Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS
Search by expression pattern Search by expression pattern


VPS4A Gene

protein-coding   GIFtS: 52

GC16P055223
vacuolar protein sorting 4 homolog A (S. cerevisiae)
(Previous names: vacuolar protein sorting 4A (yeast homolog), vacuolar protein sorting 4A (yeast) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

Aliases &
Descriptions
for VPS4A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
vacuolar protein sorting 4 homolog A (S. cerevisiae)1 2     vacuolar protein sorting 4A (yeast)1
VPS41 2 3 5     vacuolar protein sorting 4A (yeast homolog)1
VPS4-11 2 3     vacuolar sorting protein 42
SKD21 2     vacuolar protein sorting factor 4A2
SKD1A1 2     SKD1-homolog2
FLJ221971 2     vacuolar protein sorting-associated protein 4A2
SKD11 2     Protein SKD23
hVPS42 3     

External Ids:    HGNC: 134881   Entrez Gene: 271832   Ensembl: ENSG000001326127   UniProtKB: Q9UN373   

Export aliases for VPS4A gene to outside databases

Previous GC identifers: GC16P060030 GC16P069723 GC16P069080 GC16P069121 GC16P067902 GC16P069345


Summaries
for VPS4A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for VPS4A:
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular
activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been
identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and
mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4
ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are
involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has
been mapped to chromosome 16; the gene for the other resides on chromosome 18. (provided by RefSeq)

UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37
Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated
ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the
ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs)
that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to
lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and
lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission
events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
Involved in cytokinesis

Gene Wiki entry for VPS4A

Genomic Views
for VPS4A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the VPS4A gene promoter:
         CUTL1   LUN-1   oct-B3   POU2F1   POU2F2C   POU2F2   oct-B2   POU2F2B   POU2F2 (Oct-2.1)   Oct-B1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for VPS4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for VPS4A 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q23.1

VPS4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
VPS4A gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P055223:  view genomic region     (about GC identifiers)

Start:
 55,223,517 bp from pter
End:
 55,237,174 bp from pter
Size:
 13,658 bases
Orientation:
 plus strand

1 alternative location:
Chr16+ 69,345,279-69,358,951     
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  

Proteins
for VPS4A gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37 (See protein sequence)
Recommended Name: Vacuolar protein sorting-associated protein 4A  
Size: 437 amino acids; 48898 Da
Subunit: Proposed to be monomeric or homodimeric in nucleotide-free form and to oligomerize upon binding to ATP to form
two stacked hexameric or heptameric rings with a central pore through which ESCRT-III substrates are translocated in
an ATP-dependent manner (By similarity). Interacts with CHMP1A, CHMP1B, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C
and CHMP6. Interacts with VPS4B; the interaction suggests a heteromeric assembly with VPS4B. Interacts with SPAST.
Interacts with IST1
Subcellular location: Prevacuolar compartment membrane; Peripheral membrane protein. Late endosome membrane; Peripheral
membrane protein (Probable). Note=Membrane-associated in the prevacuolar endosomal compartment. Localizes to the
midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body
Sequence caution: Sequence=AAL75948.1; Type=Frameshift; Positions=123, 133, 157, 163;
PDB structures from and Proteopedia :
1YXR (3D)    2JQ9 (3D)    2K3W (3D)    
Secondary accessions: B2RCB7 Q8TF07 Q9UI03 Q9Y582

Explore the universe of human proteins at neXtProt for VPS4A: NX_Q9UN37 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_037377.1  

    ENSEMBL proteins: 
    ENSP00000254950 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for VPS4A 
    Novus Biologicals Protein for VPS4A
    Novus Biologicals Lysate for VPS4A
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000815colocalizes with ESCRT III complex IDA18606141
    GO:0005737 cytoplasm IDA11563910
    GO:0005769 early endosome IEA--
    GO:0016020 membrane IEA--
    GO:0030496 midbody IDA17853893
    About this table

    VPS4A for ontologies           About GeneDecksing



    Antibodies for VPS4A: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for VPS4A
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for VPS4A 
    Novus Biologicals Antibody for VPS4A
    Browse antibodies at Epitomics

