00	1.00	1.00	1
52192_r_at²^{, 3}	U95-C	1	0.31	1.00	0.86	0.56	AI793191	0.40	1.00	0.76	1
52189_s_at²^{, 3}	U95-C	1	0.31	1.00	0.30	1.83	AI793191	0.40	1.00	0.76	1
205844_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_004666	0.60	1.00	0.82	1
1558549_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205844_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

VNN1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

VNN1 gene electronic northern expression

About these images

CGAP SAGE TAG: CCCTTCTGCA TTGAAGCACC

SOURCE GeneReport for Unigene clusters: Hs.12114 Hs.720659

Expression variation in blood from EXPOLDB for VNN1

UniProtKB/Swiss-Prot: VNN1_HUMAN, O95497

Tissue specificity: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional

psoriatic skin

Primers:		OriGene genome-wide validated SYBR primer pairs: VNN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for VNN1: PPH07829A

SABiosciences Custom PCR Arrays for VNN1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for VNN1 gene from 5/7 species (see all 7)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	VNN1¹	--	vanin 1	84.8(n) 79.73(a)	442973 NM_001003372.1 NP_001003372.1
chimpanzee (Pan troglodytes)	VNN1¹	--	vanin 1	99.74(n) 99.61(a)	746544 XM_001169280.1 XP_001169280.1
cow (Bos taurus)	VNN1¹	--	vanin 1	85.49(n) 83.4(a)	526704 NM_001024556.1 NP_001019727.1
rat (Rattus norvegicus)	Vnn1¹	--	vanin 1	80.55(n) 78.67(a)	29142 NM_001025623.1 NP_001020794.1
mouse (Mus musculus)	Vnn1^{1 , 5}	10 (11.33 cM)⁵	vanin 1^{1, 5}	79.97(n)¹ 78(a)¹	22361¹ NM_011704.1¹ NP_035834.1¹ AI644483⁵ AJ132098⁵ (see all 14)

About this table Species with no ortholog for VNN1

ENSEMBL Gene Tree for VNN1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for VNN1 gene

BTD² VNN2²

VNN1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs742516^1,2	C,F,O,A,	133014623(+)	`CTAAAC/TTGGGC`	1	--	int¹		32		NS EA NA WA	2244
rs752776^1,2	--	133014485(+)	`AAAAAA/TTTATT`	1	--	int¹ trp³		0	--	--	--	--
rs909975^1,2	C,F,O,A,	133014991(+)	`TCCACG/ACTTTA`	1	--	int¹		24		NA NS EA WA	1392
rs909976^1,2	C,F,	133015018(+)	`TTTGCC/GCCTAC`	1	--	int¹		15		NS EA WA	1080
rs909977^1,2	C,F,O,A,H,	133015041(+)	`GTGTGC/TTTATC`	1	--	int¹		22		NA NS EA WA	1386
rs963348^1,2	C,F,A,H,	133036822(+)	`AGGCAG/ACAGAG`	1	--	ng5¹		12		MN NS EA NA WA	702
rs990499^1,2	C,F,O,	133022468(+)	`CACCCT/ACAAGG`	1	--	int¹		19		NS EA NA WA	1194
rs990500^1,2	C,F,A,	133022761(+)	`ccagcA/Gattgt`	1	--	int¹		15		NS EA NA WA	1060
rs1044593^1,2	C,F,A,	133003865(-)	`CTTTTT/AGTTTT`	1	--	ut3¹		19		NS EA NA WA	962
rs1073954^1,2	C,F,	133026689(-)	`catggG/Atctgt`	1	--	int¹		7		NA EA WA	348

About this table

HapMap Linkage Disequilibrium images for VNN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for VNN1: --

QIAGEN SeqTarget long-range PCR primers for resequencing VNN1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

VNN1 for disorders About GeneDecksing

OMIM: 603570

Human Gene Mutation Database (HGMD): VNN1
Human Genome Epidemiology (HuGE) Navigator: VNN1 (2 documents)

Export disorders and mutations for VNN1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/31 PubMed articles for VNN1 gene, integrated from 7 sources (see all 31):
(articles sorted by number of sources associating them with VNN1)

Two human genes related to murine vanin-1 are located on the long arm of human chromosome 6. (PubMed id 9790769)^{1, 2, 3, 7} Galland F.... Naquet P. (1998)
Is pantetheinase the actual identity of mouse and human vanin-1 proteins? (PubMed id 10567687)^{1, 2, 7} Maras B.... Pitari G. (1999)
Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines. (PubMed id 19322213)^{1, 2, 7} Jansen P.A.M.... Schalkwijk J. (2009)
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes. (PubMed id 11491533)^{1, 2, 7} Martin F....Galland F. (2001)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
A proteomic analysis of human bile. (PubMed id 15084671)^{1, 2} Kristiansen T.Z.... Pandey A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)^{1, 2} Mungall A.J.... Beck S. (2003)
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. (PubMed id 17145956)^{1, 7} Berruyer C....Galland F. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8876	HGNC: 12705	AceView: VNN1	Ensembl:ENSG00000112299	euGenes: HUgn8876
ECgene: VNN1	Kegg: 8876	H-InvDB: VNN1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/vnn1/

Intellectual Property for VNN1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for VNN1 gene:
Search GeneIP for patents involving VNN1

GeneCards and IP:
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	Predesigned and custom siRNAs for VNN1		Antibodies for VNN1
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VNN1
	SeqTarget long-range PCR primers for resequencing VNN1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VNN1

	GenScript Custom Purified and Recombinant Proteins Services for VNN1		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for VNN1
	GenScript Custom Assay Services for VNN1		GenScript Custom Superior Antibodies Services for VNN1
	GenScript Custom overexpressing Cell Line Services for VNN1		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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ELISAs and CLIAs for VNN1

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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VNN1 gene at Home site.

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VNN1 Gene

protein-coding GIFtS: 59

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VNN1 Gene

protein-coding GIFtS: 59

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for VNN1 gene

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Orthologs
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Intellectual Property
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