Aliases &
Descriptions
for VWA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| von Willebrand factor A domain containing 21 2 | | FLJ162131 | | AMACO1 2 3 | | colon cancer diagnostic marker2 | | CCSP-21 2 3 | | von Willebrand factor A domain-containing protein 22 | | NET421 2 | | A-domain containing protein similar to matrilin and collagen2 | | Colon cancer secreted protein 22 3 | | MGC1577552 | | A domain-containing protein similar to matrilin and collagen2 3 | | colon cancer secreted protein-22 | | FLJ458571 | | |
Export aliases for VWA2 gene to outside databasesPrevious GC identifer: GC10P115990 |
Summaries
for VWA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for VWA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the VWA2 gene promoter:
FOXD3 USF1 STAT5A FOXD1 p53 FAC1 Max1 c-Myc Pax-5 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for VWA2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for VWA2  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q25.3 Ensembl cytogenetic band: 10q25.3 HGNC cytogenetic band: 10q25.3VWA2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P109626: view genomic region
(about GC identifiers)
Start:
|
109,626,103 bp from pter |
End:
|
109,677,314 bp from pter |
Size:
|
51,212 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr10+ 115,999,089-116,051,272 |
RefSeq DNA sequence:- NC_000010.10 NT_030059.13
|
Proteins
for VWA2 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: VWA2_HUMAN, Q5GFL6 (See
protein sequence)Recommended Name: von Willebrand factor A domain-containing protein 2 precursor Size: 755 amino acids; 82012 Da
Subunit: Forms monomers and multimers (By similarity)
Subcellular location: Secreted
Miscellaneous: May be used as a serological marker for colon neoplasia
Secondary accessions: A1A5D4 B5MDJ8 Q6ZS39 Q6ZWJ7 Q708C5 Q70UZ8Alternative splicing: 3 isoforms: Q5GFL6-1 Q5GFL6-2 Q5GFL6-3 Explore the universe of human proteins at neXtProt for VWA2: NX_Q5GFL6
Post-translational modifications:
A 55 kDa form is produced by proteolytic cleavage1
REFSEQ proteins: NP_940898.1
ENSEMBL proteins: ENSP00000298715 ENSP00000376708
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
About this table
VWA2 for ontologies About GeneDecksing
Antibodies for VWA2:
Assays for VWA2: |
Protein
Domains/
Families
for VWA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
VWA2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5GFL6ProtoNet protein and cluster: Q5GFL6 UniProtKB/Swiss-Prot: VWA2_HUMAN, Q5GFL6Similarity: Contains 2 EGF-like domainsSimilarity: Contains 3 VWFA domains |
Gene Function
for VWA2 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
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|
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
-- | -- | | GO:0042802 | identical protein binding |
IEA | -- |
About this table
VWA2 for ontologies About GeneDecksing
|
Pathways & Interactions
for VWA2 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for VWA2
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for VWA2
|
Drugs & Compounds
for VWA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for VWA2
|
Transcripts
for VWA2 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for VWA2 gene: NM_198496.1 Additional cDNA sequence: AJ536328.2 AJ616914.1 AK122716.1 AK127756.1 AY572972.1 BC128588.1 BC128589.1 BC143380.1 3 DOTS entries: DT.75140981 DT.101980447 DT.101964591 8 AceView cDNA sequences: BX956774 AW206492 AJ536328 AK127756 NM_198496 AJ616914 AK122716 AW855319
 highest scoring ESTs for VWA2:AW206492 AJ536328 AK122716 AK127756 AW856235 BE143292 BF849816 BX956774 NM_198496 AW855319 Unigene Cluster for VWA2: Von Willebrand factor A domain containing 2 Hs.197741 [show with all ESTs]Unigene Representative Sequence: AY572972
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000298715(uc001lbk.1 uc009xyf.1) ENST00000392982(uc001lbl.1)
|
Expression
for VWA2 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| VWA2 expression in normal and diseased human tissues
1 Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTCACATAAA
SOURCE GeneReport for Unigene cluster: Hs.197741
UniProtKB/Swiss-Prot: VWA2_HUMAN, Q5GFL6Tissue specificity: Expression is generally absent in normal colon and other normal body tissues, but it is induced anaverage of 78-fold in Stage II, III, and IV colon cancers, as well as in colon adenomas and colon cancer cell lines
SABiosciences Custom PCR Arrays for VWA2
|
Orthologs
for VWA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for VWA2 gene from 5/6 species (see all 6)
About this table Species with no ortholog for VWA2
ENSEMBL Gene Tree for VWA2 (if available) |
Paralogs
for VWA2 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for VWA2 gene
- MATN22 VIT2 COCH2 MATN42 MATN32 MATN12
VWA2 for paralogs About GeneDecksing
|
Genomic Variants
for VWA2 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 10 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for VWA2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for VWA2
1 Indel: 101047 | | QIAGEN SeqTarget long-range PCR primers for resequencing VWA2 |
|
Disorders & Mutations
for VWA2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
VWA2 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: VWA2 (1 document)
Export disorders and mutations for VWA2 gene to outside databases
|
Medical News
for VWA2 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for VWA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for VWA2 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with VWA2)- Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney. (PubMed id 14506275)1, 2, 3, 7 Sengle G....Wagener R. (2003)
- Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia. (PubMed id 15580307)1, 2, 3, 7 Xin B.... Markowitz S. (2005)
- O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein). (PubMed id 18434322)1, 7 Gebauer J.M....Wagener R. (2008)
- Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity. (PubMed id 18492952)1 Gao W....Sadler J.E. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family. (PubMed id 15699509)1 Eller E....Fain P.R. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
|
External Searches for VWA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing VWA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing VWA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing VWA2 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for VWA2 gene:
Search GeneIP for patents involving VWA2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for VWA2 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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