    Assays for VPS4A: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for VPS4A 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for VPS4A 

    Protein Domains/
    Families
    for VPS4A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    VPS4A for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR003959 ATPase_AAA_core
     IPR015415 Vps4_C
     IPR003960 ATPase_AAA_CS
     IPR003593 ATPase_AAA+_core
     IPR007330 MIT

    Graphical View of Domain Structure for InterPro Entry Q9UN37

    ProtoNet protein and cluster: Q9UN37

    2 Blocks protein families:
    IPB003960 AAA-protein subdomain
    IPB007330 MIT


    UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37
    Domain: The MIT domain serves as an adapter for ESCRT-III proteins. It forms an asymmetric three-helix bundle that
    binds amphipathic MIM (MIT interacting motif) helices along the groove between MIT helices 2 and 3 present in a subset
    of ESCRT-III proteins thus establishing the canonical MIM-MIT interaction. In an extended conformation along the
    groove between helices 1 and 3, also binds to a type-2 MIT interacting motif (MIM2)
    Similarity: Belongs to the AAA ATPase family
    Similarity: Contains 1 MIT domain


    Gene Function
    for VPS4A gene

    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37
    Function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated
    ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the
    ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs)
    that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to
    lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and
    lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission
    events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
    Involved in cytokinesis

    Inhib.
    RNA:            		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VPS4A
    Sigma-Aldrich shRNA for VPS4A
    OriGene 29mer shRNA kits in GFP-retroviral vector: VPS4A
    OriGene shRNA RFP: VPS4A
    OriGene basic RS shRNA: VPS4A
    OriGene siRNA: VPS4A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VPS4A 
    miRNA:Sigma-Aldrich microRNA Mimics for VPS4A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VPS4A 
    8/11 SABiosciences Assays for microRNAs that regulate VPS4A (see all 11):
    hsa-miR-1224-3p hsa-miR-15a hsa-miR-497 hsa-miR-1260 hsa-miR-103 hsa-miR-424 hsa-miR-665 hsa-miR-593

    Gene
    Editing:    		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: VPS4A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VPS4A
    OriGene untagged cDNA clones in CMV expression vector: VPS4A
    OriGene 3'-UTR clone: VPS4A 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: VPS4A 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:          		GenScript Custom overexpressing Cell Line Services for VPS4A 

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005515 protein binding IPI11559748
    GO:0005524 ATP binding IEA--
    GO:0008022 protein C-terminus binding IPI17928862
    GO:0017048 Rho GTPase binding IEA--
    About this table

    VPS4A for ontologies           About GeneDecksing

    Animal Models: 1 MGI phenotypic allele for Vps4a (no phenotypes)


    VPS4A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for VPS4A gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    VPS4A for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  VPS4A
        Mechanisms of Viral Exit from Host Cells

    1 Kegg Pathway  (Kegg details for VPS4A):
        hsa04144 Endocytosis

        SABiosciences Pathway-Focused PCR Array including VPS4A: PAHS-051A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for VPS4A
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for VPS4A

    5/6 Interacting proteins for VPS4A (Q9UN372 ENSP000002549503) via UniProtKB, MINT, and/or STRING (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDCD6IPQ8WUM42MINT-6173868
    TUBA1AQ71U362MINT-6173858
    CHMP7ENSP000003244913STRING: ENSP00000324491
    CHMP1AENSP000002534753STRING: ENSP00000253475
    CHMP4BENSP000002174023STRING: ENSP00000217402
    About this table

    5 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910 cytokinesis IDA17853893
    GO:0007049 cell cycle IEA--
    GO:0015031 protein transport IEA--
    GO:0016192 vesicle-mediated transport IDA11563910
    GO:0016197 endosome transport IMP11559748
    About this table

    VPS4A for ontologies           About GeneDecksing



    Drugs & Compounds
    for VPS4A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    VPS4A for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for VPS4A
    1 Novoseek chemical compound relationship for VPS4A gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 19.3 5 16193069 (1), 10637304 (1), 17408385 (1)
    About this table



    Transcripts
    for VPS4A gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section
    Inhib.
    RNA:             		Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for VPS4A
    Sigma-Aldrich shRNA for VPS4A
    OriGene 29mer shRNA kits in GFP-retroviral vector: VPS4A
    OriGene shRNA RFP: VPS4A
    OriGene basic RS shRNA: VPS4A
    OriGene siRNA: VPS4A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VPS4A 
    miRNA: Sigma-Aldrich microRNA Mimics for VPS4A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VPS4A 
    8/11 SABiosciences Assays for microRNAs that regulate VPS4A (see all 11):
    hsa-miR-1224-3p hsa-miR-15a hsa-miR-497 hsa-miR-1260 hsa-miR-103 hsa-miR-424 hsa-miR-665 hsa-miR-593
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: VPS4A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: VPS4A
    OriGene untagged cDNA clones in CMV expression vector: VPS4A
    OriGene 3'-UTR Clone: VPS4A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: VPS4A 
    Primers: OriGene genome-wide validated SYBR primer pairs: VPS4A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for VPS4A: PPH06944A

    REFSEQ mRNAs for VPS4A gene: 

    NM_013245.2  

    Additional cDNA sequence: 

    AF112215.1 AF132747.1 AF155740.1 AF159063.1 AF255952.1 AK000200.1 AK025850.1 AK092372.1 
    AK315026.1 AL133634.1 BC013021.2 BC035121.1 BC047932.1 CR603988.1 

    17 DOTS entries:

    DT.447740  DT.100654733  DT.100791140  DT.101984310  DT.91838215  DT.97839394  DT.120681088  DT.100791136 
    DT.100769230  DT.100791139  DT.100791143  DT.100892940  DT.120681031  DT.120681079  DT.95171111  DT.97839393 
    DT.100791128 

    24/648 AceView cDNA sequences (see all 648):

    BU742039 BX353662 BU849977 BQ679105 BQ009595 AA828210 AF255952 BM554319 
    AA035252 AL133634 BC048215 BQ021302 BM700179 BU581525 AW173040 AI628916 
    AI432600 BE675711 AA243640 BE464460 AI247245 AI588965 AI621122 BU753098 

    highest scoring ESTs for VPS4A:

    AA195247 AI870011 AA148653 AA176600 AA176831 AA176853 AA195432 AA243640 AA243759 AA258378 

    Unigene Cluster for VPS4A:

    Vacuolar protein sorting 4 homolog A (S. cerevisiae)
    Hs.128420  [show with all ESTs]
    Unigene Representative Sequence: AK092372


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000254950(uc002eww.2)

    Expression
    for VPS4A gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    VPS4A expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching VPS4A gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    44787_s_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI870011 1.00 0.90 0.95 1
    45802_at2, 3 U95-B 1 0.94 1.00 1.00 1.00 AA195247 1.00 0.90 0.95 1
    217913_at2, 3 U133-A 1 1.00 1.00 -- -- NM_013245 0.60 0.83 0.73 1
    217913_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    VPS4A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    VPS4A gene expression
    VPS4A gene electronic northern expression
    VPS4A gene sage expression
    About these images

    CGAP SAGE TAG: TCAACAGCCA

    SOURCE GeneReport for Unigene cluster: Hs.128420

    UniProtKB/Swiss-Prot: VPS4A_HUMAN, Q9UN37
    Tissue specificity: Ubiquitously expressed

    Primers: OriGene genome-wide validated SYBR primer pairs: VPS4A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for VPS4A: PPH06944A
        SABiosciences Expression via Pathway-Focused PCR Array including VPS4A: PAHS-051A 


    Orthologs
    for VPS4A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for VPS4A gene from 5/13 species (see all 13)
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 VPS4A1   -- vacuolar protein sorting 4 homolog A (S. cerevisiae) 92.14(n)
    98.86(a)    		 479674  XM_536805.2  XP_536805.2 
    chimpanzee
    (Pan troglodytes)    		 VPS4A1   -- vacuolar protein sorting 4 homolog A (S. cerevisiae) 99.53(n)
    100(a)    		 743569  XM_001147558.1  XP_001147558.1 
    rat
    (Rattus norvegicus)    		 Vps4a1   -- vacuolar protein sorting 4 homolog A (S. cerevisiae) 88.94(n)
    99.08(a)    		 246772  NM_145678.1  NP_663711.1 
    mouse
    (Mus musculus)    		 Vps4a1 , 5 8 (53.53 cM)5
    		 vacuolar protein sorting 4a (yeast)1, 5 89.09(n)1
    99.08(a)1    		 1167331  NM_126165.11  NP_569053.11 
     AA0445055  AI3259715  (see all 16)
    zebrafish
    (Danio rerio)    		 vps4a1   -- vacuolar protein sorting 4a (yeast) 80.23(n)
    90.07(a)    		 767670  NM_001076609.1  NP_001070077.1 
    About this table        Species with no ortholog for VPS4A

    ENSEMBL Gene Tree for VPS4A (if available)

    Paralogs
    for VPS4A gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for VPS4A gene
    VPS4B2  KATNAL12  KATNAL22  KATNA12  

    VPS4A for paralogs           About GeneDecksing



    Genomic Variants
    for VPS4A gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section
    QIAGEN SeqTarget long-range PCR primers for resequencing VPS4A 

    Disorders & Mutations
    for VPS4A gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    VPS4A for disorders           About GeneDecksing

    OMIM: 609982


    Export disorders and mutations for VPS4A gene to outside databases

    Medical News
    for VPS4A gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for VPS4A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/57 PubMed articles for VPS4A gene, integrated from 7 sources (see all 57):
    (articles sorted by number of sources associating them with VPS4A)
    1. Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. (PubMed id 11563910)1, 2, 3, 7 Scheuring S.... Koehrer K. (2001)
    2. Comparative sequence and expression analyses of four mammalian VPS4 genes. (PubMed id 12594041)1, 2, 7 Beyer A....Koehrer K. (2003)
    3. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. (PubMed id 10637304)2, 3, 7 Bishop N. and Woodman P. (2000)
    4. Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. (PubMed id 18606141)1, 2, 7 Kieffer C....Sundquist W.I. (2008)
    5. ESCRT-III recognition by VPS4 ATPases. (PubMed id 17928862)1, 2, 7 Stuchell-Brereton M.D.... Sundquist W.I. (2007)
    6. Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. (PubMed id 17853893)1, 2, 7 Morita E....Sundquist W.I. (2007)
    7. Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. (PubMed id 16174732)1, 2, 7 Scott A....Sundquist W.I. (2005)
    8. ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles. (PubMed id 15075231)1, 2 Sachse M.... Klumperman J. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)

    External Searches for VPS4A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing VPS4A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27183 HGNC: 13488 AceView: SNTB2andVPS4A Ensembl:ENSG00000132612 euGenes: HUgn27183
    ECgene: VPS4A Kegg: 27183 H-InvDB: VPS4A

    Other Databases showing VPS4A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing VPS4A gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for VPS4A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for VPS4A gene:
    Search GeneIP for patents involving VPS4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for VPS4A gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for VPS4A Antibodies for VPS4A
     Super-pooled esiRNAs for VPS4A Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for VPS4A microRNA Mimics for VPS4A
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of VPS4A
     SeqTarget long-range PCR primers for resequencing VPS4A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for VPS4A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of VPS4A
     GenScript Custom Purified and Recombinant Proteins Services for VPS4A GenScript cDNA clones with any tag delivered in your preferred vector for VPS4A
     GenScript Custom Assay Services for VPS4A GenScript Custom Superior Antibodies Services for VPS4A
     GenScript Custom overexpressing Cell Line Services for VPS4A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in VPS4A promoter
     Search Chromatin IP Primers for VPS4A
     RT2 qPCR Primer Assay for VPS4A
     GNC Network for VPS4A
     Assays for microRNAs that regulate VPS4A
     SABiosciences PCR Arrays including VPS4A
     Search Tocris compounds for VPS4A
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for VPS4A
     Proteins for VPS4A
     Lysates for VPS4A
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for VPS4A
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    VPS4A gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4